ENSG00000005483

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000257745 ENSG00000005483 HEK293_OSMI2_2hA HEK293_TMG_2hB KMT2E protein_coding nonsense_mediated_decay 7.507142 2.080732 9.844122 0.2036556 0.7044532 2.236719 0.6285696 0.3102105 0.5451923 0.10220532 0.07278566 0.793967 0.13200417 0.14606667 0.05620000 -0.08986667 9.364695e-02 8.430646e-12 FALSE TRUE
ENST00000311117 ENSG00000005483 HEK293_OSMI2_2hA HEK293_TMG_2hB KMT2E protein_coding protein_coding 7.507142 2.080732 9.844122 0.2036556 0.7044532 2.236719 3.4397452 1.3707624 4.8580100 0.02213304 0.05340882 1.817867 0.50889583 0.66973333 0.49810000 -0.17163333 1.205856e-01 8.430646e-12 FALSE TRUE
ENST00000476671 ENSG00000005483 HEK293_OSMI2_2hA HEK293_TMG_2hB KMT2E protein_coding protein_coding 7.507142 2.080732 9.844122 0.2036556 0.7044532 2.236719 0.3980073 0.1644081 0.4792414 0.04171627 0.15573740 1.488080 0.05558333 0.07656667 0.04896667 -0.02760000 5.808915e-01 8.430646e-12 FALSE TRUE
ENST00000478079 ENSG00000005483 HEK293_OSMI2_2hA HEK293_TMG_2hB KMT2E protein_coding nonsense_mediated_decay 7.507142 2.080732 9.844122 0.2036556 0.7044532 2.236719 0.6018759 0.1407961 0.4313067 0.14079605 0.43130667 1.549183 0.06648333 0.05803333 0.03926667 -0.01876667 8.537360e-01 8.430646e-12 FALSE FALSE
ENST00000478990 ENSG00000005483 HEK293_OSMI2_2hA HEK293_TMG_2hB KMT2E protein_coding protein_coding 7.507142 2.080732 9.844122 0.2036556 0.7044532 2.236719 0.6446242 0.0000000 0.9350898 0.00000000 0.50713098 6.562380 0.05062917 0.00000000 0.08833333 0.08833333 3.991214e-01 8.430646e-12 FALSE TRUE
ENST00000495267 ENSG00000005483 HEK293_OSMI2_2hA HEK293_TMG_2hB KMT2E protein_coding protein_coding 7.507142 2.080732 9.844122 0.2036556 0.7044532 2.236719 1.1519870 0.0000000 2.0847287 0.00000000 0.03552030 7.710620 0.09960000 0.00000000 0.21350000 0.21350000 8.430646e-12 8.430646e-12 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000005483 E001 0.0000000       7 104940943 104940943 1 +      
ENSG00000005483 E002 0.0000000       7 104940944 104941062 119 +      
ENSG00000005483 E003 0.0000000       7 104941063 104941551 489 +      
ENSG00000005483 E004 0.0000000       7 104941552 104941661 110 +      
ENSG00000005483 E005 0.0000000       7 104941662 104941670 9 +      
ENSG00000005483 E006 0.0000000       7 104941671 104941745 75 +      
ENSG00000005483 E007 0.0000000       7 104961984 104962199 216 +      
ENSG00000005483 E008 0.0000000       7 104962200 104962284 85 +      
ENSG00000005483 E009 0.0000000       7 104962285 104962357 73 +      
ENSG00000005483 E010 0.0000000       7 104962358 104963216 859 +      
ENSG00000005483 E011 0.0000000       7 105000193 105000255 63 +      
ENSG00000005483 E012 0.0000000       7 105000256 105000713 458 +      
ENSG00000005483 E013 1.0675023 0.0114768195 6.420156e-01 7.549314e-01 7 105013317 105014163 847 + 0.289 0.224 -0.485
ENSG00000005483 E014 0.3289534 0.0296793383 3.419674e-01   7 105014164 105014189 26 + 0.063 0.224 2.100
