ENSG00000001497

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000374807 ENSG00000001497 HEK293_OSMI2_2hA HEK293_TMG_2hB LAS1L protein_coding protein_coding 90.11394 131.9517 64.38898 3.633035 1.041139 -1.035009 56.03204 88.81272 34.072538 2.9080903 1.4579363 -1.3818960 0.6050667 0.67356667 0.5289000 -0.14466667 0.001554819 1.29559e-05 FALSE TRUE
ENST00000374811 ENSG00000001497 HEK293_OSMI2_2hA HEK293_TMG_2hB LAS1L protein_coding protein_coding 90.11394 131.9517 64.38898 3.633035 1.041139 -1.035009 16.16341 24.49051 13.941650 2.5974813 0.4182657 -0.8123763 0.1797792 0.18490000 0.2168333 0.03193333 0.500902979 1.29559e-05 FALSE TRUE
MSTRG.34367.10 ENSG00000001497 HEK293_OSMI2_2hA HEK293_TMG_2hB LAS1L protein_coding   90.11394 131.9517 64.38898 3.633035 1.041139 -1.035009 8.05432 12.20900 7.291864 0.9776638 0.5100259 -0.7427891 0.0910750 0.09276667 0.1134000 0.02063333 0.498608325 1.29559e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000001497 E001 0.4804688 0.0212084404 1.846577e-01 3.070448e-01 X 65438549 65439966 1418 - 0.302 0.083 -2.249
ENSG00000001497 E002 7.0744959 0.1253890408 9.169885e-01 9.515713e-01 X 65499118 65499159 42 - 0.879 0.843 -0.138
ENSG00000001497 E003 6.3342636 0.0069395414 9.161113e-01 9.509682e-01 X 65512582 65512582 1 - 0.815 0.838 0.090
ENSG00000001497 E004 6.9640697 0.0145579049 9.097056e-01 9.466171e-01 X 65512583 65512587 5 - 0.847 0.874 0.105
ENSG00000001497 E005 8.9892718 0.0052815768 7.691313e-01 8.508392e-01 X 65512588 65512589 2 - 0.980 0.954 -0.096
ENSG00000001497 E006 35.6489601 0.0006260932 2.258675e-01 3.574316e-01 X 65512590 65512602 13 - 1.441 1.530 0.305
ENSG00000001497 E007 41.4336617 0.0005184748 6.873040e-03 2.089474e-02 X 65512603 65512622 20 - 1.433 1.615 0.624
ENSG00000001497 E008 924.9846560 0.0021794354 4.689307e-09 6.149627e-08 X 65512623 65512901 279 - 2.785 2.946 0.534
ENSG00000001497 E009 1141.2866911 0.0021121090 1.445537e-09 2.079209e-08 X 65514823 65514970 148 - 2.879 3.036 0.524
ENSG00000001497 E010 450.5473330 0.0003557549 1.706540e-09 2.422440e-08 X 65514971 65514973 3 - 2.494 2.630 0.454
ENSG00000001497 E011 897.0649978 0.0014092063 6.687972e-07 5.766766e-06 X 65517987 65518073 87 - 2.805 2.924 0.395
ENSG00000001497 E012 1852.2977572 0.0002912847 2.058992e-07 1.968658e-06 X 65518074 65518465 392 - 3.160 3.227 0.223
ENSG00000001497 E013 27.6916622 0.0006975620 1.654325e-06 1.309791e-05 X 65518466 65520428 1963 - 1.609 1.296 -1.081
ENSG00000001497 E014 5.2272875 0.0034153963 1.729372e-01 2.920106e-01 X 65520429 65520466 38 - 0.877 0.699 -0.706
ENSG00000001497 E015 6.3334945 0.0028338999 6.724034e-01 7.783741e-01 X 65520467 65520494 28 - 0.847 0.797 -0.193
ENSG00000001497 E016 20.3285926 0.0009092887 5.950901e-01 7.172315e-01 X 65520495 65520626 132 - 1.303 1.267 -0.126
ENSG00000001497 E017 19.4004062 0.0057644076 1.100624e-01 2.056343e-01 X 65520627 65520701 75 - 1.354 1.224 -0.456
ENSG00000001497 E018 28.9350946 0.0006790094 3.319327e-02 7.818432e-02 X 65520702 65520817 116 - 1.520 1.384 -0.472
ENSG00000001497 E019 39.5944513 0.0015873905 6.162683e-05 3.394295e-04 X 65520818 65521147 330 - 1.714 1.484 -0.784
ENSG00000001497 E020 23.9486102 0.0009247285 7.341363e-03 2.210600e-02 X 65521148 65521287 140 - 1.479 1.291 -0.652
ENSG00000001497 E021 36.8025202 0.0017240940 1.520385e-05 9.690229e-05 X 65521288 65522285 998 - 1.697 1.437 -0.886
ENSG00000001497 E022 2.0489502 0.3822402275 1.858161e-01 3.085324e-01 X 65522286 65522313 28 - 0.699 0.312 -1.931
