ENSG00000227372

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000423764 ENSG00000227372 HEK293_DMSO_2hB HEK293_TMG_2hB TP73-AS1 transcribed_unitary_pseudogene processed_transcript 24.0652 19.56483 19.35517 0.8631529 0.5425565 -0.0155359 1.2182983 3.1304556 0.6919332 0.07413437 0.69193317 -2.1615683 0.048479167 0.16040000 0.0375000 -0.12290000 6.142558e-01 2.248885e-12 TRUE TRUE
ENST00000452079 ENSG00000227372 HEK293_DMSO_2hB HEK293_TMG_2hB TP73-AS1 transcribed_unitary_pseudogene processed_transcript 24.0652 19.56483 19.35517 0.8631529 0.5425565 -0.0155359 4.6572478 3.9840885 4.4118142 0.14224325 0.03927017 0.1467721 0.201075000 0.20386667 0.2284000 0.02453333 9.311750e-01 2.248885e-12 TRUE TRUE
ENST00000624167 ENSG00000227372 HEK293_DMSO_2hB HEK293_TMG_2hB TP73-AS1 transcribed_unitary_pseudogene processed_transcript 24.0652 19.56483 19.35517 0.8631529 0.5425565 -0.0155359 1.5865351 0.4132353 0.8374512 0.21116488 0.52916265 1.0016702 0.058125000 0.02123333 0.0418000 0.02056667 1.000000e+00 2.248885e-12   FALSE
ENST00000647817 ENSG00000227372 HEK293_DMSO_2hB HEK293_TMG_2hB TP73-AS1 transcribed_unitary_pseudogene processed_transcript 24.0652 19.56483 19.35517 0.8631529 0.5425565 -0.0155359 2.0067218 0.9995474 2.0661435 0.06972016 0.23357911 1.0401975 0.084091667 0.05160000 0.1067000 0.05510000 6.666329e-02 2.248885e-12 TRUE TRUE
ENST00000648270 ENSG00000227372 HEK293_DMSO_2hB HEK293_TMG_2hB TP73-AS1 transcribed_unitary_pseudogene processed_transcript 24.0652 19.56483 19.35517 0.8631529 0.5425565 -0.0155359 2.5580233 0.5611364 1.8787810 0.56113638 0.94515067 1.7255482 0.105166667 0.02646667 0.0951000 0.06863333 9.311750e-01 2.248885e-12 TRUE FALSE
ENST00000648600 ENSG00000227372 HEK293_DMSO_2hB HEK293_TMG_2hB TP73-AS1 transcribed_unitary_pseudogene processed_transcript 24.0652 19.56483 19.35517 0.8631529 0.5425565 -0.0155359 3.9980962 3.4474577 3.9663690 0.06835988 0.61062921 0.2017400 0.166266667 0.17713333 0.2036667 0.02653333 9.311750e-01 2.248885e-12 TRUE TRUE
ENST00000649413 ENSG00000227372 HEK293_DMSO_2hB HEK293_TMG_2hB TP73-AS1 transcribed_unitary_pseudogene processed_transcript 24.0652 19.56483 19.35517 0.8631529 0.5425565 -0.0155359 0.1484282 1.1874253 0.0000000 0.19568248 0.00000000 -6.9037918 0.007629167 0.06103333 0.0000000 -0.06103333 2.248885e-12 2.248885e-12 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_DMSO_2hB log2fold_HEK293_DMSO_2hB_HEK293_TMG_2hB
ENSG00000227372 E001 0.1720618 0.0410113964 4.927954e-01   1 3735511 3735542 32 - 0.000 0.124 9.013
ENSG00000227372 E002 0.0000000       1 3735601 3735610 10 -      
ENSG00000227372 E003 0.0000000       1 3735611 3735624 14 -      
ENSG00000227372 E004 0.1743023 0.0415216005 4.923867e-01   1 3735625 3735649 25 - 0.000 0.124 11.713
ENSG00000227372 E005 2.4751329 0.0128496348 6.929337e-02   1 3735650 3735685 36 - 0.669 0.365 -1.478
