ENSG00000173230

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000393667 ENSG00000173230 HEK293_DMSO_2hB HEK293_TMG_2hB GOLGB1 protein_coding protein_coding 11.55965 10.05279 11.79269 0.7381611 0.6539397 0.2300848 0.5050594 1.7370552 0.7276284 0.07407087 0.4694113 -1.24395905 0.04444167 0.17390000 0.06346667 -0.110433333 8.863660e-01 4.591799e-07 FALSE TRUE
ENST00000482512 ENSG00000173230 HEK293_DMSO_2hB HEK293_TMG_2hB GOLGB1 protein_coding nonsense_mediated_decay 11.55965 10.05279 11.79269 0.7381611 0.6539397 0.2300848 0.3479158 0.7096848 0.0000000 0.14354026 0.0000000 -6.16929324 0.02841667 0.07340000 0.00000000 -0.073400000 4.591799e-07 4.591799e-07 FALSE TRUE
ENST00000494517 ENSG00000173230 HEK293_DMSO_2hB HEK293_TMG_2hB GOLGB1 protein_coding protein_coding 11.55965 10.05279 11.79269 0.7381611 0.6539397 0.2300848 2.3822316 3.4417068 3.2730465 0.33586020 0.1065596 -0.07227471 0.19308333 0.34130000 0.27833333 -0.062966667 6.142558e-01 4.591799e-07 FALSE TRUE
ENST00000614479 ENSG00000173230 HEK293_DMSO_2hB HEK293_TMG_2hB GOLGB1 protein_coding protein_coding 11.55965 10.05279 11.79269 0.7381611 0.6539397 0.2300848 0.4085518 0.4062152 1.7984314 0.40621525 0.2752778 2.11933717 0.03529167 0.04546667 0.15170000 0.106233333 6.142558e-01 4.591799e-07 FALSE TRUE
ENST00000694981 ENSG00000173230 HEK293_DMSO_2hB HEK293_TMG_2hB GOLGB1 protein_coding retained_intron 11.55965 10.05279 11.79269 0.7381611 0.6539397 0.2300848 0.7496613 0.2342909 0.1819961 0.03774082 0.1297715 -0.34752339 0.06989167 0.02406667 0.01563333 -0.008433333 9.311750e-01 4.591799e-07 TRUE TRUE
ENST00000695039 ENSG00000173230 HEK293_DMSO_2hB HEK293_TMG_2hB GOLGB1 protein_coding retained_intron 11.55965 10.05279 11.79269 0.7381611 0.6539397 0.2300848 1.3478189 0.0000000 0.6437674 0.00000000 0.1329645 6.03070552 0.11684583 0.00000000 0.05576667 0.055766667 9.353397e-07 4.591799e-07 FALSE TRUE
ENST00000695118 ENSG00000173230 HEK293_DMSO_2hB HEK293_TMG_2hB GOLGB1 protein_coding protein_coding 11.55965 10.05279 11.79269 0.7381611 0.6539397 0.2300848 1.7263449 0.7094775 1.1226350 0.70947755 0.4075067 0.65466148 0.15683333 0.06196667 0.09253333 0.030566667 7.824611e-01 4.591799e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_DMSO_2hB log2fold_HEK293_DMSO_2hB_HEK293_TMG_2hB
ENSG00000173230 E001 0.0000000       3 121663199 121663200 2 -      
ENSG00000173230 E002 0.0000000       3 121663201 121663202 2 -      
ENSG00000173230 E003 0.0000000       3 121663203 121663203 1 -      
ENSG00000173230 E004 0.0000000       3 121663204 121663220 17 -      
ENSG00000173230 E005 1.8965777 5.242662e-01 0.5724061010   3 121663221 121663233 13 - 0.515 0.414 -0.509
ENSG00000173230 E006 10.2663435 3.537968e-02 0.3769580734 0.95301007 3 121663234 121663253 20 - 1.105 0.999 -0.386
ENSG00000173230 E007 22.7083553 1.692270e-02 0.9907919469 0.99943420 3 121663254 121663343 90 - 1.377 1.381 0.015
