ENSG00000005700

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000306270 ENSG00000005700 HEK293_OSMI2_2hA HEK293_TMG_2hB IBTK protein_coding protein_coding 7.246914 2.60238 11.79619 0.3218823 0.1387719 2.176107 4.8248229 0.908244059 8.2733875 0.082550684 0.62776227 3.1732713 0.59367917 0.3666333 0.70216667 0.33553333 0.01783445 0.01783445 FALSE TRUE
ENST00000445419 ENSG00000005700 HEK293_OSMI2_2hA HEK293_TMG_2hB IBTK protein_coding retained_intron 7.246914 2.60238 11.79619 0.3218823 0.1387719 2.176107 0.5787935 0.635611383 0.4880672 0.382537967 0.15700045 -0.3743257 0.15022500 0.2184333 0.04130000 -0.17713333 0.08920738 0.01783445 TRUE TRUE
ENST00000508381 ENSG00000005700 HEK293_OSMI2_2hA HEK293_TMG_2hB IBTK protein_coding retained_intron 7.246914 2.60238 11.79619 0.3218823 0.1387719 2.176107 0.1899341 0.535971792 0.1158229 0.349108054 0.02713959 -2.1174317 0.06187500 0.2063333 0.00980000 -0.19653333 0.21384988 0.01783445 FALSE FALSE
ENST00000510291 ENSG00000005700 HEK293_OSMI2_2hA HEK293_TMG_2hB IBTK protein_coding protein_coding 7.246914 2.60238 11.79619 0.3218823 0.1387719 2.176107 0.2739822 0.009002128 0.7374216 0.009002128 0.25442830 5.2976893 0.02395000 0.0028000 0.06286667 0.06006667 0.05221710 0.01783445 FALSE TRUE
ENST00000610980 ENSG00000005700 HEK293_OSMI2_2hA HEK293_TMG_2hB IBTK protein_coding protein_coding 7.246914 2.60238 11.79619 0.3218823 0.1387719 2.176107 0.4044139 0.417889476 0.4828819 0.242044827 0.05248120 0.2040037 0.07532500 0.1729000 0.04100000 -0.13190000 0.74413528 0.01783445 FALSE TRUE
MSTRG.28584.7 ENSG00000005700 HEK293_OSMI2_2hA HEK293_TMG_2hB IBTK protein_coding   7.246914 2.60238 11.79619 0.3218823 0.1387719 2.176107 0.6478979 0.000000000 1.2678648 0.000000000 0.63516008 6.9975914 0.05272083 0.0000000 0.10630000 0.10630000 0.37623864 0.01783445 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000005700 E001 0.0000000       6 82169986 82169986 1 -      
ENSG00000005700 E002 1.9007697 0.4160431562 4.209720e-02 9.490740e-02 6 82169987 82170235 249 - 0.253 0.756 2.573
ENSG00000005700 E003 1.6178853 0.3501964827 1.881338e-02 4.892435e-02 6 82170236 82170238 3 - 0.145 0.776 3.649
ENSG00000005700 E004 129.8211249 0.0204130387 1.338156e-11 2.730607e-10 6 82170239 82170742 504 - 1.832 2.391 1.875
ENSG00000005700 E005 152.0501576 0.0083363572 6.364691e-12 1.368329e-10 6 82170743 82171402 660 - 1.954 2.370 1.391
ENSG00000005700 E006 29.3962657 0.0007352626 1.893162e-02 4.918052e-02 6 82171403 82171411 9 - 1.306 1.548 0.834
ENSG00000005700 E007 48.3257561 0.0039589319 5.466535e-03 1.719954e-02 6 82171412 82171507 96 - 1.513 1.762 0.846
ENSG00000005700 E008 46.4898106 0.0237946485 2.931490e-01 4.341887e-01 6 82171508 82171556 49 - 1.513 1.695 0.621
ENSG00000005700 E009 65.0570047 0.0056789694 6.799105e-02 1.400320e-01 6 82172380 82172512 133 - 1.656 1.839 0.618
ENSG00000005700 E010 1.6962512 0.0082691251 3.592199e-01 5.035497e-01 6 82172513 82173366 854 - 0.314 0.531 1.172
ENSG00000005700 E011 48.2181290 0.0004486035 5.709701e-02 1.216334e-01 6 82173367 82173438 72 - 1.529 1.710 0.617
ENSG00000005700 E012 0.5848434 0.0225881972 5.659662e-01 6.929976e-01 6 82173439 82173578 140 - 0.185 0.000 -9.723
ENSG00000005700 E013 0.4502799 0.0295007300 8.454790e-01 9.039137e-01 6 82174898 82175002 105 - 0.146 0.000 -9.309
ENSG00000005700 E014 62.6482142 0.0004208067 2.419232e-02 6.020496e-02 6 82181879 82182028 150 - 1.636 1.823 0.633
ENSG00000005700 E015 54.3441077 0.0006122826 1.749686e-01 2.946268e-01 6 82191073 82191216 144 - 1.585 1.730 0.494
