ENSG00000005889

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000304543 ENSG00000005889 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFX protein_coding protein_coding 7.590824 2.16685 13.21002 0.1930478 0.2832658 2.602411 0.79221155 0.14575495 1.7936765 0.14575495 0.5001324 3.5335907 0.11147500 0.06610000 0.13476667 0.06866667 3.955059e-01 7.185592e-05 FALSE TRUE
ENST00000338565 ENSG00000005889 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFX protein_coding protein_coding 7.590824 2.16685 13.21002 0.1930478 0.2832658 2.602411 0.05631891 0.20966024 0.0000000 0.10495161 0.0000000 -4.4572019 0.02537500 0.09960000 0.00000000 -0.09960000 1.655110e-02 7.185592e-05 FALSE TRUE
ENST00000379188 ENSG00000005889 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFX protein_coding protein_coding 7.590824 2.16685 13.21002 0.1930478 0.2832658 2.602411 0.72079723 0.05206337 1.0943241 0.02725195 0.3700355 4.1532779 0.07280417 0.02566667 0.08213333 0.05646667 3.045198e-01 7.185592e-05 FALSE TRUE
ENST00000497813 ENSG00000005889 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFX protein_coding processed_transcript 7.590824 2.16685 13.21002 0.1930478 0.2832658 2.602411 0.55372845 0.44661887 0.8905365 0.08958898 0.2648088 0.9797943 0.12270833 0.20183333 0.06680000 -0.13503333 5.129722e-02 7.185592e-05 FALSE FALSE
ENST00000539115 ENSG00000005889 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFX protein_coding protein_coding 7.590824 2.16685 13.21002 0.1930478 0.2832658 2.602411 0.06171116 0.15862319 0.0000000 0.15862319 0.0000000 -4.0757311 0.02878750 0.06393333 0.00000000 -0.06393333 4.543534e-01 7.185592e-05 FALSE TRUE
MSTRG.34029.20 ENSG00000005889 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFX protein_coding   7.590824 2.16685 13.21002 0.1930478 0.2832658 2.602411 0.93395626 0.00000000 1.6503150 0.00000000 0.4241191 7.3753132 0.07882500 0.00000000 0.12610000 0.12610000 1.397150e-04 7.185592e-05 FALSE TRUE
MSTRG.34029.23 ENSG00000005889 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFX protein_coding   7.590824 2.16685 13.21002 0.1930478 0.2832658 2.602411 0.81906328 0.97813923 1.1275043 0.09753362 0.4663502 0.2030858 0.17478333 0.46700000 0.08696667 -0.38003333 3.037902e-03 7.185592e-05 FALSE TRUE
MSTRG.34029.3 ENSG00000005889 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFX protein_coding   7.590824 2.16685 13.21002 0.1930478 0.2832658 2.602411 0.45814636 0.00000000 0.9077343 0.00000000 0.1251421 6.5200047 0.04580417 0.00000000 0.06913333 0.06913333 3.616245e-04 7.185592e-05 FALSE TRUE
MSTRG.34029.6 ENSG00000005889 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFX protein_coding   7.590824 2.16685 13.21002 0.1930478 0.2832658 2.602411 1.32248379 0.03588463 1.9761101 0.03588463 0.2554133 5.4357910 0.11463333 0.01446667 0.14910000 0.13463333 7.185592e-05 7.185592e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000005889 E001 0.5975289 0.0273818447 5.869110e-01 7.103428e-01 X 24149086 24149122 37 + 0.176 0.000 -9.946
ENSG00000005889 E002 0.7341688 0.2930416491 5.706442e-01 6.970677e-01 X 24149123 24149138 16 + 0.211 0.000 -11.036
ENSG00000005889 E003 0.7341688 0.2930416491 5.706442e-01 6.970677e-01 X 24149139 24149172 34 + 0.211 0.000 -11.036
ENSG00000005889 E004 2.9497018 0.0052758516 1.655071e-02 4.394941e-02 X 24149173 24149253 81 + 0.544 0.000 -13.411
ENSG00000005889 E005 2.3844382 0.0201035209 2.529851e-01 3.894373e-01 X 24149254 24149615 362 + 0.459 0.266 -1.146
