ENSG00000005007

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262803 ENSG00000005007 HEK293_OSMI2_2hA HEK293_TMG_2hB UPF1 protein_coding protein_coding 67.62644 97.34415 49.94773 6.719486 0.7914502 -0.9625345 23.627107 20.07013 30.4461555 6.366202 0.3356386 0.6009654 0.3670417 0.2003667 0.6100667 0.40970000 0.0002256367 1.677994e-05 FALSE TRUE
ENST00000599848 ENSG00000005007 HEK293_OSMI2_2hA HEK293_TMG_2hB UPF1 protein_coding protein_coding 67.62644 97.34415 49.94773 6.719486 0.7914502 -0.9625345 9.932447 15.75738 6.3883682 1.813878 0.6624169 -1.3011668 0.1448208 0.1609000 0.1275333 -0.03336667 0.3021774653 1.677994e-05 FALSE TRUE
MSTRG.16747.4 ENSG00000005007 HEK293_OSMI2_2hA HEK293_TMG_2hB UPF1 protein_coding   67.62644 97.34415 49.94773 6.719486 0.7914502 -0.9625345 15.529500 27.06775 7.2873829 1.725272 0.8619944 -1.8916566 0.2324458 0.2826667 0.1455333 -0.13713333 0.0108901514 1.677994e-05 TRUE TRUE
MSTRG.16747.5 ENSG00000005007 HEK293_OSMI2_2hA HEK293_TMG_2hB UPF1 protein_coding   67.62644 97.34415 49.94773 6.719486 0.7914502 -0.9625345 13.195287 28.59132 0.8264616 2.117566 0.8264616 -5.0956387 0.1710208 0.2949333 0.0165000 -0.27843333 0.0170352777 1.677994e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000005007 E001 53.1646966 0.0329909752 2.460788e-10 4.056285e-09 19 18831959 18832000 42 + 2.011 1.417 -2.018
ENSG00000005007 E002 193.0843676 0.0162300336 3.594701e-13 9.450532e-12 19 18832001 18832268 268 + 2.504 2.064 -1.471
ENSG00000005007 E003 116.8060567 0.0067971556 9.993529e-29 1.503768e-26 19 18832269 18832359 91 + 2.328 1.789 -1.807
ENSG00000005007 E004 83.0067468 0.0003799885 5.976377e-72 9.514342e-69 19 18832360 18832440 81 + 2.230 1.552 -2.286
ENSG00000005007 E005 0.4782907 0.0234827091 2.593313e-01 3.967051e-01 19 18833130 18833283 154 + 0.000 0.234 11.943
ENSG00000005007 E006 303.1945492 0.0045295868 2.338008e-13 6.313122e-12 19 18845980 18846119 140 + 2.599 2.358 -0.802
ENSG00000005007 E007 364.4642007 0.0012818946 3.186466e-09 4.302376e-08 19 18847744 18847833 90 + 2.600 2.488 -0.373
ENSG00000005007 E008 0.8502072 0.0142696769 7.470884e-01 8.346867e-01 19 18848133 18848434 302 + 0.276 0.235 -0.308
ENSG00000005007 E009 0.6934063 0.1347084358 1.846482e-01 3.070319e-01 19 18849008 18849031 24 + 0.000 0.291 12.357
ENSG00000005007 E010 0.6934063 0.1347084358 1.846482e-01 3.070319e-01 19 18849032 18849076 45 + 0.000 0.291 12.357
ENSG00000005007 E011 0.6934063 0.1347084358 1.846482e-01 3.070319e-01 19 18849082 18849165 84 + 0.000 0.291 12.357
ENSG00000005007 E012 0.0000000       19 18849166 18849181 16 +      
ENSG00000005007 E013 0.4439371 0.0215622195 1.979530e-02 5.105385e-02 19 18849182 18849446 265 + 0.367 0.000 -14.007
ENSG00000005007 E014 0.4741261 0.0209443577 2.400257e-01 3.741732e-01 19 18849813 18849985 173 + 0.276 0.093 -1.892
ENSG00000005007 E015 525.1482727 0.0003913535 6.421187e-09 8.209993e-08 19 18850075 18850242 168 + 2.729 2.661 -0.227
ENSG00000005007 E016 177.8612570 0.0002207951 3.919704e-04 1.743832e-03 19 18850688 18850691 4 + 2.257 2.194 -0.210
ENSG00000005007 E017 493.4616907 0.0016785800 4.431178e-05 2.528687e-04 19 18850692 18850868 177 + 2.700 2.637 -0.210
ENSG00000005007 E018 4.5255766 0.0691489164 5.952790e-02 1.258131e-01 19 18851050 18851129 80 + 0.884 0.593 -1.190
ENSG00000005007 E019 555.4540987 0.0023963041 1.600086e-06 1.271152e-05 19 18852135 18852296 162 + 2.771 2.678 -0.307