ENSG00000005483 E015 1.4319302 0.0095969365 9.466409e-01 9.704928e-01 7 105014190 105014204 15 + 0.322 0.371 0.293
ENSG00000005483 E016 1.4319302 0.0095969365 9.466409e-01 9.704928e-01 7 105014205 105014205 1 + 0.322 0.371 0.293
ENSG00000005483 E017 1.4319302 0.0095969365 9.466409e-01 9.704928e-01 7 105014206 105014206 1 + 0.322 0.371 0.293
ENSG00000005483 E018 1.4319302 0.0095969365 9.466409e-01 9.704928e-01 7 105014207 105014207 1 + 0.322 0.371 0.293
ENSG00000005483 E019 3.5001004 0.0044399207 1.060530e-01 1.996882e-01 7 105014208 105014217 10 + 0.634 0.371 -1.292
ENSG00000005483 E020 26.0577169 0.0007570188 8.865426e-02 1.730707e-01 7 105014218 105014431 214 + 1.365 1.283 -0.285
ENSG00000005483 E021 15.7587685 0.0012568908 2.632886e-02 6.460538e-02 7 105014432 105014460 29 + 1.176 0.990 -0.675
ENSG00000005483 E022 21.4494059 0.0401672662 1.013508e-01 1.925316e-01 7 105014461 105014535 75 + 1.295 1.151 -0.508
ENSG00000005483 E023 7.3730703 0.0022481809 9.968771e-01 1.000000e+00 7 105038126 105038199 74 + 0.834 0.889 0.212
ENSG00000005483 E024 0.4460135 0.0338488669 5.510768e-01 6.805909e-01 7 105038385 105038525 141 + 0.168 0.000 -10.508
ENSG00000005483 E025 0.0000000       7 105039153 105039269 117 +      
ENSG00000005483 E026 11.5316838 0.0015246003 6.145443e-01 7.329614e-01 7 105040839 105040847 9 + 1.018 1.018 0.000
ENSG00000005483 E027 12.2659663 0.0014034548 4.306222e-01 5.732280e-01 7 105040848 105040857 10 + 1.050 1.018 -0.115
ENSG00000005483 E028 31.2834098 0.0006323929 4.507060e-03 1.456260e-02 7 105040858 105041023 166 + 1.462 1.298 -0.569
ENSG00000005483 E029 0.2955422 0.0308074325 3.419227e-01   7 105061918 105062163 246 + 0.063 0.223 2.097
ENSG00000005483 E030 17.6617844 0.0010224486 8.779878e-03 2.573273e-02 7 105062164 105062197 34 + 1.235 1.018 -0.780
ENSG00000005483 E031 25.6634776 0.0007118842 3.042429e-07 2.811879e-06 7 105062198 105062278 81 + 1.415 0.958 -1.629
ENSG00000005483 E032 45.0249418 0.0004750517 4.673125e-05 2.651897e-04 7 105063351 105063580 230 + 1.620 1.402 -0.747
ENSG00000005483 E033 0.5975289 0.0301177614 3.727824e-01 5.172108e-01 7 105063581 105063827 247 + 0.212 0.000 -10.904
ENSG00000005483 E034 0.0000000       7 105064028 105064116 89 +      
ENSG00000005483 E035 27.6288704 0.0006910189 5.610894e-02 1.198944e-01 7 105066727 105066807 81 + 1.393 1.298 -0.331
ENSG00000005483 E036 0.1515154 0.0429473320 1.000000e+00   7 105068475 105068545 71 + 0.063 0.000 -8.962
ENSG00000005483 E037 29.9584808 0.0015095936 4.032228e-02 9.162362e-02 7 105073619 105073677 59 + 1.430 1.327 -0.360
ENSG00000005483 E038 43.8342957 0.0005557333 2.033368e-02 5.218390e-02 7 105074643 105074815 173 + 1.586 1.496 -0.309
ENSG00000005483 E039 25.5663695 0.0008482076 3.602848e-03 1.201861e-02 7 105076043 105076081 39 + 1.379 1.180 -0.698
ENSG00000005483 E040 43.4685405 0.0005423324 3.502668e-02 8.170031e-02 7 105076963 105077115 153 + 1.581 1.505 -0.259
ENSG00000005483 E041 27.4489703 0.0210120157 7.453511e-01 8.334191e-01 7 105077116 105077193 78 + 1.367 1.394 0.095
