ENSG00000005339

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262367 ENSG00000005339 HEK293_OSMI2_2hA HEK293_TMG_2hB CREBBP protein_coding protein_coding 20.28563 18.13551 19.93053 0.8974543 0.07302448 0.1360915 9.5231469 13.640073623 6.4550881 1.470638116 0.2843031 -1.078167 0.47855833 0.7477333333 0.32383333 -0.4239000 4.618778e-08 2.233807e-44 FALSE TRUE
ENST00000570939 ENSG00000005339 HEK293_OSMI2_2hA HEK293_TMG_2hB CREBBP protein_coding protein_coding 20.28563 18.13551 19.93053 0.8974543 0.07302448 0.1360915 1.1719739 0.064614958 1.3673875 0.032528967 0.3731040 4.206326 0.05545000 0.0034666667 0.06846667 0.0650000 2.252907e-06 2.233807e-44 FALSE TRUE
ENST00000571763 ENSG00000005339 HEK293_OSMI2_2hA HEK293_TMG_2hB CREBBP protein_coding retained_intron 20.28563 18.13551 19.93053 0.8974543 0.07302448 0.1360915 1.3020219 1.864945391 0.7771667 0.174884131 0.3348558 -1.252107 0.06402500 0.1031000000 0.03900000 -0.0641000 7.371746e-02 2.233807e-44   FALSE
ENST00000638158 ENSG00000005339 HEK293_OSMI2_2hA HEK293_TMG_2hB CREBBP protein_coding processed_transcript 20.28563 18.13551 19.93053 0.8974543 0.07302448 0.1360915 0.2528705 0.879061629 0.0000000 0.879061629 0.0000000 -6.474212 0.01412917 0.0535000000 0.00000000 -0.0535000 7.929722e-01 2.233807e-44   FALSE
MSTRG.11955.10 ENSG00000005339 HEK293_OSMI2_2hA HEK293_TMG_2hB CREBBP protein_coding   20.28563 18.13551 19.93053 0.8974543 0.07302448 0.1360915 2.9242055 0.000000000 4.4398659 0.000000000 0.2269793 8.797618 0.14245417 0.0000000000 0.22276667 0.2227667 2.233807e-44 2.233807e-44 FALSE TRUE
MSTRG.11955.13 ENSG00000005339 HEK293_OSMI2_2hA HEK293_TMG_2hB CREBBP protein_coding   20.28563 18.13551 19.93053 0.8974543 0.07302448 0.1360915 0.3911677 0.003987874 1.3490937 0.003987874 0.1523042 6.602324 0.02001667 0.0002333333 0.06773333 0.0675000 1.519234e-15 2.233807e-44 FALSE TRUE
MSTRG.11955.3 ENSG00000005339 HEK293_OSMI2_2hA HEK293_TMG_2hB CREBBP protein_coding   20.28563 18.13551 19.93053 0.8974543 0.07302448 0.1360915 1.3289106 0.005644128 2.5378916 0.005644128 0.2882243 7.347539 0.06440417 0.0003333333 0.12723333 0.1269000 6.240343e-22 2.233807e-44 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000005339 E001 729.0519629 0.0087645692 7.743333e-22 6.044299e-20 16 3725054 3727141 2088 - 2.540 3.019 1.594
ENSG00000005339 E002 340.9017675 0.0040912205 3.826000e-40 1.339786e-37 16 3727142 3727538 397 - 2.154 2.701 1.825
ENSG00000005339 E003 505.8271735 0.0034864264 9.715221e-14 2.767698e-12 16 3727539 3728339 801 - 2.527 2.807 0.934
ENSG00000005339 E004 466.1631917 0.0002924074 2.660886e-25 2.981057e-23 16 3728340 3729392 1053 - 2.523 2.751 0.760
ENSG00000005339 E005 165.3012918 0.0016090618 1.473768e-04 7.358429e-04 16 3729393 3729647 255 - 2.113 2.282 0.563
ENSG00000005339 E006 181.4395505 0.0004524022 2.892190e-04 1.335959e-03 16 3729648 3729874 227 - 2.171 2.311 0.469
ENSG00000005339 E007 0.4439371 0.0215593964 7.284583e-02 1.480732e-01 16 3730512 3730552 41 - 0.295 0.000 -13.603
ENSG00000005339 E008 199.0034091 0.0002573187 5.355299e-03 1.689782e-02 16 3731192 3731473 282 - 2.228 2.339 0.370
ENSG00000005339 E009 152.2907076 0.0002429039 2.845929e-03 9.811874e-03 16 3731776 3731907 132 - 2.107 2.232 0.420
