ENSG00000004766

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000251739 ENSG00000004766 HEK293_OSMI2_2hA HEK293_TMG_2hB VPS50 protein_coding protein_coding 8.627536 1.25341 13.70796 0.2258644 1.529114 3.440671 1.4317297 0.1205710 3.20309360 0.1021786 0.42139581 4.621057 0.10450000 0.07896667 0.245366667 0.166400000 2.477381e-01 2.202316e-05 FALSE TRUE
ENST00000305866 ENSG00000004766 HEK293_OSMI2_2hA HEK293_TMG_2hB VPS50 protein_coding protein_coding 8.627536 1.25341 13.70796 0.2258644 1.529114 3.440671 3.1488506 0.5159451 4.79136927 0.2595834 0.18107087 3.190462 0.43118333 0.37290000 0.357666667 -0.015233333 9.698858e-01 2.202316e-05 FALSE TRUE
ENST00000443443 ENSG00000004766 HEK293_OSMI2_2hA HEK293_TMG_2hB VPS50 protein_coding protein_coding 8.627536 1.25341 13.70796 0.2258644 1.529114 3.440671 0.4381510 0.0000000 0.12031425 0.0000000 0.12031425 3.703923 0.06171250 0.00000000 0.007233333 0.007233333 1.000000e+00 2.202316e-05 FALSE TRUE
ENST00000458707 ENSG00000004766 HEK293_OSMI2_2hA HEK293_TMG_2hB VPS50 protein_coding protein_coding 8.627536 1.25341 13.70796 0.2258644 1.529114 3.440671 0.5379299 0.2906670 0.91071529 0.0658483 0.16234386 1.614588 0.10690000 0.22786667 0.065500000 -0.162366667 6.936613e-05 2.202316e-05 FALSE TRUE
ENST00000474412 ENSG00000004766 HEK293_OSMI2_2hA HEK293_TMG_2hB VPS50 protein_coding processed_transcript 8.627536 1.25341 13.70796 0.2258644 1.529114 3.440671 0.8236379 0.0000000 2.09768441 0.0000000 0.40914521 7.719515 0.09189583 0.00000000 0.150800000 0.150800000 2.202316e-05 2.202316e-05 TRUE FALSE
ENST00000484954 ENSG00000004766 HEK293_OSMI2_2hA HEK293_TMG_2hB VPS50 protein_coding retained_intron 8.627536 1.25341 13.70796 0.2258644 1.529114 3.440671 0.8845932 0.0000000 0.97165608 0.0000000 0.49411220 6.617146 0.05633333 0.00000000 0.065900000 0.065900000 5.598963e-01 2.202316e-05 FALSE FALSE
ENST00000544910 ENSG00000004766 HEK293_OSMI2_2hA HEK293_TMG_2hB VPS50 protein_coding protein_coding 8.627536 1.25341 13.70796 0.2258644 1.529114 3.440671 0.1090278 0.2067185 0.08723035 0.2067185 0.04456996 -1.156343 0.03758333 0.23240000 0.007100000 -0.225300000 8.553243e-01 2.202316e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000004766 E001 0.6299079 0.0274772582 4.726378e-01 0.6116891190 7 93232340 93232365 26 + 0.134 0.274 1.285
ENSG00000004766 E002 0.3332198 0.0297019190 1.599311e-01   7 93232366 93232368 3 + 0.049 0.274 2.870
ENSG00000004766 E003 0.4804688 0.0213184097 3.142861e-01 0.4569953635 7 93232369 93232371 3 + 0.094 0.274 1.870
ENSG00000004766 E004 0.9201396 0.0146495602 7.578608e-01 0.8425532831 7 93232372 93232374 3 + 0.205 0.274 0.548
ENSG00000004766 E005 1.0673886 0.0513883813 8.864463e-01 0.9313813979 7 93232375 93232375 1 + 0.236 0.274 0.286
ENSG00000004766 E006 12.5361177 0.0013706585 2.453448e-01 0.3804389444 7 93232376 93232427 52 + 1.006 0.855 -0.571
