ENSG00000004700

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000421138 ENSG00000004700 HEK293_OSMI2_2hA HEK293_TMG_2hB RECQL protein_coding protein_coding 15.61372 3.52419 29.46815 0.4447495 0.5724088 3.060194 1.481311 0.000000000 3.242153 0.000000000 1.2523838 8.345251 0.05963333 0.00000000 0.1101667 0.11016667 1.750200e-04 9.975425e-08 FALSE TRUE
ENST00000444129 ENSG00000004700 HEK293_OSMI2_2hA HEK293_TMG_2hB RECQL protein_coding protein_coding 15.61372 3.52419 29.46815 0.4447495 0.5724088 3.060194 7.956590 2.786567696 13.839839 0.260589355 0.6202396 2.308140 0.60697917 0.80006667 0.4693000 -0.33076667 7.346899e-03 9.975425e-08 FALSE TRUE
MSTRG.6936.3 ENSG00000004700 HEK293_OSMI2_2hA HEK293_TMG_2hB RECQL protein_coding   15.61372 3.52419 29.46815 0.4447495 0.5724088 3.060194 2.380285 0.324523244 3.592540 0.167317339 0.8562772 3.428836 0.15148333 0.08693333 0.1221000 0.03516667 7.923346e-01 9.975425e-08 TRUE TRUE
MSTRG.6936.4 ENSG00000004700 HEK293_OSMI2_2hA HEK293_TMG_2hB RECQL protein_coding   15.61372 3.52419 29.46815 0.4447495 0.5724088 3.060194 1.101467 0.009010063 2.714152 0.009010063 0.2195733 7.162900 0.05134167 0.00290000 0.0919000 0.08900000 9.975425e-08 9.975425e-08 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000004700 E001 1.697170 0.2251135725 6.025842e-01 7.235295e-01 12 21468910 21468925 16 - 0.325 0.434 0.622
ENSG00000004700 E002 1.987515 0.1108520816 7.947420e-01 8.688813e-01 12 21468926 21468938 13 - 0.373 0.433 0.332
ENSG00000004700 E003 134.729965 0.0035057007 2.955539e-13 7.857396e-12 12 21468939 21469392 454 - 1.916 2.255 1.133
ENSG00000004700 E004 47.996132 0.0114505559 4.770797e-04 2.072396e-03 12 21469393 21469408 16 - 1.493 1.781 0.981
ENSG00000004700 E005 71.937403 0.0117339503 6.969633e-05 3.785265e-04 12 21469409 21469514 106 - 1.661 1.958 1.002
ENSG00000004700 E006 52.524903 0.0004819876 4.385701e-08 4.783443e-07 12 21469515 21469605 91 - 1.515 1.847 1.127
ENSG00000004700 E007 85.290099 0.0031258171 7.954864e-06 5.405399e-05 12 21469606 21469801 196 - 1.738 1.991 0.854
ENSG00000004700 E008 47.427606 0.0190404857 1.179681e-02 3.304737e-02 12 21469802 21469824 23 - 1.486 1.742 0.870
ENSG00000004700 E009 55.340736 0.0005317510 1.486338e-08 1.774641e-07 12 21469825 21469915 91 - 1.531 1.868 1.142
ENSG00000004700 E010 114.924211 0.0004178698 6.372816e-07 5.521155e-06 12 21469916 21470346 431 - 1.872 2.094 0.746
ENSG00000004700 E011 136.303644 0.0002980789 9.959353e-01 1.000000e+00 12 21470969 21471098 130 - 1.988 2.001 0.043
ENSG00000004700 E012 179.550878 0.0001935839 2.490978e-01 3.848542e-01 12 21471428 21471647 220 - 2.101 2.155 0.182
ENSG00000004700 E013 113.506814 0.0002566636 8.833627e-01 9.293898e-01 12 21473551 21473642 92 - 1.909 1.928 0.066
ENSG00000004700 E014 140.037529 0.0002368815 3.995610e-01 5.433026e-01 12 21474841 21474979 139 - 2.005 1.982 -0.077
ENSG00000004700 E015 116.512146 0.0022730848 1.396525e-01 2.475438e-01 12 21475468 21475585 118 - 1.932 1.868 -0.217
ENSG00000004700 E016 123.318915 0.0003612884 3.857078e-03 1.274105e-02 12 21475676 21475824 149 - 1.963 1.836 -0.427
ENSG00000004700 E017 83.323580 0.0027138501 9.301032e-04 3.719686e-03 12 21476911 21476992 82 - 1.802 1.598 -0.694
ENSG00000004700 E018 115.751835 0.0020057773 3.542709e-05 2.068443e-04 12 21477803 21477969 167 - 1.947 1.726 -0.744
ENSG00000004700 E019 82.222326 0.0004032154 1.426661e-03 5.395498e-03 12 21483376 21483441 66 - 1.796 1.615 -0.615
ENSG00000004700 E020 70.955186 0.0068430407 6.233788e-03 1.922719e-02 12 21483442 21483476 35 - 1.737 1.536 -0.684
ENSG00000004700 E021 88.608134 0.0027209452 6.374138e-03 1.959531e-02 12 21483477 21483574 98 - 1.826 1.667 -0.540
ENSG00000004700 E022 93.573143 0.0006376598 8.977826e-03 2.622540e-02 12 21486479 21486585 107 - 1.846 1.711 -0.454
ENSG00000004700 E023 81.790735 0.0004585816 1.110769e-02 3.142509e-02 12 21490199 21490273 75 - 1.789 1.649 -0.471
ENSG00000004700 E024 53.500891 0.0004566021 3.191231e-02 7.568751e-02 12 21490274 21490302 29 - 1.610 1.466 -0.495
ENSG00000004700 E025 60.623911 0.0003777348 9.180563e-02 1.779517e-01 12 21490303 21490374 72 - 1.658 1.557 -0.343
ENSG00000004700 E026 27.599239 0.0008140859 8.872408e-01 9.319526e-01 12 21490375 21490378 4 - 1.316 1.315 -0.002
ENSG00000004700 E027 112.708504 0.0028971236 2.921656e-02 7.042598e-02 12 21491519 21491716 198 - 1.924 1.814 -0.369
ENSG00000004700 E028 53.223000 0.0004409530 1.489288e-01 2.602298e-01 12 21499555 21499615 61 - 1.604 1.514 -0.308
ENSG00000004700 E029 44.305944 0.0005616614 4.266575e-02 9.593262e-02 12 21501170 21501215 46 - 1.532 1.382 -0.519
ENSG00000004700 E030 46.792253 0.0015387617 1.126081e-02 3.178568e-02 12 21501216 21501372 157 - 1.561 1.366 -0.673
ENSG00000004700 E031 18.907972 0.0009714482 3.765302e-01 5.208426e-01 12 21501373 21501412 40 - 1.172 1.083 -0.320
ENSG00000004700 E032 48.352570 0.0005071790 1.648042e-02 4.379837e-02 12 21501413 21501462 50 - 1.572 1.397 -0.601
ENSG00000004700 E033 49.973357 0.0052970356 3.067506e-03 1.046553e-02 12 21501463 21501480 18 - 1.594 1.349 -0.844
ENSG00000004700 E034 68.560591 0.0003645649 2.922450e-08 3.296121e-07 12 21501481 21501669 189 - 1.739 1.333 -1.393