ENSG00000006576

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000275575 ENSG00000006576 HEK293_OSMI2_2hA HEK293_TMG_2hB PHTF2 protein_coding protein_coding 8.705823 1.625903 14.50493 0.1950788 0.5201242 3.149379 0.1114278 0.19131939 0.0000000 0.19131939 0.00000000 -4.3314142 0.05830417 0.12500000 0.00000000 -0.12500000 0.406194440 0.005919194 FALSE TRUE
ENST00000307305 ENSG00000006576 HEK293_OSMI2_2hA HEK293_TMG_2hB PHTF2 protein_coding protein_coding 8.705823 1.625903 14.50493 0.1950788 0.5201242 3.149379 4.4004923 0.83817416 7.4848329 0.13348991 0.31824879 3.1434639 0.45455000 0.53960000 0.51580000 -0.02380000 0.961190342 0.005919194 FALSE TRUE
ENST00000424760 ENSG00000006576 HEK293_OSMI2_2hA HEK293_TMG_2hB PHTF2 protein_coding protein_coding 8.705823 1.625903 14.50493 0.1950788 0.5201242 3.149379 2.2205098 0.20021658 4.0426724 0.07006205 0.19588043 4.2689252 0.19770833 0.11716667 0.27850000 0.16133333 0.005919194 0.005919194 FALSE TRUE
ENST00000470215 ENSG00000006576 HEK293_OSMI2_2hA HEK293_TMG_2hB PHTF2 protein_coding processed_transcript 8.705823 1.625903 14.50493 0.1950788 0.5201242 3.149379 0.3097683 0.19898081 0.3006204 0.19898081 0.01495931 0.5717823 0.09758333 0.09943333 0.02080000 -0.07863333 1.000000000 0.005919194 FALSE TRUE
MSTRG.30133.5 ENSG00000006576 HEK293_OSMI2_2hA HEK293_TMG_2hB PHTF2 protein_coding   8.705823 1.625903 14.50493 0.1950788 0.5201242 3.149379 0.7493126 0.03668019 0.9621253 0.03668019 0.16375206 4.3802601 0.07577500 0.02726667 0.06583333 0.03856667 0.187634144 0.005919194 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000006576 E001 0.4396707 0.0330653861 1.000000e+00 1.000000e+00 7 77798773 77798791 19 + 0.128 0.000 -8.302
ENSG00000006576 E002 1.0224378 0.1554340863 5.353848e-01 6.672349e-01 7 77798792 77798804 13 + 0.255 0.000 -10.847
ENSG00000006576 E003 1.6136240 0.0505387721 2.461207e-01 3.813900e-01 7 77798805 77798812 8 + 0.353 0.000 -11.839
ENSG00000006576 E004 2.0534085 0.0575543096 1.639628e-01 2.803074e-01 7 77798813 77798831 19 + 0.414 0.000 -12.110
ENSG00000006576 E005 8.1188593 0.0255167945 1.911279e-01 3.151453e-01 7 77798832 77798887 56 + 0.834 0.578 -1.064
ENSG00000006576 E006 11.1648173 0.0127087657 6.714038e-01 7.776334e-01 7 77798888 77798900 13 + 0.937 0.874 -0.239
ENSG00000006576 E007 23.7775783 0.0133737844 3.145941e-02 7.480345e-02 7 77798901 77798971 71 + 1.259 0.970 -1.040
ENSG00000006576 E008 0.0000000       7 77840130 77840179 50 +      
ENSG00000006576 E009 0.1472490 0.0443903869 6.928834e-01   7 77840180 77840220 41 + 0.047 0.000 -8.588
ENSG00000006576 E010 37.8158435 0.0005877342 7.922319e-04 3.231547e-03 7 77840221 77840300 80 + 1.455 1.115 -1.193
ENSG00000006576 E011 0.0000000       7 77854733 77854834 102 +      
ENSG00000006576 E012 40.8067788 0.0005839487 1.109786e-02 3.140058e-02 7 77893608 77893664 57 + 1.479 1.247 -0.805
