ENSG00000006530

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000473884 ENSG00000006530 HEK293_OSMI2_2hA HEK293_TMG_2hB AGK protein_coding nonsense_mediated_decay 48.30122 32.35149 61.15072 2.617716 1.411558 0.9183274 1.747324 0.08599138 3.364959 0.08599138 1.3140968 5.1358211 0.03069583 0.002333333 0.05436667 0.05203333 1.329118e-02 8.321924e-12 FALSE FALSE
ENST00000648690 ENSG00000006530 HEK293_OSMI2_2hA HEK293_TMG_2hB AGK protein_coding protein_coding 48.30122 32.35149 61.15072 2.617716 1.411558 0.9183274 3.549236 2.37598318 5.274119 0.65071289 1.0274381 1.1470790 0.06599167 0.071300000 0.08606667 0.01476667 8.283576e-01 8.321924e-12 FALSE FALSE
ENST00000649286 ENSG00000006530 HEK293_OSMI2_2hA HEK293_TMG_2hB AGK protein_coding protein_coding 48.30122 32.35149 61.15072 2.617716 1.411558 0.9183274 17.802966 17.45890238 20.211250 1.17719886 0.5644601 0.2110832 0.39995833 0.541266667 0.33070000 -0.21056667 8.321924e-12 8.321924e-12 FALSE TRUE
ENST00000650006 ENSG00000006530 HEK293_OSMI2_2hA HEK293_TMG_2hB AGK protein_coding protein_coding 48.30122 32.35149 61.15072 2.617716 1.411558 0.9183274 18.667033 9.66784204 22.752287 0.54293754 0.3760249 1.2338882 0.37640000 0.300633333 0.37273333 0.07210000 1.065025e-01 8.321924e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000006530 E001 2.109909 0.1260382668 8.203063e-01 8.866379e-01 7 141551278 141551394 117 + 0.514 0.460 -0.270
ENSG00000006530 E002 2.515238 0.0058282218 1.313563e-01 2.360366e-01 7 141551395 141551402 8 + 0.643 0.398 -1.181
ENSG00000006530 E003 3.107367 0.0051417350 4.472614e-01 5.886601e-01 7 141551403 141551403 1 + 0.670 0.559 -0.490
ENSG00000006530 E004 3.397712 0.0045174773 2.704937e-01 4.091587e-01 7 141551404 141551406 3 + 0.720 0.559 -0.696
ENSG00000006530 E005 8.447665 0.0019661556 5.817040e-01 7.062062e-01 7 141551407 141551409 3 + 1.002 0.947 -0.204
ENSG00000006530 E006 9.440968 0.0017567447 6.756601e-01 7.808700e-01 7 141551410 141551411 2 + 1.037 0.999 -0.140
ENSG00000006530 E007 14.154583 0.0012663184 2.331744e-01 3.661958e-01 7 141551412 141551417 6 + 1.226 1.126 -0.359
ENSG00000006530 E008 15.366112 0.0011903181 1.491370e-01 2.604999e-01 7 141551418 141551418 1 + 1.268 1.149 -0.421
ENSG00000006530 E009 80.037414 0.0068972287 3.273768e-01 4.708228e-01 7 141551419 141551431 13 + 1.935 1.878 -0.191
ENSG00000006530 E010 86.602448 0.0163373033 7.363202e-01 8.268348e-01 7 141551432 141551433 2 + 1.957 1.925 -0.106
ENSG00000006530 E011 86.930369 0.0163118254 7.745202e-01 8.546845e-01 7 141551434 141551434 1 + 1.957 1.929 -0.094
ENSG00000006530 E012 1.797417 0.0117847458 1.932232e-01 3.178256e-01 7 141551435 141551499 65 + 0.550 0.327 -1.182
ENSG00000006530 E013 1.929251 0.0398108616 3.562201e-01 5.006144e-01 7 141551564 141551618 55 + 0.550 0.395 -0.779
ENSG00000006530 E014 3.334111 0.0064500083 3.550499e-01 4.993933e-01 7 141555252 141555317 66 + 0.696 0.559 -0.596
ENSG00000006530 E015 1.359721 0.0381741934 5.112254e-01 6.462973e-01 7 141555439 141555452 14 + 0.329 0.456 0.715
ENSG00000006530 E016 94.473068 0.0134774183 3.710705e-01 5.154810e-01 7 141555453 141555455 3 + 2.009 1.944 -0.219
ENSG00000006530 E017 115.152471 0.0136274531 2.817586e-01 4.216763e-01 7 141555456 141555463 8 + 2.099 2.023 -0.256
ENSG00000006530 E018 117.544205 0.0134261851 2.961942e-01 4.373995e-01 7 141555464 141555465 2 + 2.107 2.033 -0.246
ENSG00000006530 E019 233.545548 0.0020049985 3.714532e-02 8.575832e-02 7 141555466 141555567 102 + 2.400 2.337 -0.211
ENSG00000006530 E020 0.000000       7 141562107 141562110 4 +      
ENSG00000006530 E021 141.575573 0.0010323539 3.196236e-01 4.627179e-01 7 141593146 141593154 9 + 2.169 2.142 -0.092
ENSG00000006530 E022 192.576236 0.0022578908 4.517619e-01 5.926853e-01 7 141593155 141593185 31 + 2.299 2.277 -0.073
ENSG00000006530 E023 2.151827 0.0223458658 7.344310e-01 8.253806e-01 7 141593305 141594195 891 + 0.514 0.459 -0.271
