ENSG00000006125

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000610402 ENSG00000006125 HEK293_OSMI2_2hA HEK293_TMG_2hB AP2B1 protein_coding protein_coding 47.20275 52.34965 43.09916 4.967707 1.297989 -0.2804611 6.4631067 8.591844 3.390581 3.399195 0.8448605 -1.3388647 0.134675000 0.15656667 0.0797000 -0.07686667 3.791467e-01 3.940346e-18 FALSE  
ENST00000612035 ENSG00000006125 HEK293_OSMI2_2hA HEK293_TMG_2hB AP2B1 protein_coding protein_coding 47.20275 52.34965 43.09916 4.967707 1.297989 -0.2804611 1.3150365 0.000000 3.164520 0.000000 0.6845347 8.3103948 0.029712500 0.00000000 0.0727000 0.07270000 3.940346e-18 3.940346e-18 FALSE  
ENST00000616681 ENSG00000006125 HEK293_OSMI2_2hA HEK293_TMG_2hB AP2B1 protein_coding protein_coding 47.20275 52.34965 43.09916 4.967707 1.297989 -0.2804611 0.3915077 3.132061 0.000000 1.624376 0.0000000 -8.2955676 0.008041667 0.06433333 0.0000000 -0.06433333 1.797202e-01 3.940346e-18 FALSE  
ENST00000621914 ENSG00000006125 HEK293_OSMI2_2hA HEK293_TMG_2hB AP2B1 protein_coding protein_coding 47.20275 52.34965 43.09916 4.967707 1.297989 -0.2804611 29.0219799 31.720856 24.005372 1.332309 0.3174244 -0.4019283 0.611708333 0.61276667 0.5576000 -0.05516667 5.785239e-01 3.940346e-18 FALSE  
MSTRG.14177.14 ENSG00000006125 HEK293_OSMI2_2hA HEK293_TMG_2hB AP2B1 protein_coding   47.20275 52.34965 43.09916 4.967707 1.297989 -0.2804611 3.4104833 1.722163 5.731932 1.722163 0.6897063 1.7289612 0.072887500 0.02860000 0.1324667 0.10386667 9.427914e-02 3.940346e-18 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000006125 E001 0.5858876 0.0213683507 2.191807e-01 3.493860e-01 17 35578046 35578121 76 + 0.295 0.123 -1.578
ENSG00000006125 E002 0.0000000       17 35585652 35585707 56 +      
ENSG00000006125 E003 0.1451727 0.0436250465 4.004324e-01   17 35586899 35587058 160 + 0.122 0.000 -26.606
ENSG00000006125 E004 0.8083901 0.0147592435 8.519745e-01 9.082336e-01 17 35587059 35587273 215 + 0.217 0.296 0.593
ENSG00000006125 E005 9.0993557 0.0018816867 2.178831e-02 5.523424e-02 17 35587274 35587313 40 + 1.080 0.930 -0.555
ENSG00000006125 E006 10.7977824 0.0015912173 1.273011e-02 3.527706e-02 17 35587314 35587321 8 + 1.145 0.992 -0.558
ENSG00000006125 E007 58.1082716 0.0061537019 2.556909e-05 1.546710e-04 17 35587322 35587366 45 + 1.846 1.700 -0.490
ENSG00000006125 E008 100.5893541 0.0057033564 1.144627e-08 1.396215e-07 17 35587367 35587415 49 + 2.098 1.913 -0.621
ENSG00000006125 E009 67.9205560 0.0101207143 2.102103e-08 2.440501e-07 17 35587416 35587428 13 + 1.960 1.697 -0.886
ENSG00000006125 E010 5.7593827 0.0065363867 5.001435e-02 1.092000e-01 17 35587429 35587451 23 + 0.911 0.746 -0.643
ENSG00000006125 E011 19.2634760 0.0011302793 2.306671e-06 1.770416e-05 17 35587452 35587514 63 + 1.436 1.167 -0.939
ENSG00000006125 E012 21.5736032 0.0008402174 1.782397e-08 2.097070e-07 17 35587515 35587530 16 + 1.503 1.186 -1.102
ENSG00000006125 E013 30.5744498 0.0006491711 3.658411e-09 4.883217e-08 17 35587531 35587565 35 + 1.629 1.359 -0.926
ENSG00000006125 E014 33.5412459 0.0042798596 2.636905e-06 1.998615e-05 17 35587566 35587597 32 + 1.645 1.432 -0.728
ENSG00000006125 E015 10.2419744 0.0179668154 7.111171e-03 2.151373e-02 17 35587598 35587663 66 + 1.165 0.943 -0.808
ENSG00000006125 E016 1.5446472 0.0086228566 7.147677e-01 8.108711e-01 17 35587738 35587893 156 + 0.419 0.420 0.007
ENSG00000006125 E017 0.0000000       17 35588625 35588733 109 +      
ENSG00000006125 E018 127.5168641 0.0057112999 2.811914e-11 5.442225e-10 17 35594008 35594030 23 + 2.214 1.997 -0.726
