ENSG00000179134

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000596271 ENSG00000179134 HEK293_DMSO_2hB HEK293_TMG_2hB SAMD4B protein_coding retained_intron 91.99091 66.23171 59.08284 1.601389 1.440611 -0.1647567 22.5542424 7.286189 5.937890 2.3177432 1.8747778 -0.29476505 0.21145833 0.10840000 0.09913333 -0.009266667 1.000000e+00 8.453083e-09   FALSE
ENST00000598605 ENSG00000179134 HEK293_DMSO_2hB HEK293_TMG_2hB SAMD4B protein_coding protein_coding 91.99091 66.23171 59.08284 1.601389 1.440611 -0.1647567 16.1901395 11.148548 11.576986 0.9376987 0.6793381 0.05435610 0.18115417 0.16913333 0.19613333 0.027000000 9.311750e-01 8.453083e-09   FALSE
ENST00000598913 ENSG00000179134 HEK293_DMSO_2hB HEK293_TMG_2hB SAMD4B protein_coding protein_coding 91.99091 66.23171 59.08284 1.601389 1.440611 -0.1647567 7.2076138 6.741632 8.609583 0.8070865 0.8295371 0.35238195 0.08418750 0.10243333 0.14636667 0.043933333 7.557772e-01 8.453083e-09 FALSE TRUE
ENST00000599712 ENSG00000179134 HEK293_DMSO_2hB HEK293_TMG_2hB SAMD4B protein_coding protein_coding 91.99091 66.23171 59.08284 1.601389 1.440611 -0.1647567 0.6874788 4.581437 0.000000 1.7089860 0.0000000 -8.84280187 0.01063750 0.06890000 0.00000000 -0.068900000 8.453083e-09 8.453083e-09 FALSE FALSE
ENST00000610417 ENSG00000179134 HEK293_DMSO_2hB HEK293_TMG_2hB SAMD4B protein_coding protein_coding 91.99091 66.23171 59.08284 1.601389 1.440611 -0.1647567 33.8834856 23.155023 23.627098 1.0007449 0.2988354 0.02910478 0.36917917 0.35073333 0.40046667 0.049733333 9.311750e-01 8.453083e-09 FALSE TRUE
MSTRG.17126.3 ENSG00000179134 HEK293_DMSO_2hB HEK293_TMG_2hB SAMD4B protein_coding   91.99091 66.23171 59.08284 1.601389 1.440611 -0.1647567 4.2547106 4.328251 4.619181 0.3871953 0.5309867 0.09364366 0.05300417 0.06570000 0.07800000 0.012300000 9.311750e-01 8.453083e-09 FALSE TRUE
MSTRG.17126.5 ENSG00000179134 HEK293_DMSO_2hB HEK293_TMG_2hB SAMD4B protein_coding   91.99091 66.23171 59.08284 1.601389 1.440611 -0.1647567 2.9001030 4.254116 0.000000 2.3593981 0.0000000 -8.73610300 0.03822500 0.06296667 0.00000000 -0.062966667 6.142558e-01 8.453083e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_DMSO_2hB log2fold_HEK293_DMSO_2hB_HEK293_TMG_2hB
ENSG00000179134 E001 0.0000000       19 39342421 39342441 21 +      
ENSG00000179134 E002 0.1450127 4.185446e-02 0.5232319997   19 39342442 39342451 10 + 0.000 0.119 9.272
ENSG00000179134 E003 1.9683362 2.385648e-02 0.0679938147   19 39342452 39342463 12 + 0.614 0.290 -1.714
ENSG00000179134 E004 4.2387481 5.303688e-02 0.3936779667   19 39342464 39342467 4 + 0.792 0.649 -0.586
ENSG00000179134 E005 113.3742025 1.657345e-04 0.8207288639 0.99189044 19 39342468 39342576 109 + 2.057 2.061 0.011
ENSG00000179134 E006 29.5022393 1.929457e-02 0.8723558929 0.99562487 19 39348288 39348389 102 + 1.497 1.474 -0.080
ENSG00000179134 E007 26.6673471 1.017618e-03 0.5181699145 0.96972192 19 39349800 39351816 2017 + 1.468 1.420 -0.164
ENSG00000179134 E008 17.9710245 3.163025e-03 0.0271374618 0.58479531 19 39351817 39352374 558 + 1.364 1.174 -0.667
ENSG00000179134 E009 5.0030925 3.677899e-03 0.8332043164   19 39352375 39352489 115 + 0.792 0.760 -0.128
ENSG00000179134 E010 1.9798231 1.151692e-02 0.6651823947   19 39354004 39354005 2 + 0.436 0.507 0.357
ENSG00000179134 E011 124.3408427 1.561491e-04 0.5061175016 0.96926659 19 39354006 39354066 61 + 2.111 2.085 -0.085