ENSG00000227372 E006 6.1105477 0.0548510341 1.696535e-01   1 3735686 3735763 78 - 0.953 0.722 -0.899
ENSG00000227372 E007 28.3523832 0.0007353546 8.993724e-01 0.9963852 1 3735764 3735983 220 - 1.462 1.471 0.032
ENSG00000227372 E008 29.0199633 0.0072436666 9.479740e-01 0.9985329 1 3735984 3736056 73 - 1.472 1.477 0.016
ENSG00000227372 E009 35.5588874 0.0102598474 3.433430e-01 0.9485496 1 3736057 3736174 118 - 1.595 1.523 -0.245
ENSG00000227372 E010 18.6759800 0.0076049278 1.169236e-01 0.8256634 1 3736175 3736192 18 - 1.355 1.217 -0.485
ENSG00000227372 E011 43.3402645 0.0006109830 4.286198e-01 0.9592072 1 3736193 3736407 215 - 1.666 1.624 -0.141
ENSG00000227372 E012 19.8884772 0.0009358437 4.210745e-01 0.9592072 1 3736408 3736448 41 - 1.349 1.288 -0.212
ENSG00000227372 E013 19.9747592 0.0009380394 8.594275e-01 0.9950416 1 3736449 3736481 33 - 1.329 1.317 -0.043
ENSG00000227372 E014 13.2522272 0.0040736850 1.766307e-01 0.8792712 1 3736482 3736482 1 - 1.213 1.085 -0.456
ENSG00000227372 E015 27.5240621 0.0023055777 5.921997e-01 0.9767309 1 3736483 3736533 51 - 1.472 1.436 -0.124
ENSG00000227372 E016 25.0609648 0.0027797756 9.948388e-01 0.9996589 1 3736534 3736558 25 - 1.415 1.415 0.000
ENSG00000227372 E017 28.5641925 0.0007168667 4.709108e-01 0.9633041 1 3736559 3736758 200 - 1.447 1.495 0.165
ENSG00000227372 E018 17.3379142 0.0010570980 8.015973e-02 0.7679368 1 3736759 3736925 167 - 1.185 1.330 0.509
ENSG00000227372 E019 36.7190908 0.0006935765 9.320518e-01 0.9981760 1 3736926 3737103 178 - 1.572 1.578 0.020
ENSG00000227372 E020 13.4695027 0.0015943350 2.469866e-01 0.9171709 1 3737104 3737142 39 - 1.213 1.108 -0.373
ENSG00000227372 E021 9.3579797 0.0021454565 2.170970e-01   1 3737143 3737148 6 - 1.079 0.949 -0.479
ENSG00000227372 E022 11.9373320 0.0057604242 3.990118e-01 0.9560508 1 3737149 3737165 17 - 1.156 1.073 -0.298
ENSG00000227372 E023 15.8958047 0.0314596152 9.952013e-01 0.9996589 1 3737166 3737192 27 - 1.229 1.237 0.026
ENSG00000227372 E024 17.4837091 0.0644816415 6.902005e-01 0.9855581 1 3737193 3737205 13 - 1.238 1.301 0.222
ENSG00000227372 E025 16.2581564 0.0479948190 7.864757e-01 0.9908091 1 3737206 3737211 6 - 1.221 1.260 0.135
ENSG00000227372 E026 64.0645893 0.0004507668 5.283608e-01 0.9709581 1 3737212 3737337 126 - 1.801 1.831 0.099
ENSG00000227372 E027 141.8004680 0.0016284840 1.433870e-01 0.8502909 1 3737338 3737528 191 - 2.180 2.130 -0.166
ENSG00000227372 E028 59.6046820 0.0006248012 1.211229e-02 0.4445033 1 3737529 3737538 10 - 1.837 1.721 -0.390
ENSG00000227372 E029 85.5361628 0.0007083280 3.840941e-02 0.6420374 1 3737539 3737593 55 - 1.976 1.895 -0.271
ENSG00000227372 E030 136.3115398 0.0003123442 5.053291e-02 0.6898333 1 3737594 3737780 187 - 2.166 2.107 -0.198
ENSG00000227372 E031 74.9923690 0.0003109727 1.704145e-01 0.8742891 1 3737781 3737854 74 - 1.907 1.852 -0.185
ENSG00000227372 E032 135.3476943 0.0001950388 6.665998e-01 0.9837993 1 3737855 3738074 220 - 2.141 2.129 -0.040
