ENSG00000006025

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000007414 ENSG00000006025 HEK293_OSMI2_2hA HEK293_TMG_2hB OSBPL7 protein_coding protein_coding 3.922452 2.741445 3.132355 0.3822891 0.09215781 0.1916571 1.9672612 2.23031846 1.5145536 0.210814542 0.05033437 -0.555317 0.54664167 0.82323333 0.48403333 -0.33920000 1.329869e-05 1.329869e-05 FALSE TRUE
ENST00000580226 ENSG00000006025 HEK293_OSMI2_2hA HEK293_TMG_2hB OSBPL7 protein_coding retained_intron 3.922452 2.741445 3.132355 0.3822891 0.09215781 0.1916571 0.5305982 0.13125470 0.4709709 0.035754890 0.05258437 1.767651 0.12302917 0.04840000 0.15010000 0.10170000 2.492438e-02 1.329869e-05 FALSE TRUE
ENST00000583167 ENSG00000006025 HEK293_OSMI2_2hA HEK293_TMG_2hB OSBPL7 protein_coding retained_intron 3.922452 2.741445 3.132355 0.3822891 0.09215781 0.1916571 0.2664238 0.09023845 0.2449179 0.039483150 0.04630034 1.346597 0.06299583 0.03050000 0.07746667 0.04696667 2.421691e-01 1.329869e-05 FALSE TRUE
ENST00000584698 ENSG00000006025 HEK293_OSMI2_2hA HEK293_TMG_2hB OSBPL7 protein_coding retained_intron 3.922452 2.741445 3.132355 0.3822891 0.09215781 0.1916571 0.4599898 0.12970349 0.3322291 0.004752145 0.18183111 1.292594 0.11075417 0.04906667 0.10776667 0.05870000 8.967504e-01 1.329869e-05 FALSE FALSE
ENST00000585051 ENSG00000006025 HEK293_OSMI2_2hA HEK293_TMG_2hB OSBPL7 protein_coding retained_intron 3.922452 2.741445 3.132355 0.3822891 0.09215781 0.1916571 0.1918152 0.00000000 0.3832199 0.000000000 0.13038453 5.297265 0.04657917 0.00000000 0.12270000 0.12270000 8.097287e-04 1.329869e-05 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000006025 E001 0.0000000       17 47807372 47807372 1 -      
ENSG00000006025 E002 0.2987644 0.0290785164 1.287013e-01   17 47807373 47807373 1 - 0.247 0.000 -10.557
ENSG00000006025 E003 0.2987644 0.0290785164 1.287013e-01   17 47807374 47807374 1 - 0.247 0.000 -13.318
ENSG00000006025 E004 36.2387718 0.0010320075 5.192428e-02 1.125903e-01 17 47807375 47807836 462 - 1.478 1.590 0.384
ENSG00000006025 E005 41.1511916 0.0009196745 2.198279e-04 1.048879e-03 17 47807837 47808190 354 - 1.467 1.674 0.708
ENSG00000006025 E006 12.3816776 0.0020759141 4.433755e-03 1.435439e-02 17 47808191 47808215 25 - 0.917 1.203 1.039
ENSG00000006025 E007 26.8219026 0.0019873293 1.630445e-04 8.049905e-04 17 47808216 47808399 184 - 1.242 1.513 0.940
ENSG00000006025 E008 26.9318055 0.0007810599 5.982401e-03 1.856213e-02 17 47808538 47808660 123 - 1.304 1.490 0.645
ENSG00000006025 E009 22.3769372 0.0010887104 2.725196e-02 6.650096e-02 17 47808864 47808946 83 - 1.242 1.404 0.567
ENSG00000006025 E010 18.3830334 0.0140426807 2.187543e-02 5.541977e-02 17 47808947 47808990 44 - 1.109 1.337 0.805
ENSG00000006025 E011 17.7365590 0.0026639027 2.449152e-01 3.799414e-01 17 47809076 47809115 40 - 1.191 1.286 0.332
ENSG00000006025 E012 20.8695473 0.0110344501 6.069302e-01 7.269923e-01 17 47809116 47809220 105 - 1.304 1.343 0.135
ENSG00000006025 E013 25.1542580 0.0008170427 8.233604e-01 8.886967e-01 17 47809334 47809478 145 - 1.393 1.404 0.039
ENSG00000006025 E014 17.7224157 0.0010715620 9.846992e-01 9.945053e-01 17 47810594 47810672 79 - 1.251 1.246 -0.018
ENSG00000006025 E015 12.7697572 0.0018460264 9.891388e-01 9.972676e-01 17 47810772 47810835 64 - 1.122 1.120 -0.007
ENSG00000006025 E016 21.4223514 0.0021797277 6.194794e-01 7.368665e-01 17 47813266 47813403 138 - 1.351 1.310 -0.142
ENSG00000006025 E017 21.9447085 0.0303331690 8.861808e-01 9.312030e-01 17 47813587 47813819 233 - 1.336 1.335 -0.005
