ENSG00000006453

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000005260 ENSG00000006453 HEK293_OSMI2_2hA HEK293_TMG_2hB BAIAP2L1 protein_coding protein_coding 15.44825 17.43914 17.40859 0.2645346 0.3309196 -0.002527735 14.086958 17.29649 13.738414 0.1860077 0.2383643 -0.3320479 0.9144708 0.9919333 0.7898333 -0.2021 1.939340e-08 1.023443e-31 FALSE TRUE
ENST00000462558 ENSG00000006453 HEK293_OSMI2_2hA HEK293_TMG_2hB BAIAP2L1 protein_coding processed_transcript 15.44825 17.43914 17.40859 0.2645346 0.3309196 -0.002527735 1.221189 0.00000 3.455996 0.0000000 0.3694864 8.4371264 0.0763250 0.0000000 0.1980000 0.1980 1.023443e-31 1.023443e-31 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000006453 E001 741.8953577 0.0011337634 1.020431e-09 1.511356e-08 7 98291650 98293596 1947 - 2.786 2.905 0.397
ENSG00000006453 E002 156.0973081 0.0077521944 6.569651e-02 1.362035e-01 7 98294074 98294111 38 - 2.121 2.226 0.351
ENSG00000006453 E003 255.1933999 0.0015073547 2.876316e-02 6.952948e-02 7 98304196 98304365 170 - 2.354 2.428 0.247
ENSG00000006453 E004 112.6532830 0.0004292027 5.470967e-01 6.771803e-01 7 98304366 98304376 11 - 2.054 2.046 -0.028
ENSG00000006453 E005 158.4244571 0.0002359731 7.576736e-01 8.424094e-01 7 98306439 98306516 78 - 2.182 2.203 0.069
ENSG00000006453 E006 0.0000000       7 98306517 98306957 441 -      
ENSG00000006453 E007 243.2258263 0.0002590308 7.698782e-01 8.514184e-01 7 98307689 98307896 208 - 2.375 2.380 0.017
ENSG00000006453 E008 1.2327474 0.2666374652 2.253321e-01 3.568078e-01 7 98308304 98308382 79 - 0.506 0.197 -1.947
ENSG00000006453 E009 190.3284304 0.0002255908 5.072609e-01 6.428418e-01 7 98310445 98310592 148 - 2.252 2.282 0.097
ENSG00000006453 E010 175.4406845 0.0002624681 1.283996e-01 2.319242e-01 7 98312097 98312264 168 - 2.204 2.257 0.179
ENSG00000006453 E011 173.5058779 0.0032529735 9.941351e-01 1.000000e+00 7 98315460 98315612 153 - 2.224 2.236 0.038
ENSG00000006453 E012 108.4199166 0.0029655836 2.896023e-01 4.303048e-01 7 98317219 98317236 18 - 2.049 2.014 -0.115
ENSG00000006453 E013 195.9753009 0.0082502583 1.480946e-01 2.590938e-01 7 98317237 98317356 120 - 2.320 2.258 -0.205
ENSG00000006453 E014 152.8087789 0.0005773926 3.681303e-03 1.224241e-02 7 98320058 98320129 72 - 2.219 2.144 -0.253
ENSG00000006453 E015 126.1813234 0.0028186431 8.273003e-02 1.638248e-01 7 98320237 98320298 62 - 2.126 2.068 -0.195
ENSG00000006453 E016 0.6652806 0.0186983304 4.511341e-01 5.921240e-01 7 98355041 98355041 1 - 0.135 0.271 1.245
ENSG00000006453 E017 121.8946243 0.0016946628 1.429564e-02 3.889900e-02 7 98355042 98355128 87 - 2.124 2.045 -0.265
ENSG00000006453 E018 0.5149111 0.0203451932 7.272579e-01 8.200611e-01 7 98355129 98355426 298 - 0.135 0.198 0.662
ENSG00000006453 E019 88.2871417 0.0003743345 1.625844e-14 5.200258e-13 7 98362357 98362432 76 - 2.085 1.809 -0.929
ENSG00000006453 E020 0.9619818 0.0256118950 7.524579e-01 8.386334e-01 7 98399981 98400337 357 - 0.322 0.271 -0.340
ENSG00000006453 E021 92.1842156 0.0004967065 5.626649e-22 4.469400e-20 7 98400802 98401090 289 - 2.135 1.787 -1.169