ENSG00000005889 E006 1.5113257 0.0159552446 5.991789e-01 7.206329e-01 X 24149616 24149628 13 + 0.327 0.266 -0.410
ENSG00000005889 E007 1.6564984 0.0092826338 5.156136e-01 6.502616e-01 X 24149629 24149644 16 + 0.352 0.266 -0.562
ENSG00000005889 E008 2.4034664 0.0063194265 2.432714e-01 3.780105e-01 X 24149645 24149714 70 + 0.459 0.266 -1.148
ENSG00000005889 E009 1.3297351 0.0100763585 1.598492e-01 2.749144e-01 X 24149715 24149723 9 + 0.327 0.000 -12.496
ENSG00000005889 E010 1.6264232 0.0085793234 1.028947e-01 1.948842e-01 X 24149724 24149728 5 + 0.376 0.000 -12.739
ENSG00000005889 E011 1.6264232 0.0085793234 1.028947e-01 1.948842e-01 X 24149729 24149732 4 + 0.376 0.000 -12.739
ENSG00000005889 E012 4.8917276 0.0034487529 1.399439e-03 5.305018e-03 X 24149733 24149744 12 + 0.710 0.000 -13.915
ENSG00000005889 E013 8.9549016 0.0020169231 2.046497e-04 9.839419e-04 X 24149745 24149794 50 + 0.923 0.266 -3.123
ENSG00000005889 E014 0.6256415 0.0175556392 6.229529e-01 7.396561e-01 X 24149854 24150130 277 + 0.138 0.266 1.175
ENSG00000005889 E015 6.3326484 0.0026123922 6.455076e-02 1.342949e-01 X 24150506 24150819 314 + 0.665 1.014 1.361
ENSG00000005889 E016 1.3297351 0.0100763585 1.598492e-01 2.749144e-01 X 24151426 24151481 56 + 0.327 0.000 -12.496
ENSG00000005889 E017 8.4071389 0.0028754821 2.953202e-01 4.364598e-01 X 24151691 24151800 110 + 0.853 0.784 -0.270
ENSG00000005889 E018 14.3829314 0.0016385427 2.913240e-04 1.344469e-03 X 24152720 24152830 111 + 1.097 0.642 -1.764
ENSG00000005889 E019 0.1472490 0.0425363527 1.000000e+00   X 24159757 24159802 46 + 0.051 0.000 -9.366
ENSG00000005889 E020 1.7757486 0.0076655331 8.295007e-02 1.641645e-01 X 24161715 24161718 4 + 0.398 0.000 -12.844
ENSG00000005889 E021 5.3441975 0.0033586222 8.049619e-04 3.276636e-03 X 24161719 24161842 124 + 0.741 0.000 -13.997
ENSG00000005889 E022 24.2676658 0.0007934359 1.435897e-08 1.718966e-07 X 24172715 24172755 41 + 1.320 0.642 -2.553
ENSG00000005889 E023 27.6739110 0.0006768374 3.222422e-05 1.902038e-04 X 24172756 24172800 45 + 1.357 1.013 -1.224
ENSG00000005889 E024 0.4470576 0.0229388554 4.302205e-01 5.728543e-01 X 24172801 24172914 114 + 0.097 0.266 1.757
ENSG00000005889 E025 6.6128572 0.0025595002 7.023528e-02 1.437524e-01 X 24173607 24173723 117 + 0.787 0.549 -1.013
ENSG00000005889 E026 3.0112231 0.0212201129 5.576147e-01 6.859905e-01 X 24175389 24175443 55 + 0.459 0.643 0.858
ENSG00000005889 E027 0.9620705 0.0130749229 1.000000e+00 1.000000e+00 X 24176619 24176667 49 + 0.211 0.267 0.439
ENSG00000005889 E028 1.7185017 0.0983501080 8.287897e-01 8.924357e-01 X 24177684 24177866 183 + 0.328 0.431 0.587
ENSG00000005889 E029 126.2635036 0.0015031705 1.840004e-08 2.160952e-07 X 24179183 24179770 588 + 1.983 1.815 -0.566
ENSG00000005889 E030 60.5807403 0.0004166382 9.067942e-06 6.085997e-05 X 24207326 24207475 150 + 1.671 1.474 -0.673
ENSG00000005889 E031 58.1282922 0.0006566809 6.653938e-04 2.772126e-03 X 24207712 24207855 144 + 1.645 1.521 -0.423
ENSG00000005889 E032 44.8080897 0.0012276724 8.545908e-02 1.681480e-01 X 24208218 24208370 153 + 1.520 1.498 -0.075
ENSG00000005889 E033 34.0398907 0.0023083137 1.131267e-01 2.100934e-01 X 24208900 24209040 141 + 1.409 1.378 -0.108
ENSG00000005889 E034 256.6471422 0.0002874065 5.742220e-02 1.222093e-01 X 24210193 24211722 1530 + 2.257 2.312 0.183
ENSG00000005889 E035 25.2916908 0.0009525651 6.373573e-01 7.512595e-01 X 24211723 24211894 172 + 1.270 1.329 0.205
ENSG00000005889 E036 358.7381955 0.0095231627 2.734098e-16 1.115826e-14 X 24211895 24216255 4361 + 2.326 2.714 1.291