ENSG00000002919

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359238 ENSG00000002919 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX11 protein_coding protein_coding 26.60633 41.66952 18.51469 3.176434 0.8909525 -1.169889 8.799345 16.734488 4.121615 0.5754239 0.6197275 -2.018908507 0.31634583 0.40700000 0.22670000 -0.18030000 6.894025e-02 2.413769e-05 FALSE  
ENST00000580875 ENSG00000002919 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX11 protein_coding retained_intron 26.60633 41.66952 18.51469 3.176434 0.8909525 -1.169889 1.712290 1.222856 1.811789 0.2724753 0.1344853 0.563350823 0.07519167 0.02950000 0.09773333 0.06823333 2.413769e-05 2.413769e-05 FALSE  
ENST00000581298 ENSG00000002919 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX11 protein_coding protein_coding 26.60633 41.66952 18.51469 3.176434 0.8909525 -1.169889 6.591678 8.685003 5.063472 2.3790764 0.4460143 -0.777213194 0.25534583 0.20156667 0.27243333 0.07086667 5.209404e-01 2.413769e-05 FALSE  
ENST00000582104 ENSG00000002919 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX11 protein_coding protein_coding 26.60633 41.66952 18.51469 3.176434 0.8909525 -1.169889 1.310235 0.968844 0.969739 0.1571930 0.5193562 0.001318505 0.05199167 0.02353333 0.05376667 0.03023333 9.653669e-01 2.413769e-05 FALSE  
MSTRG.14584.7 ENSG00000002919 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX11 protein_coding   26.60633 41.66952 18.51469 3.176434 0.8909525 -1.169889 4.832511 8.136378 3.573062 0.7303094 0.4081070 -1.184965961 0.17518750 0.19483333 0.19253333 -0.00230000 9.902260e-01 2.413769e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000002919 E001 0.0000000       17 48103357 48103389 33 +      
ENSG00000002919 E002 2.2852579 0.0066073607 1.461431e-02 3.962498e-02 17 48107549 48107557 9 + 0.722 0.341 -1.840
ENSG00000002919 E003 2.9549066 0.0052998495 1.901387e-03 6.919170e-03 17 48107558 48107558 1 + 0.837 0.379 -2.077
ENSG00000002919 E004 4.5748944 0.0109894245 5.854451e-03 1.822962e-02 17 48107559 48107559 1 + 0.928 0.555 -1.528
ENSG00000002919 E005 12.1980488 0.0017970135 8.540944e-02 1.680699e-01 17 48107560 48107575 16 + 1.156 1.006 -0.545
ENSG00000002919 E006 26.7238656 0.0014558069 1.670707e-03 6.188977e-03 17 48107576 48107596 21 + 1.511 1.311 -0.692
ENSG00000002919 E007 23.0316723 0.0009307309 1.381068e-02 3.779821e-02 17 48107597 48107602 6 + 1.425 1.262 -0.567
ENSG00000002919 E008 75.1467357 0.0035974446 1.083091e-01 2.030341e-01 17 48107603 48107765 163 + 1.847 1.791 -0.189
ENSG00000002919 E009 64.1794347 0.0050652904 5.162641e-02 1.120496e-01 17 48107766 48107787 22 + 1.802 1.717 -0.286
ENSG00000002919 E010 104.9486264 0.0030856882 1.113407e-01 2.075190e-01 17 48107788 48107838 51 + 1.982 1.939 -0.146
ENSG00000002919 E011 0.8438776 0.2959605427 4.988966e-01 6.352846e-01 17 48107894 48107979 86 + 0.316 0.204 -0.831
ENSG00000002919 E012 4.3071621 0.0039422049 1.633640e-01 2.795562e-01 17 48110708 48110767 60 + 0.802 0.621 -0.748
ENSG00000002919 E013 0.6621601 0.0172671820 3.065899e-01 4.487707e-01 17 48111949 48112030 82 + 0.315 0.145 -1.425
ENSG00000002919 E014 132.1032643 0.0003941575 6.292941e-02 1.315929e-01 17 48112031 48112085 55 + 2.077 2.041 -0.121
ENSG00000002919 E015 13.7198964 0.0013116677 2.360018e-03 8.338122e-03 17 48112086 48112111 26 + 1.282 1.022 -0.928
ENSG00000002919 E016 13.8772116 0.0012848766 1.228025e-12 2.971588e-11 17 48112112 48112455 344 + 1.474 0.867 -2.180
ENSG00000002919 E017 3.8782924 0.0223812667 6.196946e-03 1.913349e-02 17 48112566 48112573 8 + 0.900 0.503 -1.668
ENSG00000002919 E018 177.7562395 0.0016272803 9.473710e-01 9.709258e-01 17 48112574 48112660 87 + 2.157 2.185 0.094
ENSG00000002919 E019 0.5514428 0.0196925122 4.062596e-01 5.499153e-01 17 48112751 48112873 123 + 0.000 0.203 10.453
ENSG00000002919 E020 213.2476149 0.0015851292 4.804438e-01 6.187409e-01 17 48113301 48113399 99 + 2.214 2.268 0.180
ENSG00000002919 E021 102.9238595 0.0003081763 2.350156e-01 3.683697e-01 17 48113400 48113401 2 + 1.882 1.960 0.262
ENSG00000002919 E022 0.2924217 0.0290785164 3.824282e-02   17 48113402 48113563 162 + 0.315 0.000 -12.218
ENSG00000002919 E023 241.1865991 0.0002235932 5.022216e-01 6.382872e-01 17 48118704 48118799 96 + 2.301 2.313 0.039
ENSG00000002919 E024 370.3948013 0.0001897341 2.455724e-01 3.807272e-01 17 48118974 48119186 213 + 2.492 2.497 0.018
ENSG00000002919 E025 1472.6094714 0.0028277035 8.467455e-04 3.426099e-03 17 48121235 48123601 2367 + 3.029 3.116 0.287