ENSG00000003096

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000371882 ENSG00000003096 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHL13 protein_coding protein_coding 4.157286 2.704061 5.209796 0.4085974 0.1919217 0.9435404 0.3626237 0.9068874 0.0000000 0.453682745 0.0000000 -6.518673 0.12739583 0.31480000 0.00000000 -0.314800000 8.955047e-02 1.503066e-07 FALSE TRUE
ENST00000469946 ENSG00000003096 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHL13 protein_coding protein_coding 4.157286 2.704061 5.209796 0.4085974 0.1919217 0.9435404 0.1954931 0.0000000 0.3232392 0.000000000 0.3232392 5.058486 0.03597083 0.00000000 0.06513333 0.065133333 9.332481e-01 1.503066e-07 FALSE TRUE
ENST00000540167 ENSG00000003096 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHL13 protein_coding protein_coding 4.157286 2.704061 5.209796 0.4085974 0.1919217 0.9435404 0.3824531 0.1148831 0.2881584 0.008832715 0.1465771 1.255500 0.07556667 0.04523333 0.05516667 0.009933333 1.000000e+00 1.503066e-07 FALSE TRUE
ENST00000541812 ENSG00000003096 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHL13 protein_coding protein_coding 4.157286 2.704061 5.209796 0.4085974 0.1919217 0.9435404 0.4370800 1.0019306 0.0000000 0.591972349 0.0000000 -6.660967 0.11686250 0.32466667 0.00000000 -0.324666667 9.130346e-02 1.503066e-07 FALSE TRUE
ENST00000545703 ENSG00000003096 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHL13 protein_coding protein_coding 4.157286 2.704061 5.209796 0.4085974 0.1919217 0.9435404 2.0793919 0.6739773 3.0500581 0.673977274 0.3556503 2.161539 0.49392500 0.31343333 0.58870000 0.275266667 2.730049e-01 1.503066e-07 FALSE TRUE
MSTRG.34760.2 ENSG00000003096 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHL13 protein_coding   4.157286 2.704061 5.209796 0.4085974 0.1919217 0.9435404 0.5259776 0.0000000 1.4172821 0.000000000 0.3890228 7.157127 0.11601667 0.00000000 0.26753333 0.267533333 1.503066e-07 1.503066e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000003096 E001 1.0392854 0.0144209360 1.953660e-02 5.049250e-02 X 117897813 117897813 1 - 0.095 0.500 3.143
ENSG00000003096 E002 83.3499106 0.0011957994 3.136006e-22 2.558600e-20 X 117897814 117898571 758 - 1.739 2.101 1.217
ENSG00000003096 E003 106.8134437 0.0004853114 1.707405e-06 1.348436e-05 X 117898572 117899395 824 - 1.965 2.114 0.501
ENSG00000003096 E004 27.7927792 0.0013144913 2.496620e-01 3.855185e-01 X 117901833 117901946 114 - 1.482 1.409 -0.253
ENSG00000003096 E005 100.9910376 0.0005278219 4.631776e-05 2.631147e-04 X 117909301 117910096 796 - 2.054 1.922 -0.444
ENSG00000003096 E006 33.8192250 0.0006867123 2.477934e-05 1.504510e-04 X 117919521 117919717 197 - 1.624 1.363 -0.898
ENSG00000003096 E007 20.3877891 0.0008865772 1.424797e-03 5.389199e-03 X 117920238 117920344 107 - 1.410 1.159 -0.882
ENSG00000003096 E008 13.4731444 0.0013443244 1.702432e-05 1.072673e-04 X 117920345 117920370 26 - 1.287 0.849 -1.600
ENSG00000003096 E009 23.0968878 0.0055793462 3.411557e-04 1.544831e-03 X 117945434 117945575 142 - 1.472 1.172 -1.047
ENSG00000003096 E010 0.0000000       X 117945576 117947942 2367 -      
ENSG00000003096 E011 0.2998086 0.0280438554 6.814550e-01   X 117972731 117973309 579 - 0.095 0.156 0.820
ENSG00000003096 E012 0.1515154 0.0436114974 8.789991e-01   X 117973310 117973738 429 - 0.095 0.000 -8.666
ENSG00000003096 E013 0.6696487 0.0242801335 6.503078e-01 7.613659e-01 X 117983480 117983545 66 - 0.239 0.156 -0.760
ENSG00000003096 E014 0.0000000       X 117985240 117985320 81 -      
ENSG00000003096 E015 4.9071522 0.0034224139 2.618717e-03 9.122819e-03 X 118028424 118028497 74 - 0.895 0.436 -1.985
ENSG00000003096 E016 2.3710994 0.0063522693 3.283412e-02 7.747805e-02 X 118028936 118029095 160 - 0.646 0.271 -1.986
ENSG00000003096 E017 18.1287279 0.0128480358 4.686000e-02 1.035831e-01 X 118116508 118116865 358 - 1.344 1.146 -0.698
ENSG00000003096 E018 0.0000000       X 118117277 118117340 64 -