ENSG00000170776

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394510 ENSG00000170776 HEK293_DMSO_6hB HEK293_TMG_6hB AKAP13 protein_coding protein_coding 7.199587 5.613673 5.497444 0.4225422 0.1461419 -0.0301298 2.7543173 0.5151178 0.0000000 0.183015541 0.0000000 -5.71456928 0.32110000 0.09683333 0.0000 -0.096833333 0.01433105 0.01433105 FALSE TRUE
ENST00000394518 ENSG00000170776 HEK293_DMSO_6hB HEK293_TMG_6hB AKAP13 protein_coding protein_coding 7.199587 5.613673 5.497444 0.4225422 0.1461419 -0.0301298 1.1516499 1.3268878 1.4625532 0.209325624 0.1753299 0.13944138 0.18831250 0.24433333 0.2649 0.020566667 0.98142075 0.01433105 FALSE TRUE
ENST00000559391 ENSG00000170776 HEK293_DMSO_6hB HEK293_TMG_6hB AKAP13 protein_coding retained_intron 7.199587 5.613673 5.497444 0.4225422 0.1461419 -0.0301298 0.3403135 0.3480519 0.4193776 0.009248594 0.1554083 0.26207830 0.05033333 0.06246667 0.0769 0.014433333 1.00000000 0.01433105   FALSE
ENST00000560185 ENSG00000170776 HEK293_DMSO_6hB HEK293_TMG_6hB AKAP13 protein_coding processed_transcript 7.199587 5.613673 5.497444 0.4225422 0.1461419 -0.0301298 0.8307956 0.0000000 0.0000000 0.000000000 0.0000000 0.00000000 0.08565417 0.00000000 0.0000 0.000000000   0.01433105   FALSE
MSTRG.11463.4 ENSG00000170776 HEK293_DMSO_6hB HEK293_TMG_6hB AKAP13 protein_coding   7.199587 5.613673 5.497444 0.4225422 0.1461419 -0.0301298 1.5209949 2.3301090 2.2149939 0.338963611 0.3940701 -0.07277435 0.24957083 0.41196667 0.4066 -0.005366667 1.00000000 0.01433105 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_DMSO_6hB log2fold_HEK293_DMSO_6hB_HEK293_TMG_6hB
ENSG00000170776 E001 0.1501209 0.0437236793 4.091608e-01   15 85380571 85380586 16 + 0.128 0.000 -10.211
ENSG00000170776 E002 0.3039796 0.0309630883 8.983399e-01   15 85380587 85380594 8 + 0.128 0.119 -0.127
ENSG00000170776 E003 0.7886995 0.0169173139 2.399343e-01   15 85380595 85380595 1 + 0.128 0.354 1.873
ENSG00000170776 E004 1.1261556 0.0131208440 3.635817e-01 0.94041302 15 85380596 85380602 7 + 0.228 0.411 1.194
ENSG00000170776 E005 2.0936726 0.0226837001 1.102995e-01 0.94041302 15 85380603 85380616 14 + 0.308 0.618 1.607
ENSG00000170776 E006 2.4130006 0.0333660094 5.625751e-02 0.94041302 15 85380617 85380625 9 + 0.308 0.679 1.869
ENSG00000170776 E007 3.4133489 0.1331022727 1.802505e-01 0.94041302 15 85380626 85380639 14 + 0.437 0.778 1.526
ENSG00000170776 E008 7.2391444 0.0037964733 1.369289e-01 0.94041302 15 85380640 85380728 89 + 0.790 1.006 0.822
ENSG00000170776 E009 7.6581559 0.0049948973 7.463202e-01 0.96746288 15 85380729 85380755 27 + 0.934 0.933 -0.004
ENSG00000170776 E010 9.2465974 0.0032451482 9.110531e-01 0.99132992 15 85380756 85380798 43 + 0.983 1.032 0.182
ENSG00000170776 E011 0.0000000       15 85381687 85382170 484 +      
ENSG00000170776 E012 0.1501209 0.0437236793 4.091608e-01   15 85480873 85481026 154 + 0.128 0.000 -12.818
ENSG00000170776 E013 10.1284088 0.0042891968 6.803289e-01 0.95793076 15 85485710 85485753 44 + 0.998 1.080 0.300
ENSG00000170776 E014 17.3094137 0.0019920580 6.600485e-01 0.95429110 15 85521428 85521575 148 + 1.261 1.263 0.010
ENSG00000170776 E015 30.5875469 0.0494677546 2.493552e-01 0.94041302 15 85533584 85533880 297 + 1.543 1.453 -0.310
