ENSG00000146872

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000343388 ENSG00000146872 HEK293_DMSO_6hB HEK293_TMG_6hB TLK2 protein_coding protein_coding 28.5274 34.90642 32.31408 0.5294569 1.15535 -0.1112962 4.7410515 4.418777 5.318261 1.3092986 0.2708351 0.26675634 0.17681250 0.1273000 0.1649000 0.03760000 9.505325e-01 5.267611e-25 FALSE TRUE
ENST00000581041 ENSG00000146872 HEK293_DMSO_6hB HEK293_TMG_6hB TLK2 protein_coding protein_coding 28.5274 34.90642 32.31408 0.5294569 1.15535 -0.1112962 3.0649180 6.128581 6.527030 0.8581107 1.2634538 0.09072998 0.08620833 0.1757333 0.1998000 0.02406667 9.509148e-01 5.267611e-25 FALSE TRUE
ENST00000583310 ENSG00000146872 HEK293_DMSO_6hB HEK293_TMG_6hB TLK2 protein_coding retained_intron 28.5274 34.90642 32.31408 0.5294569 1.15535 -0.1112962 10.2069527 11.423137 9.028838 0.4568793 0.7799284 -0.33901211 0.35697083 0.3273000 0.2796333 -0.04766667 9.505325e-01 5.267611e-25   FALSE
MSTRG.14865.11 ENSG00000146872 HEK293_DMSO_6hB HEK293_TMG_6hB TLK2 protein_coding   28.5274 34.90642 32.31408 0.5294569 1.15535 -0.1112962 3.3704083 3.450033 1.458891 0.7343283 0.3142908 -1.23605871 0.11457500 0.0994000 0.0446000 -0.05480000 7.053845e-01 5.267611e-25 TRUE TRUE
MSTRG.14865.27 ENSG00000146872 HEK293_DMSO_6hB HEK293_TMG_6hB TLK2 protein_coding   28.5274 34.90642 32.31408 0.5294569 1.15535 -0.1112962 0.5399934 0.000000 2.959303 0.0000000 0.3162267 8.21398036 0.01869167 0.0000000 0.0916000 0.09160000 5.267611e-25 5.267611e-25 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_DMSO_6hB log2fold_HEK293_DMSO_6hB_HEK293_TMG_6hB
ENSG00000146872 E001 0.0000000       17 62458658 62458765 108 +      
ENSG00000146872 E002 0.0000000       17 62470917 62470932 16 +      
ENSG00000146872 E003 0.0000000       17 62470933 62470941 9 +      
ENSG00000146872 E004 0.0000000       17 62470942 62470958 17 +      
ENSG00000146872 E005 0.0000000       17 62470959 62471078 120 +      
ENSG00000146872 E006 0.7467603 1.0223548675 3.487738e-01   17 62477496 62477697 202 + 0.383 0.000 -11.545
ENSG00000146872 E007 0.0000000       17 62477768 62477838 71 +      
ENSG00000146872 E008 0.7042412 0.1228290437 9.910073e-01   17 62477839 62478065 227 + 0.223 0.219 -0.037
ENSG00000146872 E009 1.0082209 0.0139299488 9.832826e-01   17 62478066 62478081 16 + 0.301 0.296 -0.028
ENSG00000146872 E010 8.8828160 0.0037923125 1.031839e-05 0.04450784 17 62478825 62478987 163 + 0.668 1.186 1.972
ENSG00000146872 E011 4.0377220 0.0055272064 9.433280e-06 0.04398917 17 62478988 62479024 37 + 0.222 0.930 3.496
ENSG00000146872 E012 1.2916248 0.0121989077 1.605055e-01 0.94041302 17 62479025 62479117 93 + 0.221 0.471 1.558
ENSG00000146872 E013 0.9519332 0.0656888244 4.271281e-01   17 62479118 62479129 12 + 0.367 0.218 -1.026
ENSG00000146872 E014 0.9519332 0.0656888244 4.271281e-01   17 62479130 62479149 20 + 0.367 0.218 -1.026
ENSG00000146872 E015 1.4578739 0.0126248077 7.234352e-01 0.96447960 17 62479150 62479168 19 + 0.425 0.363 -0.350
ENSG00000146872 E016 1.7655914 0.1310834327 9.051001e-01 0.99045575 17 62479169 62479178 10 + 0.425 0.469 0.228
