ENSG00000004897

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000066544 ENSG00000004897 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC27 protein_coding protein_coding 33.8213 6.830853 55.50758 0.1098324 1.67041 3.020696 13.864544 5.1007409 22.340060 0.4679264 1.1246056 2.128674 0.47980417 0.74606667 0.40406667 -0.34200000 1.944705e-03 3.928195e-22 FALSE TRUE
ENST00000527547 ENSG00000004897 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC27 protein_coding protein_coding 33.8213 6.830853 55.50758 0.1098324 1.67041 3.020696 6.580050 0.0000000 12.522771 0.0000000 1.4531997 10.291490 0.11937083 0.00000000 0.22483333 0.22483333 3.928195e-22 3.928195e-22 FALSE TRUE
ENST00000531206 ENSG00000004897 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC27 protein_coding protein_coding 33.8213 6.830853 55.50758 0.1098324 1.67041 3.020696 2.862721 0.4080144 5.202853 0.1762053 0.8748414 3.640449 0.05916667 0.05990000 0.09420000 0.03430000 5.997366e-01 3.928195e-22 FALSE TRUE
ENST00000570740 ENSG00000004897 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC27 protein_coding nonsense_mediated_decay 33.8213 6.830853 55.50758 0.1098324 1.67041 3.020696 4.642450 0.1617481 8.069618 0.1617481 2.4846903 5.555921 0.16196250 0.02420000 0.14346667 0.11926667 1.093298e-01 3.928195e-22   FALSE
MSTRG.14536.3 ENSG00000004897 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC27 protein_coding   33.8213 6.830853 55.50758 0.1098324 1.67041 3.020696 2.486763 0.6396921 3.557768 0.2186861 1.2270906 2.457194 0.08507500 0.09456667 0.06483333 -0.02973333 7.508985e-01 3.928195e-22 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000004897 E001 918.6764945 0.0132445623 5.959064e-08 6.322395e-07 17 47117703 47120254 2552 - 2.756 3.077 1.070
ENSG00000004897 E002 220.5151151 0.0009860737 3.158606e-03 1.073304e-02 17 47120255 47120609 355 - 2.179 2.330 0.504
ENSG00000004897 E003 202.9448876 0.0002555801 6.388208e-07 5.532972e-06 17 47120610 47120770 161 - 2.132 2.340 0.695
ENSG00000004897 E004 159.4538303 0.0001999017 1.633916e-01 2.795856e-01 17 47120771 47120809 39 - 2.049 2.153 0.346
ENSG00000004897 E005 169.7980259 0.0002232798 2.161404e-01 3.457585e-01 17 47120810 47120879 70 - 2.078 2.175 0.324
ENSG00000004897 E006 219.0741173 0.0016067493 1.583660e-01 2.729461e-01 17 47120880 47121017 138 - 2.187 2.292 0.351
ENSG00000004897 E007 179.9130263 0.0002077669 6.379236e-01 7.517071e-01 17 47122444 47122536 93 - 2.108 2.177 0.231
ENSG00000004897 E008 103.7274867 0.0002961606 7.331464e-01 8.244132e-01 17 47122537 47122551 15 - 1.878 1.914 0.121
ENSG00000004897 E009 137.0659688 0.0002612608 3.841168e-01 5.282972e-01 17 47122552 47122600 49 - 1.987 2.074 0.292
ENSG00000004897 E010 3.1595294 0.0444584243 2.539001e-01 3.905285e-01 17 47122601 47122619 19 - 0.463 0.716 1.142
ENSG00000004897 E011 146.8696954 0.0002344179 8.750827e-01 9.237452e-01 17 47123886 47123960 75 - 2.022 2.081 0.195
ENSG00000004897 E012 191.6472908 0.0002143224 9.911058e-01 9.985536e-01 17 47129393 47129521 129 - 2.137 2.189 0.173
ENSG00000004897 E013 157.3463732 0.0005624808 3.562768e-01 5.006607e-01 17 47132257 47132374 118 - 2.059 2.074 0.050
ENSG00000004897 E014 216.8198770 0.0029329962 2.268432e-01 3.586191e-01 17 47137152 47137360 209 - 2.198 2.197 -0.002