ENSG00000004766 E007 17.0538379 0.0010952449 6.331485e-02 0.1322251917 7 93232428 93232500 73 + 1.135 0.905 -0.844
ENSG00000004766 E008 20.9780802 0.0010569301 8.621542e-02 0.1693425006 7 93239866 93239934 69 + 1.215 1.029 -0.671
ENSG00000004766 E009 0.1451727 0.0429324414 7.806995e-01   7 93239935 93239950 16 + 0.049 0.000 -8.418
ENSG00000004766 E010 0.0000000       7 93240716 93240818 103 +      
ENSG00000004766 E011 0.5953508 0.0681957978 7.580993e-02 0.1527937577 7 93246102 93246129 28 + 0.094 0.439 2.858
ENSG00000004766 E012 30.2010872 0.0009604917 4.364363e-02 0.0977288528 7 93252653 93252775 123 + 1.365 1.178 -0.653
ENSG00000004766 E013 17.8213176 0.0010854877 8.557607e-02 0.1683288514 7 93253860 93253862 3 + 1.154 0.950 -0.742
ENSG00000004766 E014 28.6489911 0.0007401726 1.049922e-02 0.0299767349 7 93253863 93253931 69 + 1.351 1.095 -0.906
ENSG00000004766 E015 0.0000000       7 93256430 93256508 79 +      
ENSG00000004766 E016 25.8052903 0.0008289614 1.383610e-03 0.0052530272 7 93256509 93256562 54 + 1.314 0.950 -1.309
ENSG00000004766 E017 27.5434684 0.0008035904 1.234971e-01 0.2249391868 7 93257394 93257464 71 + 1.319 1.178 -0.496
ENSG00000004766 E018 0.2924217 0.0290785164 1.000000e+00   7 93257465 93257765 301 + 0.094 0.000 -9.418
ENSG00000004766 E019 0.3332198 0.0297019190 1.599311e-01   7 93258109 93258158 50 + 0.049 0.274 2.870
ENSG00000004766 E020 34.3964460 0.0076405112 4.357725e-01 0.5779558627 7 93258159 93258276 118 + 1.403 1.346 -0.198
ENSG00000004766 E021 0.8899626 0.1131999074 2.157033e-01 0.3452387779 7 93258277 93258356 80 + 0.171 0.437 1.851
ENSG00000004766 E022 28.5896514 0.0012996160 5.952606e-01 0.7173822383 7 93258357 93258392 36 + 1.324 1.290 -0.121
ENSG00000004766 E023 0.6319842 0.0300730876 4.735974e-01 0.6125303233 7 93259415 93259549 135 + 0.134 0.274 1.285
ENSG00000004766 E024 30.0508645 0.0006476038 7.424534e-01 0.8313399638 7 93259550 93259613 64 + 1.341 1.327 -0.049
ENSG00000004766 E025 17.0382309 0.0022335732 9.864946e-01 0.9956200441 7 93259614 93259632 19 + 1.107 1.124 0.062
ENSG00000004766 E026 0.0000000       7 93271066 93271219 154 +      
ENSG00000004766 E027 21.8839981 0.0008596337 7.859959e-01 0.8629507671 7 93271220 93271262 43 + 1.205 1.248 0.152
ENSG00000004766 E028 35.5819082 0.0062181564 6.847330e-02 0.1408414637 7 93272635 93272733 99 + 1.432 1.269 -0.564
ENSG00000004766 E029 0.1515154 0.0437312743 7.827753e-01   7 93272734 93273488 755 + 0.049 0.000 -8.418
ENSG00000004766 E030 2.2048102 0.0138696829 9.364383e-02 0.1808211451 7 93275842 93276164 323 + 0.448 0.000 -12.324
ENSG00000004766 E031 44.0520293 0.0029066076 2.095231e-01 0.3379754085 7 93276165 93276305 141 + 1.511 1.424 -0.299
ENSG00000004766 E032 0.5922303 0.0180490243 4.704733e-01 0.6097009940 7 93276306 93276428 123 + 0.134 0.274 1.283
