ENSG00000276043

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000613817 ENSG00000276043 HEK293_DMSO_2hB HEK293_TMG_2hB UHRF1 protein_coding protein_coding 57.6072 55.72333 51.77224 1.211685 0.146498 -0.106083 8.726807 0.000000 0.000000 0.0000000 0.000000 0.0000000 0.13428333 0.0000000 0.0000000 0.0000000   5.340255e-06 FALSE TRUE
ENST00000615884 ENSG00000276043 HEK293_DMSO_2hB HEK293_TMG_2hB UHRF1 protein_coding protein_coding 57.6072 55.72333 51.77224 1.211685 0.146498 -0.106083 13.309496 10.847296 9.380785 0.9424524 1.127022 -0.2093472 0.23617500 0.1943000 0.1813000 -0.0130000 9.524116e-01 5.340255e-06 FALSE TRUE
ENST00000624301 ENSG00000276043 HEK293_DMSO_2hB HEK293_TMG_2hB UHRF1 protein_coding protein_coding 57.6072 55.72333 51.77224 1.211685 0.146498 -0.106083 2.173287 6.570592 0.000000 3.9669136 0.000000 -9.3620736 0.03712917 0.1193333 0.0000000 -0.1193333 5.340255e-06 5.340255e-06 FALSE TRUE
ENST00000650932 ENSG00000276043 HEK293_DMSO_2hB HEK293_TMG_2hB UHRF1 protein_coding protein_coding 57.6072 55.72333 51.77224 1.211685 0.146498 -0.106083 31.351667 35.137067 40.386899 4.4565503 1.146358 0.2008402 0.55662083 0.6297000 0.7800333 0.1503333 6.335451e-01 5.340255e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_DMSO_2hB log2fold_HEK293_DMSO_2hB_HEK293_TMG_2hB
ENSG00000276043 E001 0.1730468 4.059801e-02 4.326601e-01   19 4903080 4903645 566 + 0.131 0.000 -9.315
ENSG00000276043 E002 3.7811252 4.658539e-03 2.558633e-01   19 4909430 4909497 68 + 0.583 0.752 0.718
ENSG00000276043 E003 3.8104147 4.661289e-03 2.551338e-01   19 4909498 4909500 3 + 0.583 0.752 0.719
ENSG00000276043 E004 186.0305135 6.272599e-04 6.649008e-01 0.98370730 19 4909501 4909655 155 + 2.265 2.278 0.043
ENSG00000276043 E005 1.7225472 4.928700e-01 5.512721e-01   19 4910116 4910145 30 + 0.492 0.394 -0.515
ENSG00000276043 E006 32.1720945 1.836369e-03 6.436541e-01 0.98159770 19 4910146 4910246 101 + 1.506 1.537 0.106
ENSG00000276043 E007 0.0000000       19 4910367 4910374 8 +      
ENSG00000276043 E008 0.8106918 1.631884e-02 2.432365e-02   19 4910375 4910494 120 + 0.000 0.407 11.311
ENSG00000276043 E009 4.3771600 4.610973e-03 8.216210e-01   19 4910495 4910875 381 + 0.719 0.752 0.133
ENSG00000276043 E010 413.0218976 3.771228e-04 7.138620e-01 0.98653436 19 4910876 4911038 163 + 2.613 2.621 0.026
ENSG00000276043 E011 653.0007425 9.891820e-04 2.384013e-01 0.91230843 19 4929222 4929476 255 + 2.803 2.826 0.077
ENSG00000276043 E012 505.0958932 5.905411e-05 4.340101e-03 0.29132645 19 4930716 4930876 161 + 2.680 2.725 0.151
ENSG00000276043 E013 581.8444407 7.839227e-05 2.906604e-01 0.93375438 19 4932741 4932956 216 + 2.757 2.773 0.054
ENSG00000276043 E014 333.9129068 8.418751e-05 2.679076e-01 0.92503525 19 4941528 4941628 101 + 2.535 2.515 -0.068
ENSG00000276043 E015 336.8287922 8.105984e-05 9.744397e-01 0.99899046 19 4941745 4941907 163 + 2.529 2.529 0.001
ENSG00000276043 E016 161.3041988 1.445908e-04 5.258896e-01 0.97069266 19 4941908 4941931 24 + 2.220 2.203 -0.056
ENSG00000276043 E017 310.7780982 1.284193e-04 4.544229e-01 0.96198701 19 4944132 4944255 124 + 2.486 2.502 0.054
ENSG00000276043 E018 227.4674946 1.160449e-04 5.116661e-01 0.96935889 19 4944343 4944369 27 + 2.351 2.367 0.055
ENSG00000276043 E019 261.5089982 1.285176e-04 2.400978e-01 0.91342779 19 4944370 4944450 81 + 2.405 2.432 0.089
ENSG00000276043 E020 173.3099686 1.279174e-04 7.223026e-01 0.98732902 19 4945861 4945965 105 + 2.246 2.237 -0.029
ENSG00000276043 E021 258.9476878 8.769994e-05 8.014087e-01 0.99088761 19 4947105 4947211 107 + 2.417 2.413 -0.015
ENSG00000276043 E022 368.8089717 1.901770e-03 6.984444e-01 0.98581699 19 4950611 4950773 163 + 2.562 2.572 0.034
ENSG00000276043 E023 417.5695363 1.498672e-03 5.801942e-01 0.97608764 19 4950859 4950996 138 + 2.628 2.614 -0.046
ENSG00000276043 E024 284.0197439 8.735098e-05 3.582141e-01 0.95123488 19 4954350 4954488 139 + 2.465 2.446 -0.061
ENSG00000276043 E025 172.1801846 1.424785e-04 2.982904e-01 0.93589274 19 4954650 4954822 173 + 2.252 2.225 -0.091
ENSG00000276043 E026 97.8063650 2.016730e-04 3.914810e-01 0.95572323 19 4956709 4956813 105 + 2.009 1.979 -0.100
ENSG00000276043 E027 783.3659731 6.392476e-05 3.668308e-05 0.01935917 19 4960657 4962154 1498 + 2.921 2.871 -0.166