ENSG00000170248

Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000307296 ENSG00000170248 HEK293_DMSO_2hB HEK293_TMG_2hB PDCD6IP protein_coding protein_coding 84.14497 119.3743 124.7424 2.289442 2.025687 0.06345436 14.056771 21.09770 21.446586 1.4680409 1.0140750 0.02365084 0.19155833 0.17686667 0.17176667 -0.005100000 1.000000000 0.007184564 FALSE TRUE
ENST00000435909 ENSG00000170248 HEK293_DMSO_2hB HEK293_TMG_2hB PDCD6IP protein_coding nonsense_mediated_decay 84.14497 119.3743 124.7424 2.289442 2.025687 0.06345436 5.889809 11.76662 12.620044 1.4889390 0.5137871 0.10093423 0.05040417 0.09823333 0.10126667 0.003033333 1.000000000 0.007184564 TRUE FALSE
ENST00000457054 ENSG00000170248 HEK293_DMSO_2hB HEK293_TMG_2hB PDCD6IP protein_coding protein_coding 84.14497 119.3743 124.7424 2.289442 2.025687 0.06345436 5.554718 8.01634 9.476179 1.6013345 0.5322578 0.24108490 0.06332083 0.06723333 0.07613333 0.008900000 0.931175028 0.007184564 FALSE TRUE
ENST00000465122 ENSG00000170248 HEK293_DMSO_2hB HEK293_TMG_2hB PDCD6IP protein_coding retained_intron 84.14497 119.3743 124.7424 2.289442 2.025687 0.06345436 15.873802 14.73016 22.212533 0.7019712 1.0991794 0.59227096 0.21335833 0.12340000 0.17786667 0.054466667 0.007184564 0.007184564 FALSE FALSE
MSTRG.22697.9 ENSG00000170248 HEK293_DMSO_2hB HEK293_TMG_2hB PDCD6IP protein_coding   84.14497 119.3743 124.7424 2.289442 2.025687 0.06345436 29.019208 44.72094 40.557233 0.3933032 0.5443318 -0.14095830 0.33572500 0.37486667 0.32523333 -0.049633333 0.164926216 0.007184564 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.