ENSG00000006607

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264042 ENSG00000006607 HEK293_OSMI2_2hA HEK293_TMG_2hB FARP2 protein_coding protein_coding 23.97119 14.50067 31.84485 1.712554 1.563767 1.134398 3.2114314 2.8228171 2.7717562 0.1062541 0.1556030 -0.02624147 0.1547875 0.20003333 0.08700000 -0.11303333 0.0001763152 5.963245e-06 FALSE TRUE
ENST00000413432 ENSG00000006607 HEK293_OSMI2_2hA HEK293_TMG_2hB FARP2 protein_coding protein_coding 23.97119 14.50067 31.84485 1.712554 1.563767 1.134398 9.0893770 5.8367854 11.2978537 0.6790331 0.2762835 0.95160958 0.3878083 0.40266667 0.35740000 -0.04526667 0.5817775566 5.963245e-06 FALSE TRUE
ENST00000422951 ENSG00000006607 HEK293_OSMI2_2hA HEK293_TMG_2hB FARP2 protein_coding protein_coding 23.97119 14.50067 31.84485 1.712554 1.563767 1.134398 0.3289241 0.8797047 0.0000000 0.4973393 0.0000000 -6.47525471 0.0211250 0.05760000 0.00000000 -0.05760000 0.0805421698 5.963245e-06   FALSE
ENST00000485051 ENSG00000006607 HEK293_OSMI2_2hA HEK293_TMG_2hB FARP2 protein_coding retained_intron 23.97119 14.50067 31.84485 1.712554 1.563767 1.134398 1.7198451 0.0000000 2.9189798 0.0000000 1.4940482 8.19425442 0.0548500 0.00000000 0.08773333 0.08773333 0.2484833644 5.963245e-06   FALSE
MSTRG.20191.3 ENSG00000006607 HEK293_OSMI2_2hA HEK293_TMG_2hB FARP2 protein_coding   23.97119 14.50067 31.84485 1.712554 1.563767 1.134398 1.8538715 3.6894448 0.3557027 1.0270998 0.1778607 -3.33856559 0.1104833 0.24573333 0.01066667 -0.23506667 0.0012170025 5.963245e-06 FALSE TRUE
MSTRG.20191.5 ENSG00000006607 HEK293_OSMI2_2hA HEK293_TMG_2hB FARP2 protein_coding   23.97119 14.50067 31.84485 1.712554 1.563767 1.134398 4.6040793 0.2546936 8.7334214 0.2546936 1.1724376 5.04580280 0.1497250 0.01866667 0.27193333 0.25326667 0.0186400716 5.963245e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000006607 E001 0.8794552 0.0167848906 2.419171e-02 6.020423e-02 2 241356285 241356288 4 + 0.398 0.000 -12.290
ENSG00000006607 E002 1.0267042 0.0140935536 1.330456e-02 3.662945e-02 2 241356289 241356292 4 + 0.440 0.000 -14.926
ENSG00000006607 E003 1.1782197 0.0104933295 7.286353e-03 2.196689e-02 2 241356293 241356294 2 + 0.477 0.000 -15.162
ENSG00000006607 E004 1.1782197 0.0104933295 7.286353e-03 2.196689e-02 2 241356295 241356295 1 + 0.477 0.000 -15.162
ENSG00000006607 E005 3.5305064 0.0781700678 3.781965e-05 2.193290e-04 2 241356296 241356296 1 + 0.845 0.000 -15.994
ENSG00000006607 E006 8.0836244 0.0023537813 2.216163e-07 2.106389e-06 2 241356297 241356298 2 + 1.123 0.493 -2.535
ENSG00000006607 E007 34.6053577 0.0006446580 1.312364e-10 2.271986e-09 2 241356299 241356388 90 + 1.661 1.320 -1.172
ENSG00000006607 E008 0.0000000       2 241372560 241372677 118 +      
ENSG00000006607 E009 0.4502799 0.0298493114 1.596376e-01 2.746305e-01 2 241372678 241372706 29 + 0.243 0.000 -13.554
ENSG00000006607 E010 0.0000000       2 241372849 241373081 233 +      
ENSG00000006607 E011 0.0000000       2 241373082 241373083 2 +      
ENSG00000006607 E012 56.0569044 0.0004457721 2.008114e-11 3.978574e-10 2 241373084 241373188 105 + 1.844 1.582 -0.887
