ENSG00000006042

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000395149 ENSG00000006042 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM98 protein_coding protein_coding 39.63856 62.50567 29.42438 3.38746 0.9932873 -1.086716 4.045247 6.387754 2.634767 1.1185524 0.1193903 -1.2744251 0.10197083 0.10173333 0.09003333 -0.01170000 0.8505141689 0.0004123551 FALSE FALSE
ENST00000578289 ENSG00000006042 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM98 protein_coding protein_coding 39.63856 62.50567 29.42438 3.38746 0.9932873 -1.086716 2.600704 2.646031 4.331904 0.6519849 0.6830286 0.7090558 0.07513333 0.04146667 0.14713333 0.10566667 0.0004123551 0.0004123551 FALSE TRUE
ENST00000579849 ENSG00000006042 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM98 protein_coding protein_coding 39.63856 62.50567 29.42438 3.38746 0.9932873 -1.086716 11.524031 19.118847 8.162037 0.8848226 0.4108109 -1.2269823 0.28751250 0.30620000 0.27733333 -0.02886667 0.4244511876 0.0004123551 FALSE TRUE
ENST00000582227 ENSG00000006042 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM98 protein_coding retained_intron 39.63856 62.50567 29.42438 3.38746 0.9932873 -1.086716 3.665517 7.467790 2.302182 0.3126759 1.1618671 -1.6933569 0.08842083 0.11996667 0.07660000 -0.04336667 0.7501720437 0.0004123551 FALSE TRUE
ENST00000583120 ENSG00000006042 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM98 protein_coding retained_intron 39.63856 62.50567 29.42438 3.38746 0.9932873 -1.086716 15.802224 23.936929 10.386226 1.0940658 1.5108417 -1.2037807 0.39678750 0.38346667 0.35370000 -0.02976667 0.8466202214 0.0004123551 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000006042 E001 4.283519 0.0135230643 5.038181e-03 1.603501e-02 17 32927910 32928044 135 + 0.929 0.523 -1.683
ENSG00000006042 E002 3.315106 0.0117009695 6.680150e-02 1.380653e-01 17 32928045 32928070 26 + 0.778 0.494 -1.237
ENSG00000006042 E003 20.476265 0.0010101857 4.127271e-01 5.562941e-01 17 32928071 32928152 82 + 1.217 1.289 0.251
ENSG00000006042 E004 96.498462 0.0003336626 1.390511e-01 2.467780e-01 17 32928153 32928203 51 + 1.971 1.914 -0.192
ENSG00000006042 E005 108.287411 0.0004127107 2.275052e-02 5.723339e-02 17 32928204 32928209 6 + 2.037 1.954 -0.281
ENSG00000006042 E006 201.626493 0.0002665418 8.647389e-03 2.540253e-02 17 32928210 32928237 28 + 2.297 2.226 -0.237
ENSG00000006042 E007 2.821287 0.2090195158 1.811410e-01 3.026504e-01 17 32930900 32930971 72 + 0.741 0.454 -1.290
ENSG00000006042 E008 2.877599 0.0198849913 3.411864e-01 4.850969e-01 17 32931034 32931326 293 + 0.653 0.494 -0.722
ENSG00000006042 E009 228.908842 0.0002025891 1.142447e-03 4.445856e-03 17 32931327 32931386 60 + 2.360 2.278 -0.272
ENSG00000006042 E010 187.803457 0.0002854336 8.049416e-04 3.276636e-03 17 32931387 32931402 16 + 2.282 2.188 -0.313
ENSG00000006042 E011 26.604933 0.0129146833 5.458344e-01 6.761126e-01 17 32931403 32931474 72 + 1.332 1.391 0.206
ENSG00000006042 E012 484.038921 0.0001764334 2.082745e-01 3.364086e-01 17 32931475 32931659 185 + 2.642 2.621 -0.070
ENSG00000006042 E013 479.053360 0.0001332064 7.637319e-01 8.469929e-01 17 32933174 32933305 132 + 2.624 2.620 -0.013
ENSG00000006042 E014 280.156609 0.0006349772 4.989462e-01 6.353326e-01 17 32934291 32934324 34 + 2.400 2.385 -0.052
ENSG00000006042 E015 1.170845 0.3978272229 3.878640e-02 8.878752e-02 17 32934325 32934363 39 + 0.651 0.082 -4.067
ENSG00000006042 E016 514.198049 0.0001651439 8.168967e-01 8.841680e-01 17 32936332 32936447 116 + 2.650 2.655 0.018
ENSG00000006042 E017 1.513411 0.0093093412 8.159774e-01 8.835317e-01 17 32936448 32936468 21 + 0.398 0.356 -0.239
ENSG00000006042 E018 428.568967 0.0001941319 6.080336e-01 7.278906e-01 17 32939477 32939536 60 + 2.581 2.572 -0.028
ENSG00000006042 E019 376.438163 0.0001485611 7.613387e-01 8.452344e-01 17 32940786 32940837 52 + 2.522 2.518 -0.016
ENSG00000006042 E020 445.361578 0.0006496811 6.859287e-01 7.885333e-01 17 32940838 32940946 109 + 2.584 2.595 0.036
ENSG00000006042 E021 1097.001606 0.0001616095 7.098687e-14 2.059772e-12 17 32940947 32944315 3369 + 2.913 3.004 0.305
ENSG00000006042 E022 1.218916 0.0102417338 5.833560e-02 1.237737e-01 17 32944878 32945106 229 + 0.544 0.213 -1.977