ENSG00000146872 E017 3.3548900 0.3253925987 5.946853e-01 0.94365268 17 62479179 62479183 5 + 0.664 0.623 -0.175
ENSG00000146872 E018 5.0151151 0.2662160482 8.707542e-01 0.98555513 17 62479184 62479205 22 + 0.753 0.809 0.220
ENSG00000146872 E019 4.7111355 0.2466673391 9.163911e-01 0.99188427 17 62479206 62479208 3 + 0.729 0.787 0.236
ENSG00000146872 E020 11.3191371 0.0670081241 6.770714e-01 0.95725797 17 62479209 62479245 37 + 1.114 1.068 -0.168
ENSG00000146872 E021 11.6170895 0.0484681631 9.354875e-01 0.99497640 17 62479246 62479257 12 + 1.102 1.103 0.003
ENSG00000146872 E022 14.5855417 0.0516774064 8.128695e-01 0.97710175 17 62479258 62479290 33 + 1.204 1.184 -0.072
ENSG00000146872 E023 0.3733802 0.4989764592 3.147000e-01   17 62479302 62479443 142 + 0.226 0.000 -12.619
ENSG00000146872 E024 0.3368109 0.0290785164 1.954214e-01   17 62479444 62479516 73 + 0.222 0.000 -14.015
ENSG00000146872 E025 0.3368109 0.0290785164 1.954214e-01   17 62479517 62479613 97 + 0.222 0.000 -14.015
ENSG00000146872 E026 8.1112070 0.0871959757 9.641761e-01 0.99796883 17 62481121 62481123 3 + 0.966 0.960 -0.023
ENSG00000146872 E027 14.1940333 0.0577147273 9.850891e-01 0.99995769 17 62481124 62481125 2 + 1.175 1.192 0.063
ENSG00000146872 E028 22.2435938 0.0385433589 9.117079e-01 0.99135286 17 62481126 62481137 12 + 1.358 1.381 0.079
ENSG00000146872 E029 55.7538269 0.0017017585 2.666386e-01 0.94041302 17 62481138 62481206 69 + 1.729 1.783 0.185
ENSG00000146872 E030 0.0000000       17 62486004 62486097 94 +      
ENSG00000146872 E031 0.0000000       17 62507381 62507449 69 +      
ENSG00000146872 E032 7.1463999 0.0071795135 6.170214e-01 0.94714838 17 62508408 62508553 146 + 0.938 0.877 -0.231
ENSG00000146872 E033 86.8511355 0.0004693640 8.904649e-01 0.98839101 17 62520773 62520844 72 + 1.948 1.942 -0.022
ENSG00000146872 E034 105.6698337 0.0005308422 3.380687e-01 0.94041302 17 62522204 62522273 70 + 2.046 2.011 -0.117
ENSG00000146872 E035 78.8732687 0.0059003179 4.583494e-01 0.94041302 17 62523134 62523177 44 + 1.924 1.882 -0.142
ENSG00000146872 E036 29.8964798 0.0011505228 7.439520e-01 0.96717125 17 62524236 62524331 96 + 1.481 1.501 0.068
ENSG00000146872 E037 98.7552709 0.0004017943 2.987967e-01 0.94041302 17 62536170 62536337 168 + 2.018 1.979 -0.129
ENSG00000146872 E038 68.4250290 0.0006831729 6.458335e-01 0.95203697 17 62552302 62552397 96 + 1.851 1.830 -0.070
ENSG00000146872 E039 0.3307837 0.4011383733 3.045918e-01   17 62552687 62552874 188 + 0.000 0.219 11.960
ENSG00000146872 E040 0.6714099 0.0186287262 3.217866e-01   17 62553444 62553662 219 + 0.125 0.296 1.556
ENSG00000146872 E041 101.4220364 0.0004568339 5.134311e-01 0.94041302 17 62553663 62553755 93 + 1.998 2.020 0.075
ENSG00000146872 E042 137.9496508 0.0004335278 5.192935e-01 0.94041302 17 62560016 62560126 111 + 2.152 2.131 -0.070
ENSG00000146872 E043 0.0000000       17 62560127 62560309 183 +      
ENSG00000146872 E044 0.1719870 0.0433309317 4.792185e-01   17 62564760 62565000 241 + 0.125 0.000 -12.852