ENSG00000005007 E020 268.2581796 0.0001915614 1.294212e-07 1.286653e-06 19 18852987 18852997 11 + 2.448 2.364 -0.282
ENSG00000005007 E021 472.2700679 0.0001170631 8.954574e-13 2.216959e-11 19 18852998 18853071 74 + 2.694 2.607 -0.289
ENSG00000005007 E022 71.2894828 0.0003809164 1.096193e-01 2.050094e-01 19 18853072 18853104 33 + 1.841 1.807 -0.114
ENSG00000005007 E023 522.9130583 0.0002788854 2.074556e-12 4.833581e-11 19 18853252 18853350 99 + 2.738 2.651 -0.286
ENSG00000005007 E024 411.6126048 0.0001778151 6.875437e-05 3.741293e-04 19 18854601 18854709 109 + 2.601 2.563 -0.127
ENSG00000005007 E025 302.6520594 0.0021687479 1.011212e-02 2.903736e-02 19 18854879 18854912 34 + 2.469 2.431 -0.125
ENSG00000005007 E026 543.8072521 0.0019509179 4.208308e-04 1.854288e-03 19 18854913 18855038 126 + 2.732 2.682 -0.165
ENSG00000005007 E027 12.8439753 0.0014067461 1.853919e-05 1.159025e-04 19 18855039 18855123 85 + 1.321 0.960 -1.297
ENSG00000005007 E028 596.6817601 0.0023968327 1.451253e-03 5.477896e-03 19 18855124 18855242 119 + 2.769 2.725 -0.146
ENSG00000005007 E029 9.1746832 0.0018672162 2.787951e-04 1.293454e-03 19 18855243 18855680 438 + 1.182 0.828 -1.307
ENSG00000005007 E030 627.2035545 0.0019304029 1.100770e-02 3.118039e-02 19 18855925 18856089 165 + 2.776 2.754 -0.073
ENSG00000005007 E031 428.1679007 0.0015253485 4.692287e-01 6.085003e-01 19 18856186 18856300 115 + 2.579 2.602 0.076
ENSG00000005007 E032 428.6630059 0.0027676552 6.127799e-01 7.316492e-01 19 18856877 18857020 144 + 2.553 2.614 0.201
ENSG00000005007 E033 661.4321761 0.0009116159 1.139949e-01 2.113462e-01 19 18857320 18857533 214 + 2.776 2.786 0.031
ENSG00000005007 E034 34.2378845 0.0007797520 2.967377e-12 6.742962e-11 19 18859383 18860320 938 + 1.734 1.352 -1.307
ENSG00000005007 E035 638.4703326 0.0001074744 1.120788e-04 5.774222e-04 19 18860321 18860438 118 + 2.780 2.759 -0.070
ENSG00000005007 E036 709.6091374 0.0001563871 4.362239e-12 9.626244e-11 19 18860826 18860982 157 + 2.856 2.792 -0.214
ENSG00000005007 E037 682.6910851 0.0001004304 1.733668e-05 1.090613e-04 19 18862010 18862152 143 + 2.814 2.788 -0.084
ENSG00000005007 E038 3.0665638 0.0133632046 9.769787e-01 9.896308e-01 19 18862933 18863437 505 + 0.564 0.587 0.107
ENSG00000005007 E039 800.0143031 0.0001030169 7.028943e-02 1.438417e-01 19 18863438 18863612 175 + 2.819 2.883 0.214
ENSG00000005007 E040 630.8192677 0.0001680086 3.730570e-06 2.735082e-05 19 18864170 18864251 82 + 2.680 2.795 0.384
ENSG00000005007 E041 884.6821708 0.0012094311 1.209292e-05 7.882489e-05 19 18865289 18865450 162 + 2.815 2.949 0.446
ENSG00000005007 E042 3.1365979 0.0049370528 2.893437e-02 6.987469e-02 19 18865451 18865560 110 + 0.769 0.464 -1.352
ENSG00000005007 E043 1097.1761238 0.0009637849 3.765267e-06 2.757106e-05 19 18865561 18865778 218 + 2.913 3.040 0.425
ENSG00000005007 E044 666.1936574 0.0007609580 4.106171e-04 1.814898e-03 19 18866044 18866166 123 + 2.707 2.818 0.370
ENSG00000005007 E045 379.9836124 0.0001438885 4.236637e-05 2.427762e-04 19 18866521 18866574 54 + 2.453 2.576 0.411
ENSG00000005007 E046 675.6502738 0.0014353688 1.100297e-03 4.304374e-03 19 18866575 18866874 300 + 2.705 2.826 0.403
ENSG00000005007 E047 2538.1897649 0.0024902190 3.862205e-17 1.745427e-15 19 18866875 18867667 793 + 3.188 3.431 0.808
ENSG00000005007 E048 1814.1724268 0.0060523659 3.665727e-14 1.109363e-12 19 18867668 18868346 679 + 2.973 3.302 1.092
ENSG00000005007 E049 1.2899917 0.0125075841 9.397456e-02 1.813452e-01 19 18868521 18869563 1043 + 0.507 0.235 -1.629