ENSG00000172530

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000412691 ENSG00000172530 HEK293_DMSO_6hB HEK293_TMG_6hB BANP protein_coding protein_coding 17.16117 15.74869 14.46184 0.266887 1.249311 -0.1228988 1.6270393 2.0753837 1.4762397 0.2292972 0.3900266 -0.4886460 0.09580000 0.13163333 0.10076667 -0.03086667 9.505325e-01 3.311732e-05 FALSE FALSE
ENST00000439677 ENSG00000172530 HEK293_DMSO_6hB HEK293_TMG_6hB BANP protein_coding protein_coding 17.16117 15.74869 14.46184 0.266887 1.249311 -0.1228988 0.9835111 0.4758219 0.7375399 0.4758219 0.3690251 0.6217232 0.05955000 0.02926667 0.04743333 0.01816667 9.505325e-01 3.311732e-05 FALSE TRUE
ENST00000612301 ENSG00000172530 HEK293_DMSO_6hB HEK293_TMG_6hB BANP protein_coding processed_transcript 17.16117 15.74869 14.46184 0.266887 1.249311 -0.1228988 2.8484232 3.3258581 1.2889972 0.1461460 0.1554284 -1.3606596 0.16366250 0.21156667 0.08876667 -0.12280000 3.311732e-05 3.311732e-05   FALSE
ENST00000682872 ENSG00000172530 HEK293_DMSO_6hB HEK293_TMG_6hB BANP protein_coding protein_coding 17.16117 15.74869 14.46184 0.266887 1.249311 -0.1228988 0.2857556 0.0000000 0.9709644 0.0000000 0.6853707 6.6161288 0.01751667 0.00000000 0.06463333 0.06463333 7.053845e-01 3.311732e-05 FALSE TRUE
MSTRG.13221.11 ENSG00000172530 HEK293_DMSO_6hB HEK293_TMG_6hB BANP protein_coding   17.16117 15.74869 14.46184 0.266887 1.249311 -0.1228988 3.9368890 5.1856454 3.5679759 0.6680500 0.9108322 -0.5381593 0.23160000 0.33070000 0.24266667 -0.08803333 9.505325e-01 3.311732e-05 FALSE TRUE
MSTRG.13221.12 ENSG00000172530 HEK293_DMSO_6hB HEK293_TMG_6hB BANP protein_coding   17.16117 15.74869 14.46184 0.266887 1.249311 -0.1228988 1.0458550 0.8204314 0.9683173 0.4103440 0.4861890 0.2364415 0.06016667 0.05143333 0.06216667 0.01073333 1.000000e+00 3.311732e-05 FALSE TRUE
MSTRG.13221.13 ENSG00000172530 HEK293_DMSO_6hB HEK293_TMG_6hB BANP protein_coding   17.16117 15.74869 14.46184 0.266887 1.249311 -0.1228988 1.0750540 0.0000000 1.3122166 0.0000000 0.6757957 7.0468147 0.06407500 0.00000000 0.09980000 0.09980000 7.053845e-01 3.311732e-05 FALSE TRUE
MSTRG.13221.14 ENSG00000172530 HEK293_DMSO_6hB HEK293_TMG_6hB BANP protein_coding   17.16117 15.74869 14.46184 0.266887 1.249311 -0.1228988 1.1552297 0.8801296 0.5489988 0.5652819 0.5489988 -0.6711702 0.06342917 0.05470000 0.03323333 -0.02146667 9.505325e-01 3.311732e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_DMSO_6hB log2fold_HEK293_DMSO_6hB_HEK293_TMG_6hB
ENSG00000172530 E001 0.0000000       16 87949244 87949761 518 +      
ENSG00000172530 E002 1.6398142 0.0204505386 4.730662e-01 0.940413016 16 87950436 87950927 492 + 0.357 0.484 0.684
ENSG00000172530 E003 0.3521593 0.0341288745 9.641027e-01   16 87951432 87951433 2 + 0.120 0.127 0.096
ENSG00000172530 E004 0.3521593 0.0341288745 9.641027e-01   16 87951434 87951434 1 + 0.120 0.127 0.096
ENSG00000172530 E005 0.8243880 0.0164664042 1.942602e-01   16 87951435 87951439 5 + 0.357 0.127 -1.901
ENSG00000172530 E006 1.1765473 0.0158115961 2.935861e-01 0.940413016 16 87951440 87951440 1 + 0.414 0.226 -1.224
ENSG00000172530 E007 2.7955072 0.0075400795 1.189077e-01 0.940413016 16 87951441 87951442 2 + 0.683 0.432 -1.165
ENSG00000172530 E008 8.7848429 0.0029633859 3.271825e-01 0.940413016 16 87951443 87951444 2 + 1.037 0.929 -0.397
ENSG00000172530 E009 23.5683448 0.0012585137 2.409045e-01 0.940413016 16 87951445 87951466 22 + 1.428 1.345 -0.288
ENSG00000172530 E010 32.2184338 0.0009965954 2.759678e-01 0.940413016 16 87951467 87951478 12 + 1.553 1.487 -0.227
ENSG00000172530 E011 34.8999349 0.0009275034 1.558185e-01 0.940413016 16 87951479 87951480 2 + 1.594 1.510 -0.285
ENSG00000172530 E012 37.1965333 0.0008785023 2.796838e-01 0.940413016 16 87951481 87951484 4 + 1.611 1.549 -0.210
ENSG00000172530 E013 39.0289101 0.0008549175 2.204843e-01 0.940413016 16 87951485 87951486 2 + 1.634 1.566 -0.232