ENSG00000006025 E018 6.3463714 0.0030351006 4.365894e-01 5.786484e-01 17 47813820 47813834 15 - 0.897 0.797 -0.387
ENSG00000006025 E019 11.5436392 0.0231159083 5.011192e-01 6.372907e-01 17 47814521 47814614 94 - 1.008 1.100 0.335
ENSG00000006025 E020 4.1039629 0.1328333368 6.572101e-01 7.666183e-01 17 47814615 47814707 93 - 0.718 0.652 -0.273
ENSG00000006025 E021 3.1848872 0.0055821534 3.341837e-03 1.126795e-02 17 47814708 47815214 507 - 0.829 0.377 -2.051
ENSG00000006025 E022 10.8720436 0.0122156823 7.915185e-01 8.666374e-01 17 47815215 47815287 73 - 1.024 1.055 0.114
ENSG00000006025 E023 10.0853137 0.0041854458 4.316969e-01 5.742357e-01 17 47815288 47815337 50 - 1.069 0.983 -0.316
ENSG00000006025 E024 7.3068180 0.0214612356 1.592617e-01 2.741307e-01 17 47815338 47815352 15 - 1.007 0.818 -0.718
ENSG00000006025 E025 1.7725118 0.0142851901 8.372579e-03 2.471925e-02 17 47815353 47816106 754 - 0.648 0.192 -2.634
ENSG00000006025 E026 12.4887775 0.0020807071 7.357480e-02 1.492475e-01 17 47816107 47816202 96 - 1.202 1.030 -0.620
ENSG00000006025 E027 1.4715823 0.0098949072 4.294809e-01 5.722033e-01 17 47816203 47816265 63 - 0.464 0.324 -0.788
ENSG00000006025 E028 1.2511693 0.4658788109 2.918697e-01 4.327845e-01 17 47816266 47816387 122 - 0.518 0.193 -2.040
ENSG00000006025 E029 11.7457653 0.0035222760 2.739060e-02 6.678679e-02 17 47816388 47816482 95 - 1.212 0.994 -0.788
ENSG00000006025 E030 6.6928298 0.0028778416 3.287195e-01 4.721982e-01 17 47816563 47816586 24 - 0.937 0.816 -0.465
ENSG00000006025 E031 11.1738057 0.0017103335 3.081755e-01 4.504368e-01 17 47816587 47816695 109 - 1.122 1.018 -0.378
ENSG00000006025 E032 0.9545818 0.0132026350 2.336803e-01 3.667644e-01 17 47816696 47816779 84 - 0.403 0.191 -1.466
ENSG00000006025 E033 12.3682307 0.0014713478 8.611679e-01 9.144373e-01 17 47816780 47816872 93 - 1.122 1.101 -0.074
ENSG00000006025 E034 1.5133995 0.0116134826 4.306171e-01 5.732280e-01 17 47816873 47817001 129 - 0.464 0.324 -0.787
ENSG00000006025 E035 12.4622867 0.0039589057 9.910461e-01 9.985257e-01 17 47817256 47817359 104 - 1.122 1.119 -0.009
ENSG00000006025 E036 13.4167904 0.0022755141 3.507468e-01 4.949271e-01 17 47818269 47818386 118 - 1.096 1.179 0.298
ENSG00000006025 E037 12.5804792 0.0015167634 5.027114e-01 6.387310e-01 17 47818506 47818616 111 - 1.158 1.092 -0.238
ENSG00000006025 E038 15.9847618 0.0013945991 8.091722e-02 1.609659e-01 17 47818986 47819099 114 - 1.304 1.155 -0.526
ENSG00000006025 E039 3.1051889 0.0111630297 2.639336e-01 4.018633e-01 17 47819100 47819138 39 - 0.717 0.542 -0.761
ENSG00000006025 E040 6.3029545 0.0069504145 2.177909e-07 2.072838e-06 17 47819333 47819720 388 - 1.146 0.468 -2.748
ENSG00000006025 E041 1.4520025 0.0642557205 1.794699e-01 3.004678e-01 17 47819721 47819728 8 - 0.518 0.263 -1.467
ENSG00000006025 E042 9.4713452 0.0019034115 1.287991e-02 3.563484e-02 17 47819729 47819782 54 - 1.146 0.883 -0.969
ENSG00000006025 E043 2.2498747 0.0064110108 2.933396e-05 1.749703e-04 17 47819783 47819970 188 - 0.803 0.106 -4.274
ENSG00000006025 E044 13.1581302 0.0013950939 6.880039e-04 2.855396e-03 17 47819971 47820096 126 - 1.304 0.994 -1.111
ENSG00000006025 E045 14.7383600 0.0012528399 4.561034e-02 1.013185e-01 17 47820204 47820365 162 - 1.278 1.102 -0.628
ENSG00000006025 E046 0.2934659 0.0299897505 8.185716e-01   17 47820366 47820858 493 - 0.141 0.106 -0.469
ENSG00000006025 E047 8.4642327 0.0023232479 4.909029e-01 6.282226e-01 17 47821666 47821834 169 - 1.008 0.928 -0.296