ENSG00000004777

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000007510 ENSG00000004777 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP33 protein_coding protein_coding 6.285555 5.834549 5.551145 0.9656768 1.228713 -0.07170961 2.9340241 3.46134685 1.8796192 0.37176014 0.22490895 -0.8774000 0.48148333 0.60800000 0.38156667 -0.22643333 0.287378648 0.008020653 FALSE TRUE
ENST00000378944 ENSG00000004777 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP33 protein_coding protein_coding 6.285555 5.834549 5.551145 0.9656768 1.228713 -0.07170961 0.3635505 0.62395435 0.4833473 0.29301257 0.02877178 -0.3617753 0.06395417 0.12833333 0.09330000 -0.03503333 1.000000000 0.008020653 FALSE TRUE
ENST00000586918 ENSG00000004777 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP33 protein_coding retained_intron 6.285555 5.834549 5.551145 0.9656768 1.228713 -0.07170961 0.6147785 0.80307762 0.6240693 0.80307762 0.62406929 -0.3587526 0.07774583 0.10440000 0.07796667 -0.02643333 1.000000000 0.008020653   FALSE
ENST00000593034 ENSG00000004777 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP33 protein_coding retained_intron 6.285555 5.834549 5.551145 0.9656768 1.228713 -0.07170961 0.3947527 0.00000000 0.3291523 0.00000000 0.17106661 5.0838615 0.06117083 0.00000000 0.07056667 0.07056667 0.008020653 0.008020653 FALSE FALSE
ENST00000601474 ENSG00000004777 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP33 protein_coding retained_intron 6.285555 5.834549 5.551145 0.9656768 1.228713 -0.07170961 0.5914610 0.03164000 1.1264450 0.03164000 0.76434941 4.7704139 0.09425000 0.00710000 0.16720000 0.16010000 0.346611748 0.008020653 FALSE FALSE
MSTRG.16988.4 ENSG00000004777 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP33 protein_coding   6.285555 5.834549 5.551145 0.9656768 1.228713 -0.07170961 0.4154572 0.28372870 0.1038510 0.14588936 0.05948034 -1.3673373 0.06321250 0.04476667 0.01693333 -0.02783333 0.538743253 0.008020653 FALSE TRUE
MSTRG.16988.6 ENSG00000004777 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP33 protein_coding   6.285555 5.834549 5.551145 0.9656768 1.228713 -0.07170961 0.4574856 0.08664633 0.7972239 0.08664633 0.08860474 3.0621820 0.08427500 0.01616667 0.16236667 0.14620000 0.041997094 0.008020653 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000004777 E001 0.0000000       19 35774532 35774816 285 +      
ENSG00000004777 E002 0.5848434 0.0211370952 1.354502e-02 3.718555e-02 19 35775515 35775529 15 + 0.408 0.000 -13.880
ENSG00000004777 E003 1.3911426 0.0195826029 5.730994e-01 6.990932e-01 19 35775530 35775541 12 + 0.408 0.320 -0.518
ENSG00000004777 E004 1.3911426 0.0195826029 5.730994e-01 6.990932e-01 19 35775542 35775542 1 + 0.408 0.320 -0.518
ENSG00000004777 E005 1.6125878 0.0564541009 8.017762e-01 8.737027e-01 19 35775543 35775551 9 + 0.408 0.376 -0.182
ENSG00000004777 E006 2.2853571 0.0071005943 6.490921e-01 7.604642e-01 19 35775552 35775563 12 + 0.524 0.463 -0.298
ENSG00000004777 E007 3.9032554 0.0221298873 9.251608e-01 9.568962e-01 19 35775564 35775574 11 + 0.654 0.659 0.020
ENSG00000004777 E008 16.4231033 0.0011911659 2.736473e-01 4.127189e-01 19 35775575 35775664 90 + 1.259 1.188 -0.253
ENSG00000004777 E009 0.6579068 0.3913820655 7.547300e-01 8.402808e-01 19 35777585 35777644 60 + 0.250 0.189 -0.511
ENSG00000004777 E010 25.6381012 0.0151500913 2.572864e-01 3.943634e-01 19 35777645 35777742 98 + 1.446 1.373 -0.250
ENSG00000004777 E011 27.2131192 0.0007932891 3.145097e-02 7.478714e-02 19 35777824 35777908 85 + 1.503 1.382 -0.417
ENSG00000004777 E012 28.1874182 0.0029949065 1.154610e-01 2.135191e-01 19 35778280 35778360 81 + 1.497 1.411 -0.298
ENSG00000004777 E013 33.9947311 0.0006613355 4.254363e-02 9.571255e-02 19 35778464 35778601 138 + 1.585 1.486 -0.339
