ENSG00000005882

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000505897 ENSG00000005882 HEK293_OSMI2_2hA HEK293_TMG_2hB PDK2 protein_coding retained_intron 37.54591 67.54011 25.29126 2.343765 0.7422328 -1.416749 5.642742 11.62105 2.316802 0.4037182 0.1929832 -2.321561 0.1429375 0.1722333 0.09156667 -0.08066667 5.509583e-06 5.509583e-06 FALSE TRUE
ENST00000512204 ENSG00000005882 HEK293_OSMI2_2hA HEK293_TMG_2hB PDK2 protein_coding retained_intron 37.54591 67.54011 25.29126 2.343765 0.7422328 -1.416749 12.414410 24.38688 6.841390 0.7478880 0.9996765 -1.832228 0.3145208 0.3612333 0.26860000 -0.09263333 1.642219e-01 5.509583e-06 FALSE TRUE
MSTRG.14651.6 ENSG00000005882 HEK293_OSMI2_2hA HEK293_TMG_2hB PDK2 protein_coding   37.54591 67.54011 25.29126 2.343765 0.7422328 -1.416749 15.637916 26.14892 12.727954 1.8026126 0.4138709 -1.038169 0.4313458 0.3862000 0.50320000 0.11700000 1.986433e-04 5.509583e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000005882 E001 0.5848540 0.0417317496 4.338375e-01 5.762326e-01 17 50094737 50094783 47 + 0.000 0.195 9.290
ENSG00000005882 E002 1.5510891 0.0091320969 5.736664e-01 6.995945e-01 17 50094784 50094898 115 + 0.429 0.328 -0.579
ENSG00000005882 E003 1.2242120 0.0121989077 8.248529e-01 8.896538e-01 17 50095285 50095317 33 + 0.327 0.288 -0.258
ENSG00000005882 E004 4.4181901 0.1695924600 9.818849e-01 9.926728e-01 17 50095318 50095350 33 + 0.642 0.658 0.070
ENSG00000005882 E005 5.1513373 0.1424395614 7.390003e-01 8.287440e-01 17 50095351 50095351 1 + 0.642 0.726 0.352
ENSG00000005882 E006 33.8391046 0.0057243313 2.892616e-02 6.985665e-02 17 50095352 50095374 23 + 1.304 1.492 0.650
ENSG00000005882 E007 44.7396611 0.0063602452 3.003635e-02 7.203089e-02 17 50095375 50095380 6 + 1.439 1.609 0.582
ENSG00000005882 E008 55.2108917 0.0184837917 7.694837e-02 1.546108e-01 17 50095381 50095386 6 + 1.534 1.697 0.554
ENSG00000005882 E009 200.6794762 0.0006694662 2.293946e-01 3.617161e-01 17 50095387 50095553 167 + 2.184 2.227 0.143
ENSG00000005882 E010 0.0000000       17 50095695 50095736 42 +      
ENSG00000005882 E011 0.3289534 0.0279183996 4.206592e-01   17 50095737 50095810 74 + 0.194 0.075 -1.579
ENSG00000005882 E012 0.6568746 0.0189291734 1.000000e+00 1.000000e+00 17 50095811 50095973 163 + 0.194 0.194 0.004
ENSG00000005882 E013 0.9900944 0.0629117471 6.528099e-01 7.634552e-01 17 50095974 50096039 66 + 0.327 0.244 -0.582
ENSG00000005882 E014 0.6966286 0.5353982732 8.727203e-01 9.221455e-01 17 50096040 50096131 92 + 0.194 0.196 0.016
ENSG00000005882 E015 0.9630260 0.0696009272 6.546988e-01 7.648091e-01 17 50096132 50096286 155 + 0.328 0.243 -0.590
ENSG00000005882 E016 240.4901415 0.0020342560 1.382391e-01 2.456407e-01 17 50097423 50097512 90 + 2.251 2.307 0.188
ENSG00000005882 E017 209.9803577 0.0005838983 6.631908e-01 7.713103e-01 17 50097513 50097564 52 + 2.223 2.241 0.061
ENSG00000005882 E018 1.2242120 0.0121989077 8.248529e-01 8.896538e-01 17 50097565 50097796 232 + 0.327 0.288 -0.258
ENSG00000005882 E019 0.0000000       17 50104324 50104393 70 +      
ENSG00000005882 E020 1.1394067 0.0118116659 3.045175e-01 4.465234e-01 17 50105279 50105370 92 + 0.429 0.244 -1.165
ENSG00000005882 E021 225.1060442 0.0003707885 6.039956e-01 7.246581e-01 17 50105371 50105442 72 + 2.278 2.268 -0.031
ENSG00000005882 E022 380.2245931 0.0003033996 1.674863e-02 4.438351e-02 17 50105885 50106069 185 + 2.531 2.486 -0.151
ENSG00000005882 E023 56.1197804 0.0004469199 3.457652e-06 2.554267e-05 17 50106070 50106368 299 + 1.429 1.725 1.010
ENSG00000005882 E024 2.0605878 0.0070167517 9.908515e-01 9.984411e-01 17 50106441 50106793 353 + 0.429 0.430 0.005
ENSG00000005882 E025 198.9096607 0.0014098964 1.474878e-06 1.181343e-05 17 50106794 50106883 90 + 2.325 2.177 -0.497
ENSG00000005882 E026 197.4297497 0.0002057256 2.306119e-07 2.184983e-06 17 50107076 50107153 78 + 2.316 2.177 -0.465
ENSG00000005882 E027 0.1482932 0.0411577591 1.000000e+00   17 50108001 50108007 7 + 0.000 0.075 9.354
ENSG00000005882 E028 1.2125587 0.0117638991 3.057848e-01 4.479343e-01 17 50108008 50108155 148 + 0.429 0.244 -1.163
ENSG00000005882 E029 195.2861265 0.0001994853 1.002688e-03 3.967672e-03 17 50108156 50108232 77 + 2.275 2.186 -0.297
ENSG00000005882 E030 2.0628822 0.0072438620 9.214778e-04 3.690411e-03 17 50108233 50108318 86 + 0.783 0.244 -2.749
ENSG00000005882 E031 220.8889680 0.0003145155 3.157245e-01 4.584958e-01 17 50108319 50108417 99 + 2.279 2.256 -0.077
ENSG00000005882 E032 221.6756393 0.0038484558 9.581745e-01 9.777663e-01 17 50108612 50108719 108 + 2.257 2.265 0.026
ENSG00000005882 E033 198.9171769 0.0002628952 6.987104e-01 7.986111e-01 17 50109287 50109400 114 + 2.202 2.218 0.055
ENSG00000005882 E034 860.8386801 0.0006438078 4.682181e-05 2.656639e-04 17 50109957 50111176 1220 + 2.794 2.866 0.240
ENSG00000005882 E035 42.0793989 0.0046992322 2.276809e-01 3.596343e-01 17 50111177 50111263 87 + 1.481 1.575 0.321
ENSG00000005882 E036 28.6317599 0.0007464969 5.319663e-01 6.643555e-01 17 50111264 50112152 889 + 1.350 1.403 0.183
ENSG00000005882 E037 1.0747875 0.0406018638 3.112371e-01 4.536833e-01 17 50119534 50119608 75 + 0.430 0.243 -1.175