ENSG00000173230 E008 20.0833331 2.879631e-02 0.4884971726 0.96648082 3 121663344 121663378 35 - 1.359 1.292 -0.231
ENSG00000173230 E009 16.8155885 4.142151e-02 0.5387543741 0.97255154 3 121663379 121663389 11 - 1.285 1.219 -0.232
ENSG00000173230 E010 16.7493572 3.166435e-02 0.1280778134 0.83751261 3 121663390 121663401 12 - 1.327 1.155 -0.604
ENSG00000173230 E011 19.7110920 1.462017e-02 0.2799582491 0.93097672 3 121663402 121663420 19 - 1.365 1.264 -0.351
ENSG00000173230 E012 103.8759836 1.510048e-03 0.1533842287 0.85834831 3 121663421 121664097 677 - 2.047 1.990 -0.190
ENSG00000173230 E013 14.8520303 7.851355e-03 0.5970789867 0.97686582 3 121664098 121664100 3 - 1.177 1.225 0.172
ENSG00000173230 E014 15.6421313 3.650012e-03 0.5233740155 0.97033624 3 121664101 121664108 8 - 1.195 1.251 0.197
ENSG00000173230 E015 18.2119512 7.896180e-03 0.3691596175 0.95206599 3 121664109 121664135 27 - 1.246 1.325 0.277
ENSG00000173230 E016 27.5635521 1.001507e-02 0.0428139333 0.66019493 3 121664136 121664146 11 - 1.371 1.537 0.573
ENSG00000173230 E017 37.4825467 1.217017e-03 0.0385547936 0.64267998 3 121664147 121664191 45 - 1.526 1.647 0.412
ENSG00000173230 E018 37.5551479 5.819005e-04 0.0461798396 0.67433733 3 121664192 121664206 15 - 1.530 1.644 0.387
ENSG00000173230 E019 177.0472045 3.275727e-03 0.8342127562 0.99265648 3 121664207 121664614 408 - 2.247 2.256 0.029
ENSG00000173230 E020 0.8328398 1.577461e-02 0.1598499318   3 121664615 121664925 311 - 0.122 0.370 2.046
ENSG00000173230 E021 74.7890446 1.873602e-03 0.3527480318 0.95019149 3 121664926 121665031 106 - 1.859 1.901 0.141
ENSG00000173230 E022 8.3931584 5.534772e-02 0.8929982213   3 121665032 121667475 2444 - 0.991 0.956 -0.130
ENSG00000173230 E023 80.1098579 2.350344e-04 0.9312023468 0.99817602 3 121667476 121667610 135 - 1.908 1.910 0.010
ENSG00000173230 E024 1.4758320 4.989391e-02 0.3667492712   3 121667611 121668060 450 - 0.471 0.302 -0.958
ENSG00000173230 E025 72.7767769 2.472339e-04 0.5961743766 0.97686582 3 121668061 121668158 98 - 1.857 1.879 0.072
ENSG00000173230 E026 0.5184259 4.145872e-02 0.0808666985   3 121668159 121668313 155 - 0.000 0.304 11.451
ENSG00000173230 E027 6.1449625 1.157971e-02 0.0263279822   3 121668314 121668508 195 - 0.691 0.988 1.157
ENSG00000173230 E028 0.3144139 3.016432e-02 0.9837988728   3 121668509 121668669 161 - 0.122 0.126 0.044
ENSG00000173230 E029 2.5241871 8.098830e-02 0.5738117805   3 121668670 121669196 527 - 0.596 0.480 -0.542
ENSG00000173230 E030 10.4955540 1.856316e-03 0.2673834843 0.92480266 3 121669197 121669211 15 - 1.005 1.117 0.408
ENSG00000173230 E031 94.0489143 1.947403e-04 0.8899614312 0.99613784 3 121669212 121669355 144 - 1.975 1.980 0.015
ENSG00000173230 E032 5.0941583 4.135578e-02 0.6926589073   3 121669356 121675037 5682 - 0.816 0.754 -0.245
ENSG00000173230 E033 112.5247468 1.692269e-04 0.9049268992 0.99664597 3 121676893 121677030 138 - 2.053 2.057 0.012
ENSG00000173230 E034 96.5822196 2.771341e-04 0.4264390335 0.95920724 3 121677285 121677450 166 - 2.003 1.974 -0.098