ENSG00000006576 E013 0.1451727 0.0436063666 6.918321e-01   7 77893982 77893993 12 + 0.047 0.000 -8.595
ENSG00000006576 E014 44.8790231 0.0004886601 4.514362e-01 5.923728e-01 7 77900711 77900780 70 + 1.502 1.445 -0.194
ENSG00000006576 E015 66.7476436 0.0045303365 9.917880e-01 9.989541e-01 7 77901762 77901920 159 + 1.662 1.666 0.012
ENSG00000006576 E016 0.4396707 0.0330653861 1.000000e+00 1.000000e+00 7 77906261 77906496 236 + 0.128 0.000 -10.225
ENSG00000006576 E017 2.5926463 0.0057525530 4.655142e-01 6.052112e-01 7 77907854 77907983 130 + 0.452 0.285 -0.980
ENSG00000006576 E018 65.3086718 0.0019820144 3.405221e-01 4.844651e-01 7 77908793 77908934 142 + 1.662 1.601 -0.209
ENSG00000006576 E019 31.3342578 0.0007269263 9.751384e-01 9.885206e-01 7 77908935 77908958 24 + 1.347 1.348 0.003
ENSG00000006576 E020 0.0000000       7 77908959 77910244 1286 +      
ENSG00000006576 E021 69.4459938 0.0004006291 1.120219e-01 2.085126e-01 7 77910245 77910409 165 + 1.692 1.591 -0.344
ENSG00000006576 E022 55.9815280 0.0004921880 8.400040e-01 9.000816e-01 7 77920279 77920424 146 + 1.584 1.601 0.059
ENSG00000006576 E023 36.8970216 0.0005961631 7.983122e-01 8.712718e-01 7 77920425 77920465 41 + 1.406 1.431 0.086
ENSG00000006576 E024 67.0434292 0.0005302736 6.205413e-01 7.376898e-01 7 77922623 77922778 156 + 1.658 1.692 0.117
ENSG00000006576 E025 5.6603863 0.0028896344 6.716616e-02 1.386408e-01 7 77922779 77924151 1373 + 0.635 0.925 1.161
ENSG00000006576 E026 74.8687515 0.0003741860 4.391538e-01 5.809194e-01 7 77929109 77929327 219 + 1.704 1.753 0.165
ENSG00000006576 E027 49.5670779 0.0004754461 4.238378e-01 5.668695e-01 7 77937710 77937838 129 + 1.530 1.591 0.207
ENSG00000006576 E028 4.0212525 0.0038636481 8.449378e-02 1.665896e-01 7 77937839 77938013 175 + 0.517 0.817 1.283
ENSG00000006576 E029 54.9544326 0.0006626994 2.817545e-01 4.216740e-01 7 77940030 77940198 169 + 1.588 1.512 -0.259
ENSG00000006576 E030 35.5791383 0.0028762804 6.903423e-01 7.920547e-01 7 77940199 77940302 104 + 1.400 1.366 -0.117
ENSG00000006576 E031 2.9841546 0.0052420814 2.118586e-01 3.406907e-01 7 77940303 77940459 157 + 0.434 0.673 1.114
ENSG00000006576 E032 32.6015771 0.0007221803 3.988679e-02 9.082251e-02 7 77940528 77940659 132 + 1.380 1.173 -0.724
ENSG00000006576 E033 31.2170752 0.0006695826 7.855573e-03 2.341875e-02 7 77942700 77942786 87 + 1.369 1.084 -1.010
ENSG00000006576 E034 45.8087939 0.0022848062 4.612564e-04 2.011409e-03 7 77949678 77949833 156 + 1.533 1.200 -1.159
ENSG00000006576 E035 37.7430758 0.0005913638 9.870396e-03 2.844672e-02 7 77951617 77951712 96 + 1.447 1.199 -0.863
ENSG00000006576 E036 38.7117336 0.0222582765 5.284780e-01 6.613963e-01 7 77953769 77953894 126 + 1.439 1.369 -0.244
ENSG00000006576 E037 310.0672509 0.0007615702 6.846677e-14 1.991223e-12 7 77954858 77957503 2646 + 2.290 2.483 0.645