ENSG00000004766 E033 38.1253062 0.0008028918 2.127169e-02 0.0541589433 7 93291703 93291835 133 + 1.461 1.270 -0.666
ENSG00000004766 E034 26.8462462 0.0017093384 2.420039e-01 0.3765541739 7 93294545 93294636 92 + 1.307 1.203 -0.364
ENSG00000004766 E035 0.0000000       7 93295415 93295431 17 +      
ENSG00000004766 E036 17.8092125 0.0168760833 2.192287e-01 0.3494389557 7 93296742 93296836 95 + 1.146 0.992 -0.558
ENSG00000004766 E037 0.0000000       7 93296837 93296959 123 +      
ENSG00000004766 E038 23.5069830 0.0008473404 5.934290e-01 0.7158270422 7 93297145 93297243 99 + 1.243 1.203 -0.140
ENSG00000004766 E039 28.6990843 0.0117472167 1.321995e-01 0.2371689883 7 93303460 93303550 91 + 1.293 1.454 0.558
ENSG00000004766 E040 53.7060950 0.0005479737 1.696927e-01 0.2878004568 7 93305828 93306004 177 + 1.565 1.670 0.356
ENSG00000004766 E041 48.0288593 0.0005844905 3.763021e-01 0.5206310442 7 93308824 93308942 119 + 1.522 1.599 0.264
ENSG00000004766 E042 41.7390962 0.0005663350 4.468156e-01 0.5882799712 7 93311166 93311272 107 + 1.465 1.537 0.248
ENSG00000004766 E043 5.0813018 0.0032429092 7.187106e-05 0.0003892997 7 93320376 93320852 477 + 0.517 1.095 2.322
ENSG00000004766 E044 3.1001044 0.0068601465 2.338213e-04 0.0011076676 7 93320853 93321170 318 + 0.343 0.950 2.718
ENSG00000004766 E045 0.6653823 0.0172671820 4.699509e-01 0.6091657389 7 93323250 93323610 361 + 0.134 0.274 1.286
ENSG00000004766 E046 39.1499972 0.0058149471 7.092841e-01 0.8067177675 7 93323611 93323732 122 + 1.454 1.438 -0.057
ENSG00000004766 E047 0.0000000       7 93333899 93333925 27 +      
ENSG00000004766 E048 34.7826610 0.0138840373 9.565930e-01 0.9767784825 7 93334117 93334197 81 + 1.402 1.422 0.069
ENSG00000004766 E049 0.2944980 0.3701111646 1.000000e+00   7 93340598 93340870 273 + 0.094 0.000 -9.417
ENSG00000004766 E050 46.6588521 0.0007397786 9.586956e-01 0.9781225224 7 93341427 93341575 149 + 1.525 1.537 0.041
ENSG00000004766 E051 33.6748285 0.0006434802 4.778217e-01 0.6163190977 7 93348711 93348807 97 + 1.378 1.451 0.254
ENSG00000004766 E052 18.7611482 0.0012217225 6.969979e-01 0.7972381338 7 93349875 93349878 4 + 1.153 1.124 -0.104
ENSG00000004766 E053 22.9650620 0.0032783317 3.376713e-01 0.4815664717 7 93349879 93349897 19 + 1.218 1.327 0.381
ENSG00000004766 E054 43.4049234 0.0005523806 9.193705e-01 0.9530602471 7 93349898 93350033 136 + 1.494 1.502 0.028
ENSG00000004766 E055 34.5319528 0.0005635821 3.678644e-01 0.5122516065 7 93353640 93353761 122 + 1.407 1.345 -0.218
ENSG00000004766 E056 45.6346971 0.0005075529 4.149122e-01 0.5583255513 7 93355891 93356080 190 + 1.506 1.579 0.251
ENSG00000004766 E057 0.3268771 0.0289400445 1.593264e-01   7 93356081 93356186 106 + 0.049 0.274 2.870
ENSG00000004766 E058 112.9950540 0.0109197747 5.829858e-05 0.0003230800 7 93358317 93361123 2807 + 1.856 2.113 0.864