ENSG00000005700 E016 1.7916537 0.1859796104 8.693156e-01 9.200105e-01 6 82191217 82191330 114 - 0.342 0.421 0.446
ENSG00000005700 E017 2.7668595 0.0055904175 5.867705e-02 1.243672e-01 6 82191331 82191786 456 - 0.391 0.763 1.714
ENSG00000005700 E018 44.2293489 0.0048863966 5.220712e-01 6.559371e-01 6 82191787 82191879 93 - 1.511 1.621 0.374
ENSG00000005700 E019 54.6163440 0.0229518648 5.286003e-01 6.615152e-01 6 82194479 82194595 117 - 1.593 1.725 0.450
ENSG00000005700 E020 42.7898025 0.0234692411 7.635819e-01 8.468662e-01 6 82194596 82194642 47 - 1.496 1.600 0.355
ENSG00000005700 E021 58.4177777 0.0112584050 6.055937e-01 7.259514e-01 6 82196298 82196401 104 - 1.626 1.735 0.370
ENSG00000005700 E022 37.2481583 0.0417824286 7.658883e-01 8.485548e-01 6 82196402 82196446 45 - 1.435 1.550 0.395
ENSG00000005700 E023 61.8892976 0.0056650572 1.772458e-01 2.976491e-01 6 82200141 82200253 113 - 1.673 1.648 -0.084
ENSG00000005700 E024 54.7534208 0.0027298090 5.258126e-02 1.137557e-01 6 82200587 82200708 122 - 1.628 1.559 -0.234
ENSG00000005700 E025 39.8281046 0.0012005629 5.011645e-04 2.164314e-03 6 82201422 82201482 61 - 1.515 1.287 -0.789
ENSG00000005700 E026 49.2713383 0.0009853349 2.254279e-01 3.569237e-01 6 82202528 82202645 118 - 1.576 1.558 -0.061
ENSG00000005700 E027 42.6563252 0.0006559472 3.665659e-02 8.482224e-02 6 82204857 82204958 102 - 1.529 1.437 -0.316
ENSG00000005700 E028 4.4683007 0.0302079944 1.400880e-01 2.481486e-01 6 82204959 82205929 971 - 0.674 0.414 -1.222
ENSG00000005700 E029 35.0559745 0.0026713695 2.088714e-01 3.371654e-01 6 82210814 82210910 97 - 1.438 1.397 -0.140
ENSG00000005700 E030 21.2069092 0.0053806351 5.850840e-01 7.088471e-01 6 82211367 82211404 38 - 1.225 1.230 0.016
ENSG00000005700 E031 29.3660506 0.0007075702 5.355591e-01 6.673649e-01 6 82211490 82211572 83 - 1.357 1.368 0.037
ENSG00000005700 E032 33.0035595 0.0043169636 2.073938e-01 3.353802e-01 6 82212707 82212793 87 - 1.416 1.368 -0.166
ENSG00000005700 E033 116.3180288 0.0003176642 2.029906e-11 4.017967e-10 6 82214227 82214829 603 - 1.979 1.710 -0.909
ENSG00000005700 E034 51.0116102 0.0005790116 1.671538e-04 8.229053e-04 6 82216076 82216250 175 - 1.621 1.411 -0.720
ENSG00000005700 E035 44.9093616 0.1169175270 6.851660e-02 1.409151e-01 6 82217960 82218137 178 - 1.572 1.330 -0.832
ENSG00000005700 E036 42.6551269 0.0005229384 3.622937e-06 2.663179e-05 6 82220590 82220713 124 - 1.557 1.229 -1.135
ENSG00000005700 E037 48.2561172 0.0004476875 1.585708e-07 1.549771e-06 6 82223440 82223620 181 - 1.611 1.249 -1.249
ENSG00000005700 E038 45.1689964 0.0023763359 1.518840e-06 1.213017e-05 6 82224068 82224185 118 - 1.582 1.229 -1.220
ENSG00000005700 E039 45.5648553 0.0004606715 1.041438e-04 5.411335e-04 6 82225477 82225647 171 - 1.576 1.337 -0.820
ENSG00000005700 E040 0.2944980 0.3553646796 1.000000e+00   6 82227164 82227191 28 - 0.102 0.000 -8.723
ENSG00000005700 E041 36.3123127 0.0005558734 1.297796e-04 6.578641e-04 6 82227192 82227302 111 - 1.484 1.208 -0.959
ENSG00000005700 E042 45.4100115 0.0006537836 1.470493e-06 1.178179e-05 6 82231718 82231842 125 - 1.583 1.249 -1.155
ENSG00000005700 E043 34.6901333 0.0005664626 2.682907e-06 2.030235e-05 6 82234159 82234255 97 - 1.474 1.085 -1.367
ENSG00000005700 E044 82.8559133 0.0024598544 9.702134e-09 1.199530e-07 6 82240166 82240843 678 - 1.837 1.528 -1.048
ENSG00000005700 E045 24.4286189 0.0065329582 6.278659e-06 4.371456e-05 6 82247562 82247754 193 - 1.339 0.819 -1.899