ENSG00000005339 E010 73.6080326 0.0069895994 1.976041e-02 5.097844e-02 16 3731908 3731910 3 - 1.768 1.942 0.587
ENSG00000005339 E011 94.2228528 0.0040695723 1.839006e-02 4.799082e-02 16 3731911 3731937 27 - 1.887 2.039 0.510
ENSG00000005339 E012 118.4368919 0.0026177194 2.679451e-01 4.063285e-01 16 3736036 3736082 47 - 2.024 2.109 0.284
ENSG00000005339 E013 176.0376072 0.0043718825 6.279204e-01 7.435874e-01 16 3736083 3736203 121 - 2.228 2.253 0.086
ENSG00000005339 E014 1.1145414 0.3201416327 7.647601e-01 8.477461e-01 16 3736508 3736649 142 - 0.296 0.358 0.393
ENSG00000005339 E015 199.4307041 0.0002875647 2.770536e-01 4.165600e-01 16 3736650 3736815 166 - 2.288 2.298 0.034
ENSG00000005339 E016 5.6034678 0.0092991753 1.003735e-01 1.910391e-01 16 3736816 3736999 184 - 0.659 0.914 1.018
ENSG00000005339 E017 136.9673215 0.0013089210 4.313595e-02 9.679880e-02 16 3738559 3738672 114 - 2.146 2.116 -0.100
ENSG00000005339 E018 1.5950989 0.0099177701 1.679214e-01 2.854955e-01 16 3739446 3739577 132 - 0.514 0.297 -1.205
ENSG00000005339 E019 154.6505823 0.0003993404 3.350790e-01 4.788356e-01 16 3739578 3739724 147 - 2.176 2.186 0.033
ENSG00000005339 E020 116.4154395 0.0002660999 3.497649e-01 4.939611e-01 16 3740399 3740442 44 - 2.058 2.064 0.023
ENSG00000005339 E021 160.6812642 0.0012484186 5.041388e-02 1.099039e-01 16 3740443 3740549 107 - 2.212 2.189 -0.078
ENSG00000005339 E022 3.7399240 0.0064723766 1.296874e-01 2.337134e-01 16 3740550 3743468 2919 - 0.514 0.772 1.118
ENSG00000005339 E023 0.4396707 0.0252817668 7.365376e-02 1.493805e-01 16 3743663 3743732 70 - 0.295 0.000 -13.508
ENSG00000005339 E024 127.1111570 0.0002761003 1.698522e-02 4.490118e-02 16 3744894 3744961 68 - 2.119 2.080 -0.128
ENSG00000005339 E025 116.8746256 0.0002786394 5.501176e-03 1.729082e-02 16 3745277 3745354 78 - 2.093 2.039 -0.181
ENSG00000005339 E026 1.7316475 0.0083045200 6.787913e-02 1.398501e-01 16 3745355 3745555 201 - 0.217 0.559 2.017
ENSG00000005339 E027 1.0631447 0.0121989077 9.993207e-03 2.874731e-02 16 3745556 3745595 40 - 0.000 0.472 14.347
ENSG00000005339 E028 0.3666179 0.0287650310 9.570045e-01 9.770460e-01 16 3745596 3745654 59 - 0.122 0.123 0.020
ENSG00000005339 E029 98.3895361 0.0003276045 5.266853e-05 2.950818e-04 16 3749627 3749683 57 - 2.047 1.939 -0.362
ENSG00000005339 E030 95.8912970 0.0004486226 1.470327e-02 3.982173e-02 16 3751726 3751806 81 - 2.004 1.952 -0.175
ENSG00000005339 E031 1.7725369 0.0079974438 3.075881e-01 4.498084e-01 16 3751807 3751836 30 - 0.514 0.364 -0.790
ENSG00000005339 E032 86.3585137 0.0047766764 7.066469e-01 8.047667e-01 16 3757288 3757376 89 - 1.903 1.963 0.205
ENSG00000005339 E033 188.5183970 0.0046621368 9.166613e-03 2.670030e-02 16 3757809 3758048 240 - 2.307 2.243 -0.213
ENSG00000005339 E034 132.9270641 0.0003746219 1.712797e-06 1.352243e-05 16 3758854 3758972 119 - 2.177 2.065 -0.377
ENSG00000005339 E035 0.7748771 0.2887556080 6.459544e-02 1.343663e-01 16 3767302 3767719 418 - 0.000 0.409 11.715
ENSG00000005339 E036 169.4919643 0.0012677956 2.768080e-10 4.530492e-09 16 3767720 3767909 190 - 2.306 2.144 -0.539
ENSG00000005339 E037 169.9492342 0.0036452915 5.834597e-07 5.096818e-06 16 3769174 3769353 180 - 2.304 2.149 -0.519