ENSG00000227372 E033 138.6044951 0.0002156121 7.914139e-01 0.9908091 1 3738075 3738222 148 - 2.149 2.142 -0.023
ENSG00000227372 E034 188.2357929 0.0001141615 7.852235e-01 0.9908091 1 3738223 3738433 211 - 2.280 2.274 -0.019
ENSG00000227372 E035 74.8382274 0.0002377765 3.664506e-01 0.9517804 1 3738434 3738446 13 - 1.861 1.899 0.127
ENSG00000227372 E036 95.4479932 0.0001932365 6.987316e-01 0.9858170 1 3738447 3738513 67 - 1.978 1.993 0.051
ENSG00000227372 E037 121.6617390 0.0006910724 6.260979e-01 0.9796923 1 3738514 3739058 545 - 2.097 2.082 -0.051
ENSG00000227372 E038 45.7214168 0.0036145441 7.014731e-01 0.9859242 1 3739059 3739216 158 - 1.681 1.660 -0.072
ENSG00000227372 E039 21.4433717 0.0015407328 4.920707e-01 0.9668259 1 3739217 3739227 11 - 1.374 1.323 -0.176
ENSG00000227372 E040 25.5077259 0.0007262916 4.416831e-01 0.9603258 1 3739228 3739299 72 - 1.398 1.452 0.186
ENSG00000227372 E041 9.0455195 0.0022621158 9.427677e-01   1 3739300 3739335 36 - 1.000 1.009 0.033
ENSG00000227372 E042 2.7653096 0.0193229738 2.927530e-02   1 3739336 3739371 36 - 0.727 0.364 -1.723
ENSG00000227372 E043 8.1522369 0.2421695989 5.094902e-01   1 3739372 3739407 36 - 0.985 0.946 -0.148
ENSG00000227372 E044 7.0057102 0.0027250161 6.938233e-01   1 3739408 3739457 50 - 0.884 0.932 0.182
ENSG00000227372 E045 15.9661593 0.0243310060 6.860987e-01 0.9853105 1 3739458 3739515 58 - 1.254 1.213 -0.145
ENSG00000227372 E046 16.0806600 0.0686211805 5.605301e-01 0.9743145 1 3739516 3739551 36 - 1.284 1.177 -0.380
ENSG00000227372 E047 17.2558180 0.0635438585 3.565091e-01 0.9507313 1 3739552 3739587 36 - 1.315 1.203 -0.391
ENSG00000227372 E048 19.0525221 0.0201126260 1.279317e-01 0.8375126 1 3739588 3739623 36 - 1.374 1.222 -0.530
ENSG00000227372 E049 25.5600476 0.0008082808 1.086359e-01 0.8145955 1 3739624 3739659 36 - 1.477 1.368 -0.375
ENSG00000227372 E050 24.7055794 0.0027147827 6.846079e-01 0.9847144 1 3739660 3739695 36 - 1.426 1.398 -0.097
ENSG00000227372 E051 24.0769886 0.0020979847 5.472515e-01 0.9732790 1 3739696 3739704 9 - 1.380 1.425 0.156
ENSG00000227372 E052 47.4088642 0.0004391812 6.303270e-01 0.9803155 1 3739705 3739799 95 - 1.696 1.672 -0.080
ENSG00000227372 E053 30.5927047 0.0316157651 5.200718e-01 0.9699273 1 3739800 3739835 36 - 1.461 1.531 0.239
ENSG00000227372 E054 31.1731963 0.0006560292 5.923151e-01 0.9767406 1 3739836 3739847 12 - 1.523 1.490 -0.111
ENSG00000227372 E055 32.8923907 0.0006468008 3.092106e-01 0.9381862 1 3739848 3739907 60 - 1.560 1.499 -0.208
ENSG00000227372 E056 27.8242992 0.0043066709 6.429018e-01 0.9814564 1 3739908 3739943 36 - 1.442 1.476 0.117
ENSG00000227372 E057 24.2008484 0.0018708620 1.496156e-01 0.8556104 1 3739944 3739979 36 - 1.447 1.344 -0.358
ENSG00000227372 E058 24.5543445 0.0110139890 4.326744e-01 0.9592323 1 3739980 3739988 9 - 1.437 1.370 -0.230
ENSG00000227372 E059 37.3051975 0.0004988315 2.694034e-01 0.9254520 1 3739989 3740039 51 - 1.613 1.551 -0.212