ENSG00000006125 E019 155.7984418 0.0088208852 1.471634e-08 1.758851e-07 17 35594031 35594067 37 + 2.292 2.093 -0.664
ENSG00000006125 E020 252.3970636 0.0088723521 3.362225e-06 2.489986e-05 17 35598230 35598335 106 + 2.469 2.339 -0.432
ENSG00000006125 E021 1.5499206 0.1800807768 8.975920e-02 1.747594e-01 17 35600937 35600985 49 + 0.555 0.219 -1.987
ENSG00000006125 E022 2.1672674 0.0089068417 4.995952e-01 6.358792e-01 17 35600986 35601071 86 + 0.515 0.471 -0.212
ENSG00000006125 E023 256.5630463 0.0055227238 2.831695e-06 2.131416e-05 17 35605705 35605840 136 + 2.459 2.364 -0.314
ENSG00000006125 E024 0.0000000       17 35607837 35608055 219 +      
ENSG00000006125 E025 241.0962719 0.0055822405 8.505635e-07 7.173428e-06 17 35608142 35608255 114 + 2.437 2.332 -0.351
ENSG00000006125 E026 252.8290678 0.0053892301 5.037582e-08 5.429566e-07 17 35608256 35608387 132 + 2.467 2.343 -0.417
ENSG00000006125 E027 0.0000000       17 35621275 35621363 89 +      
ENSG00000006125 E028 326.0261827 0.0071935535 1.158640e-07 1.163658e-06 17 35624397 35624581 185 + 2.583 2.444 -0.464
ENSG00000006125 E029 146.5853158 0.0083369409 1.588412e-03 5.921404e-03 17 35624582 35624587 6 + 2.201 2.137 -0.216
ENSG00000006125 E030 378.9589892 0.0046500553 8.270669e-06 5.599505e-05 17 35626621 35626842 222 + 2.612 2.548 -0.215
ENSG00000006125 E031 337.6777468 0.0047603392 3.113758e-05 1.845779e-04 17 35627385 35627505 121 + 2.559 2.501 -0.191
ENSG00000006125 E032 320.2406442 0.0045870776 4.292406e-03 1.396167e-02 17 35627631 35627726 96 + 2.509 2.503 -0.020
ENSG00000006125 E033 300.3369601 0.0044340757 1.992310e-03 7.202586e-03 17 35636341 35636456 116 + 2.485 2.471 -0.047
ENSG00000006125 E034 350.0191299 0.0051106571 2.870722e-02 6.941860e-02 17 35639595 35639760 166 + 2.533 2.554 0.069
ENSG00000006125 E035 252.4382596 0.0015960903 1.098465e-02 3.112534e-02 17 35641877 35641975 99 + 2.388 2.415 0.090
ENSG00000006125 E036 236.5713433 0.0002144561 7.542650e-05 4.062930e-04 17 35650530 35650602 73 + 2.371 2.380 0.030
ENSG00000006125 E037 226.4371300 0.0001771001 7.716978e-09 9.712718e-08 17 35650603 35650649 47 + 2.376 2.340 -0.118
ENSG00000006125 E038 344.4561152 0.0002360493 2.585207e-06 1.963437e-05 17 35650650 35650789 140 + 2.534 2.543 0.028
ENSG00000006125 E039 0.1472490 0.0442796126 4.000093e-01   17 35650914 35651005 92 + 0.122 0.000 -26.607
ENSG00000006125 E040 378.1007449 0.0001369916 3.187132e-05 1.884202e-04 17 35657599 35657791 193 + 2.566 2.592 0.085
ENSG00000006125 E041 13.5291513 0.0091241104 4.423430e-01 5.839713e-01 17 35659764 35660120 357 + 1.156 1.176 0.071
ENSG00000006125 E042 61.0245438 0.0037545999 1.523787e-02 4.102547e-02 17 35670857 35670898 42 + 1.810 1.786 -0.082
ENSG00000006125 E043 334.6183373 0.0001542801 1.134912e-04 5.838738e-04 17 35671754 35671900 147 + 2.513 2.539 0.088
ENSG00000006125 E044 358.8206645 0.0004162352 3.293988e-03 1.113317e-02 17 35674176 35674321 146 + 2.534 2.575 0.139
ENSG00000006125 E045 357.6667321 0.0004360552 8.274789e-02 1.638516e-01 17 35682695 35682824 130 + 2.519 2.585 0.222
ENSG00000006125 E046 10.8823577 0.0021131542 1.640443e-01 2.804113e-01 17 35707914 35708009 96 + 1.092 1.046 -0.165
ENSG00000006125 E047 286.6818681 0.0001825040 8.170574e-01 8.842968e-01 17 35709224 35709308 85 + 2.403 2.501 0.325
ENSG00000006125 E048 298.1537431 0.0007107833 9.624552e-01 9.803232e-01 17 35710234 35710320 87 + 2.417 2.517 0.332
ENSG00000006125 E049 395.9291739 0.0006063331 5.905856e-01 7.134183e-01 17 35717195 35717349 155 + 2.534 2.646 0.376
ENSG00000006125 E050 4250.0157638 0.0101325864 1.695384e-13 4.672466e-12 17 35723625 35726413 2789 + 3.408 3.750 1.140