ENSG00000116679

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000422754 ENSG00000116679 HEK293_DMSO_6hB HEK293_TMG_6hB IVNS1ABP protein_coding protein_coding 23.07795 34.33911 32.97683 2.150241 0.4984862 -0.05838266 1.541307 2.083838 3.208622 0.40341008 0.3438853 0.62029312 0.06235417 0.05983333 0.0972000 0.03736667 0.70538448 0.01058871 FALSE TRUE
ENST00000475046 ENSG00000116679 HEK293_DMSO_6hB HEK293_TMG_6hB IVNS1ABP protein_coding retained_intron 23.07795 34.33911 32.97683 2.150241 0.4984862 -0.05838266 7.227123 9.378372 7.291654 0.12738999 0.7146178 -0.36265178 0.33907500 0.27486667 0.2218000 -0.05306667 0.95053252 0.01058871 FALSE TRUE
ENST00000480769 ENSG00000116679 HEK293_DMSO_6hB HEK293_TMG_6hB IVNS1ABP protein_coding retained_intron 23.07795 34.33911 32.97683 2.150241 0.4984862 -0.05838266 5.539677 8.715727 9.270903 0.63568533 0.5153678 0.08898993 0.23450417 0.25363333 0.2809667 0.02733333 0.95053252 0.01058871 FALSE TRUE
MSTRG.2748.4 ENSG00000116679 HEK293_DMSO_6hB HEK293_TMG_6hB IVNS1ABP protein_coding   23.07795 34.33911 32.97683 2.150241 0.4984862 -0.05838266 4.277653 6.803429 3.566135 0.09244332 0.3520966 -0.92997985 0.18971667 0.19963333 0.1078667 -0.09176667 0.01058871 0.01058871 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_DMSO_6hB log2fold_HEK293_DMSO_6hB_HEK293_TMG_6hB
ENSG00000116679 E001 30.874838 0.0102385685 5.362388e-01 0.9404130 1 185296388 185296670 283 - 1.523 1.476 -0.162
ENSG00000116679 E002 27.971344 0.0010905977 9.083427e-01 0.9909537 1 185296671 185296738 68 - 1.463 1.456 -0.023
ENSG00000116679 E003 56.129088 0.0021247575 4.209872e-01 0.9404130 1 185296739 185297014 276 - 1.773 1.733 -0.135
ENSG00000116679 E004 164.525853 0.0003257031 1.078712e-01 0.9404130 1 185297015 185297770 756 - 2.238 2.194 -0.148
ENSG00000116679 E005 123.044159 0.0003802787 9.314853e-01 0.9943689 1 185297771 185297957 187 - 2.089 2.093 0.013
ENSG00000116679 E006 64.255416 0.0054151174 6.197772e-01 0.9476872 1 185297958 185297974 17 - 1.824 1.799 -0.085
ENSG00000116679 E007 71.199556 0.0018830154 6.660514e-01 0.9556303 1 185297975 185297987 13 - 1.864 1.845 -0.063
ENSG00000116679 E008 390.388574 0.0002952075 3.300581e-01 0.9404130 1 185297988 185298288 301 - 2.581 2.601 0.064
ENSG00000116679 E009 9.393945 0.1427754497 8.662825e-01 0.9849826 1 185298405 185299709 1305 - 1.058 0.961 -0.358
ENSG00000116679 E010 341.102334 0.0011664340 4.390398e-01 0.9404130 1 185299710 185299883 174 - 2.523 2.542 0.064
ENSG00000116679 E011 234.106705 0.0002513572 6.521880e-01 0.9529996 1 185299999 185300096 98 - 2.365 2.376 0.039
ENSG00000116679 E012 151.067397 0.0029828615 4.669898e-01 0.9404130 1 185300097 185300130 34 - 2.165 2.195 0.099
ENSG00000116679 E013 158.495329 0.0015446586 1.222534e-01 0.9404130 1 185300217 185300245 29 - 2.174 2.227 0.176
ENSG00000116679 E014 252.993746 0.0006211438 3.134480e-01 0.9404130 1 185300246 185300343 98 - 2.391 2.416 0.085
ENSG00000116679 E015 4.307299 0.0052855699 3.069198e-01 0.9404130 1 185300344 185300436 93 - 0.792 0.648 -0.589
ENSG00000116679 E016 263.314063 0.0003882492 3.141369e-01 0.9404130 1 185300437 185300558 122 - 2.409 2.433 0.080
ENSG00000116679 E017 1.164002 0.0215198743 3.200282e-01 0.9404130 1 185300559 185300918 360 - 0.229 0.410 1.181
ENSG00000116679 E018 273.396570 0.0009526040 2.283920e-01 0.9404130 1 185300972 185301196 225 - 2.421 2.453 0.104
ENSG00000116679 E019 11.028680 0.0024355821 1.020933e-01 0.9404130 1 185301197 185301433 237 - 0.985 1.152 0.606
ENSG00000116679 E020 215.730355 0.0003302885 3.816089e-01 0.9404130 1 185301434 185301563 130 - 2.345 2.324 -0.069
ENSG00000116679 E021 31.440423 0.0017509849 8.993369e-02 0.9404130 1 185301564 185301714 151 - 1.564 1.456 -0.369
ENSG00000116679 E022 205.584585 0.0002591419 9.156436e-01 0.9918626 1 185305536 185305643 108 - 2.315 2.314 -0.006
ENSG00000116679 E023 284.421584 0.0003693083 3.373750e-06 0.0232840 1 185305644 185306484 841 - 2.503 2.401 -0.340
ENSG00000116679 E024 108.233900 0.0004078963 8.900290e-03 0.7672950 1 185306485 185306625 141 - 2.082 1.992 -0.300
ENSG00000116679 E025 12.407696 0.0021042339 9.537459e-02 0.9404130 1 185306750 185307013 264 - 1.201 1.043 -0.568
ENSG00000116679 E026 130.455480 0.0003139548 2.956216e-01 0.9404130 1 185307014 185307079 66 - 2.099 2.133 0.114
ENSG00000116679 E027 122.491681 0.0003289683 4.620225e-01 0.9404130 1 185307080 185307139 60 - 2.077 2.102 0.084
ENSG00000116679 E028 195.252506 0.0002290679 4.370050e-01 0.9404130 1 185307489 185307662 174 - 2.280 2.302 0.071
ENSG00000116679 E029 4.249899 0.0620488926 9.390271e-01 0.9952936 1 185307680 185308017 338 - 0.711 0.732 0.084
ENSG00000116679 E030 114.468140 0.0003753297 9.995725e-01 1.0000000 1 185308800 185308875 76 - 2.062 2.063 0.004
ENSG00000116679 E031 143.160910 0.0006469583 5.847083e-01 0.9423101 1 185309003 185309172 170 - 2.147 2.165 0.061
ENSG00000116679 E032 162.176237 0.0038332830 9.328223e-01 0.9945945 1 185309383 185309511 129 - 2.212 2.211 -0.004
ENSG00000116679 E033 232.941064 0.0005836549 5.381387e-01 0.9404130 1 185311095 185311322 228 - 2.375 2.361 -0.048
ENSG00000116679 E034 148.770312 0.0021064331 3.740292e-01 0.9404130 1 185316953 185318670 1718 - 2.157 2.189 0.108