ENSG00000002746

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000395891 ENSG00000002746 HEK293_OSMI2_2hA HEK293_TMG_2hB HECW1 protein_coding protein_coding 0.1883846 0.3056349 0.2078944 0.1103539 0.09120205 -0.5346279 0.010873512 0.012568311 0.030430961 0.006301573 0.011623852 0.8411620 0.10757917 0.07546667 0.40250000 0.32703333 0.72516408 0.02992722 FALSE TRUE
ENST00000429529 ENSG00000002746 HEK293_OSMI2_2hA HEK293_TMG_2hB HECW1 protein_coding protein_coding 0.1883846 0.3056349 0.2078944 0.1103539 0.09120205 -0.5346279 0.033283308 0.000000000 0.154575103 0.000000000 0.086724655 4.0406742 0.09358750 0.00000000 0.52266667 0.52266667 0.02992722 0.02992722 FALSE FALSE
ENST00000453890 ENSG00000002746 HEK293_OSMI2_2hA HEK293_TMG_2hB HECW1 protein_coding protein_coding 0.1883846 0.3056349 0.2078944 0.1103539 0.09120205 -0.5346279 0.043253052 0.060747091 0.016382066 0.040290893 0.016382066 -1.4231133 0.39957500 0.17006667 0.04596667 -0.12410000 0.80006725 0.02992722 FALSE TRUE
ENST00000464944 ENSG00000002746 HEK293_OSMI2_2hA HEK293_TMG_2hB HECW1 protein_coding processed_transcript 0.1883846 0.3056349 0.2078944 0.1103539 0.09120205 -0.5346279 0.020845564 0.000000000 0.000000000 0.000000000 0.000000000 0.0000000 0.05148333 0.00000000 0.00000000 0.00000000   0.02992722   FALSE
ENST00000471527 ENSG00000002746 HEK293_OSMI2_2hA HEK293_TMG_2hB HECW1 protein_coding processed_transcript 0.1883846 0.3056349 0.2078944 0.1103539 0.09120205 -0.5346279 0.060036614 0.160258767 0.000000000 0.120577283 0.000000000 -4.0896572 0.23168750 0.54323333 0.00000000 -0.54323333 0.28699457 0.02992722   FALSE
ENST00000492310 ENSG00000002746 HEK293_OSMI2_2hA HEK293_TMG_2hB HECW1 protein_coding processed_transcript 0.1883846 0.3056349 0.2078944 0.1103539 0.09120205 -0.5346279 0.007048696 0.008136855 0.006506243 0.008136855 0.006506243 -0.1359126 0.06877917 0.01680000 0.02886667 0.01206667 0.96574664 0.02992722 FALSE TRUE
ENST00000493057 ENSG00000002746 HEK293_OSMI2_2hA HEK293_TMG_2hB HECW1 protein_coding processed_transcript 0.1883846 0.3056349 0.2078944 0.1103539 0.09120205 -0.5346279 0.007990488 0.063923904 0.000000000 0.063923904 0.000000000 -2.8860409 0.02430417 0.19443333 0.00000000 -0.19443333 0.83770833 0.02992722   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000002746 E001 0.0000000       7 43112629 43112644 16 +      
ENSG00000002746 E002 0.0000000       7 43112645 43112646 2 +      
ENSG00000002746 E003 0.2214452 0.05440717 0.56833119   7 43112647 43112937 291 + 0.000 0.119 13.255
ENSG00000002746 E004 0.0000000       7 43113741 43114156 416 +      
ENSG00000002746 E005 0.2214452 0.05440717 0.56833119   7 43114157 43114391 235 + 0.000 0.119 13.261
ENSG00000002746 E006 0.0000000       7 43243875 43243932 58 +      
ENSG00000002746 E007 0.0000000       7 43248587 43248647 61 +      
ENSG00000002746 E008 0.0000000       7 43248936 43249136 201 +      
ENSG00000002746 E009 0.1817044 0.03877626 0.57262639   7 43249137 43249218 82 + 0.000 0.119 13.256
ENSG00000002746 E010 0.7331471 0.01761094 0.05870788 0.12441735 7 43249219 43249479 261 + 0.000 0.355 15.256
ENSG00000002746 E011 1.0277444 0.04192669 0.03198991 0.07583928 7 43258535 43258709 175 + 0.000 0.414 15.591
ENSG00000002746 E012 0.0000000       7 43258710 43258740 31 +      
ENSG00000002746 E013 0.1451727 0.04998930 0.41670545   7 43311763 43311984 222 + 0.126 0.000 -13.710
ENSG00000002746 E014 0.1451727 0.04998930 0.41670545   7 43311985 43311993 9 + 0.126 0.000 -13.710
ENSG00000002746 E015 0.6955713 0.01879746 0.81580307 0.88343428 7 43311994 43312087 94 + 0.223 0.213 -0.088