ENSG00000006530 E024 1.514557 0.0096681985 4.705248e-01 6.097552e-01 7 141594675 141594928 254 + 0.329 0.458 0.727
ENSG00000006530 E025 264.531391 0.0002018545 5.168382e-02 1.121536e-01 7 141596562 141596641 80 + 2.445 2.408 -0.122
ENSG00000006530 E026 15.538418 0.0015529855 2.228165e-10 3.700203e-09 7 141596642 141597340 699 + 1.413 0.795 -2.248
ENSG00000006530 E027 4.806012 0.0046934700 5.606763e-03 1.757027e-02 7 141599002 141599308 307 + 0.907 0.511 -1.654
ENSG00000006530 E028 6.011753 0.3623119086 3.768550e-02 8.673905e-02 7 141600492 141600557 66 + 1.016 0.483 -2.200
ENSG00000006530 E029 142.694490 0.0002234800 6.786341e-01 7.830604e-01 7 141601205 141601213 9 + 2.164 2.158 -0.019
ENSG00000006530 E030 152.828540 0.0002202892 6.487998e-01 7.602577e-01 7 141601214 141601220 7 + 2.193 2.187 -0.022
ENSG00000006530 E031 239.089880 0.0003903767 2.804620e-02 6.810835e-02 7 141601221 141601280 60 + 2.404 2.357 -0.159
ENSG00000006530 E032 308.239692 0.0001857348 2.090439e-01 3.373864e-01 7 141611195 141611287 93 + 2.503 2.483 -0.064
ENSG00000006530 E033 1.902834 0.0505012345 5.393968e-01 6.706633e-01 7 141613952 141614145 194 + 0.513 0.398 -0.591
ENSG00000006530 E034 187.007176 0.0002231097 5.824503e-01 7.068133e-01 7 141614146 141614178 33 + 2.282 2.274 -0.026
ENSG00000006530 E035 1.212573 0.0108930936 7.345627e-01 8.254925e-01 7 141614179 141614582 404 + 0.383 0.327 -0.334
ENSG00000006530 E036 294.576546 0.0001857057 5.868487e-01 7.103070e-01 7 141615471 141615565 95 + 2.477 2.472 -0.016
ENSG00000006530 E037 2.630120 0.0058938764 2.401234e-01 3.742917e-01 7 141615566 141615569 4 + 0.643 0.458 -0.860
ENSG00000006530 E038 4.363835 0.0595701429 2.035473e-01 3.306512e-01 7 141615570 141615873 304 + 0.823 0.634 -0.777
ENSG00000006530 E039 2.661241 0.1325259027 3.605568e-01 5.048776e-01 7 141615874 141616024 151 + 0.643 0.500 -0.648
ENSG00000006530 E040 2.220730 0.0064969583 1.555127e-03 5.814025e-03 7 141616163 141616368 206 + 0.696 0.138 -3.404
ENSG00000006530 E041 301.355950 0.0012630282 6.230017e-02 1.305148e-01 7 141621732 141621801 70 + 2.503 2.461 -0.142
ENSG00000006530 E042 3.509791 0.0667494992 1.001721e-02 2.880542e-02 7 141624180 141624296 117 + 0.823 0.327 -2.330
ENSG00000006530 E043 14.571606 0.0093411530 3.964606e-09 5.262390e-08 7 141624297 141625283 987 + 1.394 0.740 -2.404
ENSG00000006530 E044 3.327867 0.0059754997 7.673737e-01 8.496198e-01 7 141625375 141625585 211 + 0.643 0.602 -0.179
ENSG00000006530 E045 303.117220 0.0024926604 2.699780e-01 4.085473e-01 7 141633901 141633980 80 + 2.499 2.471 -0.093
ENSG00000006530 E046 271.733625 0.0011585818 7.189810e-01 8.139595e-01 7 141636960 141637017 58 + 2.440 2.437 -0.011
ENSG00000006530 E047 401.244840 0.0001525588 6.385472e-01 7.521706e-01 7 141641248 141641398 151 + 2.601 2.616 0.050
ENSG00000006530 E048 335.397921 0.0003308517 5.972325e-01 7.190269e-01 7 141641811 141641908 98 + 2.522 2.539 0.057
ENSG00000006530 E049 0.000000       7 141649131 141649262 132 +      
ENSG00000006530 E050 267.561591 0.0014653136 7.212336e-01 8.156799e-01 7 141649263 141649333 71 + 2.424 2.439 0.051
ENSG00000006530 E051 12.925112 0.0356341066 2.244953e-02 5.661453e-02 7 141649711 141650472 762 + 1.261 0.951 -1.119
ENSG00000006530 E052 5.569179 0.1858799262 7.477904e-01 8.352100e-01 7 141650473 141650599 127 + 0.823 0.788 -0.139
ENSG00000006530 E053 132.784600 0.0016175022 1.356853e-01 2.420768e-01 7 141651525 141651527 3 + 2.100 2.160 0.202
ENSG00000006530 E054 301.843519 0.0002299836 1.196351e-01 2.194475e-01 7 141651528 141651609 82 + 2.466 2.505 0.130
ENSG00000006530 E055 31.904839 0.0195367401 1.095548e-04 5.659740e-04 7 141651610 141652786 1177 + 1.655 1.292 -1.250
ENSG00000006530 E056 1352.253793 0.0006719773 3.358367e-17 1.531246e-15 7 141652787 141655497 2711 + 3.073 3.191 0.391
ENSG00000006530 E057 2.448238 0.1878228644 4.167906e-01 5.601688e-01 7 141664494 141664664 171 + 0.432 0.659 1.062