ENSG00000179134 E012 21.5412864 8.785080e-04 0.0302441367 0.60310987 19 39355055 39355150 96 + 1.431 1.265 -0.575
ENSG00000179134 E013 140.2003617 1.889600e-04 0.1351322964 0.84444927 19 39356689 39356707 19 + 2.174 2.125 -0.165
ENSG00000179134 E014 269.9789976 9.783913e-05 0.5588768950 0.97420223 19 39356708 39356815 108 + 2.441 2.424 -0.057
ENSG00000179134 E015 517.4643077 7.033577e-05 0.0012406779 0.16057915 19 39356816 39357089 274 + 2.690 2.736 0.153
ENSG00000179134 E016 2.9586606 1.375518e-02 0.4537689201   19 39359905 39360148 244 + 0.534 0.651 0.523
ENSG00000179134 E017 0.3463641 2.841308e-02 0.2207334840   19 39369553 39369654 102 + 0.000 0.213 10.307
ENSG00000179134 E018 678.7869728 6.886765e-05 0.0004521263 0.09131792 19 39369655 39370091 437 + 2.809 2.853 0.144
ENSG00000179134 E019 208.1728682 1.299386e-04 0.3617285870 0.95123488 19 39370092 39370125 34 + 2.311 2.329 0.061
ENSG00000179134 E020 488.7199376 3.007941e-04 0.1721524170 0.87579218 19 39375650 39375889 240 + 2.704 2.676 -0.095
ENSG00000179134 E021 248.8774383 6.606246e-04 0.2653060620 0.92369267 19 39376437 39376495 59 + 2.415 2.382 -0.108
ENSG00000179134 E022 292.8110134 2.557024e-04 0.5860456975 0.97611755 19 39376496 39376546 51 + 2.477 2.461 -0.053
ENSG00000179134 E023 321.7072861 1.047458e-04 0.6264646148 0.97971823 19 39376705 39376791 87 + 2.517 2.503 -0.046
ENSG00000179134 E024 597.9916128 5.749423e-05 0.4477145225 0.96106697 19 39377485 39377824 340 + 2.774 2.780 0.022
ENSG00000179134 E025 158.1124653 3.728546e-03 0.3483783101 0.94935483 19 39378504 39378504 1 + 2.184 2.216 0.109
ENSG00000179134 E026 305.4246131 1.542545e-03 0.5273828603 0.97089078 19 39378505 39378589 85 + 2.480 2.492 0.041
ENSG00000179134 E027 282.5391304 2.266936e-04 0.2374388929 0.91230843 19 39379966 39380084 119 + 2.442 2.463 0.072
ENSG00000179134 E028 203.6117487 3.564485e-03 0.1614206634 0.86653457 19 39380587 39380733 147 + 2.285 2.336 0.170
ENSG00000179134 E029 164.3931400 3.721859e-03 0.5823644441 0.97608764 19 39380734 39380785 52 + 2.210 2.229 0.064
ENSG00000179134 E030 280.1240203 1.014480e-04 0.4955614884 0.96779982 19 39380990 39381113 124 + 2.444 2.454 0.034
ENSG00000179134 E031 1.3270210 1.017194e-01 0.5635874165   19 39381114 39381296 183 + 0.309 0.413 0.620
ENSG00000179134 E032 243.1887783 9.364177e-05 0.7429531181 0.98807258 19 39383208 39383291 84 + 2.393 2.382 -0.039
ENSG00000179134 E033 120.8602002 1.801248e-03 0.1941149939 0.89039084 19 39383292 39383498 207 + 2.113 2.059 -0.179
ENSG00000179134 E034 269.0472841 1.014916e-04 0.0910923585 0.78941512 19 39383499 39383707 209 + 2.415 2.448 0.108
ENSG00000179134 E035 1488.7932415 2.038561e-03 0.1180727079 0.82765768 19 39383708 39385120 1413 + 3.191 3.155 -0.121
ENSG00000179134 E036 333.1257898 8.495119e-04 0.1299828438 0.83952028 19 39385121 39385351 231 + 2.543 2.503 -0.135
ENSG00000179134 E037 270.4214224 1.133444e-03 0.7184894309 0.98679464 19 39385352 39385578 227 + 2.441 2.426 -0.049
ENSG00000179134 E038 77.5381702 3.240863e-04 0.3575899195 0.95118612 19 39385579 39385710 132 + 1.915 1.874 -0.140
ENSG00000179134 E039 0.9802428 8.899332e-02 0.5034039808   19 39390526 39390528 3 + 0.229 0.355 0.866
ENSG00000179134 E040 11.6120292 1.668249e-03 0.8823693262 0.99591352 19 39390529 39391138 610 + 1.094 1.104 0.037