ENSG00000138074

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310574 ENSG00000138074 HEK293_DMSO_2hB HEK293_TMG_2hB SLC5A6 protein_coding protein_coding 83.11924 67.45247 66.87517 2.229398 3.258577 -0.01239876 44.715693 28.544764 26.669318 0.7548127 0.3073403 -0.09800972 0.5300833 0.42476667 0.40043333 -0.02433333 0.93117503 7.304842e-06 FALSE TRUE
ENST00000445802 ENSG00000138074 HEK293_DMSO_2hB HEK293_TMG_2hB SLC5A6 protein_coding nonsense_mediated_decay 83.11924 67.45247 66.87517 2.229398 3.258577 -0.01239876 11.816087 12.397605 11.616162 1.0408168 1.1281451 -0.09384972 0.1441333 0.18356667 0.17323333 -0.01033333 0.95033267 7.304842e-06 TRUE TRUE
ENST00000461757 ENSG00000138074 HEK293_DMSO_2hB HEK293_TMG_2hB SLC5A6 protein_coding retained_intron 83.11924 67.45247 66.87517 2.229398 3.258577 -0.01239876 4.770906 4.167310 5.397595 0.3836293 0.3605127 0.37241299 0.0584625 0.06153333 0.08066667 0.01913333 0.61425578 7.304842e-06 FALSE FALSE
MSTRG.18114.10 ENSG00000138074 HEK293_DMSO_2hB HEK293_TMG_2hB SLC5A6 protein_coding   83.11924 67.45247 66.87517 2.229398 3.258577 -0.01239876 8.509469 9.780514 5.656850 0.4886728 0.3903887 -0.78883770 0.1017750 0.14486667 0.08536667 -0.05950000 0.02615511 7.304842e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_DMSO_2hB log2fold_HEK293_DMSO_2hB_HEK293_TMG_2hB
ENSG00000138074 E001 0.8364855 1.586377e-02 2.113333e-01   2 27199587 27199588 2 - 0.130 0.353 1.837
ENSG00000138074 E002 1.5314541 3.208284e-02 2.457175e-02   2 27199589 27199592 4 - 0.130 0.546 2.842
ENSG00000138074 E003 8.8847838 2.082782e-03 1.399811e-01   2 27199593 27199594 2 - 0.903 1.066 0.603
ENSG00000138074 E004 64.6032161 4.009049e-04 9.094648e-01 0.9966460 2 27199595 27199617 23 - 1.820 1.816 -0.016
ENSG00000138074 E005 178.5334602 1.251510e-04 4.999622e-02 0.6872895 2 27199618 27199716 99 - 2.281 2.229 -0.174
ENSG00000138074 E006 149.6258136 1.710282e-04 9.481979e-03 0.4056836 2 27199717 27199719 3 - 2.216 2.141 -0.252
ENSG00000138074 E007 323.7102886 7.784302e-05 1.886881e-02 0.5174166 2 27199720 27199807 88 - 2.535 2.488 -0.154
ENSG00000138074 E008 279.8841744 6.336496e-04 2.299695e-02 0.5532331 2 27199808 27199837 30 - 2.475 2.420 -0.185
ENSG00000138074 E009 570.2502846 4.449397e-04 6.671054e-02 0.7388359 2 27199838 27200104 267 - 2.773 2.740 -0.108
ENSG00000138074 E010 620.7786928 1.821805e-04 2.231931e-01 0.9079548 2 27200105 27200435 331 - 2.784 2.803 0.062
ENSG00000138074 E011 421.4544771 6.501575e-05 3.107067e-02 0.6063652 2 27200436 27200579 144 - 2.606 2.643 0.125
ENSG00000138074 E012 358.9927321 7.635702e-05 9.578486e-01 0.9988909 2 27200998 27201101 104 - 2.556 2.558 0.004
ENSG00000138074 E013 215.3289363 1.297770e-04 8.666224e-01 0.9954388 2 27201102 27201113 12 - 2.338 2.334 -0.013
ENSG00000138074 E014 75.4605877 2.542007e-04 2.019279e-03 0.2039985 2 27201114 27201349 236 - 1.946 1.820 -0.423
ENSG00000138074 E015 310.8556982 8.120324e-05 9.344139e-01 0.9983642 2 27201350 27201411 62 - 2.495 2.493 -0.005
ENSG00000138074 E016 288.9570912 8.486154e-05 9.491819e-01 0.9985329 2 27201412 27201453 42 - 2.462 2.463 0.005
ENSG00000138074 E017 57.3606694 2.869915e-03 4.827780e-03 0.3052565 2 27201454 27201665 212 - 1.837 1.686 -0.508
ENSG00000138074 E018 313.6149054 1.619523e-03 8.878136e-01 0.9960600 2 27201666 27201711 46 - 2.500 2.496 -0.014
ENSG00000138074 E019 308.7652214 1.214887e-03 4.885211e-01 0.9664808 2 27201712 27201783 72 - 2.500 2.482 -0.061
ENSG00000138074 E020 250.3240970 1.066371e-04 5.454128e-01 0.9732730 2 27201784 27201847 64 - 2.407 2.394 -0.045
ENSG00000138074 E021 8.7908190 2.098086e-03 5.888747e-01   2 27201848 27201987 140 - 1.019 0.961 -0.217
ENSG00000138074 E022 257.8084150 8.952768e-05 7.312715e-01 0.9877949 2 27201988 27202074 87 - 2.409 2.417 0.026
ENSG00000138074 E023 248.4800093 8.873753e-05 5.834393e-01 0.9760876 2 27202813 27202880 68 - 2.391 2.404 0.042