ENSG00000004777 E014 0.1472490 0.0425742400 3.300728e-01   19 35778655 35778699 45 + 0.143 0.000 -11.885
ENSG00000004777 E015 30.9609349 0.0008486403 2.067937e-01 3.347127e-01 19 35779032 35779124 93 + 1.523 1.466 -0.198
ENSG00000004777 E016 0.1482932 0.0421700267 7.055621e-01   19 35779125 35779170 46 + 0.000 0.104 10.560
ENSG00000004777 E017 0.3686942 0.0289041935 7.653031e-01 8.481069e-01 19 35779852 35780210 359 + 0.143 0.104 -0.520
ENSG00000004777 E018 34.8806245 0.0006239308 1.307615e-01 2.352128e-01 19 35780211 35780333 123 + 1.576 1.508 -0.232
ENSG00000004777 E019 30.0374317 0.0006774255 6.134083e-01 7.320765e-01 19 35780421 35780498 78 + 1.481 1.470 -0.038
ENSG00000004777 E020 24.8463732 0.0008369628 9.581014e-01 9.777390e-01 19 35780582 35780648 67 + 1.381 1.405 0.086
ENSG00000004777 E021 1.2427608 0.3432859899 6.729057e-01 7.787297e-01 19 35780754 35780756 3 + 0.250 0.379 0.837
ENSG00000004777 E022 23.9399729 0.0010815619 6.377992e-01 7.516026e-01 19 35780757 35780816 60 + 1.336 1.392 0.193
ENSG00000004777 E023 34.1476598 0.0009106977 3.983289e-01 5.420630e-01 19 35780920 35781072 153 + 1.538 1.509 -0.102
ENSG00000004777 E024 13.9896540 0.0113897873 2.936152e-01 4.346922e-01 19 35781150 35781169 20 + 1.199 1.116 -0.298
ENSG00000004777 E025 29.0346466 0.0016041210 1.586941e-03 5.916504e-03 19 35781170 35781252 83 + 1.562 1.377 -0.636
ENSG00000004777 E026 33.2997405 0.0069703177 3.599915e-03 1.201094e-02 19 35782373 35782472 100 + 1.623 1.439 -0.629
ENSG00000004777 E027 29.2942845 0.0157429897 3.368137e-02 7.911955e-02 19 35782473 35782517 45 + 1.557 1.395 -0.558
ENSG00000004777 E028 24.1235738 0.0517962535 3.643236e-01 5.086970e-01 19 35782597 35782624 28 + 1.451 1.344 -0.372
ENSG00000004777 E029 24.4412032 0.0365431302 1.588667e-01 2.736398e-01 19 35782625 35782679 55 + 1.474 1.335 -0.483
ENSG00000004777 E030 31.3708568 0.0010481567 3.758409e-02 8.655613e-02 19 35782762 35782869 108 + 1.558 1.450 -0.371
ENSG00000004777 E031 1.2878147 0.0794752256 2.306970e-01 3.632838e-01 19 35782870 35782912 43 + 0.470 0.259 -1.257
ENSG00000004777 E032 31.6113541 0.0007625111 1.456159e-01 2.556934e-01 19 35784172 35784317 146 + 1.538 1.470 -0.235
ENSG00000004777 E033 1.2072627 0.0228425945 4.988236e-02 1.089630e-01 19 35784318 35784393 76 + 0.524 0.188 -2.109
ENSG00000004777 E034 4.5897463 0.0043704066 1.033102e-02 2.958476e-02 19 35784495 35784831 337 + 0.904 0.570 -1.370
ENSG00000004777 E035 1.4229595 0.2335598727 2.424750e-02 6.032327e-02 19 35784832 35784906 75 + 0.617 0.106 -3.509
ENSG00000004777 E036 1.4435834 0.0091248675 1.084172e-01 2.031986e-01 19 35784907 35784952 46 + 0.524 0.259 -1.523
ENSG00000004777 E037 29.6244641 0.0031162629 8.464656e-01 9.045924e-01 19 35784953 35785106 154 + 1.458 1.467 0.031
ENSG00000004777 E038 32.4930761 0.0007305397 8.668983e-01 9.183430e-01 19 35785189 35785334 146 + 1.497 1.508 0.037
ENSG00000004777 E039 31.6209816 0.0073734514 6.623124e-01 7.706436e-01 19 35785409 35785483 75 + 1.458 1.513 0.189
ENSG00000004777 E040 56.3012012 0.0007628693 1.612505e-02 4.301079e-02 19 35786413 35786895 483 + 1.639 1.780 0.479
ENSG00000004777 E041 27.1949026 0.0008121571 1.454528e-03 5.488708e-03 19 35786896 35787072 177 + 1.259 1.508 0.863
ENSG00000004777 E042 52.2299106 0.0005792761 1.052216e-05 6.960167e-05 19 35787168 35787559 392 + 1.529 1.782 0.860
ENSG00000004777 E043 21.0329950 0.0009149957 2.195303e-02 5.557696e-02 19 35787560 35787643 84 + 1.177 1.382 0.717
ENSG00000004777 E044 158.1177375 0.0178458608 7.893245e-04 3.221074e-03 19 35787644 35788704 1061 + 2.018 2.258 0.804
ENSG00000004777 E045 30.7555002 0.0481597941 2.425383e-02 6.033595e-02 19 35788705 35788822 118 + 1.269 1.577 1.064