ENSG00000138593

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261847 ENSG00000138593 HEK293_DMSO_2hB HEK293_TMG_2hB SECISBP2L protein_coding protein_coding 3.323327 5.546324 5.6768 0.2251664 0.3975651 0.03348627 0.3384790 0.0000000 0.8269422 0.00000000 0.3223674 6.38705601 0.11075000 0.0000000 0.1391 0.13910000 0.001124899 0.001124899 FALSE TRUE
ENST00000559471 ENSG00000138593 HEK293_DMSO_2hB HEK293_TMG_2hB SECISBP2L protein_coding protein_coding 3.323327 5.546324 5.6768 0.2251664 0.3975651 0.03348627 2.5260044 4.5131858 4.3809509 0.09996092 0.1350691 -0.04280587 0.77296667 0.8170667 0.7822 -0.03486667 1.000000000 0.001124899 FALSE TRUE
MSTRG.10753.4 ENSG00000138593 HEK293_DMSO_2hB HEK293_TMG_2hB SECISBP2L protein_coding   3.323327 5.546324 5.6768 0.2251664 0.3975651 0.03348627 0.2325828 0.7544781 0.1754267 0.13907928 0.1754267 -2.04362617 0.03812917 0.1345000 0.0281 -0.10640000 0.614255781 0.001124899 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_DMSO_2hB log2fold_HEK293_DMSO_2hB_HEK293_TMG_2hB
ENSG00000138593 E001 0.0000000       15 48988476 48988621 146 -      
ENSG00000138593 E002 4.9177347 4.020799e-03 0.4292612504   15 48988638 48988769 132 - 0.720 0.826 0.427
ENSG00000138593 E003 480.2192803 6.472449e-05 0.0003733581 0.08200807 15 48988770 48992766 3997 - 2.705 2.656 -0.163
ENSG00000138593 E004 41.3417054 5.861364e-04 0.5954381822 0.97686582 15 48992767 48992797 31 - 1.638 1.609 -0.099
ENSG00000138593 E005 66.2739570 1.962217e-03 0.6782955660 0.98442711 15 48992798 48992926 129 - 1.834 1.814 -0.067
ENSG00000138593 E006 30.5549070 7.280185e-04 0.4822708094 0.96616599 15 48996367 48996383 17 - 1.473 1.517 0.152
ENSG00000138593 E007 67.7980711 2.487441e-03 0.8360692141 0.99303246 15 48996384 48996586 203 - 1.830 1.840 0.035
ENSG00000138593 E008 41.9569666 4.535703e-04 0.7294004705 0.98779490 15 48999833 48999919 87 - 1.624 1.643 0.063
ENSG00000138593 E009 36.5831189 1.125463e-03 0.5519976006 0.97375634 15 48999920 48999987 68 - 1.559 1.594 0.118
ENSG00000138593 E010 59.8600727 2.204324e-03 0.1283796464 0.83762322 15 49000877 49001097 221 - 1.747 1.822 0.255
ENSG00000138593 E011 0.1630933 4.090271e-02 0.5000101015   15 49001691 49001941 251 - 0.123 0.000 -10.206
ENSG00000138593 E012 55.6718516 3.298658e-04 0.3058589755 0.93713007 15 49009216 49009378 163 - 1.729 1.776 0.161
ENSG00000138593 E013 0.6373746 2.221381e-02 0.3017954324   15 49011547 49011730 184 - 0.123 0.302 1.624
ENSG00000138593 E014 45.3831455 4.199045e-04 0.9465955844 0.99850987 15 49011731 49011863 133 - 1.666 1.663 -0.012
ENSG00000138593 E015 47.3329215 1.294880e-03 0.7727569321 0.99033428 15 49012648 49012817 170 - 1.675 1.691 0.052
ENSG00000138593 E016 0.3144139 3.132810e-02 0.9858726185   15 49012818 49013141 324 - 0.123 0.126 0.039
ENSG00000138593 E017 0.0000000       15 49016436 49016559 124 -      
ENSG00000138593 E018 42.1054911 6.708321e-03 0.9131437503 0.99682070 15 49016560 49016701 142 - 1.637 1.630 -0.023
ENSG00000138593 E019 32.9145679 2.490597e-03 0.3156179790 0.94008634 15 49016848 49016916 69 - 1.559 1.495 -0.221
ENSG00000138593 E020 30.2842581 3.439411e-03 0.6973277726 0.98581699 15 49016917 49016946 30 - 1.482 1.508 0.090
ENSG00000138593 E021 23.0180536 9.505471e-04 0.6774085935 0.98442711 15 49016947 49016951 5 - 1.365 1.395 0.103
ENSG00000138593 E022 28.8307337 6.310141e-04 0.7380628797 0.98797119 15 49016952 49017015 64 - 1.463 1.485 0.074
ENSG00000138593 E023 0.1730468 3.999615e-02 0.5000899216   15 49017016 49017053 38 - 0.123 0.000 -10.215
ENSG00000138593 E024 29.5474281 6.218288e-04 0.5262199896 0.97072480 15 49017548 49017628 81 - 1.463 1.504 0.138
ENSG00000138593 E025 0.5045563 2.299376e-02 0.5835015163   15 49017629 49017793 165 - 0.218 0.126 -0.958
ENSG00000138593 E026 38.7444720 4.744946e-04 0.7094209771 0.98616038 15 49019418 49019552 135 - 1.607 1.587 -0.070
ENSG00000138593 E027 0.3373956 3.107118e-02 0.9827278279   15 49019553 49019647 95 - 0.123 0.126 0.042
ENSG00000138593 E028 42.1993402 4.034258e-03 0.3796187084 0.95390418 15 49027365 49027480 116 - 1.660 1.605 -0.188
ENSG00000138593 E029 23.4565383 1.795986e-02 0.5975001961 0.97688520 15 49028144 49028168 25 - 1.366 1.407 0.141
ENSG00000138593 E030 28.0777020 1.358096e-02 0.6471671572 0.98216106 15 49028453 49028487 35 - 1.483 1.439 -0.152
ENSG00000138593 E031 48.3853291 3.890348e-04 0.9141324539 0.99682070 15 49028488 49028682 195 - 1.696 1.690 -0.018
ENSG00000138593 E032 26.3131231 7.219225e-04 0.1752802786 0.87784739 15 49032965 49033018 54 - 1.389 1.480 0.314
ENSG00000138593 E033 34.5242593 5.177012e-04 0.0744284953 0.75683548 15 49033019 49033100 82 - 1.496 1.601 0.360
ENSG00000138593 E034 47.1288279 2.008368e-03 0.1385055130 0.84698143 15 49035334 49035456 123 - 1.641 1.722 0.274
ENSG00000138593 E035 52.8540718 3.511815e-04 0.3010103282 0.93677404 15 49035457 49035658 202 - 1.707 1.756 0.167
ENSG00000138593 E036 0.0000000       15 49037395 49037590 196 -      
ENSG00000138593 E037 43.4089111 4.132644e-03 0.4110112431 0.95812893 15 49037591 49037769 179 - 1.624 1.674 0.170
ENSG00000138593 E038 33.3205504 9.751356e-04 0.5461044989 0.97327902 15 49046276 49046447 172 - 1.518 1.555 0.126