ENSG00000005893

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000200639 ENSG00000005893 HEK293_OSMI2_2hA HEK293_TMG_2hB LAMP2 protein_coding protein_coding 57.21664 31.29601 80.27335 3.341637 0.9043708 1.358661 3.323737 1.845842 5.070505 0.1602535 0.01071533 1.45289788 0.0595500 0.05920000 0.06316667 0.003966667 8.399760e-01 1.11091e-28 FALSE TRUE
ENST00000371335 ENSG00000005893 HEK293_OSMI2_2hA HEK293_TMG_2hB LAMP2 protein_coding protein_coding 57.21664 31.29601 80.27335 3.341637 0.9043708 1.358661 18.457749 10.833475 28.861772 2.0333281 0.76263400 1.41283244 0.3166000 0.34116667 0.35946667 0.018300000 8.650335e-01 1.11091e-28 FALSE TRUE
MSTRG.34818.4 ENSG00000005893 HEK293_OSMI2_2hA HEK293_TMG_2hB LAMP2 protein_coding   57.21664 31.29601 80.27335 3.341637 0.9043708 1.358661 18.433407 17.401603 17.526481 1.6467367 0.94732824 0.01031025 0.3964833 0.55763333 0.21816667 -0.339466667 1.110910e-28 1.11091e-28 FALSE TRUE
MSTRG.34818.6 ENSG00000005893 HEK293_OSMI2_2hA HEK293_TMG_2hB LAMP2 protein_coding   57.21664 31.29601 80.27335 3.341637 0.9043708 1.358661 16.597063 1.060159 28.320115 1.0601593 0.56072206 4.72643900 0.2199958 0.03796667 0.35303333 0.315066667 3.801993e-02 1.11091e-28 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000005893 E001 127.079599 0.0032700667 8.000205e-01 8.724871e-01 X 120426148 120427826 1679 - 2.097 2.085 -0.042
ENSG00000005893 E002 61.424434 0.0004013582 2.277642e-06 1.749852e-05 X 120427827 120428626 800 - 1.852 1.612 -0.814
ENSG00000005893 E003 268.027407 0.0012590368 2.422788e-01 3.768669e-01 X 120428627 120431247 2621 - 2.429 2.391 -0.127
ENSG00000005893 E004 289.322999 0.0005709331 6.705191e-88 1.443498e-84 X 120431248 120431462 215 - 2.226 2.684 1.527
ENSG00000005893 E005 3.093764 0.0205950244 8.771399e-01 9.250973e-01 X 120434009 120434042 34 - 0.615 0.585 -0.131
ENSG00000005893 E006 1285.514150 0.0062253856 6.150261e-01 7.333835e-01 X 120436494 120439075 2582 - 3.099 3.082 -0.057
ENSG00000005893 E007 267.747365 0.0002627780 3.855640e-43 1.605361e-40 X 120439076 120439293 218 - 2.513 2.151 -1.208
ENSG00000005893 E008 550.161078 0.0008275695 1.806795e-06 1.419356e-05 X 120441730 120441894 165 - 2.693 2.784 0.302
ENSG00000005893 E009 372.936766 0.0001650596 7.232189e-04 2.982015e-03 X 120442599 120442662 64 - 2.537 2.600 0.212
ENSG00000005893 E010 460.514175 0.0003684027 9.926897e-02 1.893722e-01 X 120446305 120446427 123 - 2.642 2.671 0.099
ENSG00000005893 E011 559.480083 0.0001353738 4.227437e-02 9.522837e-02 X 120447841 120448025 185 - 2.747 2.713 -0.112
ENSG00000005893 E012 483.877360 0.0010453839 4.697916e-02 1.037896e-01 X 120448970 120449128 159 - 2.688 2.637 -0.169
ENSG00000005893 E013 550.859889 0.0024403556 1.581534e-02 4.232355e-02 X 120455357 120455570 214 - 2.752 2.674 -0.261
ENSG00000005893 E014 324.589814 0.0002819260 1.938259e-03 7.035375e-03 X 120456651 120456769 119 - 2.521 2.451 -0.233
ENSG00000005893 E015 2.611573 0.1024045540 2.889362e-01 4.295947e-01 X 120468902 120469105 204 - 0.616 0.384 -1.140
ENSG00000005893 E016 247.147844 0.0038028033 2.128588e-02 5.418922e-02 X 120469106 120469365 260 - 2.412 2.315 -0.325