ENSG00000138796

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000309522 ENSG00000138796 HEK293_DMSO_2hB HEK293_TMG_2hB HADH protein_coding protein_coding 67.73926 75.07217 67.91856 4.324462 1.719447 -0.1444521 37.851846 37.530584 37.488287 2.8480028 1.8918052 -0.001626408 0.54992917 0.49893333 0.5513000 0.052366667 6.142558e-01 4.541763e-17 FALSE  
ENST00000638621 ENSG00000138796 HEK293_DMSO_2hB HEK293_TMG_2hB HADH protein_coding protein_coding 67.73926 75.07217 67.91856 4.324462 1.719447 -0.1444521 8.571741 8.235613 7.981683 0.5318865 0.5415766 -0.045127529 0.12806667 0.10986667 0.1175667 0.007700000 9.320321e-01 4.541763e-17 FALSE  
ENST00000681992 ENSG00000138796 HEK293_DMSO_2hB HEK293_TMG_2hB HADH protein_coding processed_transcript 67.73926 75.07217 67.91856 4.324462 1.719447 -0.1444521 1.610479 4.274184 0.000000 0.9549758 0.0000000 -8.742876533 0.02343333 0.05643333 0.0000000 -0.056433333 4.541763e-17 4.541763e-17 FALSE  
MSTRG.25288.7 ENSG00000138796 HEK293_DMSO_2hB HEK293_TMG_2hB HADH protein_coding   67.73926 75.07217 67.91856 4.324462 1.719447 -0.1444521 12.452814 15.070447 13.145966 0.9800965 0.7423016 -0.196962031 0.18791250 0.20113333 0.1939000 -0.007233333 9.876358e-01 4.541763e-17 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_DMSO_2hB log2fold_HEK293_DMSO_2hB_HEK293_TMG_2hB
ENSG00000138796 E001 2.9827710 6.019205e-03 0.2743455591   4 107989714 107989828 115 + 0.681 0.508 -0.770
ENSG00000138796 E002 10.3047516 2.322077e-03 0.5834239043 0.97608764 4 107989829 107989836 8 + 1.080 1.023 -0.211
ENSG00000138796 E003 21.0229998 1.786454e-03 0.8033116438 0.99088761 4 107989837 107989846 10 + 1.350 1.329 -0.071
ENSG00000138796 E004 21.1860932 1.704640e-03 0.7356831734 0.98779490 4 107989847 107989848 2 + 1.356 1.329 -0.094
ENSG00000138796 E005 26.7580269 6.726494e-04 0.7969393482 0.99080909 4 107989849 107989853 5 + 1.451 1.432 -0.064
ENSG00000138796 E006 26.9030396 6.881563e-04 0.8554097591 0.99457913 4 107989854 107989854 1 + 1.451 1.437 -0.046
ENSG00000138796 E007 39.5983894 4.472128e-04 0.4587873157 0.96227142 4 107989855 107989857 3 + 1.586 1.626 0.137
ENSG00000138796 E008 55.0544478 7.523822e-04 0.5294497993 0.97102560 4 107989858 107989863 6 + 1.733 1.762 0.099
ENSG00000138796 E009 167.4597705 2.824777e-04 0.2495904742 0.91805531 4 107989864 107989888 25 + 2.211 2.242 0.104
ENSG00000138796 E010 175.8411277 1.919326e-04 0.2421981633 0.91482002 4 107989889 107989895 7 + 2.232 2.263 0.102
ENSG00000138796 E011 201.9767187 4.741408e-04 0.3747991211 0.95259113 4 107989896 107989901 6 + 2.296 2.319 0.075
ENSG00000138796 E012 319.6163339 8.562519e-05 0.0289038845 0.59560620 4 107989902 107989945 44 + 2.484 2.526 0.141
ENSG00000138796 E013 352.3593840 7.421919e-05 0.1355149459 0.84478914 4 107989946 107989988 43 + 2.534 2.561 0.090
ENSG00000138796 E014 289.4167376 6.876370e-04 0.1314108377 0.84107939 4 107989989 107990015 27 + 2.444 2.480 0.119
ENSG00000138796 E015 333.5472065 1.115384e-03 0.0299308021 0.60215263 4 107990016 107990052 37 + 2.495 2.549 0.178
ENSG00000138796 E016 287.5823315 8.826621e-04 0.0018884575 0.19763394 4 107990053 107990064 12 + 2.418 2.495 0.258
ENSG00000138796 E017 0.6825043 1.844352e-02 0.9388115247   4 108004451 108004459 9 + 0.228 0.214 -0.117
ENSG00000138796 E018 0.5082020 2.252510e-02 0.5227051332   4 108004460 108004481 22 + 0.228 0.120 -1.117
ENSG00000138796 E019 0.8506500 1.553582e-02 0.1457249747   4 108004482 108004545 64 + 0.376 0.120 -2.117
ENSG00000138796 E020 2.3259091 8.214002e-03 0.5045508105   4 108004546 108004663 118 + 0.575 0.463 -0.532
ENSG00000138796 E021 7.1354825 2.683692e-03 0.6181235040   4 108004664 108004825 162 + 0.878 0.936 0.219