ENSG00000170776 E016 2.1247661 0.0111962475 2.884349e-01 0.94041302 15 85533881 85536997 3117 + 0.376 0.584 1.043
ENSG00000170776 E017 21.0341289 0.0358772377 5.372659e-01 0.94041302 15 85543772 85543955 184 + 1.350 1.334 -0.056
ENSG00000170776 E018 0.1654692 0.0456545321 5.860964e-01   15 85544040 85544143 104 + 0.000 0.119 11.946
ENSG00000170776 E019 0.0000000       15 85555446 85555491 46 +      
ENSG00000170776 E020 26.6035310 0.0021438822 6.681890e-01 0.95575728 15 85575131 85575329 199 + 1.434 1.444 0.034
ENSG00000170776 E021 275.8065267 0.0007216436 5.900981e-01 0.94308915 15 85578930 85582107 3178 + 2.429 2.457 0.092
ENSG00000170776 E022 0.0000000       15 85582910 85583164 255 +      
ENSG00000170776 E023 27.8816327 0.0016865224 4.400496e-01 0.94041302 15 85585702 85585823 122 + 1.466 1.454 -0.042
ENSG00000170776 E024 0.0000000       15 85619696 85619949 254 +      
ENSG00000170776 E025 0.0000000       15 85619950 85620172 223 +      
ENSG00000170776 E026 0.0000000       15 85635097 85635105 9 +      
ENSG00000170776 E027 23.9197401 0.0049038325 6.337850e-01 0.95021870 15 85639374 85639449 76 + 1.394 1.398 0.013
ENSG00000170776 E028 28.4871625 0.0053343160 1.346871e-01 0.94041302 15 85645818 85645918 101 + 1.501 1.434 -0.230
ENSG00000170776 E029 20.1964251 0.0059479335 1.587416e-02 0.82888478 15 85645919 85645954 36 + 1.400 1.240 -0.558
ENSG00000170776 E030 60.3067416 0.0184140511 6.140202e-01 0.94657243 15 85655417 85655787 371 + 1.779 1.793 0.048
ENSG00000170776 E031 7.2789374 0.0617975764 7.303217e-01 0.96559642 15 85658537 85658590 54 + 0.918 0.915 -0.012
ENSG00000170776 E032 0.1866901 0.0641238099 4.064443e-01   15 85662388 85662453 66 + 0.129 0.000 -12.684
ENSG00000170776 E033 37.8987229 0.0496139207 3.530814e-01 0.94041302 15 85664563 85664755 193 + 1.616 1.562 -0.186
ENSG00000170776 E034 33.1212380 0.0086487155 1.929408e-01 0.94041302 15 85669722 85669830 109 + 1.558 1.508 -0.171
ENSG00000170776 E035 0.1866901 0.0641238099 4.064443e-01   15 85677037 85677098 62 + 0.129 0.000 -12.684
ENSG00000170776 E036 16.5590034 0.0097901413 6.306585e-01 0.94985272 15 85682158 85682167 10 + 1.198 1.286 0.307
ENSG00000170776 E037 21.1845082 0.0158386533 5.421689e-01 0.94065042 15 85682168 85682212 45 + 1.350 1.340 -0.035
ENSG00000170776 E038 0.1719870 0.0418534680 4.086020e-01   15 85683527 85683612 86 + 0.129 0.000 -12.835
ENSG00000170776 E039 0.5174738 0.2957241037 7.890705e-01   15 85684422 85684740 319 + 0.130 0.213 0.864
ENSG00000170776 E040 27.9444689 0.0031602332 1.374706e-01 0.94041302 15 85684741 85684873 133 + 1.491 1.429 -0.213
ENSG00000170776 E041 0.1653919 0.0439292326 5.868240e-01   15 85684874 85685446 573 + 0.000 0.119 11.956
ENSG00000170776 E042 0.0000000       15 85689869 85690104 236 +      
ENSG00000170776 E043 0.0000000       15 85693099 85693276 178 +      
ENSG00000170776 E044 32.5385650 0.0011256949 6.805020e-01 0.95801463 15 85693277 85693451 175 + 1.519 1.533 0.048
ENSG00000170776 E045 22.3692141 0.0332374654 6.006342e-01 0.94461870 15 85708019 85708086 68 + 1.371 1.363 -0.025
ENSG00000170776 E046 0.1719870 0.0418534680 4.086020e-01   15 85710443 85710578 136 + 0.129 0.000 -12.835
ENSG00000170776 E047 11.6426276 0.0649471339 6.369065e-01 0.95043996 15 85710579 85710581 3 + 1.108 1.091 -0.061
