ENSG00000005812

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355619 ENSG00000005812 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXL3 protein_coding protein_coding 32.74339 9.338131 59.06077 0.7324157 0.8579144 2.659695 19.685862 5.19606580 38.733237 0.31334851 1.5503480 2.8956791 0.55527500 0.558500000 0.65596667 0.09746667 1.620788e-01 3.854351e-07 FALSE TRUE
ENST00000477982 ENSG00000005812 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXL3 protein_coding processed_transcript 32.74339 9.338131 59.06077 0.7324157 0.8579144 2.659695 2.549662 1.22996805 3.825687 0.13549088 0.6117355 1.6291819 0.08824583 0.131866667 0.06510000 -0.06676667 4.088416e-02 3.854351e-07 FALSE FALSE
ENST00000485797 ENSG00000005812 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXL3 protein_coding processed_transcript 32.74339 9.338131 59.06077 0.7324157 0.8579144 2.659695 1.807200 1.21053474 1.482320 0.63815576 0.7429643 0.2900431 0.10966667 0.130400000 0.02493333 -0.10546667 7.480611e-01 3.854351e-07   FALSE
MSTRG.8917.2 ENSG00000005812 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXL3 protein_coding   32.74339 9.338131 59.06077 0.7324157 0.8579144 2.659695 1.124433 0.75937863 0.943360 0.41765402 0.4906603 0.3093274 0.07265000 0.076766667 0.01620000 -0.06056667 7.545247e-01 3.854351e-07   FALSE
MSTRG.8917.9 ENSG00000005812 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXL3 protein_coding   32.74339 9.338131 59.06077 0.7324157 0.8579144 2.659695 4.615225 0.04872593 8.765897 0.04872593 1.3837975 7.2234052 0.08271250 0.004666667 0.14800000 0.14333333 3.854351e-07 3.854351e-07   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000005812 E001 10.9294723 0.0016895329 1.223148e-10 2.128426e-09 13 76992348 76992520 173 - 0.745 1.420 2.474
ENSG00000005812 E002 12.5081610 0.0345319078 6.635258e-08 6.977684e-07 13 76992598 76992720 123 - 0.803 1.488 2.472
ENSG00000005812 E003 29.1136104 0.0081727332 8.265566e-17 3.594781e-15 13 76992721 76992951 231 - 1.158 1.816 2.266
ENSG00000005812 E004 224.0130007 0.0003634933 5.149193e-50 3.126600e-47 13 76999137 77002049 2913 - 2.131 2.535 1.348
ENSG00000005812 E005 1211.2642433 0.0025099416 7.606255e-01 8.446505e-01 13 77005260 77007564 2305 - 2.958 2.968 0.034
ENSG00000005812 E006 264.5882673 0.0002216873 4.796598e-10 7.532961e-09 13 77007565 77007788 224 - 2.328 2.132 -0.657
ENSG00000005812 E007 1.3705332 0.0119991007 7.726235e-01 8.532376e-01 13 77015165 77015408 244 - 0.316 0.253 -0.439
ENSG00000005812 E008 248.7529764 0.0002174959 3.014845e-01 4.433043e-01 13 77015409 77015510 102 - 2.279 2.252 -0.089
ENSG00000005812 E009 217.6960040 0.0001797635 1.796927e-01 3.007744e-01 13 77015511 77015580 70 - 2.223 2.184 -0.131
ENSG00000005812 E010 0.7427016 0.0156418951 4.979994e-01 6.345090e-01 13 77015581 77015581 1 - 0.223 0.000 -9.386
ENSG00000005812 E011 248.5043131 0.0002386727 1.073434e-01 2.016229e-01 13 77018600 77018722 123 - 2.280 2.235 -0.151
ENSG00000005812 E012 0.4460135 0.0331418925 1.000000e+00 1.000000e+00 13 77018723 77018744 22 - 0.147 0.000 -8.649
ENSG00000005812 E013 175.6246195 0.0002020938 5.519427e-08 5.891587e-07 13 77021513 77021656 144 - 2.153 1.940 -0.714
ENSG00000005812 E014 132.9998512 0.0002821060 1.229987e-06 1.002010e-05 13 77021657 77021751 95 - 2.034 1.813 -0.743
ENSG00000005812 E015 121.1700107 0.0035931086 8.401853e-05 4.470958e-04 13 77021752 77021861 110 - 1.995 1.775 -0.740
ENSG00000005812 E016 158.4139366 0.0074821098 7.715770e-02 1.549345e-01 13 77026827 77027011 185 - 2.095 1.995 -0.336
ENSG00000005812 E017 131.6592866 0.0195923925 3.764243e-01 5.207519e-01 13 77027012 77027197 186 - 2.011 1.939 -0.243