ENSG00000006607 E013 61.5758584 0.0134004411 5.678556e-04 2.413320e-03 2 241373189 241373290 102 + 1.859 1.676 -0.621
ENSG00000006607 E014 0.0000000       2 241386743 241386802 60 +      
ENSG00000006607 E015 0.3268771 0.0294459650 7.941289e-01   2 241387155 241387312 158 + 0.097 0.153 0.758
ENSG00000006607 E016 4.0578990 0.0162205408 2.524549e-02 6.237728e-02 2 241395443 241395458 16 + 0.796 0.494 -1.310
ENSG00000006607 E017 15.3711188 0.0470830252 8.285008e-03 2.450538e-02 2 241395459 241395984 526 + 1.312 0.998 -1.124
ENSG00000006607 E018 64.0858620 0.0054012242 1.617595e-03 6.016818e-03 2 241403828 241403932 105 + 1.853 1.741 -0.379
ENSG00000006607 E019 47.5174862 0.0038988864 6.895613e-03 2.095294e-02 2 241404799 241404841 43 + 1.716 1.624 -0.314
ENSG00000006607 E020 0.4031496 0.0265446233 1.186324e-01 2.179880e-01 2 241405252 241405255 4 + 0.000 0.267 13.333
ENSG00000006607 E021 1.1448044 0.2419895166 2.892504e-01 4.299269e-01 2 241405256 241405403 148 + 0.176 0.442 1.818
ENSG00000006607 E022 64.4895482 0.0004198511 1.215590e-07 1.215122e-06 2 241407537 241407615 79 + 1.873 1.703 -0.572
ENSG00000006607 E023 0.0000000       2 241410941 241410944 4 +      
ENSG00000006607 E024 0.0000000       2 241410945 241411032 88 +      
ENSG00000006607 E025 75.5066258 0.0003755748 2.959666e-07 2.742076e-06 2 241411033 241411130 98 + 1.934 1.792 -0.478
ENSG00000006607 E026 82.6402074 0.0171489479 2.688134e-04 1.252789e-03 2 241413307 241413421 115 + 1.995 1.777 -0.735
ENSG00000006607 E027 98.3263643 0.0108832560 2.546458e-08 2.907714e-07 2 241417962 241418109 148 + 2.091 1.804 -0.965
ENSG00000006607 E028 93.5604255 0.0038322288 5.349626e-14 1.581324e-12 2 241431679 241431774 96 + 2.073 1.770 -1.019
ENSG00000006607 E029 1.1845624 0.0107213412 7.283870e-03 2.196116e-02 2 241432211 241432451 241 + 0.477 0.000 -15.159
ENSG00000006607 E030 2.0469876 0.1751936134 8.768144e-01 9.249323e-01 2 241432452 241432479 28 + 0.477 0.493 0.082
ENSG00000006607 E031 70.7760932 0.0003660695 6.045882e-16 2.350932e-14 2 241434158 241434229 72 + 1.951 1.661 -0.978
ENSG00000006607 E032 66.3595307 0.0003958260 6.337721e-10 9.760687e-09 2 241434230 241434321 92 + 1.899 1.692 -0.700
ENSG00000006607 E033 51.5445480 0.0004574087 7.716423e-06 5.260735e-05 2 241434962 241435030 69 + 1.773 1.619 -0.522
ENSG00000006607 E034 48.9179134 0.0006354166 1.879625e-05 1.173122e-04 2 241436481 241436538 58 + 1.749 1.597 -0.516
ENSG00000006607 E035 100.8476590 0.0081291090 4.196266e-02 9.465505e-02 2 241441304 241441556 253 + 2.022 1.971 -0.172
ENSG00000006607 E036 696.4719878 0.0012261163 2.618736e-19 1.547447e-17 2 241441557 241444488 2932 + 2.877 2.782 -0.317
ENSG00000006607 E037 818.6317241 0.0189483108 2.762085e-07 2.574888e-06 2 241444489 241447149 2661 + 2.729 3.076 1.153
ENSG00000006607 E038 0.3697384 0.0248662552 1.198764e-01 2.198015e-01 2 241456435 241456746 312 + 0.000 0.266 13.350
ENSG00000006607 E039 30.2286879 0.0052632108 5.051151e-05 2.843676e-04 2 241456747 241456922 176 + 1.302 1.658 1.226
ENSG00000006607 E040 14.6999906 0.0056698863 1.433902e-02 3.900024e-02 2 241462523 241462531 9 + 1.042 1.337 1.050
