ENSG00000005961

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000589645 ENSG00000005961 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA2B protein_coding retained_intron 2.045493 3.384762 1.381297 0.3005828 0.2869814 -1.28688 0.1444362 0.00000000 0.33140913 0.00000000 0.214429181 5.09342972 0.08147083 0.00000000 0.20090000 0.20090000 0.000466906 0.000466906 FALSE FALSE
ENST00000592226 ENSG00000005961 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA2B protein_coding retained_intron 2.045493 3.384762 1.381297 0.3005828 0.2869814 -1.28688 0.1411231 0.06525697 0.06026423 0.01192151 0.003309683 -0.09903467 0.07899583 0.02026667 0.04753333 0.02726667 0.595482237 0.000466906 TRUE TRUE
ENST00000592253 ENSG00000005961 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA2B protein_coding retained_intron 2.045493 3.384762 1.381297 0.3005828 0.2869814 -1.28688 0.2266206 0.46291378 0.00000000 0.20281850 0.000000000 -5.56350529 0.09457083 0.13283333 0.00000000 -0.13283333 0.003327913 0.000466906 FALSE FALSE
ENST00000592462 ENSG00000005961 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA2B protein_coding retained_intron 2.045493 3.384762 1.381297 0.3005828 0.2869814 -1.28688 0.1247558 0.06030823 0.06735077 0.03479795 0.036899412 0.13772201 0.07214167 0.01696667 0.06136667 0.04440000 0.583520524 0.000466906 FALSE TRUE
ENST00000648408 ENSG00000005961 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA2B protein_coding protein_coding 2.045493 3.384762 1.381297 0.3005828 0.2869814 -1.28688 0.2924520 0.40185762 0.42587581 0.23876317 0.220758332 0.08177145 0.16170833 0.11783333 0.28806667 0.17023333 0.801062757 0.000466906 FALSE TRUE
MSTRG.14446.1 ENSG00000005961 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA2B protein_coding   2.045493 3.384762 1.381297 0.3005828 0.2869814 -1.28688 0.9372476 2.13898468 0.44710888 0.54179513 0.158132333 -2.23304545 0.40742083 0.63900000 0.36220000 -0.27680000 0.462323423 0.000466906 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000005961 E001 0.3729606 0.0284299150 0.411127812 0.554718610 17 44372022 44372179 158 - 0.196 0.074 -1.616
ENSG00000005961 E002 0.0000000       17 44372180 44372180 1 -      
ENSG00000005961 E003 13.6255791 0.0013508828 0.160352503 0.275611391 17 44372181 44372423 243 - 0.954 1.110 0.574
ENSG00000005961 E004 0.1817044 0.0404730083 1.000000000   17 44373924 44374353 430 - 0.000 0.074 9.187
ENSG00000005961 E005 15.9461043 0.0020366828 0.007469238 0.022435069 17 44374354 44374470 117 - 0.895 1.195 1.100
ENSG00000005961 E006 1.3995737 0.0099638891 0.975590874 0.988753587 17 44374471 44374658 188 - 0.331 0.325 -0.033
ENSG00000005961 E007 4.6716270 0.0393926069 0.931952231 0.961118544 17 44374659 44374760 102 - 0.698 0.688 -0.043
ENSG00000005961 E008 0.8783198 0.0137080506 0.821340371 0.887368236 17 44374761 44374997 237 - 0.196 0.241 0.382
ENSG00000005961 E009 14.8819038 0.1093007699 0.370676487 0.515088411 17 44374998 44375111 114 - 0.979 1.151 0.625
ENSG00000005961 E010 1.9261406 0.0938338468 0.096987107 0.185882389 17 44375112 44375590 479 - 0.646 0.324 -1.630
ENSG00000005961 E011 19.3300685 0.0010593471 0.105973149 0.199579445 17 44375591 44375716 126 - 1.094 1.248 0.551
ENSG00000005961 E012 25.1519718 0.0008452407 0.164391441 0.280898209 17 44375833 44375985 153 - 1.230 1.346 0.408
ENSG00000005961 E013 23.1776405 0.0009006728 0.333620954 0.477356925 17 44376085 44376184 100 - 1.230 1.312 0.288
ENSG00000005961 E014 21.3218220 0.0009592171 0.048139358 0.105877415 17 44376308 44376388 81 - 1.113 1.296 0.647
ENSG00000005961 E015 19.9577253 0.0009941305 0.241398723 0.375818813 17 44377009 44377088 80 - 1.150 1.257 0.381