ENSG00000227372 E060 37.2454797 0.0004986382 7.522493e-01 0.9883901 1 3740040 3740111 72 - 1.591 1.574 -0.058
ENSG00000227372 E061 25.0262394 0.0007659973 1.047778e-01 0.8104264 1 3740112 3740123 12 - 1.467 1.356 -0.384
ENSG00000227372 E062 27.2115626 0.0006798875 5.210986e-01 0.9700305 1 3740124 3740136 13 - 1.472 1.431 -0.142
ENSG00000227372 E063 27.5170080 0.0007018501 4.285267e-01 0.9592072 1 3740137 3740159 23 - 1.482 1.431 -0.175
ENSG00000227372 E064 44.3931625 0.0006973618 2.515843e-01 0.9183244 1 3740160 3740232 73 - 1.687 1.628 -0.202
ENSG00000227372 E065 97.1804770 0.0037791357 9.333567e-01 0.9982658 1 3740233 3740274 42 - 1.994 1.994 -0.002
ENSG00000227372 E066 147.1562628 0.0039310796 3.550557e-01 0.9501915 1 3740275 3740387 113 - 2.151 2.194 0.142
ENSG00000227372 E067 9.1894248 0.0034707882 8.463103e-01   1 3740388 3741219 832 - 1.000 1.022 0.083
ENSG00000227372 E068 2.5544608 0.0076469057 1.914220e-01   1 3741220 3741373 154 - 0.637 0.423 -1.018
ENSG00000227372 E069 9.7493224 0.0987827805 3.027524e-01   1 3741374 3742429 1056 - 1.104 0.954 -0.549
ENSG00000227372 E070 7.5528876 0.0174543282 3.899506e-01   1 3742430 3742517 88 - 0.985 0.878 -0.403
ENSG00000227372 E071 2.2301853 0.1166343529 7.495732e-01   1 3742518 3742803 286 - 0.477 0.555 0.372
ENSG00000227372 E072 144.1246424 0.0011464263 6.483766e-02 0.7355192 1 3742804 3742911 108 - 2.131 2.193 0.208
ENSG00000227372 E073 59.1925391 0.0008297002 7.246747e-02 0.7525651 1 3742912 3742957 46 - 1.735 1.820 0.289
ENSG00000227372 E074 27.8959281 0.0115612549 8.858898e-01 0.9960113 1 3742958 3742960 3 - 1.452 1.464 0.041
ENSG00000227372 E075 6.4496336 0.0028630901 8.351922e-01   1 3742961 3742983 23 - 0.885 0.860 -0.093
ENSG00000227372 E076 142.2994091 0.0002163574 8.369458e-02 0.7741926 1 3743061 3743190 130 - 2.129 2.182 0.176
ENSG00000227372 E077 1.3240899 0.0113603744 1.476726e-01   1 3743191 3743261 71 - 0.477 0.219 -1.604
ENSG00000227372 E078 0.8429369 0.0155010974 1.660440e-01   1 3743280 3743300 21 - 0.368 0.124 -2.018
ENSG00000227372 E079 1.8556953 0.0093984188 1.251573e-01   1 3743301 3743371 71 - 0.564 0.298 -1.433
ENSG00000227372 E080 6.3072516 0.0417068760 2.018245e-01   1 3745381 3745606 226 - 0.753 0.950 0.761
ENSG00000227372 E081 368.3705570 0.0001309592 1.068415e-01 0.8120107 1 3745607 3746181 575 - 2.552 2.582 0.102
ENSG00000227372 E082 67.5596137 0.0067788769 7.365171e-01 0.9878704 1 3746182 3746186 5 - 1.826 1.846 0.068
ENSG00000227372 E083 109.3936798 0.0029152183 3.741083e-01 0.9525911 1 3746187 3746286 100 - 2.024 2.061 0.125
ENSG00000227372 E084 127.5279928 0.0001671405 3.356881e-01 0.9454547 1 3746287 3746436 150 - 2.093 2.124 0.104
ENSG00000227372 E085 105.8589770 0.0012204279 4.536062e-01 0.9619444 1 3746437 3746527 91 - 2.014 2.043 0.098
ENSG00000227372 E086 277.0832657 0.0006880101 4.753888e-05 0.0228369 1 3746528 3747373 846 - 2.393 2.491 0.327