ENSG00000006607 E041 22.8059201 0.0021563695 1.056063e-04 5.478013e-04 2 241462532 241462612 81 + 1.184 1.542 1.246
ENSG00000006607 E042 9.9567266 0.0019211355 4.283995e-04 1.883651e-03 2 241463335 241463335 1 + 0.796 1.233 1.613
ENSG00000006607 E043 26.7391556 0.0008464293 5.738287e-04 2.436081e-03 2 241463336 241463468 133 + 1.285 1.587 1.043
ENSG00000006607 E044 0.1515154 0.0428851167 6.920163e-01   2 241463469 241463525 57 + 0.097 0.000 -11.868
ENSG00000006607 E045 0.5922303 0.0179301821 5.051992e-01 6.410205e-01 2 241463580 241463898 319 + 0.243 0.153 -0.829
ENSG00000006607 E046 25.2468239 0.0008670415 3.294589e-03 1.113440e-02 2 241463899 241463980 82 + 1.279 1.553 0.945
ENSG00000006607 E047 1.1770712 0.0225343556 4.084726e-01 5.520797e-01 2 241465460 241465673 214 + 0.243 0.430 1.174
ENSG00000006607 E048 9.7258684 0.0758812517 2.989824e-02 7.176420e-02 2 241465674 241466036 363 + 0.779 1.241 1.714
ENSG00000006607 E049 36.4467141 0.0006137550 4.351364e-03 1.412627e-02 2 241468140 241468377 238 + 1.459 1.696 0.808
ENSG00000006607 E050 0.1817044 0.0404993217 3.430950e-01   2 241471312 241471432 121 + 0.000 0.153 12.215
ENSG00000006607 E051 23.6755252 0.0009763584 9.980698e-04 3.951460e-03 2 241475857 241475987 131 + 1.243 1.547 1.051
ENSG00000006607 E052 0.1515154 0.0428851167 6.920163e-01   2 241478113 241478278 166 + 0.097 0.000 -11.868
ENSG00000006607 E053 15.9142483 0.0011904420 1.598163e-02 4.268897e-02 2 241483465 241483533 69 + 1.089 1.362 0.966
ENSG00000006607 E054 0.0000000       2 241484090 241484241 152 +      
ENSG00000006607 E055 18.1724519 0.0019829457 5.712948e-02 1.216865e-01 2 241484242 241484331 90 + 1.169 1.393 0.784
ENSG00000006607 E056 2.0283131 0.0243689867 1.911561e-01 3.151779e-01 2 241488148 241488437 290 + 0.544 0.356 -0.978
ENSG00000006607 E057 12.7948135 0.0059503180 6.125209e-01 7.314437e-01 2 241488438 241489960 1523 + 1.131 1.149 0.066
ENSG00000006607 E058 2.0013715 0.0093620108 1.746193e-01 2.941969e-01 2 241489961 241489961 1 + 0.544 0.356 -0.980
ENSG00000006607 E059 22.1099486 0.0018756380 7.948063e-03 2.364877e-02 2 241489962 241490044 83 + 1.224 1.492 0.930
ENSG00000006607 E060 20.9142153 0.0009274413 7.927742e-03 2.359721e-02 2 241491061 241491179 119 + 1.205 1.474 0.938
ENSG00000006607 E061 26.6212604 0.0007457823 5.577661e-02 1.193062e-01 2 241491516 241491679 164 + 1.343 1.542 0.687
ENSG00000006607 E062 23.3616088 0.0130525750 3.715607e-06 2.725483e-05 2 241492929 241493036 108 + 1.114 1.593 1.670
ENSG00000006607 E063 27.0799516 0.0014026836 5.330623e-11 9.848553e-10 2 241493293 241493392 100 + 1.147 1.673 1.825
ENSG00000006607 E064 22.1102289 0.0008817666 3.316322e-10 5.356986e-09 2 241493393 241493444 52 + 1.061 1.601 1.887
ENSG00000006607 E065 32.7156913 0.0006636925 7.074976e-10 1.080478e-08 2 241494008 241494141 134 + 1.279 1.731 1.553
ENSG00000006607 E066 57.8218082 0.0027328265 7.162738e-15 2.413230e-13 2 241494142 241494476 335 + 1.499 1.979 1.627
ENSG00000006607 E067 39.8695809 0.0008046970 3.192650e-12 7.217491e-11 2 241494477 241494841 365 + 1.353 1.820 1.597