ENSG00000003056

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000000412 ENSG00000003056 HEK293_OSMI2_2hA HEK293_TMG_2hB M6PR protein_coding protein_coding 64.90625 48.42131 76.05983 7.29557 2.547542 0.6513842 54.96773 44.400773 59.530561 7.2224603 0.8181466 0.4229631 0.85326667 0.91330000 0.78510000 -0.12820000 0.01970663 2.418642e-05 FALSE TRUE
ENST00000537621 ENSG00000003056 HEK293_OSMI2_2hA HEK293_TMG_2hB M6PR protein_coding protein_coding 64.90625 48.42131 76.05983 7.29557 2.547542 0.6513842 4.17460 2.304056 6.394917 0.4183989 1.2099372 1.4687563 0.06302917 0.04863333 0.08396667 0.03533333 0.27378884 2.418642e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000003056 E001 0.8416995 0.0414073679 9.615490e-03 2.781828e-02 12 8940361 8940362 2 - 0.000 0.454 11.797
ENSG00000003056 E002 2.0520932 0.0584116085 1.340491e-03 5.111651e-03 12 8940363 8940363 1 - 0.109 0.703 3.819
ENSG00000003056 E003 34.9626214 0.0107666277 1.295057e-05 8.379611e-05 12 8940364 8940750 387 - 1.368 1.707 1.159
ENSG00000003056 E004 5.8938169 0.0031792198 6.808511e-01 7.846865e-01 12 8940751 8940869 119 - 0.809 0.862 0.206
ENSG00000003056 E005 3.1293247 0.1139589836 7.454756e-01 8.334998e-01 12 8940870 8940903 34 - 0.647 0.560 -0.385
ENSG00000003056 E006 744.5167649 0.0005612012 1.067707e-09 1.574851e-08 12 8940904 8941648 745 - 2.830 2.924 0.314
ENSG00000003056 E007 766.1103980 0.0005472192 2.466196e-03 8.662687e-03 12 8941649 8941940 292 - 2.868 2.916 0.158
ENSG00000003056 E008 28.3964317 0.0185049291 4.504795e-02 1.002857e-01 12 8942179 8942415 237 - 1.553 1.367 -0.641
ENSG00000003056 E009 278.4436644 0.0040869287 9.878344e-01 9.964559e-01 12 8942416 8942450 35 - 2.452 2.449 -0.008
ENSG00000003056 E010 458.7565252 0.0019964316 5.865169e-01 7.100744e-01 12 8942451 8942542 92 - 2.675 2.658 -0.056
ENSG00000003056 E011 6.5007545 0.2994280521 6.086892e-02 1.281000e-01 12 8943296 8943404 109 - 1.045 0.529 -2.081
ENSG00000003056 E012 510.4258664 0.0008706258 2.724667e-02 6.648976e-02 12 8943405 8943535 131 - 2.736 2.689 -0.155
ENSG00000003056 E013 3.8460191 0.0375617527 5.243921e-03 1.659476e-02 12 8943536 8943584 49 - 0.864 0.392 -2.106
ENSG00000003056 E014 264.8252918 0.0006241858 1.859448e-01 3.086757e-01 12 8943801 8943824 24 - 2.447 2.416 -0.102
ENSG00000003056 E015 409.3818153 0.0001486555 6.581352e-01 7.673336e-01 12 8943825 8943910 86 - 2.624 2.619 -0.017
ENSG00000003056 E016 4.2618422 0.0036391853 9.093701e-04 3.646855e-03 12 8945237 8945417 181 - 0.897 0.394 -2.220
ENSG00000003056 E017 254.6534985 0.0001962842 6.490996e-01 7.604681e-01 12 8945418 8945432 15 - 2.409 2.422 0.042
ENSG00000003056 E018 352.9198492 0.0007049531 8.441158e-01 9.029605e-01 12 8945433 8945484 52 - 2.554 2.558 0.015
ENSG00000003056 E019 427.4030515 0.0001442081 3.951993e-01 5.390237e-01 12 8945485 8945584 100 - 2.645 2.632 -0.042
ENSG00000003056 E020 362.3348231 0.0005417946 1.974508e-02 5.095002e-02 12 8946229 8946302 74 - 2.589 2.540 -0.163
ENSG00000003056 E021 356.8629234 0.0018458453 1.372350e-01 2.442253e-01 12 8946303 8946387 85 - 2.580 2.532 -0.158
ENSG00000003056 E022 208.2952288 0.0019822140 1.715047e-01 2.901608e-01 12 8946388 8946405 18 - 2.348 2.300 -0.162
ENSG00000003056 E023 10.1980450 0.0022503612 6.635582e-03 2.027730e-02 12 8946406 8946715 310 - 1.169 0.883 -1.050
ENSG00000003056 E024 5.3234251 0.1199518690 9.366643e-02 1.808537e-01 12 8946716 8946824 109 - 0.940 0.560 -1.550
ENSG00000003056 E025 1.7963725 0.0143289588 5.063881e-02 1.102940e-01 12 8946825 8946848 24 - 0.587 0.240 -1.957
ENSG00000003056 E026 311.8732155 0.0049408517 1.346736e-01 2.406465e-01 12 8949488 8949761 274 - 2.531 2.459 -0.238