ENSG00000006634

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265728 ENSG00000006634 HEK293_OSMI2_2hA HEK293_TMG_2hB DBF4 protein_coding protein_coding 18.81422 5.393383 35.34623 0.3815048 0.8595993 2.71003 8.752236 2.0697020 16.644678 0.3475926 0.8598441 3.001479 0.47465417 0.3870000 0.47046667 0.08346667 5.995665e-01 5.579142e-21 FALSE TRUE
ENST00000486925 ENSG00000006634 HEK293_OSMI2_2hA HEK293_TMG_2hB DBF4 protein_coding retained_intron 18.81422 5.393383 35.34623 0.3815048 0.8595993 2.71003 2.773501 0.0000000 7.546003 0.0000000 0.6190425 9.561479 0.08286250 0.0000000 0.21326667 0.21326667 5.579142e-21 5.579142e-21 FALSE TRUE
MSTRG.30178.3 ENSG00000006634 HEK293_OSMI2_2hA HEK293_TMG_2hB DBF4 protein_coding   18.81422 5.393383 35.34623 0.3815048 0.8595993 2.71003 1.135744 0.9179137 2.225650 0.2539008 0.3752386 1.268632 0.06540417 0.1706333 0.06313333 -0.10750000 8.617343e-02 5.579142e-21 FALSE TRUE
MSTRG.30178.7 ENSG00000006634 HEK293_OSMI2_2hA HEK293_TMG_2hB DBF4 protein_coding   18.81422 5.393383 35.34623 0.3815048 0.8595993 2.71003 4.317013 1.6359306 6.396054 0.2935198 0.3547506 1.960533 0.24103333 0.3024667 0.18106667 -0.12140000 8.871158e-02 5.579142e-21 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000006634 E001 1.1081867 0.2785411905 4.642697e-01 0.604012625 7 87876216 87876277 62 + 0.217 0.422 1.338
ENSG00000006634 E002 1.2554357 0.3633536759 5.762486e-01 0.701732826 7 87876278 87876310 33 + 0.250 0.422 1.077
ENSG00000006634 E003 2.5915135 0.0136331065 6.680143e-01 0.775116704 7 87876311 87876486 176 + 0.469 0.421 -0.252
ENSG00000006634 E004 1.4896696 0.0103442104 1.360568e-01 0.242550649 7 87876487 87876492 6 + 0.361 0.000 -11.230
ENSG00000006634 E005 3.8136267 0.0082043740 2.684621e-01 0.406923537 7 87876493 87876505 13 + 0.600 0.421 -0.868
ENSG00000006634 E006 4.9218994 0.0304617935 9.270603e-01 0.958104246 7 87876506 87876508 3 + 0.641 0.709 0.289
ENSG00000006634 E007 13.6567266 0.0105004076 4.220434e-02 0.095100567 7 87876509 87876511 3 + 1.066 0.829 -0.889
ENSG00000006634 E008 45.7426378 0.0006231425 6.311453e-02 0.131901505 7 87876512 87876533 22 + 1.547 1.471 -0.260
ENSG00000006634 E009 85.2320819 0.0018026807 1.439438e-03 0.005437739 7 87876534 87876582 49 + 1.818 1.693 -0.425
ENSG00000006634 E010 85.8994664 0.0013439257 2.111448e-03 0.007570165 7 87876583 87876599 17 + 1.821 1.707 -0.387
ENSG00000006634 E011 174.7474311 0.0004748094 1.182543e-02 0.033114455 7 87876600 87876778 179 + 2.116 2.083 -0.109
ENSG00000006634 E012 147.3964972 0.0002366502 1.463259e-02 0.039667170 7 87878053 87878133 81 + 2.043 2.006 -0.122
ENSG00000006634 E013 138.9517831 0.0002371222 2.327163e-02 0.058313581 7 87878134 87878225 92 + 2.017 1.985 -0.107
ENSG00000006634 E014 0.1515154 0.0429648382 1.000000e+00   7 87878226 87878557 332 + 0.053 0.000 -7.908
ENSG00000006634 E015 202.5244967 0.0001818001 3.648577e-03 0.012150827 7 87884979 87885158 180 + 2.180 2.143 -0.124
ENSG00000006634 E016 0.4460135 0.0334472315 1.000000e+00 1.000000000 7 87885159 87885183 25 + 0.143 0.000 -9.493
ENSG00000006634 E017 131.9521856 0.0002402462 3.401075e-02 0.079780519 7 87886844 87886894 51 + 1.994 1.966 -0.094
ENSG00000006634 E018 110.1698293 0.0002983093 9.954209e-01 1.000000000 7 87887329 87887398 70 + 1.901 1.962 0.207
ENSG00000006634 E019 0.8921407 0.0131587810 3.438732e-01 0.487926140 7 87887968 87887982 15 + 0.250 0.000 -10.493
ENSG00000006634 E020 128.7861184 0.0007883015 1.483876e-01 0.259482752 7 87887983 87888059 77 + 1.979 1.978 -0.006
ENSG00000006634 E021 1.8831524 0.0072438620 3.177171e-02 0.075409739 7 87896183 87896473 291 + 0.281 0.706 2.169
ENSG00000006634 E022 111.3671448 0.0003205641 2.623168e-02 0.064419491 7 87896474 87896510 37 + 1.924 1.882 -0.141
ENSG00000006634 E023 71.4343511 0.0003653254 1.720999e-02 0.045406673 7 87897294 87897296 3 + 1.741 1.662 -0.268
ENSG00000006634 E024 101.3134672 0.0002679451 2.932640e-01 0.434307967 7 87897297 87897339 43 + 1.875 1.886 0.039
ENSG00000006634 E025 107.5508735 0.0002571377 9.590316e-01 0.978324723 7 87900221 87900281 61 + 1.891 1.954 0.214
ENSG00000006634 E026 130.3808897 0.0002331394 3.772209e-01 0.521565714 7 87900282 87900349 68 + 1.981 2.006 0.084
ENSG00000006634 E027 163.1118243 0.0002910666 6.496240e-01 0.760842459 7 87900764 87900878 115 + 2.075 2.120 0.151
ENSG00000006634 E028 120.7330796 0.0005371984 9.749459e-01 0.988406645 7 87904292 87904416 125 + 1.939 2.000 0.202
ENSG00000006634 E029 724.8885381 0.0122579969 3.785972e-05 0.000219521 7 87907188 87909553 2366 + 2.679 2.918 0.796