ENSG00000170776 E048 22.7831973 0.0438922966 1.656200e-01 0.94041302 15 85710582 85710645 64 + 1.431 1.314 -0.406
ENSG00000170776 E049 36.2959993 0.0278239961 1.742895e-01 0.94041302 15 85715788 85715923 136 + 1.610 1.529 -0.277
ENSG00000170776 E050 0.0000000       15 85717152 85717289 138 +      
ENSG00000170776 E051 37.9485290 0.0213814545 4.046671e-01 0.94041302 15 85717290 85717402 113 + 1.599 1.579 -0.066
ENSG00000170776 E052 10.4230201 0.0058516456 9.204398e-01 0.99246045 15 85718007 85718012 6 + 1.041 1.069 0.103
ENSG00000170776 E053 43.6301717 0.0097071702 8.675443e-01 0.98523933 15 85718013 85718159 147 + 1.617 1.676 0.201
ENSG00000170776 E054 0.0000000       15 85718801 85718875 75 +      
ENSG00000170776 E055 33.6062988 0.0032793530 7.073493e-01 0.96217840 15 85719076 85719211 136 + 1.532 1.549 0.058
ENSG00000170776 E056 35.0354274 0.0072271796 2.840576e-01 0.94041302 15 85719212 85719326 115 + 1.573 1.541 -0.110
ENSG00000170776 E057 37.7693808 0.0087291724 6.613523e-02 0.94041302 15 85721991 85722116 126 + 1.630 1.545 -0.288
ENSG00000170776 E058 0.1654692 0.0456545321 5.860964e-01   15 85722117 85722229 113 + 0.000 0.119 11.946
ENSG00000170776 E059 42.1533797 0.0014446410 4.290067e-05 0.09869329 15 85722230 85722347 118 + 1.722 1.533 -0.642
ENSG00000170776 E060 64.9449256 0.0006057204 2.229161e-01 0.94041302 15 85723072 85723320 249 + 1.829 1.815 -0.047
ENSG00000170776 E061 30.5203072 0.3659545612 2.409234e-01 0.94041302 15 85726410 85726486 77 + 1.371 1.595 0.769
ENSG00000170776 E062 46.8072319 0.2380071485 2.134122e-01 0.94041302 15 85727066 85727247 182 + 1.562 1.770 0.706
ENSG00000170776 E063 32.5048102 0.0012969251 3.588028e-01 0.94041302 15 85727381 85727463 83 + 1.476 1.571 0.327
ENSG00000170776 E064 48.1059255 0.0032963348 9.064653e-01 0.99058832 15 85730513 85730707 195 + 1.674 1.706 0.111
ENSG00000170776 E065 47.8225858 0.0018479550 5.679953e-01 0.94157178 15 85734992 85735150 159 + 1.683 1.692 0.032
ENSG00000170776 E066 29.0509999 0.0012693025 3.760881e-01 0.94041302 15 85735560 85735598 39 + 1.486 1.468 -0.062
ENSG00000170776 E067 25.4878233 0.0085938948 4.427859e-01 0.94041302 15 85735599 85735630 32 + 1.429 1.414 -0.055
ENSG00000170776 E068 21.0709682 0.0014559306 5.119354e-01 0.94041302 15 85736090 85736134 45 + 1.349 1.339 -0.037
ENSG00000170776 E069 19.6310377 0.0016773211 3.784777e-01 0.94041302 15 85740222 85740272 51 + 1.329 1.299 -0.104
ENSG00000170776 E070 3.3648986 0.0554737085 2.414775e-01 0.94041302 15 85740273 85740562 290 + 0.712 0.547 -0.717
ENSG00000170776 E071 59.8864498 0.0230575026 5.591990e-01 0.94134549 15 85741046 85741495 450 + 1.782 1.786 0.013
ENSG00000170776 E072 45.0348491 0.0016439493 8.583882e-01 0.98360786 15 85743492 85743825 334 + 1.647 1.678 0.104
ENSG00000170776 E073 282.8025014 1.4493011257 4.815793e-01 0.94041302 15 85744628 85747603 2976 + 2.345 2.535 0.633
ENSG00000170776 E074 40.3805064 0.4663126297 3.150992e-01 0.94041302 15 85747604 85747809 206 + 1.512 1.698 0.632
ENSG00000170776 E075 108.7337147 1.0984288672 4.814000e-01 0.94041302 15 85747810 85748751 942 + 1.959 2.106 0.494
ENSG00000170776 E076 41.1247505 0.1570110009 4.044777e-01 0.94041302 15 85748752 85749358 607 + 1.560 1.681 0.413