ENSG00000138074 E024 65.9096058 5.652749e-03 6.637726e-02 0.7378735 2 27202881 27203158 278 - 1.877 1.775 -0.343
ENSG00000138074 E025 42.7044857 6.352572e-03 1.886856e-01 0.8868066 2 27203159 27203232 74 - 1.684 1.599 -0.290
ENSG00000138074 E026 395.6976854 2.027519e-04 3.452993e-01 0.9490858 2 27203233 27203345 113 - 2.588 2.606 0.059
ENSG00000138074 E027 341.1833909 1.392489e-03 1.863831e-01 0.8848409 2 27203779 27203867 89 - 2.516 2.549 0.111
ENSG00000138074 E028 339.0085539 7.035667e-04 2.335102e-01 0.9112925 2 27204461 27204590 130 - 2.517 2.543 0.089
ENSG00000138074 E029 7.6060021 2.777839e-02 3.061547e-01   2 27204591 27204672 82 - 1.005 0.860 -0.545
ENSG00000138074 E030 321.2929003 7.163614e-05 8.788330e-01 0.9956948 2 27204791 27204931 141 - 2.507 2.510 0.011
ENSG00000138074 E031 44.8114708 3.989704e-04 1.418898e-05 0.0104529 2 27204932 27205081 150 - 1.767 1.537 -0.779
ENSG00000138074 E032 48.1992235 3.797483e-04 4.624086e-02 0.6744648 2 27205135 27205349 215 - 1.743 1.642 -0.341
ENSG00000138074 E033 220.5214437 2.166205e-03 8.357492e-02 0.7740571 2 27205350 27205406 57 - 2.315 2.373 0.193
ENSG00000138074 E034 164.7112157 1.873253e-03 1.313265e-01 0.8409912 2 27205407 27205411 5 - 2.192 2.245 0.177
ENSG00000138074 E035 339.4452995 1.940740e-03 4.386478e-01 0.9599037 2 27205412 27205504 93 - 2.521 2.543 0.075
ENSG00000138074 E036 305.9978871 5.419449e-04 2.723871e-01 0.9266693 2 27206026 27206093 68 - 2.474 2.500 0.085
ENSG00000138074 E037 14.7147228 1.020285e-02 9.218831e-02 0.7910135 2 27206094 27206319 226 - 1.275 1.110 -0.588
ENSG00000138074 E038 256.3798589 9.718134e-05 3.101294e-01 0.9386132 2 27206483 27206534 52 - 2.400 2.423 0.077
ENSG00000138074 E039 196.7091095 2.253969e-03 7.969202e-01 0.9908091 2 27206877 27206893 17 - 2.292 2.301 0.029
ENSG00000138074 E040 264.9881201 1.031266e-04 6.105261e-01 0.9791095 2 27206894 27206936 43 - 2.420 2.431 0.038
ENSG00000138074 E041 185.1569094 1.059670e-04 5.465821e-01 0.9732790 2 27206937 27206942 6 - 2.262 2.278 0.054
ENSG00000138074 E042 244.4327649 9.098300e-05 2.164718e-01 0.9034047 2 27207258 27207303 46 - 2.375 2.404 0.095
ENSG00000138074 E043 321.1795149 7.258175e-05 5.902311e-01 0.9763541 2 27207304 27207414 111 - 2.502 2.513 0.036
ENSG00000138074 E044 223.4410677 1.761193e-04 7.320708e-01 0.9877949 2 27207415 27207474 60 - 2.348 2.356 0.029
ENSG00000138074 E045 214.4378676 9.581776e-05 4.313560e-02 0.6618351 2 27207475 27207534 60 - 2.307 2.356 0.165
ENSG00000138074 E046 183.2849577 1.307295e-04 1.637378e-02 0.4954106 2 27207535 27207569 35 - 2.232 2.295 0.213
ENSG00000138074 E047 522.6187320 8.512114e-04 8.836941e-01 0.9959528 2 27207570 27207790 221 - 2.721 2.717 -0.012
ENSG00000138074 E048 6.4354860 3.377500e-03 3.709777e-02   2 27208394 27208448 55 - 0.989 0.731 -1.000
ENSG00000138074 E049 8.9347165 5.243199e-02 5.641512e-02   2 27208614 27208686 73 - 1.122 0.840 -1.049
ENSG00000138074 E050 309.9414647 8.355283e-05 5.007856e-01 0.9685316 2 27211467 27211533 67 - 2.500 2.487 -0.045
ENSG00000138074 E051 13.2748892 3.305057e-02 2.621544e-01 0.9223655 2 27211711 27211766 56 - 1.225 1.085 -0.500
ENSG00000138074 E052 36.9714576 5.139647e-04 1.594243e-01 0.8637415 2 27211767 27211899 133 - 1.535 1.617 0.279
ENSG00000138074 E053 74.2480878 1.823250e-03 7.488089e-01 0.9880758 2 27211900 27212019 120 - 1.869 1.883 0.048
ENSG00000138074 E054 100.5523671 2.779496e-03 7.172266e-02 0.7510950 2 27212020 27212146 127 - 2.044 1.965 -0.265
ENSG00000138074 E055 52.0200940 1.007118e-02 5.777444e-01 0.9760876 2 27212147 27212291 145 - 1.743 1.702 -0.138
ENSG00000138074 E056 0.3473491 3.137298e-02 9.355268e-01   2 27212463 27212522 60 - 0.130 0.118 -0.162
ENSG00000138074 E057 3.3417498 6.496497e-03 4.938099e-01   2 27212629 27212831 203 - 0.686 0.582 -0.451
ENSG00000138074 E058 3.3216992 4.530386e-02 5.725362e-01   2 27212832 27212958 127 - 0.580 0.678 0.428