ENSG00000172530 E014 65.0087418 0.0009033948 3.645072e-02 0.933063957 16 87951487 87951515 29 + 1.863 1.771 -0.312
ENSG00000172530 E015 13.6429191 0.0021405982 2.792954e-03 0.579892497 16 87952181 87952246 66 + 1.010 1.288 0.994
ENSG00000172530 E016 11.4831384 0.0026273193 1.385818e-03 0.488592671 16 87952247 87952273 27 + 0.920 1.240 1.160
ENSG00000172530 E017 23.6692421 0.0013026063 8.683366e-07 0.008771013 16 87952274 87952748 475 + 1.186 1.545 1.250
ENSG00000172530 E018 1.6224859 0.0108647759 4.205496e-02 0.940413016 16 87956572 87957069 498 + 0.214 0.571 2.098
ENSG00000172530 E019 0.1501209 0.0441185637 5.171546e-01   16 87959871 87959993 123 + 0.120 0.000 -10.733
ENSG00000172530 E020 0.0000000       16 87963379 87963480 102 +      
ENSG00000172530 E021 0.0000000       16 87966703 87966843 141 +      
ENSG00000172530 E022 0.0000000       16 87970018 87970170 153 +      
ENSG00000172530 E023 94.3600899 0.0010024097 1.055516e-01 0.940413016 16 87975048 87975185 138 + 2.008 1.948 -0.204
ENSG00000172530 E024 3.1616024 0.0237073434 2.188566e-02 0.872470400 16 87975186 87975203 18 + 0.762 0.374 -1.807
ENSG00000172530 E025 0.9963749 0.0142968662 1.083037e-01   16 87975204 87975207 4 + 0.414 0.127 -2.224
ENSG00000172530 E026 1.5067631 0.1039986853 4.291892e-01 0.940413016 16 87978440 87978692 253 + 0.464 0.306 -0.898
ENSG00000172530 E027 0.1538588 0.0444761113 4.615447e-01   16 87980535 87981035 501 + 0.000 0.127 10.990
ENSG00000172530 E028 85.7069188 0.0024060366 2.378384e-01 0.940413016 16 87981036 87981127 92 + 1.962 1.911 -0.171
ENSG00000172530 E029 0.0000000       16 87982618 87982747 130 +      
ENSG00000172530 E030 40.1850057 0.0009873627 6.235892e-01 0.948417757 16 87984060 87984083 24 + 1.627 1.601 -0.091
ENSG00000172530 E031 81.1991685 0.0005028773 5.781125e-01 0.942017485 16 87984084 87984259 176 + 1.905 1.927 0.074
ENSG00000172530 E032 1.3354214 0.1185885036 9.515623e-01 0.996593053 16 88003482 88003563 82 + 0.357 0.374 0.103
ENSG00000172530 E033 0.1501209 0.0441185637 5.171546e-01   16 88003811 88003931 121 + 0.120 0.000 -10.733
ENSG00000172530 E034 55.1234576 0.0006661825 3.589712e-01 0.940413016 16 88004295 88004411 117 + 1.726 1.771 0.149
ENSG00000172530 E035 79.1309100 0.0005322450 1.368985e-01 0.940413016 16 88006090 88006265 176 + 1.875 1.934 0.200
ENSG00000172530 E036 0.1719870 0.0427569275 5.164357e-01   16 88017190 88017409 220 + 0.120 0.000 -10.736
ENSG00000172530 E037 87.5956151 0.0072476927 1.829633e-01 0.940413016 16 88018428 88018667 240 + 1.910 1.983 0.246
ENSG00000172530 E038 61.0658286 0.0009952831 4.893660e-02 0.940413016 16 88027483 88027650 168 + 1.744 1.836 0.308
ENSG00000172530 E039 67.8878759 0.0016869351 1.802780e-01 0.940413016 16 88033109 88033245 137 + 1.805 1.867 0.209
ENSG00000172530 E040 0.4940948 0.0246769943 9.515486e-02   16 88035052 88035322 271 + 0.291 0.000 -12.320
ENSG00000172530 E041 21.8106458 0.0089304539 2.995823e-01 0.940413016 16 88035323 88035331 9 + 1.311 1.401 0.314
ENSG00000172530 E042 47.7425055 0.0007706655 5.048015e-01 0.940413016 16 88035332 88035394 63 + 1.702 1.669 -0.112
ENSG00000172530 E043 0.5087979 0.0221258987 9.408468e-02   16 88037273 88037972 700 + 0.291 0.000 -12.321
ENSG00000172530 E044 36.1559125 0.0010697748 4.000096e-01 0.940413016 16 88037973 88038011 39 + 1.593 1.545 -0.165
ENSG00000172530 E045 9.7022842 0.0025515361 3.684637e-01 0.940413016 16 88065267 88065332 66 + 1.073 0.979 -0.345
ENSG00000172530 E046 6.4471806 0.0501541343 2.169332e-01 0.940413016 16 88071073 88071929 857 + 0.951 0.762 -0.730
ENSG00000172530 E047 52.7542261 0.0155467615 8.603970e-01 0.983928320 16 88072069 88072212 144 + 1.734 1.727 -0.026
ENSG00000172530 E048 87.5872655 0.0006275154 4.477279e-01 0.940413016 16 88076590 88077318 729 + 1.960 1.932 -0.093