ENSG00000005175

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000005386 ENSG00000005175 HEK293_OSMI2_2hA HEK293_TMG_2hB RPAP3 protein_coding protein_coding 33.79715 13.94866 57.21248 0.9171992 2.285221 2.035422 2.9813849 1.232361 5.807843 0.15193134 0.2409712 2.22740023 0.08175417 0.08936667 0.10150000 0.01213333 7.697708e-01 6.741025e-09 FALSE TRUE
ENST00000380650 ENSG00000005175 HEK293_OSMI2_2hA HEK293_TMG_2hB RPAP3 protein_coding protein_coding 33.79715 13.94866 57.21248 0.9171992 2.285221 2.035422 9.3128033 2.993091 14.749423 0.10996626 0.1745655 2.29711607 0.26858333 0.21536667 0.25853333 0.04316667 2.413703e-01 6.741025e-09 FALSE TRUE
ENST00000432584 ENSG00000005175 HEK293_OSMI2_2hA HEK293_TMG_2hB RPAP3 protein_coding protein_coding 33.79715 13.94866 57.21248 0.9171992 2.285221 2.035422 4.1009179 2.816159 3.000292 0.03746986 0.5292964 0.09106127 0.16595833 0.20383333 0.05186667 -0.15196667 6.741025e-09 6.741025e-09 FALSE TRUE
ENST00000547706 ENSG00000005175 HEK293_OSMI2_2hA HEK293_TMG_2hB RPAP3 protein_coding processed_transcript 33.79715 13.94866 57.21248 0.9171992 2.285221 2.035422 0.6846372 1.060480 0.000000 1.06047994 0.0000000 -6.74211395 0.03505000 0.06720000 0.00000000 -0.06720000 6.259169e-01 6.741025e-09 FALSE TRUE
MSTRG.7172.5 ENSG00000005175 HEK293_OSMI2_2hA HEK293_TMG_2hB RPAP3 protein_coding   33.79715 13.94866 57.21248 0.9171992 2.285221 2.035422 10.0072190 2.040022 20.184601 0.72046366 0.7139992 3.30025857 0.24395833 0.14213333 0.35293333 0.21080000 4.077926e-02 6.741025e-09 FALSE TRUE
MSTRG.7172.7 ENSG00000005175 HEK293_OSMI2_2hA HEK293_TMG_2hB RPAP3 protein_coding   33.79715 13.94866 57.21248 0.9171992 2.285221 2.035422 6.1071345 3.476110 12.559726 0.91453703 0.7419204 1.85026320 0.18149167 0.25906667 0.21933333 -0.03973333 9.315075e-01 6.741025e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000005175 E001 165.577068 0.0089750503 8.930992e-01 9.356834e-01 12 47661249 47663289 2041 - 2.155 2.153 -0.007
ENSG00000005175 E002 8.979608 0.0019262315 2.883158e-01 4.288878e-01 12 47663290 47663291 2 - 0.910 1.024 0.426
ENSG00000005175 E003 10.083516 0.0023706049 2.416118e-01 3.760783e-01 12 47663292 47663292 1 - 0.952 1.074 0.448
ENSG00000005175 E004 14.659356 0.0013797497 1.442178e-02 3.918147e-02 12 47663293 47663322 30 - 1.071 1.290 0.781
ENSG00000005175 E005 204.426853 0.0007670987 5.520603e-16 2.159087e-14 12 47663323 47663590 268 - 2.180 2.401 0.738
ENSG00000005175 E006 4.435141 0.0083524129 7.135019e-01 8.099929e-01 12 47664590 47664843 254 - 0.697 0.623 -0.317
ENSG00000005175 E007 203.714669 0.0007655945 3.642948e-08 4.033580e-07 12 47666980 47667080 101 - 2.201 2.350 0.498
ENSG00000005175 E008 138.438181 0.0002803882 2.627404e-10 4.309930e-09 12 47667754 47667824 71 - 2.021 2.216 0.654
ENSG00000005175 E009 95.321395 0.0003282184 6.224492e-03 1.920508e-02 12 47667825 47667851 27 - 1.891 1.989 0.330
ENSG00000005175 E010 255.312414 0.0001713776 4.133818e-04 1.825755e-03 12 47668916 47669102 187 - 2.321 2.395 0.247
ENSG00000005175 E011 262.971997 0.0004891399 6.671635e-01 7.744805e-01 12 47670107 47670345 239 - 2.352 2.349 -0.011
ENSG00000005175 E012 139.578617 0.0002222233 2.634982e-01 4.014144e-01 12 47679493 47679594 102 - 2.091 2.035 -0.189
ENSG00000005175 E013 120.010612 0.0002469582 4.762058e-01 6.148629e-01 12 47679704 47679774 71 - 2.024 1.980 -0.146
ENSG00000005175 E014 169.970144 0.0008061582 6.834933e-01 7.866835e-01 12 47681696 47681817 122 - 2.163 2.161 -0.007
ENSG00000005175 E015 196.685735 0.0002015246 4.073258e-01 5.509032e-01 12 47686780 47686907 128 - 2.235 2.194 -0.137
ENSG00000005175 E016 203.123825 0.0041336519 7.377645e-02 1.495622e-01 12 47687876 47688001 126 - 2.259 2.168 -0.307
ENSG00000005175 E017 165.799301 0.0032426365 6.587143e-02 1.364960e-01 12 47689125 47689195 71 - 2.172 2.077 -0.318
ENSG00000005175 E018 168.147869 0.0127262707 1.373388e-02 3.761737e-02 12 47690518 47690639 122 - 2.192 2.023 -0.564
ENSG00000005175 E019 0.891094 0.1445022558 3.474825e-01 4.917090e-01 12 47695942 47696275 334 - 0.175 0.362 1.388
ENSG00000005175 E020 168.214976 0.0303471838 2.819837e-02 6.840948e-02 12 47696276 47696403 128 - 2.197 2.001 -0.657
ENSG00000005175 E021 189.483666 0.0017617221 3.000717e-06 2.244992e-05 12 47697597 47697719 123 - 2.248 2.051 -0.657
ENSG00000005175 E022 7.417639 0.0256491336 1.086987e-03 4.259518e-03 12 47699925 47700014 90 - 0.725 1.156 1.627
ENSG00000005175 E023 32.153533 0.0036291464 2.752758e-09 3.765355e-08 12 47700015 47700164 150 - 1.327 1.721 1.352
ENSG00000005175 E024 2.157026 0.0517416431 9.091140e-01 9.462764e-01 12 47701191 47701463 273 - 0.451 0.464 0.067
ENSG00000005175 E025 249.838751 0.0006507392 2.064634e-01 3.342837e-01 12 47701464 47701604 141 - 2.341 2.289 -0.174
ENSG00000005175 E026 266.290888 0.0002326616 4.733208e-07 4.205675e-06 12 47702688 47702846 159 - 2.389 2.235 -0.517
ENSG00000005175 E027 115.381990 0.0035969165 4.777939e-09 6.259361e-08 12 47705952 47706041 90 - 2.057 1.722 -1.126