ENSG00000006118

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000005286 ENSG00000006118 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM132A protein_coding protein_coding 30.66439 43.26158 21.53876 3.303778 0.5644149 -1.005815 10.756763 16.1389403 6.550101 2.31764086 0.2511175 -1.2996495 0.34414583 0.36900000 0.30473333 -0.06426667 3.704596e-01 1.182845e-10 FALSE TRUE
ENST00000453848 ENSG00000006118 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM132A protein_coding protein_coding 30.66439 43.26158 21.53876 3.303778 0.5644149 -1.005815 7.435632 13.9600282 4.549691 0.42644258 0.7015042 -1.6153268 0.22428333 0.32516667 0.20996667 -0.11520000 3.904650e-02 1.182845e-10 FALSE TRUE
ENST00000540112 ENSG00000006118 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM132A protein_coding protein_coding 30.66439 43.26158 21.53876 3.303778 0.5644149 -1.005815 4.568286 5.9684599 3.588509 0.68008408 0.1828652 -0.7323745 0.15186667 0.14210000 0.16686667 0.02476667 7.349892e-01 1.182845e-10 FALSE TRUE
MSTRG.5558.14 ENSG00000006118 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM132A protein_coding   30.66439 43.26158 21.53876 3.303778 0.5644149 -1.005815 1.672314 0.6297931 1.548459 0.09045282 0.1690817 1.2844426 0.06314583 0.01443333 0.07183333 0.05740000 1.182845e-10 1.182845e-10   TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000006118 E001 0.1451727 0.0426943279 1.994608e-01   11 60924460 60924462 3 + 0.174 0.000 -10.824
ENSG00000006118 E002 0.5997190 0.1686884767 8.119675e-03 2.408697e-02 11 60924463 60924469 7 + 0.474 0.000 -14.291
ENSG00000006118 E003 1.0425102 0.0119640218 2.089044e-03 7.499348e-03 11 60924470 60924480 11 + 0.598 0.084 -3.785
ENSG00000006118 E004 1.7809574 0.0308972196 1.869853e-03 6.821714e-03 11 60924481 60924482 2 + 0.735 0.215 -2.792
ENSG00000006118 E005 2.3721435 0.0074409696 2.226963e-05 1.365830e-04 11 60924483 60924486 4 + 0.870 0.216 -3.316
ENSG00000006118 E006 3.9413053 0.0475104489 4.171870e-05 2.394197e-04 11 60924487 60924491 5 + 1.016 0.360 -2.862
ENSG00000006118 E007 4.6024212 0.0179353224 1.513010e-06 1.208768e-05 11 60924492 60924497 6 + 1.074 0.399 -2.849
ENSG00000006118 E008 6.2933855 0.0036536242 4.495787e-07 4.013729e-06 11 60924498 60924501 4 + 1.156 0.554 -2.367
ENSG00000006118 E009 15.5178561 0.0149640609 8.852834e-04 3.562587e-03 11 60924502 60924543 42 + 1.365 1.049 -1.122
ENSG00000006118 E010 110.4980216 0.0118673792 3.115950e-01 4.540651e-01 11 60924544 60924733 190 + 2.015 1.982 -0.109
ENSG00000006118 E011 16.9719167 0.0010584008 1.202607e-10 2.094799e-09 11 60925208 60925703 496 + 1.506 1.001 -1.783
ENSG00000006118 E012 17.4525946 0.0025363541 4.982339e-17 2.219349e-15 11 60925704 60926084 381 + 1.591 0.919 -2.378
ENSG00000006118 E013 11.9756928 0.0014270082 3.848489e-04 1.716220e-03 11 60926579 60926721 143 + 1.273 0.952 -1.159
ENSG00000006118 E014 14.8513969 0.0012056870 1.524311e-08 1.816659e-07 11 60926832 60927048 217 + 1.433 0.962 -1.678