ENSG00000005483 E042 32.7749306 0.0012920221 8.519174e-01 9.081982e-01 7 105077303 105077433 131 + 1.438 1.486 0.167
ENSG00000005483 E043 0.0000000       7 105077434 105077808 375 +      
ENSG00000005483 E044 26.5823307 0.0021894778 4.205418e-01 5.637427e-01 7 105078846 105078963 118 + 1.359 1.354 -0.018
ENSG00000005483 E045 29.2528599 0.0060624942 4.059298e-01 5.495879e-01 7 105081688 105081797 110 + 1.401 1.392 -0.034
ENSG00000005483 E046 0.5954526 0.0183578395 3.703087e-01 5.147499e-01 7 105089226 105089361 136 + 0.212 0.000 -10.921
ENSG00000005483 E047 51.1633973 0.0005296113 8.145474e-02 1.618340e-01 7 105090009 105090273 265 + 1.644 1.603 -0.141
ENSG00000005483 E048 31.7850002 0.0006787216 4.207440e-01 5.639330e-01 7 105091216 105091314 99 + 1.433 1.436 0.010
ENSG00000005483 E049 4.1769536 0.0040231281 1.905159e-04 9.233695e-04 7 105091315 105091609 295 + 0.436 1.018 2.447
ENSG00000005483 E050 20.2244518 0.0010873229 1.444666e-02 3.923669e-02 7 105101425 105101470 46 + 1.277 1.095 -0.645
ENSG00000005483 E051 32.5225526 0.0006588380 2.027504e-05 1.255695e-04 7 105101471 105101589 119 + 1.494 1.199 -1.026
ENSG00000005483 E052 54.2220289 0.0004768801 1.330648e-02 3.663421e-02 7 105101886 105102194 309 + 1.678 1.595 -0.282
ENSG00000005483 E053 1.5530531 0.1339230820 1.030855e-01 1.951753e-01 7 105102195 105102649 455 + 0.252 0.634 2.074
ENSG00000005483 E054 41.9456410 0.0032314816 2.326089e-01 3.655534e-01 7 105105439 105105693 255 + 1.559 1.540 -0.065
ENSG00000005483 E055 25.7281894 0.0027462930 2.073861e-01 3.353718e-01 7 105105859 105105955 97 + 1.359 1.312 -0.162
ENSG00000005483 E056 20.0855546 0.0009736985 7.508191e-01 8.374128e-01 7 105105956 105106003 48 + 1.235 1.268 0.113
ENSG00000005483 E057 44.3183927 0.0019578429 8.349182e-01 8.966709e-01 7 105106522 105106772 251 + 1.561 1.611 0.170
ENSG00000005483 E058 22.2480231 0.0029641832 8.722046e-02 1.709267e-01 7 105107166 105107222 57 + 1.231 1.436 0.714
ENSG00000005483 E059 76.3062306 0.0003451410 3.918548e-01 5.358006e-01 7 105107362 105107899 538 + 1.803 1.826 0.077
ENSG00000005483 E060 21.1920899 0.0442365903 2.304623e-01 3.630068e-01 7 105107900 105107925 26 + 1.292 1.193 -0.350
ENSG00000005483 E061 0.5880631 0.2918804197 1.438069e-01 2.531909e-01 7 105108544 105108658 115 + 0.063 0.380 3.154
ENSG00000005483 E062 34.1137392 0.0064568654 6.213613e-01 7.383261e-01 7 105108942 105109039 98 + 1.462 1.486 0.081
ENSG00000005483 E063 48.9227693 0.0005002003 2.126626e-01 3.416897e-01 7 105109040 105109228 189 + 1.622 1.610 -0.041
ENSG00000005483 E064 35.2695776 0.0039174862 7.339147e-01 8.250364e-01 7 105110280 105110368 89 + 1.469 1.506 0.127
ENSG00000005483 E065 40.7556715 0.0011174773 9.993928e-01 1.000000e+00 7 105110477 105110602 126 + 1.526 1.588 0.214
ENSG00000005483 E066 41.1050389 0.0004887266 7.121906e-01 8.089986e-01 7 105110771 105110868 98 + 1.534 1.573 0.133
ENSG00000005483 E067 296.5778355 0.0069956210 9.192600e-20 5.676371e-18 7 105111825 105115345 3521 + 2.266 2.668 1.340