ENSG00000146872 E045 173.3646123 0.0002899525 5.339106e-01 0.94041302 17 62565001 62565137 137 + 2.251 2.233 -0.060
ENSG00000146872 E046 0.9672815 0.0207684185 9.836539e-01   17 62572847 62573214 368 + 0.301 0.296 -0.028
ENSG00000146872 E047 223.7023361 0.0013024992 6.477031e-01 0.95233788 17 62573215 62573367 153 + 2.347 2.358 0.037
ENSG00000146872 E048 1.3293168 0.1128382962 2.209202e-01 0.94041302 17 62574345 62574410 66 + 0.222 0.472 1.564
ENSG00000146872 E049 160.5810380 0.0003364544 8.973172e-01 0.98943539 17 62576709 62576775 67 + 2.208 2.210 0.008
ENSG00000146872 E050 197.7608108 0.0003219281 2.406477e-01 0.94041302 17 62578477 62578574 98 + 2.314 2.282 -0.104
ENSG00000146872 E051 3.0442360 0.1518238681 8.384244e-01 0.98039058 17 62578575 62580110 1536 + 0.568 0.631 0.279
ENSG00000146872 E052 144.1157578 0.0009626576 2.917682e-01 0.94041302 17 62580111 62580192 82 + 2.178 2.143 -0.117
ENSG00000146872 E053 0.0000000       17 62585596 62586134 539 +      
ENSG00000146872 E054 135.2784409 0.0004352252 2.004348e-01 0.94041302 17 62586135 62586226 92 + 2.114 2.153 0.130
ENSG00000146872 E055 0.9504308 0.0166299221 4.261473e-01   17 62586227 62586703 477 + 0.221 0.363 0.974
ENSG00000146872 E056 130.8039126 0.0003203413 1.943597e-01 0.94041302 17 62596585 62596674 90 + 2.100 2.139 0.132
ENSG00000146872 E057 0.1654692 0.0440785064 4.962380e-01   17 62597220 62597258 39 + 0.000 0.123 11.961
ENSG00000146872 E058 5.1236022 0.0341632975 6.880602e-01 0.95880912 17 62597259 62599741 2483 + 0.753 0.817 0.254
ENSG00000146872 E059 0.8461767 0.0153787590 1.649190e-01   17 62600278 62600592 315 + 0.368 0.123 -2.028
ENSG00000146872 E060 173.9672131 0.0003059142 8.355261e-01 0.97985477 17 62600651 62600820 170 + 2.240 2.245 0.016
ENSG00000146872 E061 144.1185292 0.0003533472 4.413838e-01 0.94041302 17 62602042 62602180 139 + 2.173 2.149 -0.080
ENSG00000146872 E062 0.1653919 0.0440417765 4.964805e-01   17 62606096 62606129 34 + 0.000 0.123 11.961
ENSG00000146872 E063 108.9072625 0.0003799942 7.719545e-01 0.97135303 17 62606130 62606241 112 + 2.046 2.035 -0.037
ENSG00000146872 E064 0.9897798 0.0144141706 4.057986e-01   17 62607387 62608040 654 + 0.367 0.218 -1.027
ENSG00000146872 E065 145.1620339 0.0005166337 5.361328e-01 0.94041302 17 62608041 62608148 108 + 2.155 2.173 0.060
ENSG00000146872 E066 5.3143530 0.0074639362 7.670842e-01 0.97082046 17 62611946 62612391 446 + 0.778 0.816 0.153
ENSG00000146872 E067 234.3188030 0.0003080002 3.582913e-01 0.94041302 17 62612392 62612676 285 + 2.361 2.382 0.069
ENSG00000146872 E068 343.2959922 0.0001913742 3.414632e-01 0.94041302 17 62612677 62614523 1847 + 2.529 2.546 0.057
ENSG00000146872 E069 17.4192528 0.0192225848 7.270034e-01 0.96513480 17 62614524 62614618 95 + 1.290 1.247 -0.149
ENSG00000146872 E070 29.6851724 0.0246713675 3.591772e-02 0.93246644 17 62614619 62615147 529 + 1.582 1.366 -0.743
ENSG00000146872 E071 19.8921373 0.0030461150 1.949924e-01 0.94041302 17 62615148 62615481 334 + 1.367 1.263 -0.365
ENSG00000146872 E072 0.1866901 0.0432335509 4.787102e-01   17 62616420 62616477 58 + 0.125 0.000 -12.854