ENSG00000006118 E015 6.8987763 0.0024162629 1.056562e-04 5.480302e-04 11 60927049 60927067 19 + 1.125 0.687 -1.673
ENSG00000006118 E016 16.0515591 0.0011027729 1.205012e-06 9.837366e-06 11 60927068 60927203 136 + 1.425 1.037 -1.375
ENSG00000006118 E017 200.4601211 0.0023141406 2.268475e-01 3.586229e-01 11 60927204 60927358 155 + 2.260 2.243 -0.055
ENSG00000006118 E018 143.0102552 0.0002776787 1.346765e-01 2.406465e-01 11 60927359 60927418 60 + 2.119 2.094 -0.085
ENSG00000006118 E019 290.0888981 0.0001668912 9.152087e-01 9.503228e-01 11 60927641 60927859 219 + 2.386 2.412 0.087
ENSG00000006118 E020 326.2686978 0.0011472769 8.385621e-01 8.990807e-01 11 60928629 60928960 332 + 2.440 2.461 0.068
ENSG00000006118 E021 190.6419927 0.0073646016 3.828150e-01 5.269851e-01 11 60930510 60930659 150 + 2.240 2.222 -0.061
ENSG00000006118 E022 39.6266218 0.0006510933 3.597120e-01 5.040374e-01 11 60931686 60931688 3 + 1.574 1.541 -0.113
ENSG00000006118 E023 160.9486820 0.0002702304 3.287486e-01 4.722329e-01 11 60931689 60931754 66 + 2.155 2.148 -0.023
ENSG00000006118 E024 250.1606144 0.0010837131 9.437872e-02 1.819509e-01 11 60931755 60931884 130 + 2.359 2.336 -0.075
ENSG00000006118 E025 7.8728227 0.0407143962 5.948095e-03 1.847172e-02 11 60931885 60931983 99 + 1.140 0.760 -1.429
ENSG00000006118 E026 205.7357398 0.0003082882 1.141348e-01 2.115621e-01 11 60931984 60932127 144 + 2.269 2.249 -0.067
ENSG00000006118 E027 33.9103641 0.0006337473 1.813093e-16 7.555766e-15 11 60932128 60933541 1414 + 1.772 1.299 -1.621
ENSG00000006118 E028 214.7508975 0.0036659215 7.581789e-01 8.428229e-01 11 60933542 60933744 203 + 2.247 2.286 0.131
ENSG00000006118 E029 17.7762645 0.0443382319 1.139347e-01 2.112552e-01 11 60933745 60933996 252 + 1.336 1.165 -0.602
ENSG00000006118 E030 16.8545574 0.0227284494 1.705238e-03 6.299192e-03 11 60933997 60934205 209 + 1.400 1.084 -1.118
ENSG00000006118 E031 11.0923745 0.0016650198 1.210363e-03 4.675766e-03 11 60934206 60934337 132 + 1.225 0.920 -1.110
ENSG00000006118 E032 5.7852816 0.0028656686 2.137558e-06 1.652064e-05 11 60934338 60934487 150 + 1.125 0.554 -2.258
ENSG00000006118 E033 123.1002128 0.0144714335 8.490200e-01 9.062926e-01 11 60934488 60934642 155 + 2.015 2.042 0.091
ENSG00000006118 E034 156.8315201 0.0010009495 8.837171e-02 1.726328e-01 11 60934643 60934764 122 + 2.161 2.128 -0.110
ENSG00000006118 E035 177.0091336 0.0002335431 6.785693e-01 7.830141e-01 11 60935252 60935317 66 + 2.181 2.193 0.038
ENSG00000006118 E036 239.9325466 0.0001888401 3.750000e-01 5.194329e-01 11 60935318 60935443 126 + 2.288 2.335 0.155
ENSG00000006118 E037 50.6419359 0.0033248515 3.844451e-11 7.273015e-10 11 60935444 60935863 420 + 1.886 1.540 -1.173
ENSG00000006118 E038 256.3831793 0.0002814389 1.375121e-01 2.446219e-01 11 60935864 60936016 153 + 2.305 2.366 0.207
ENSG00000006118 E039 828.9296024 0.0016564915 3.153044e-16 1.275266e-14 11 60936017 60936746 730 + 2.702 2.909 0.689
ENSG00000006118 E040 459.1045112 0.0059050562 4.717023e-06 3.377526e-05 11 60936747 60937159 413 + 2.442 2.655 0.709