ENSG00000006062

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000344686 ENSG00000006062 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K14 protein_coding protein_coding 3.081785 4.020085 2.107523 0.244704 0.1158552 -0.9284327 2.1975966 2.036913 1.6620738 0.2121588 0.1034523 -0.2918115 0.7369917 0.5038667 0.79113333 0.2872667 0.001417719 0.001417719 FALSE TRUE
ENST00000592267 ENSG00000006062 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K14 protein_coding retained_intron 3.081785 4.020085 2.107523 0.244704 0.1158552 -0.9284327 0.3969595 1.069586 0.2433035 0.2485419 0.1255511 -2.0915396 0.1155542 0.2654667 0.10926667 -0.1562000 0.405332542 0.001417719 FALSE TRUE
ENST00000680632 ENSG00000006062 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K14 protein_coding nonsense_mediated_decay 3.081785 4.020085 2.107523 0.244704 0.1158552 -0.9284327 0.3728661 0.807212 0.2021458 0.2905448 0.1035890 -1.9456540 0.1118500 0.2044333 0.09956667 -0.1048667 0.667504010 0.001417719 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000006062 E001 0.2998086 0.0295952905 6.523398e-01   17 45263119 45263127 9 - 0.158 0.094 -0.869
ENSG00000006062 E002 0.5212538 0.0201985549 9.872163e-01 9.960687e-01 17 45263128 45263134 7 - 0.158 0.171 0.134
ENSG00000006062 E003 4.3222110 0.0690121426 8.846375e-01 9.302602e-01 17 45263135 45263150 16 - 0.655 0.695 0.166
ENSG00000006062 E004 173.1947231 0.0022445414 1.833587e-06 1.438137e-05 17 45263151 45264635 1485 - 2.099 2.248 0.498
ENSG00000006062 E005 35.1923513 0.0006733278 7.732946e-01 8.537100e-01 17 45264636 45264800 165 - 1.531 1.519 -0.039
ENSG00000006062 E006 27.3686362 0.0097734403 6.057193e-01 7.260570e-01 17 45265163 45265263 101 - 1.437 1.403 -0.116
ENSG00000006062 E007 32.3580072 0.0007145194 2.283057e-01 3.604079e-01 17 45266537 45266681 145 - 1.531 1.462 -0.236
ENSG00000006062 E008 25.2673757 0.0009006728 3.315275e-01 4.751682e-01 17 45267092 45267198 107 - 1.423 1.361 -0.215
ENSG00000006062 E009 43.0904821 0.0005185936 5.087848e-02 1.107372e-01 17 45267406 45267759 354 - 1.673 1.576 -0.332
ENSG00000006062 E010 20.7027806 0.0010248260 1.160106e-01 2.142572e-01 17 45270413 45270563 151 - 1.377 1.264 -0.396
ENSG00000006062 E011 0.7331471 0.0172671820 1.282086e-01 2.316523e-01 17 45270564 45270851 288 - 0.000 0.293 10.234
ENSG00000006062 E012 2.6635265 0.0203859312 5.046048e-01 6.405169e-01 17 45270852 45271057 206 - 0.441 0.563 0.597
ENSG00000006062 E013 19.0662384 0.0463687656 6.374276e-01 7.513190e-01 17 45271058 45271221 164 - 1.299 1.247 -0.182
ENSG00000006062 E014 15.4814242 0.0101912005 6.248411e-01 7.410712e-01 17 45273503 45273607 105 - 1.138 1.192 0.194
ENSG00000006062 E015 1.9101297 0.0074447328 4.637013e-02 1.027100e-01 17 45273608 45273966 359 - 0.158 0.533 2.456
ENSG00000006062 E016 15.8889286 0.0053662456 1.093395e-01 2.045949e-01 17 45274123 45274254 132 - 1.079 1.240 0.577
ENSG00000006062 E017 17.8902845 0.0110555458 3.011877e-01 4.429710e-01 17 45274464 45274593 130 - 1.165 1.275 0.389
ENSG00000006062 E018 14.5438128 0.0012053737 5.310242e-01 6.635377e-01 17 45284812 45284949 138 - 1.190 1.139 -0.182
ENSG00000006062 E019 31.8577580 0.0247789913 4.632813e-01 6.030947e-01 17 45286431 45287045 615 - 1.520 1.460 -0.206
ENSG00000006062 E020 17.2470138 0.0011234433 1.500178e-02 4.049184e-02 17 45287154 45287364 211 - 1.353 1.161 -0.673
ENSG00000006062 E021 11.0100330 0.0265732172 3.344588e-01 4.782054e-01 17 45289236 45289305 70 - 1.123 1.009 -0.417
ENSG00000006062 E022 20.4060200 0.0130231836 2.090811e-02 5.339613e-02 17 45290490 45290765 276 - 1.423 1.219 -0.711
ENSG00000006062 E023 0.0000000       17 45290766 45290976 211 -      
ENSG00000006062 E024 0.0000000       17 45312285 45312437 153 -      
ENSG00000006062 E025 8.3993846 0.0022041713 1.998646e-01 3.260716e-01 17 45316960 45317029 70 - 1.028 0.889 -0.517