ENSG00000006432

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000553414 ENSG00000006432 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K9 protein_coding protein_coding 3.136694 3.549959 2.73778 0.3194663 0.04227942 -0.373594 0.1122595 0.01517624 0.1556578 0.008179129 0.05155107 2.7180715 0.03514167 0.004566667 0.05703333 0.05246667 0.03286314 0.03286314 FALSE  
ENST00000554752 ENSG00000006432 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K9 protein_coding protein_coding 3.136694 3.549959 2.73778 0.3194663 0.04227942 -0.373594 2.8570189 3.33813270 2.4304581 0.288981897 0.05191452 -0.4562047 0.90514167 0.940900000 0.88763333 -0.05326667 0.19489228 0.03286314 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000006432 E001 738.9236116 0.0051542010 6.867652e-11 1.245984e-09 14 70722526 70729650 7125 - 2.747 2.926 0.593
ENSG00000006432 E002 10.3821458 0.0090227739 1.993154e-02 5.134261e-02 14 70729651 70729665 15 - 1.139 0.958 -0.660
ENSG00000006432 E003 35.4319460 0.0007443030 6.892938e-02 1.415997e-01 14 70729666 70729935 270 - 1.571 1.541 -0.103
ENSG00000006432 E004 28.0047253 0.0007407480 5.426650e-01 6.733838e-01 14 70729936 70730134 199 - 1.382 1.497 0.399
ENSG00000006432 E005 46.6272852 0.0007248223 2.385561e-01 3.724584e-01 14 70730135 70730864 730 - 1.664 1.680 0.054
ENSG00000006432 E006 45.9084184 0.0005493791 8.268390e-02 1.637491e-01 14 70732539 70733342 804 - 1.670 1.658 -0.043
ENSG00000006432 E007 0.1817044 0.0391359076 6.667054e-01   14 70733757 70733798 42 - 0.000 0.113 10.005
ENSG00000006432 E008 15.1372284 0.0012153000 9.801995e-01 9.916314e-01 14 70734386 70734498 113 - 1.150 1.226 0.268
ENSG00000006432 E009 2.1788069 0.0069919691 7.243282e-01 8.178723e-01 14 70735961 70736029 69 - 0.496 0.490 -0.028
ENSG00000006432 E010 22.2717086 0.0008812715 7.549018e-02 1.522964e-01 14 70738245 70738398 154 - 1.388 1.334 -0.186
ENSG00000006432 E011 2.6175367 0.0058285971 5.914122e-04 2.502158e-03 14 70739898 70740041 144 - 0.776 0.278 -2.473
ENSG00000006432 E012 17.9750193 0.0024358668 2.048488e-03 7.376122e-03 14 70740042 70740164 123 - 1.362 1.186 -0.619
ENSG00000006432 E013 23.0602934 0.0106862931 6.868418e-03 2.088404e-02 14 70742351 70742591 241 - 1.452 1.300 -0.529
ENSG00000006432 E014 22.7371497 0.0008509744 6.503608e-06 4.511494e-05 14 70748829 70749004 176 - 1.494 1.248 -0.853
ENSG00000006432 E015 0.1482932 0.0422617585 6.669671e-01   14 70749553 70749932 380 - 0.000 0.113 9.958
ENSG00000006432 E016 21.9343970 0.0193135943 8.762253e-03 2.569036e-02 14 70749933 70750081 149 - 1.448 1.271 -0.614
ENSG00000006432 E017 0.0000000       14 70752938 70752956 19 -      
ENSG00000006432 E018 23.5802758 0.0049518878 8.760532e-06 5.898903e-05 14 70761002 70761182 181 - 1.518 1.256 -0.909
ENSG00000006432 E019 0.1482932 0.0422617585 6.669671e-01   14 70765442 70765487 46 - 0.000 0.113 9.958
ENSG00000006432 E020 0.0000000       14 70783223 70783445 223 -      
ENSG00000006432 E021 29.7522693 0.0401419847 5.665254e-04 2.408477e-03 14 70800667 70801080 414 - 1.632 1.328 -1.046
ENSG00000006432 E022 14.7756528 0.0665667265 5.924074e-02 1.253376e-01 14 70808766 70809534 769 - 1.281 1.115 -0.588