ENSG00000138796 E022 5.2838537 3.462938e-03 0.1247739589   4 108004826 108004917 92 + 0.681 0.885 0.815
ENSG00000138796 E023 4.4590571 2.548892e-01 0.8205298112   4 108005228 108005369 142 + 0.714 0.747 0.134
ENSG00000138796 E024 211.4889712 1.161878e-04 0.0023254781 0.21817166 4 108009759 108009762 4 + 2.286 2.360 0.246
ENSG00000138796 E025 285.0360494 8.556896e-05 0.0031125670 0.24918632 4 108009763 108009788 26 + 2.423 2.484 0.204
ENSG00000138796 E026 482.8111805 2.031477e-04 0.6345842554 0.98052624 4 108009789 108009887 99 + 2.680 2.687 0.023
ENSG00000138796 E027 674.3281532 5.363956e-04 0.2656161051 0.92369267 4 108014431 108014588 158 + 2.839 2.819 -0.067
ENSG00000138796 E028 0.9712757 2.417662e-01 0.4517017909   4 108018446 108018511 66 + 0.377 0.211 -1.145
ENSG00000138796 E029 632.5394606 4.904829e-04 0.1134756811 0.82131619 4 108019540 108019666 127 + 2.815 2.787 -0.091
ENSG00000138796 E030 1.6682149 1.031769e-02 0.1667646723   4 108019667 108020320 654 + 0.533 0.291 -1.340
ENSG00000138796 E031 519.7828513 2.479673e-04 0.0031946009 0.25168974 4 108023474 108023563 90 + 2.741 2.691 -0.167
ENSG00000138796 E032 41.4695776 1.573850e-02 0.0153290790 0.48430033 4 108023564 108024434 871 + 1.720 1.521 -0.674
ENSG00000138796 E033 11.2283873 1.812049e-03 0.2034638794 0.89623981 4 108024435 108024568 134 + 1.149 1.022 -0.459
ENSG00000138796 E034 54.7779645 5.208045e-03 0.0001099426 0.03803928 4 108024569 108025864 1296 + 1.850 1.619 -0.780
ENSG00000138796 E035 8.8805309 2.873147e-02 0.0555173549   4 108025865 108026063 199 + 1.105 0.848 -0.956
ENSG00000138796 E036 42.0695396 4.497082e-04 0.0834689179 0.77405711 4 108026064 108026982 919 + 1.680 1.585 -0.323
ENSG00000138796 E037 45.8652787 4.042486e-04 0.0110044888 0.42708113 4 108026983 108027618 636 + 1.733 1.600 -0.454
ENSG00000138796 E038 12.3270428 1.489589e-03 0.4301716198 0.95920724 4 108027619 108027687 69 + 1.160 1.084 -0.273
ENSG00000138796 E039 500.2561115 5.655849e-05 0.1532675923 0.85834831 4 108027688 108027760 73 + 2.711 2.687 -0.078
ENSG00000138796 E040 10.1510456 1.824115e-03 0.7423372635 0.98807258 4 108027761 108027938 178 + 1.028 1.060 0.120
ENSG00000138796 E041 12.1542895 1.550291e-03 0.1104859210 0.81779913 4 108027939 108028069 131 + 1.190 1.036 -0.555
ENSG00000138796 E042 13.3105074 1.288296e-02 0.0295683729 0.59984108 4 108028070 108028860 791 + 1.261 1.034 -0.813
ENSG00000138796 E043 3.0410270 7.490848e-02 0.4677432629   4 108028861 108028869 9 + 0.534 0.678 0.640
ENSG00000138796 E044 37.9759580 1.264564e-02 0.2218024562 0.90704963 4 108028870 108030617 1748 + 1.638 1.539 -0.337
ENSG00000138796 E045 5.6326340 3.268863e-03 0.2148025121   4 108030618 108030716 99 + 0.897 0.736 -0.633
ENSG00000138796 E046 33.0862132 9.651437e-04 0.0135669096 0.46353372 4 108030717 108032326 1610 + 1.605 1.452 -0.525
ENSG00000138796 E047 3.7725784 4.979729e-03 0.4003817184   4 108032327 108032377 51 + 0.613 0.736 0.519
ENSG00000138796 E048 19.8455334 2.141084e-02 0.1546581666 0.85952883 4 108032378 108033175 798 + 1.389 1.236 -0.536
ENSG00000138796 E049 654.1881979 5.914895e-05 0.1873569359 0.88582305 4 108033176 108033292 117 + 2.825 2.806 -0.064
ENSG00000138796 E050 617.8161979 1.114294e-03 0.9730998234 0.99899046 4 108034239 108034439 201 + 2.792 2.790 -0.005
ENSG00000138796 E051 439.3440132 2.753348e-04 0.5866151144 0.97620656 4 108034440 108034594 155 + 2.639 2.648 0.029
ENSG00000138796 E052 548.7197918 6.384908e-04 0.9694941088 0.99899046 4 108034595 108035241 647 + 2.741 2.739 -0.006
ENSG00000138796 E053 0.0000000       4 108040482 108040493 12 +