ENSG00000173230 E035 0.1730468 3.996333e-02 0.5036872781   3 121680571 121680635 65 - 0.123 0.000 -10.568
ENSG00000173230 E036 82.8032085 2.341485e-04 0.9728244565 0.99899046 3 121681687 121681834 148 - 1.923 1.921 -0.006
ENSG00000173230 E037 55.0626790 1.429138e-03 0.4849733452 0.96644991 3 121681835 121681865 31 - 1.731 1.765 0.115
ENSG00000173230 E038 4.8418492 8.962537e-03 0.0572141409   3 121681866 121682916 1051 - 0.876 0.605 -1.107
ENSG00000173230 E039 2.2009547 2.661435e-02 0.0675729886   3 121682917 121682961 45 - 0.630 0.303 -1.693
ENSG00000173230 E040 1.3390957 1.337880e-02 0.0299256498   3 121682962 121682963 2 - 0.516 0.126 -2.763
ENSG00000173230 E041 1.3389445 3.679624e-02 0.5301273207   3 121682964 121683313 350 - 0.420 0.303 -0.691
ENSG00000173230 E042 1.1943534 1.259494e-02 0.2745171102   3 121690424 121690669 246 - 0.420 0.223 -1.275
ENSG00000173230 E043 242.4211794 3.613151e-04 0.6835153373 0.98466343 3 121690670 121691332 663 - 2.381 2.390 0.030
ENSG00000173230 E044 328.1428611 8.321161e-04 0.4367300729 0.95977715 3 121691333 121692581 1249 - 2.526 2.507 -0.061
ENSG00000173230 E045 484.4115212 7.083869e-05 0.0401930104 0.64945306 3 121693741 121695595 1855 - 2.701 2.669 -0.107
ENSG00000173230 E046 416.4037463 7.253481e-05 0.1403673436 0.84806995 3 121695596 121697455 1860 - 2.632 2.607 -0.084
ENSG00000173230 E047 45.9648528 4.319845e-04 0.4923830994 0.96682588 3 121697456 121697562 107 - 1.653 1.688 0.119
ENSG00000173230 E048 54.7863498 3.459739e-04 0.5289206708 0.97095808 3 121697563 121697690 128 - 1.761 1.731 -0.103
ENSG00000173230 E049 67.3256345 4.420396e-03 0.8990557935 0.99638518 3 121697691 121697899 209 - 1.839 1.835 -0.016
ENSG00000173230 E050 46.7345645 4.895265e-04 0.0011730185 0.15628245 3 121697900 121697967 68 - 1.592 1.760 0.567
ENSG00000173230 E051 168.4609537 1.138172e-04 0.4374231274 0.95977715 3 121697968 121698627 660 - 2.219 2.239 0.068
ENSG00000173230 E052 46.5374148 5.389420e-04 0.7543380611 0.98848087 3 121698628 121698700 73 - 1.683 1.667 -0.057
ENSG00000173230 E053 43.0579593 2.776746e-03 0.8797187173 0.99569482 3 121698701 121698784 84 - 1.637 1.645 0.025
ENSG00000173230 E054 41.1266190 3.467186e-03 0.1954106937 0.89134573 3 121698785 121698883 99 - 1.585 1.663 0.266
ENSG00000173230 E055 31.7041305 7.657446e-04 0.0333091199 0.61801071 3 121698884 121698929 46 - 1.448 1.580 0.452
ENSG00000173230 E056 35.4280690 5.757679e-04 0.0347726288 0.62454042 3 121699812 121699885 74 - 1.500 1.623 0.422
ENSG00000173230 E057 0.0000000       3 121699886 121700118 233 -      
ENSG00000173230 E058 0.0000000       3 121701753 121702480 728 -      
ENSG00000173230 E059 53.8332673 3.354205e-04 0.8404929562 0.99346268 3 121702481 121702591 111 - 1.744 1.733 -0.034
ENSG00000173230 E060 35.1381898 2.032399e-03 0.8274546016 0.99216546 3 121702592 121702595 4 - 1.562 1.548 -0.049