ENSG00000005339 E038 197.5027455 0.0083239554 1.523788e-03 5.714227e-03 16 3770570 3770932 363 - 2.348 2.238 -0.368
ENSG00000005339 E039 57.3783531 0.0004246771 2.287339e-03 8.111900e-03 16 3770933 3770980 48 - 1.811 1.706 -0.356
ENSG00000005339 E040 37.5431477 0.0005556534 1.768017e-02 4.644667e-02 16 3770981 3770986 6 - 1.631 1.532 -0.335
ENSG00000005339 E041 0.1472490 0.0427150164 4.558054e-01   16 3773636 3773705 70 - 0.122 0.000 -11.541
ENSG00000005339 E042 1.8423649 0.0078250315 4.373584e-01 5.793251e-01 16 3773706 3773750 45 - 0.361 0.517 0.824
ENSG00000005339 E043 121.9977479 0.0004339913 1.700255e-06 1.343237e-05 16 3773751 3773930 180 - 2.141 2.021 -0.403
ENSG00000005339 E044 89.6427790 0.0003587801 9.078636e-03 2.647661e-02 16 3774569 3774652 84 - 1.980 1.919 -0.205
ENSG00000005339 E045 62.3742416 0.0004052927 1.167272e-02 3.275267e-02 16 3774653 3774693 41 - 1.836 1.761 -0.255
ENSG00000005339 E046 0.1451727 0.0431637071 4.554989e-01   16 3774694 3774746 53 - 0.122 0.000 -11.532
ENSG00000005339 E047 57.1721948 0.0004009786 3.063531e-02 7.320688e-02 16 3777613 3777657 45 - 1.791 1.728 -0.215
ENSG00000005339 E048 0.5944058 0.2661904108 6.790846e-01 7.833797e-01 16 3777947 3778010 64 - 0.122 0.225 1.063
ENSG00000005339 E049 109.7354901 0.0002959321 1.160926e-08 1.414821e-07 16 3778011 3778182 172 - 2.115 1.958 -0.528
ENSG00000005339 E050 108.7819544 0.0134196334 6.085522e-06 4.249793e-05 16 3778700 3778817 118 - 2.154 1.907 -0.826
ENSG00000005339 E051 130.7526095 0.0133025718 3.275489e-07 3.006743e-06 16 3780732 3780878 147 - 2.246 1.968 -0.932
ENSG00000005339 E052 88.5886061 0.0219645095 2.765998e-04 1.284433e-03 16 3781204 3781306 103 - 2.066 1.823 -0.818
ENSG00000005339 E053 107.0134495 0.0028406868 1.124403e-09 1.651406e-08 16 3782684 3782885 202 - 2.134 1.915 -0.735
ENSG00000005339 E054 34.7699499 0.0010430033 1.317953e-06 1.066517e-05 16 3782886 3782889 4 - 1.669 1.413 -0.874
ENSG00000005339 E055 62.3800976 0.0039220464 3.750351e-11 7.104927e-10 16 3782890 3782926 37 - 1.943 1.623 -1.081
ENSG00000005339 E056 0.0000000       16 3784473 3784515 43 -      
ENSG00000005339 E057 0.3729606 0.0290930430 9.565520e-01 9.767426e-01 16 3791193 3791255 63 - 0.122 0.123 0.020
ENSG00000005339 E058 95.7151704 0.0003742073 3.347209e-22 2.722708e-20 16 3791981 3792094 114 - 2.125 1.801 -1.088
ENSG00000005339 E059 150.2346261 0.0019857415 2.764949e-20 1.823855e-18 16 3793386 3793626 241 - 2.309 2.016 -0.979
ENSG00000005339 E060 98.9114867 0.0112452447 4.601961e-06 3.303879e-05 16 3810603 3810719 117 - 2.109 1.870 -0.800
ENSG00000005339 E061 78.6086510 0.0044103549 3.110321e-09 4.207361e-08 16 3810720 3810779 60 - 2.020 1.758 -0.885
ENSG00000005339 E062 0.4741261 0.0209307274 5.243948e-01 6.579141e-01 16 3812938 3812977 40 - 0.217 0.123 -0.982
ENSG00000005339 E063 0.2924217 0.0290785164 1.807552e-01   16 3812998 3813072 75 - 0.217 0.000 -12.837
ENSG00000005339 E064 223.6984663 0.0048734217 1.058981e-21 8.138771e-20 16 3850297 3851009 713 - 2.503 2.152 -1.173
ENSG00000005339 E065 0.1515154 0.0429432425 4.551601e-01   16 3854721 3854770 50 - 0.122 0.000 -11.537
ENSG00000005339 E066 58.6171097 0.0004249574 2.077165e-23 1.924267e-21 16 3879832 3880713 882 - 1.956 1.515 -1.491