ENSG00000005961 E016 16.6072621 0.0011690900 0.264554047 0.402511313 17 44377698 44377790 93 - 1.073 1.185 0.400
ENSG00000005961 E017 16.6502000 0.0011153939 0.704626490 0.803127179 17 44378362 44378509 148 - 1.132 1.169 0.131
ENSG00000005961 E018 12.3659417 0.0014610940 0.363908243 0.508326881 17 44378643 44378710 68 - 0.954 1.057 0.382
ENSG00000005961 E019 15.9306537 0.0073687590 0.839003870 0.899385621 17 44379689 44379814 126 - 1.150 1.131 -0.067
ENSG00000005961 E020 14.5280744 0.0114989889 0.379815012 0.524070026 17 44380002 44380056 55 - 1.167 1.075 -0.330
ENSG00000005961 E021 19.0544361 0.0017694159 0.324233923 0.467605637 17 44380057 44380153 97 - 1.132 1.226 0.334
ENSG00000005961 E022 16.2387343 0.0011934238 0.490095584 0.627455756 17 44380246 44380301 56 - 1.199 1.135 -0.231
ENSG00000005961 E023 18.7235540 0.0010423342 0.083051392 0.164328923 17 44380386 44380490 105 - 1.321 1.174 -0.519
ENSG00000005961 E024 11.5574958 0.0017192565 0.363800734 0.508238803 17 44380600 44380645 46 - 1.094 0.996 -0.356
ENSG00000005961 E025 1.1436731 0.0111727678 0.294095751 0.435179199 17 44380646 44380878 233 - 0.433 0.241 -1.205
ENSG00000005961 E026 18.1324101 0.0012768466 0.064007530 0.133364508 17 44380879 44381061 183 - 1.321 1.163 -0.559
ENSG00000005961 E027 16.7704812 0.0011899942 0.848246568 0.905757970 17 44383493 44383682 190 - 1.150 1.169 0.067
ENSG00000005961 E028 7.5846586 0.0024077432 0.843123580 0.902282257 17 44383683 44383704 22 - 0.826 0.853 0.105
ENSG00000005961 E029 0.8909948 0.0136041131 0.002697082 0.009364822 17 44383764 44383893 130 - 0.586 0.074 -3.942
ENSG00000005961 E030 5.1616201 0.0032075486 0.790545337 0.866012342 17 44383894 44383937 44 - 0.745 0.706 -0.159
ENSG00000005961 E031 4.5048603 0.0042321653 0.256002163 0.392970456 17 44383938 44383946 9 - 0.788 0.619 -0.700
ENSG00000005961 E032 0.4482035 0.0699422708 0.008462078 0.024942653 17 44383947 44384084 138 - 0.433 0.000 -14.285
ENSG00000005961 E033 11.6069644 0.0016040708 0.073795573 0.149587487 17 44384085 44384138 54 - 1.150 0.963 -0.682
ENSG00000005961 E034 10.1614063 0.0018595463 0.161521588 0.277086588 17 44384311 44384320 10 - 1.073 0.916 -0.580
ENSG00000005961 E035 13.0628479 0.0070596767 0.784200268 0.861563090 17 44384321 44384354 34 - 1.073 1.045 -0.102
ENSG00000005961 E036 0.6652806 0.0182339211 1.000000000 1.000000000 17 44384355 44384537 183 - 0.196 0.192 -0.035
ENSG00000005961 E037 11.0685563 0.0347085847 0.416801786 0.560175994 17 44384538 44384585 48 - 1.093 0.966 -0.465
ENSG00000005961 E038 16.7275589 0.0140950463 0.121846356 0.222555212 17 44384948 44385076 129 - 1.284 1.119 -0.587
ENSG00000005961 E039 8.9697250 0.0038664371 0.318481277 0.461455622 17 44385164 44385202 39 - 1.005 0.886 -0.448
ENSG00000005961 E040 7.0092835 0.0025062831 0.304007821 0.445986585 17 44385203 44385209 7 - 0.925 0.792 -0.512
ENSG00000005961 E041 1.7565510 0.1169767566 0.055203727 0.118338676 17 44385210 44385281 72 - 0.000 0.455 12.504
ENSG00000005961 E042 1.2782603 0.1932539857 0.148300695 0.259359536 17 44385282 44385285 4 - 0.000 0.364 12.007
ENSG00000005961 E043 7.7821715 0.0022731305 0.509546262 0.644853641 17 44385286 44385335 50 - 0.925 0.842 -0.319
ENSG00000005961 E044 2.5034914 0.0060640964 0.781740000 0.859796908 17 44385336 44385414 79 - 0.433 0.484 0.257
ENSG00000005961 E045 0.0000000       17 44385551 44385716 166 -      
ENSG00000005961 E046 0.0000000       17 44385717 44385809 93 -      
ENSG00000005961 E047 0.0000000       17 44385824 44385921 98 -      
ENSG00000005961 E048 0.0000000       17 44386010 44386131 122 -      
ENSG00000005961 E049 0.0000000       17 44389286 44389649 364 -