ENSG00000173230 E061 0.0000000       3 121702596 121703013 418 -      
ENSG00000173230 E062 0.4775072 2.390198e-02 0.5857788825   3 121712201 121714860 2660 - 0.218 0.126 -0.955
ENSG00000173230 E063 53.2823928 3.570368e-03 0.7646988160 0.98962253 3 121714861 121714971 111 - 1.741 1.723 -0.059
ENSG00000173230 E064 21.7695959 1.014967e-02 0.0832948483 0.77394129 3 121714972 121714976 5 - 1.422 1.268 -0.534
ENSG00000173230 E065 92.2762375 1.471835e-02 0.9681798895 0.99899046 3 121716737 121717139 403 - 1.969 1.967 -0.005
ENSG00000173230 E066 41.6674406 4.898669e-03 0.3478766750 0.94935483 3 121718388 121718501 114 - 1.656 1.596 -0.205
ENSG00000173230 E067 6.0784614 3.021246e-03 0.4749847343   3 121718502 121718848 347 - 0.894 0.805 -0.347
ENSG00000173230 E068 3.4399572 5.228065e-03 0.5661758194   3 121718849 121718914 66 - 0.691 0.605 -0.370
ENSG00000173230 E069 2.2479941 1.085543e-01 0.6386312315   3 121718915 121719178 264 - 0.557 0.475 -0.392
ENSG00000173230 E070 5.1507891 4.033539e-03 0.1318232308   3 121719179 121719645 467 - 0.876 0.672 -0.817
ENSG00000173230 E071 25.2616274 7.391810e-04 0.6614174158 0.98351983 3 121719646 121719750 105 - 1.432 1.402 -0.106
ENSG00000173230 E072 7.8960173 2.412327e-03 0.8620694795   3 121719751 121719753 3 - 0.961 0.941 -0.075
ENSG00000173230 E073 8.4029653 2.163791e-03 0.3937825156   3 121719754 121719768 15 - 1.019 0.924 -0.353
ENSG00000173230 E074 20.0612167 9.812533e-04 0.0002776758 0.06999249 3 121719769 121722261 2493 - 1.438 1.150 -1.009
ENSG00000173230 E075 37.1741595 1.041918e-02 0.7298905882 0.98779490 3 121722262 121722376 115 - 1.570 1.592 0.077
ENSG00000173230 E076 20.0158548 2.656620e-02 0.8538993461 0.99443298 3 121722377 121722378 2 - 1.312 1.329 0.059
ENSG00000173230 E077 40.4819888 1.157261e-03 0.5325453726 0.97175469 3 121726913 121727041 129 - 1.600 1.634 0.117
ENSG00000173230 E078 0.0000000       3 121727319 121727341 23 -      
ENSG00000173230 E079 0.0000000       3 121727342 121729187 1846 -      
ENSG00000173230 E080 36.2896001 2.358597e-03 0.1185873292 0.82816918 3 121729188 121729336 149 - 1.522 1.617 0.324
ENSG00000173230 E081 14.5467060 1.289904e-03 0.2293270710 0.91037174 3 121729337 121729340 4 - 1.137 1.243 0.375
ENSG00000173230 E082 48.3287019 4.375252e-04 0.4595002759 0.96232402 3 121729865 121730017 153 - 1.675 1.711 0.125
ENSG00000173230 E083 0.0000000       3 121730018 121730474 457 -      
ENSG00000173230 E084 3.5164718 6.339623e-03 0.4712351618   3 121730848 121730875 28 - 0.595 0.702 0.462
ENSG00000173230 E085 39.0615244 8.522316e-03 0.3954901581 0.95573686 3 121730876 121730973 98 - 1.574 1.630 0.190
ENSG00000173230 E086 6.8568991 2.179221e-02 0.2357240216   3 121749010 121749631 622 - 0.815 0.973 0.601
ENSG00000173230 E087 26.9323957 7.288979e-04 0.0815514683 0.77051623 3 121749632 121749845 214 - 1.388 1.504 0.399
ENSG00000173230 E088 0.8272466 8.212521e-02 0.2077477586   3 121749846 121749966 121 - 0.363 0.126 -1.960