ENSG00000001497 E023 2.8637717 0.0255663290 2.289680e-03 8.118640e-03 X 65522314 65522430 117 - 0.847 0.355 -2.250
ENSG00000001497 E024 3.0894847 0.0050877381 2.076466e-04 9.966818e-04 X 65522431 65522493 63 - 0.905 0.355 -2.475
ENSG00000001497 E025 4.2586410 0.0583047930 1.569364e-02 4.204954e-02 X 65522494 65522605 112 - 0.932 0.523 -1.696
ENSG00000001497 E026 7.1384065 0.0602279941 2.332905e-03 8.252946e-03 X 65522606 65522745 140 - 1.149 0.668 -1.841
ENSG00000001497 E027 5.8925107 0.1751689882 1.190429e-02 3.330476e-02 X 65522746 65522849 104 - 1.100 0.566 -2.112
ENSG00000001497 E028 4.3683011 0.0042011592 7.764970e-05 4.169525e-04 X 65522850 65522926 77 - 1.002 0.462 -2.252
ENSG00000001497 E029 12.0342624 0.0014322806 1.213159e-04 6.199203e-04 X 65522927 65523559 633 - 1.303 0.944 -1.292
ENSG00000001497 E030 864.0217857 0.0003667196 7.323554e-01 8.238134e-01 X 65523560 65523707 148 - 2.879 2.880 0.005
ENSG00000001497 E031 11.9270104 0.0139893665 1.575203e-08 1.871074e-07 X 65523708 65523876 169 - 1.409 0.799 -2.217
ENSG00000001497 E032 13.1220656 0.0356465399 2.170320e-06 1.674652e-05 X 65523877 65524055 179 - 1.442 0.843 -2.158
ENSG00000001497 E033 1015.7210688 0.0001173050 1.103918e-02 3.125417e-02 X 65524056 65524262 207 - 2.921 2.962 0.136
ENSG00000001497 E034 33.5104234 0.0066357600 1.394479e-10 2.402073e-09 X 65524263 65524563 301 - 1.762 1.314 -1.533
ENSG00000001497 E035 136.1168382 0.0042804708 3.082171e-02 7.356692e-02 X 65524564 65524614 51 - 2.147 2.060 -0.289
ENSG00000001497 E036 5.2004091 0.0407085653 1.432400e-02 3.896442e-02 X 65524764 65524964 201 - 0.980 0.600 -1.517
ENSG00000001497 E037 570.7820734 0.0021495922 4.545541e-03 1.466867e-02 X 65524965 65525050 86 - 2.636 2.719 0.278
ENSG00000001497 E038 1.6479881 0.0090969183 4.716327e-01 6.107181e-01 X 65527276 65527368 93 - 0.478 0.355 -0.668
ENSG00000001497 E039 646.7016435 0.0002431335 5.266952e-04 2.259581e-03 X 65528260 65528369 110 - 2.704 2.771 0.222
ENSG00000001497 E040 10.2218559 0.0555170003 9.821646e-03 2.832389e-02 X 65528370 65528875 506 - 1.244 0.856 -1.418
ENSG00000001497 E041 2.9316502 0.0761765079 1.226807e-01 2.237834e-01 X 65528876 65528963 88 - 0.742 0.463 -1.248
ENSG00000001497 E042 7.7581843 0.0176925992 4.291516e-05 2.456535e-04 X 65528964 65529211 248 - 1.206 0.699 -1.913
ENSG00000001497 E043 486.0509929 0.0002907641 8.771602e-01 9.251084e-01 X 65529212 65529258 47 - 2.624 2.634 0.035
ENSG00000001497 E044 1293.9486316 0.0017488788 1.159725e-03 4.504304e-03 X 65529594 65529878 285 - 3.102 3.037 -0.215
ENSG00000001497 E045 594.5913714 0.0006549187 4.313290e-09 5.682870e-08 X 65531357 65531438 82 - 2.795 2.688 -0.357
ENSG00000001497 E046 536.5843765 0.0009346376 3.085638e-05 1.830483e-04 X 65532561 65532630 70 - 2.734 2.650 -0.282
ENSG00000001497 E047 13.8512004 0.0012987150 8.993473e-10 1.344847e-08 X 65532631 65533609 979 - 1.441 0.901 -1.936
ENSG00000001497 E048 743.6282499 0.0007225792 2.541511e-07 2.387473e-06 X 65533610 65533735 126 - 2.879 2.790 -0.297
ENSG00000001497 E049 14.1494701 0.0883433183 2.860499e-03 9.854575e-03 X 65533736 65534479 744 - 1.418 0.936 -1.724
ENSG00000001497 E050 678.3580177 0.0007953988 2.611206e-05 1.576033e-04 X 65534480 65534572 93 - 2.829 2.753 -0.254
ENSG00000001497 E051 690.9244152 0.0012399209 1.217285e-07 1.216688e-06 X 65534573 65534717 145 - 2.860 2.750 -0.365
ENSG00000001497 E052 299.1219333 0.0020902020 9.799253e-10 1.455916e-08 X 65534718 65534810 93 - 2.545 2.364 -0.606