ENSG00000006015

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358607 ENSG00000006015 HEK293_OSMI2_2hA HEK293_TMG_2hB REX1BD protein_coding protein_coding 66.7936 127.7887 33.74948 12.70866 0.6263148 -1.920509 33.033519 64.759340 17.023895 6.989211 0.29517866 -1.926903 0.4705833 0.50590000 0.5050333 -0.0008666667 1.0000000000 4.422051e-11 FALSE  
ENST00000450195 ENSG00000006015 HEK293_OSMI2_2hA HEK293_TMG_2hB REX1BD protein_coding protein_coding 66.7936 127.7887 33.74948 12.70866 0.6263148 -1.920509 10.936392 21.415762 6.184015 2.578278 0.82353625 -1.790400 0.1591167 0.16683333 0.1825000 0.0156666667 0.8329209962 4.422051e-11 FALSE  
ENST00000597371 ENSG00000006015 HEK293_OSMI2_2hA HEK293_TMG_2hB REX1BD protein_coding retained_intron 66.7936 127.7887 33.74948 12.70866 0.6263148 -1.920509 7.247707 9.933307 4.016345 1.494177 0.06748525 -1.304255 0.1278750 0.07706667 0.1190000 0.0419333333 0.0010201892 4.422051e-11 FALSE  
ENST00000601736 ENSG00000006015 HEK293_OSMI2_2hA HEK293_TMG_2hB REX1BD protein_coding nonsense_mediated_decay 66.7936 127.7887 33.74948 12.70866 0.6263148 -1.920509 9.795998 23.473159 3.356896 1.466422 0.04904466 -2.802135 0.1381750 0.18620000 0.0995000 -0.0867000000 0.0001154562 4.422051e-11    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000006015 E001 0.00000       19 18588590 18588684 95 +      
ENSG00000006015 E002 32.87993 0.0034412246 9.303323e-03 2.704071e-02 19 18588685 18588795 111 + 1.193 1.438 0.854
ENSG00000006015 E003 33.28195 0.0011912121 9.384954e-03 2.724406e-02 19 18588796 18588797 2 + 1.210 1.441 0.805
ENSG00000006015 E004 36.58428 0.0006671026 1.325641e-03 5.061340e-03 19 18588798 18588801 4 + 1.210 1.486 0.958
ENSG00000006015 E005 57.72456 0.0004562837 6.064184e-02 1.277129e-01 19 18588802 18588808 7 + 1.539 1.662 0.419
ENSG00000006015 E006 432.16338 0.0005328852 5.231568e-01 6.568955e-01 19 18588809 18588900 92 + 2.493 2.517 0.079
ENSG00000006015 E007 13.62559 0.0075729391 7.934551e-03 2.361366e-02 19 18588901 18588994 94 + 1.273 1.000 -0.982
ENSG00000006015 E008 502.04474 0.0001298600 6.813050e-01 7.850224e-01 19 18588995 18589077 83 + 2.566 2.580 0.049
ENSG00000006015 E009 155.59394 0.0002638650 2.289832e-03 8.118640e-03 19 18589078 18589412 335 + 2.148 2.050 -0.328
ENSG00000006015 E010 356.50380 0.0001773520 6.018158e-01 7.228818e-01 19 18589413 18589478 66 + 2.432 2.427 -0.018
ENSG00000006015 E011 536.06738 0.0017059710 2.146750e-01 3.440623e-01 19 18589479 18589601 123 + 2.623 2.606 -0.055
ENSG00000006015 E012 392.21862 0.0004511636 9.929886e-01 9.997447e-01 19 18589602 18589683 82 + 2.462 2.471 0.030
ENSG00000006015 E013 11.59403 0.0015124915 8.407584e-14 2.416983e-12 19 18589872 18590273 402 + 1.461 0.741 -2.630
ENSG00000006015 E014 15.12160 0.0012808342 5.040056e-08 5.431568e-07 19 18590274 18590853 580 + 1.442 0.955 -1.733
ENSG00000006015 E015 447.83849 0.0002283820 1.871304e-01 3.101411e-01 19 18590854 18590933 80 + 2.500 2.535 0.117
ENSG00000006015 E016 100.87036 0.0003085633 4.483968e-08 4.881475e-07 19 18590934 18592088 1155 + 2.054 1.840 -0.721
ENSG00000006015 E017 15.06294 0.0045382216 2.604628e-01 3.979951e-01 19 18592089 18592107 19 + 1.175 1.063 -0.403
ENSG00000006015 E018 492.71938 0.0066926661 1.492789e-02 4.032551e-02 19 18592108 18592337 230 + 2.484 2.595 0.369