ENSG00000004897 E015 186.7856113 0.0027410753 3.879928e-01 5.321022e-01 17 47138739 47138891 153 - 2.132 2.145 0.045
ENSG00000004897 E016 0.8898489 0.2317533053 3.442127e-01 4.882784e-01 17 47139771 47139973 203 - 0.178 0.420 1.683
ENSG00000004897 E017 0.2966881 0.0269099789 1.000000e+00   17 47141844 47141852 9 - 0.098 0.000 -8.378
ENSG00000004897 E018 194.3419724 0.0002042240 7.158459e-02 1.459731e-01 17 47141853 47142022 170 - 2.154 2.142 -0.039
ENSG00000004897 E019 40.2137026 0.0067506894 7.356132e-03 2.214293e-02 17 47142023 47142025 3 - 1.506 1.305 -0.696
ENSG00000004897 E020 207.8375198 0.0002324739 2.133961e-03 7.639603e-03 17 47142229 47142427 199 - 2.188 2.132 -0.189
ENSG00000004897 E021 98.6777915 0.0029750516 3.035758e-02 7.267061e-02 17 47142428 47142436 9 - 1.869 1.793 -0.254
ENSG00000004897 E022 173.8195804 0.0002572807 3.579593e-03 1.195387e-02 17 47143883 47143982 100 - 2.111 2.050 -0.204
ENSG00000004897 E023 90.1565022 0.0006686627 1.928948e-02 4.996422e-02 17 47151806 47151813 8 - 1.832 1.756 -0.257
ENSG00000004897 E024 175.6378598 0.0004675970 4.594272e-05 2.612158e-04 17 47151814 47151918 105 - 2.121 2.009 -0.377
ENSG00000004897 E025 9.1415682 0.0024604253 5.929124e-02 1.254222e-01 17 47151919 47151936 18 - 0.818 1.104 1.068
ENSG00000004897 E026 115.0486718 0.0017637565 2.561722e-04 1.200967e-03 17 47154672 47154697 26 - 1.943 1.799 -0.484
ENSG00000004897 E027 123.4346420 0.0002883252 4.292401e-03 1.396167e-02 17 47154698 47154754 57 - 1.967 1.886 -0.269
ENSG00000004897 E028 84.9826629 0.0007194751 1.902760e-03 6.923336e-03 17 47154755 47154786 32 - 1.814 1.686 -0.432
ENSG00000004897 E029 3.8009387 0.0045814767 4.179704e-01 5.612847e-01 17 47154787 47154864 78 - 0.533 0.714 0.794
ENSG00000004897 E030 1.7735585 0.0108330203 1.043359e-01 1.970917e-01 17 47156647 47156912 266 - 0.402 0.000 -10.962
ENSG00000004897 E031 105.5477719 0.0003585298 9.136742e-04 3.662178e-03 17 47156913 47156983 71 - 1.904 1.786 -0.397
ENSG00000004897 E032 98.6709085 0.0003145189 9.087894e-03 2.650034e-02 17 47156984 47157054 71 - 1.870 1.786 -0.281
ENSG00000004897 E033 63.2782651 0.0005211235 1.497568e-02 4.043293e-02 17 47157055 47157059 5 - 1.684 1.577 -0.364
ENSG00000004897 E034 91.2823059 0.0003350432 9.114783e-03 2.657016e-02 17 47157060 47157124 65 - 1.838 1.749 -0.300
ENSG00000004897 E035 183.6397864 0.0003808132 6.049710e-05 3.339256e-04 17 47157230 47157384 155 - 2.141 2.036 -0.350
ENSG00000004897 E036 148.1018959 0.0002615984 4.852295e-06 3.465870e-05 17 47158206 47158303 98 - 2.054 1.905 -0.499
ENSG00000004897 E037 177.2299500 0.0024964623 1.946805e-07 1.869602e-06 17 47169917 47170042 126 - 2.136 1.937 -0.667
ENSG00000004897 E038 168.7096648 0.0166276845 1.603055e-03 5.971056e-03 17 47171917 47172064 148 - 2.114 1.925 -0.631
ENSG00000004897 E039 0.4428904 0.4846491567 3.352685e-02 7.882794e-02 17 47181282 47181561 280 - 0.000 0.442 13.523
ENSG00000004897 E040 114.7681582 0.0328903837 4.100336e-04 1.812742e-03 17 47181562 47181637 76 - 1.959 1.644 -1.065
ENSG00000004897 E041 3.6829482 0.0053977406 3.649186e-01 5.092555e-01 17 47188746 47189145 400 - 0.516 0.714 0.873
ENSG00000004897 E042 89.3393179 0.0003743126 1.251406e-09 1.819874e-08 17 47189146 47189260 115 - 1.853 1.526 -1.109
ENSG00000004897 E043 7.9079215 0.0221589954 1.377597e-01 2.449565e-01 17 47189261 47189422 162 - 0.858 0.637 -0.899