ENSG00000001036

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000002165 ENSG00000001036 HEK293_OSMI2_2hA HEK293_TMG_2hB FUCA2 protein_coding protein_coding 58.02081 65.13848 58.42195 7.655859 0.7865416 -0.1569741 21.7472 18.42109 24.80841 1.749212 0.7451812 0.4292696 0.3800958 0.2845667 0.4246667 0.1401000 1.071222e-06 1.071222e-06 FALSE TRUE
MSTRG.29082.5 ENSG00000001036 HEK293_OSMI2_2hA HEK293_TMG_2hB FUCA2 protein_coding   58.02081 65.13848 58.42195 7.655859 0.7865416 -0.1569741 16.9344 20.78861 18.37291 2.070127 0.4197245 -0.1781223 0.2912417 0.3209333 0.3144333 -0.0065000 9.420104e-01 1.071222e-06 FALSE TRUE
MSTRG.29082.8 ENSG00000001036 HEK293_OSMI2_2hA HEK293_TMG_2hB FUCA2 protein_coding   58.02081 65.13848 58.42195 7.655859 0.7865416 -0.1569741 17.0648 23.02884 13.38266 3.597155 0.9959810 -0.7826262 0.2896750 0.3506333 0.2291667 -0.1214667 2.872929e-03 1.071222e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000001036 E001 26.556685 0.0066625037 8.716606e-06 5.871413e-05 6 143494812 143495092 281 - 1.609 1.271 -1.165
ENSG00000001036 E002 26.806153 0.0353395779 3.415723e-05 2.003277e-04 6 143495093 143495171 79 - 1.661 1.190 -1.630
ENSG00000001036 E003 42.001920 0.0045162128 2.446720e-16 1.004385e-14 6 143495172 143495359 188 - 1.867 1.351 -1.763
ENSG00000001036 E004 30.608472 0.0006654721 1.164497e-14 3.791860e-13 6 143495360 143495431 72 - 1.721 1.231 -1.687
ENSG00000001036 E005 25.626845 0.0007259415 6.275514e-11 1.144141e-09 6 143495432 143495486 55 - 1.631 1.184 -1.549
ENSG00000001036 E006 19.754977 0.0009679625 1.054236e-04 5.470335e-04 6 143495487 143495490 4 - 1.467 1.176 -1.019
ENSG00000001036 E007 985.972021 0.0032324427 3.632798e-04 1.631903e-03 6 143495491 143495847 357 - 2.926 3.024 0.326
ENSG00000001036 E008 8.623290 0.0184452236 1.523441e-01 2.648814e-01 6 143496952 143497388 437 - 1.076 0.901 -0.647
ENSG00000001036 E009 717.190064 0.0009604008 6.279126e-04 2.635485e-03 6 143497389 143497497 109 - 2.811 2.877 0.217
ENSG00000001036 E010 376.657897 0.0011664545 2.860857e-02 6.922603e-02 6 143501932 143501944 13 - 2.540 2.593 0.176
ENSG00000001036 E011 954.362330 0.0003788240 9.258160e-04 3.705435e-03 6 143501945 143502122 178 - 2.948 2.994 0.153
ENSG00000001036 E012 832.721888 0.0001224755 1.095061e-01 2.048402e-01 6 143502355 143502484 130 - 2.905 2.927 0.073
ENSG00000001036 E013 596.058770 0.0001442607 4.028765e-01 5.466832e-01 6 143502485 143502565 81 - 2.764 2.778 0.047
ENSG00000001036 E014 844.436990 0.0010568922 6.283266e-01 7.438871e-01 6 143503913 143504074 162 - 2.929 2.915 -0.046
ENSG00000001036 E015 355.077155 0.0013877049 7.266695e-01 8.196216e-01 6 143504075 143504085 11 - 2.542 2.546 0.016
ENSG00000001036 E016 530.493796 0.0004557531 4.573454e-01 5.976678e-01 6 143504086 143504166 81 - 2.713 2.725 0.041
ENSG00000001036 E017 586.044300 0.0003796464 1.526521e-02 4.108755e-02 6 143504167 143504252 86 - 2.788 2.747 -0.135
ENSG00000001036 E018 657.876947 0.0030957041 1.237049e-03 4.766320e-03 6 143507237 143507424 188 - 2.869 2.768 -0.336
ENSG00000001036 E019 1.478039 0.0171540990 5.177475e-01 6.520832e-01 6 143511189 143511410 222 - 0.450 0.336 -0.639
ENSG00000001036 E020 467.155250 0.0090851250 4.622793e-03 1.488223e-02 6 143511411 143512099 689 - 2.743 2.598 -0.481