ENSG00000001629

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265742 ENSG00000001629 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKIB1 protein_coding protein_coding 5.164494 1.93259 7.922826 0.117806 0.1161651 2.029854 2.13291271 0.1834063 4.7582106 0.05901998 0.10750139 4.6237415 0.32728750 0.09703333 0.60120000 0.504166667 1.458964e-11 1.458964e-11 FALSE TRUE
ENST00000422095 ENSG00000001629 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKIB1 protein_coding nonsense_mediated_decay 5.164494 1.93259 7.922826 0.117806 0.1161651 2.029854 0.56012004 0.6631587 0.2813294 0.16291294 0.10380592 -1.2082956 0.20575833 0.35230000 0.03526667 -0.317033333 9.919809e-04 1.458964e-11 FALSE TRUE
ENST00000465883 ENSG00000001629 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKIB1 protein_coding retained_intron 5.164494 1.93259 7.922826 0.117806 0.1161651 2.029854 0.29485120 0.1250509 0.4182787 0.07001493 0.07860885 1.6650470 0.05898333 0.06070000 0.05263333 -0.008066667 1.000000e+00 1.458964e-11 FALSE FALSE
ENST00000486698 ENSG00000001629 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKIB1 protein_coding processed_transcript 5.164494 1.93259 7.922826 0.117806 0.1161651 2.029854 0.05723263 0.1364438 0.0000000 0.01732641 0.00000000 -3.8722755 0.01807917 0.07003333 0.00000000 -0.070033333 4.551201e-07 1.458964e-11 FALSE TRUE
MSTRG.30242.2 ENSG00000001629 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKIB1 protein_coding   5.164494 1.93259 7.922826 0.117806 0.1161651 2.029854 0.52269489 0.1333526 0.7645508 0.13335257 0.26326102 2.4337920 0.08970833 0.07740000 0.09573333 0.018333333 6.273580e-01 1.458964e-11 FALSE TRUE
MSTRG.30242.3 ENSG00000001629 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKIB1 protein_coding   5.164494 1.93259 7.922826 0.117806 0.1161651 2.029854 1.22055677 0.6564801 1.1722436 0.33577076 0.22364691 0.8268936 0.24649583 0.32473333 0.14886667 -0.175866667 8.650030e-01 1.458964e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000001629 E001 16.1506517 0.0010867071 5.890566e-04 0.0024935760 7 92245974 92246431 458 + 1.147 0.776 -1.388
ENSG00000001629 E002 3.3871825 0.0184088523 9.226908e-03 0.0268515648 7 92246432 92246446 15 + 0.595 0.000 -16.859
ENSG00000001629 E003 11.2466185 0.0015229072 3.406105e-03 0.0114558720 7 92246447 92246519 73 + 1.003 0.635 -1.450
ENSG00000001629 E004 0.0000000       7 92294462 92294516 55 +      
ENSG00000001629 E005 35.3454572 0.0007124745 1.777764e-03 0.0065287498 7 92294889 92295166 278 + 1.450 1.284 -0.576
ENSG00000001629 E006 46.2136375 0.0303123762 2.137314e-01 0.3429182980 7 92307359 92307656 298 + 1.542 1.517 -0.083
ENSG00000001629 E007 28.8365380 0.0032934149 1.189184e-01 0.2183926751 7 92319330 92319421 92 + 1.346 1.303 -0.150
ENSG00000001629 E008 33.5346012 0.0042861520 1.574930e-01 0.2717777574 7 92319422 92319512 91 + 1.407 1.385 -0.076
ENSG00000001629 E009 0.5514428 0.0196528800 1.875971e-03 0.0068411950 7 92319620 92319966 347 + 0.000 0.543 19.046
ENSG00000001629 E010 0.7687379 0.1313235081 8.214233e-01 0.8874101952 7 92325928 92326008 81 + 0.179 0.263 0.704
ENSG00000001629 E011 33.8248590 0.0006309786 3.483710e-01 0.4925983653 7 92327783 92327900 118 + 1.400 1.427 0.092
ENSG00000001629 E012 35.9805292 0.0005820266 1.639685e-01 0.2803095769 7 92343024 92343137 114 + 1.434 1.427 -0.026
ENSG00000001629 E013 30.0508163 0.0007398236 5.426784e-02 0.1167127857 7 92343138 92343232 95 + 1.371 1.303 -0.237
ENSG00000001629 E014 26.0423223 0.0008161355 2.653206e-02 0.0650170823 7 92344978 92345066 89 + 1.315 1.202 -0.398
ENSG00000001629 E015 1.8102039 0.0077949694 4.181582e-01 0.5614439844 7 92347947 92348016 70 + 0.381 0.262 -0.760
ENSG00000001629 E016 27.5349897 0.0008930521 8.366824e-01 0.8978681851 7 92350950 92351094 145 + 1.296 1.413 0.407
ENSG00000001629 E017 33.5758053 0.0011113255 2.883042e-01 0.4288737347 7 92352476 92352642 167 + 1.398 1.413 0.053
ENSG00000001629 E018 25.6313562 0.0097631412 2.179466e-01 0.3479516678 7 92362185 92362273 89 + 1.293 1.267 -0.093
ENSG00000001629 E019 29.7536342 0.0006697162 3.428776e-01 0.4869131344 7 92371477 92371571 95 + 1.349 1.369 0.071
ENSG00000001629 E020 17.4792593 0.0010309776 4.913146e-01 0.6285959066 7 92371572 92371607 36 + 1.131 1.155 0.085
ENSG00000001629 E021 32.0139036 0.0006674478 2.307102e-01 0.3633015638 7 92386509 92386643 135 + 1.382 1.384 0.007
ENSG00000001629 E022 27.2555977 0.0006925036 3.724003e-01 0.5168659086 7 92387798 92387884 87 + 1.315 1.337 0.076
ENSG00000001629 E023 24.1543724 0.0008060327 1.084982e-01 0.2033363698 7 92387975 92388041 67 + 1.279 1.224 -0.192
ENSG00000001629 E024 32.0560660 0.0007596252 6.067731e-03 0.0187884247 7 92389971 92390116 146 + 1.407 1.265 -0.493
ENSG00000001629 E025 37.4890626 0.0005474609 9.568992e-02 0.1839284096 7 92391166 92391344 179 + 1.454 1.427 -0.094
ENSG00000001629 E026 21.2435671 0.0008445982 3.771349e-01 0.5214736464 7 92392241 92392292 52 + 1.213 1.224 0.041
ENSG00000001629 E027 4.4212816 0.0037528582 2.486093e-01 0.3842876468 7 92395869 92396364 496 + 0.566 0.833 1.115
ENSG00000001629 E028 13.6356155 0.1952258204 7.291495e-01 0.8213872834 7 92396365 92396382 18 + 1.008 1.136 0.463
ENSG00000001629 E029 22.9415885 0.0066457732 6.466784e-01 0.7585103610 7 92396383 92396476 94 + 1.233 1.286 0.189
ENSG00000001629 E030 15.5040885 0.0013018807 4.872772e-01 0.6249539663 7 92397723 92397769 47 + 1.083 1.101 0.064
ENSG00000001629 E031 20.2453437 0.0009294355 2.476290e-01 0.3831603161 7 92397770 92397859 90 + 1.199 1.179 -0.071
ENSG00000001629 E032 333.3406061 0.0219773805 2.388733e-05 0.0001455762 7 92398212 92401383 3172 + 2.319 2.635 1.054