ENSG00000002746 E016 0.6955713 0.01879746 0.81580307 0.88343428 7 43320635 43320742 108 + 0.223 0.213 -0.088
ENSG00000002746 E017 1.0589801 0.01404594 0.59219988 0.71480624 7 43360886 43360980 95 + 0.223 0.355 0.912
ENSG00000002746 E018 0.0000000       7 43377778 43377943 166 +      
ENSG00000002746 E019 0.0000000       7 43396673 43396719 47 +      
ENSG00000002746 E020 0.3634088 0.03140864 0.26954571   7 43396814 43396889 76 + 0.000 0.213 14.257
ENSG00000002746 E021 0.1817044 0.03877626 0.57262639   7 43407562 43407731 170 + 0.000 0.119 13.256
ENSG00000002746 E022 0.8200183 0.01998804 0.49001911 0.62737774 7 43438003 43438145 143 + 0.303 0.212 -0.675
ENSG00000002746 E023 0.3729606 0.03024096 0.88594040 0.93104095 7 43438146 43438763 618 + 0.126 0.119 -0.087
ENSG00000002746 E024 0.0000000       7 43438764 43440597 1834 +      
ENSG00000002746 E025 0.4470576 0.02711870 0.45399552 0.59468080 7 43442529 43442629 101 + 0.223 0.119 -1.093
ENSG00000002746 E026 2.6529185 0.10944887 0.76211565 0.84579598 7 43444218 43445570 1353 + 0.479 0.592 0.527
ENSG00000002746 E027 0.3729606 0.03024096 0.88594040 0.93104095 7 43450828 43450929 102 + 0.126 0.119 -0.087
ENSG00000002746 E028 0.3030308 0.26998927 0.21887709   7 43456297 43456447 151 + 0.224 0.000 -14.716
ENSG00000002746 E029 0.3332198 0.02781355 0.87927009   7 43463660 43463799 140 + 0.126 0.119 -0.090
ENSG00000002746 E030 0.5514428 0.02284015 0.12069830 0.22096317 7 43466447 43466568 122 + 0.000 0.289 14.841
ENSG00000002746 E031 0.3268771 0.02816575 0.87863734   7 43468920 43469105 186 + 0.126 0.119 -0.089
ENSG00000002746 E032 0.0000000       7 43479608 43479609 2 +      
ENSG00000002746 E033 0.3729606 0.03024096 0.88594040 0.93104095 7 43479610 43479652 43 + 0.126 0.119 -0.087
ENSG00000002746 E034 1.0351207 0.01734312 0.79024339 0.86582175 7 43479653 43479744 92 + 0.303 0.289 -0.088
ENSG00000002746 E035 0.0000000       7 43484144 43484615 472 +      
ENSG00000002746 E036 0.9492964 0.01669930 0.77349938 0.85385646 7 43492075 43492180 106 + 0.303 0.289 -0.091
ENSG00000002746 E037 1.1781284 0.01371481 0.38322327 0.52740991 7 43493084 43493180 97 + 0.223 0.411 1.231
ENSG00000002746 E038 0.4783925 0.02267025 0.44669039 0.58816604 7 43500699 43500782 84 + 0.223 0.119 -1.090
ENSG00000002746 E039 0.3268771 0.02816575 0.87863734   7 43501213 43501322 110 + 0.126 0.119 -0.089
ENSG00000002746 E040 0.4751703 0.02477082 0.70248908 0.80131289 7 43507137 43507257 121 + 0.126 0.212 0.908
ENSG00000002746 E041 0.4449813 0.02585380 0.45566501 0.59617923 7 43508018 43508131 114 + 0.223 0.119 -1.093
ENSG00000002746 E042 0.4482035 0.02608130 0.05791347 0.12305304 7 43508969 43509121 153 + 0.303 0.000 -15.296
ENSG00000002746 E043 0.0000000       7 43523049 43523146 98 +      
ENSG00000002746 E044 1.1040340 0.01248400 0.13978088 0.24772509 7 43541163 43541261 99 + 0.428 0.212 -1.412
ENSG00000002746 E045 1.1707547 0.01495434 0.95958499 0.97861620 7 43541869 43541994 126 + 0.303 0.355 0.326
ENSG00000002746 E046 0.1817044 0.03877626 0.57262639   7 43541995 43541998 4 + 0.000 0.119 13.256
ENSG00000002746 E047 1.0902263 0.59044809 0.20550513 0.33304245 7 43550445 43550591 147 + 0.000 0.465 15.861
ENSG00000002746 E048 1.2040641 0.01691543 0.09221762 0.17858779 7 43552222 43552336 115 + 0.126 0.461 2.495
ENSG00000002746 E049 1.1405526 0.01255318 0.49380421 0.63081407 7 43554592 43554790 199 + 0.370 0.289 -0.505
ENSG00000002746 E050 0.9620705 0.01385492 0.04799553 0.10562854 7 43561815 43562052 238 + 0.428 0.119 -2.411
ENSG00000002746 E051 0.5954526 0.01936647 0.02174318 0.05514372 7 43562053 43566001 3949 + 0.370 0.000 -15.711