ENSG00000119812

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000238823 ENSG00000119812 HEK293_DMSO_2hB HEK293_TMG_2hB FAM98A protein_coding protein_coding 38.68734 51.18448 50.55775 0.2458654 0.6269015 -0.01777081 33.954962 40.999139 41.414410 0.4541571 1.2052817 0.0145357 0.90035833 0.8009667 0.81936667 0.01840000 9.311750e-01 7.896801e-35 FALSE TRUE
MSTRG.18205.21 ENSG00000119812 HEK293_DMSO_2hB HEK293_TMG_2hB FAM98A protein_coding   38.68734 51.18448 50.55775 0.2458654 0.6269015 -0.01777081 1.920044 8.239339 2.902708 0.3011082 1.6156012 -1.5019176 0.03798333 0.1610000 0.05686667 -0.10413333 9.311750e-01 7.896801e-35 FALSE TRUE
MSTRG.18205.22 ENSG00000119812 HEK293_DMSO_2hB HEK293_TMG_2hB FAM98A protein_coding   38.68734 51.18448 50.55775 0.2458654 0.6269015 -0.01777081 1.429940 0.000000 4.118166 0.0000000 0.3468267 8.6893573 0.02678333 0.0000000 0.08166667 0.08166667 7.896801e-35 7.896801e-35 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_DMSO_2hB log2fold_HEK293_DMSO_2hB_HEK293_TMG_2hB
ENSG00000119812 E001 0.3351552 2.989875e-02 0.9713608152   2 33532744 33533395 652 - 0.128 0.121 -0.088
ENSG00000119812 E002 0.0000000       2 33534802 33534996 195 -      
ENSG00000119812 E003 5.8674796 5.424910e-03 0.0081880901   2 33552522 33554432 1911 - 0.979 0.624 -1.410
ENSG00000119812 E004 3.7934690 2.857466e-02 0.4048105601   2 33554433 33555064 632 - 0.610 0.739 0.544
ENSG00000119812 E005 4.9272671 3.632899e-03 0.8273065010   2 33555065 33555314 250 - 0.762 0.788 0.103
ENSG00000119812 E006 0.4864757 2.354520e-02 0.5985915263   2 33562475 33563477 1003 - 0.128 0.215 0.910
ENSG00000119812 E007 1.8261122 1.075272e-02 0.4173139847   2 33563478 33563545 68 - 0.374 0.511 0.718
ENSG00000119812 E008 1.0288697 3.420369e-01 0.9353946834   2 33565233 33565233 1 - 0.307 0.297 -0.066
ENSG00000119812 E009 3.0375607 1.069120e-02 0.7243353840   2 33565234 33565265 32 - 0.572 0.625 0.234
ENSG00000119812 E010 0.0000000       2 33566179 33566296 118 -      
ENSG00000119812 E011 4.4646145 4.054938e-03 0.4149191460   2 33567036 33567204 169 - 0.677 0.788 0.451
ENSG00000119812 E012 2.8275104 7.659619e-02 0.5643078679   2 33567205 33571283 4079 - 0.529 0.626 0.438
ENSG00000119812 E013 0.6225200 2.930040e-02 0.9559749749   2 33583062 33583126 65 - 0.226 0.215 -0.092
ENSG00000119812 E014 8.6338407 2.250040e-02 0.4543610581   2 33583127 33583659 533 - 1.037 0.938 -0.367
ENSG00000119812 E015 3.6873624 3.465136e-02 0.2436966393   2 33583660 33583661 2 - 0.572 0.762 0.809
ENSG00000119812 E016 5.0600854 3.623117e-03 0.4599101288   2 33583662 33583669 8 - 0.736 0.831 0.379
ENSG00000119812 E017 6.8692443 2.870540e-03 0.6608891587   2 33583670 33583671 2 - 0.874 0.923 0.186
ENSG00000119812 E018 24.1993666 3.447752e-02 0.6366117114 0.9809418 2 33583672 33583685 14 - 1.371 1.436 0.223
ENSG00000119812 E019 29.5258038 4.460600e-02 0.7497630600 0.9881026 2 33583686 33583688 3 - 1.457 1.516 0.201
ENSG00000119812 E020 1223.4633577 1.944928e-03 0.0798993481 0.7679368 2 33583689 33584888 1200 - 3.108 3.068 -0.133
ENSG00000119812 E021 111.1355346 1.190117e-03 0.8925155299 0.9963136 2 33584889 33584897 9 - 2.048 2.048 0.002
ENSG00000119812 E022 158.7213055 1.494277e-04 0.0193940473 0.5229543 2 33584898 33584968 71 - 2.171 2.232 0.206
ENSG00000119812 E023 387.0713343 9.021607e-04 0.2517243451 0.9185767 2 33584969 33585158 190 - 2.579 2.600 0.072
ENSG00000119812 E024 196.1149777 1.614819e-04 0.5687378725 0.9753810 2 33585159 33585188 30 - 2.291 2.301 0.034
ENSG00000119812 E025 242.3326239 9.323466e-05 0.3085144635 0.9380738 2 33585189 33585242 54 - 2.376 2.395 0.063
ENSG00000119812 E026 179.0623503 1.905182e-03 0.2350951379 0.9114210 2 33585243 33585251 9 - 2.236 2.271 0.117
ENSG00000119812 E027 269.5101343 1.958457e-03 0.3777209446 0.9532439 2 33585252 33585311 60 - 2.421 2.442 0.070
ENSG00000119812 E028 415.6032709 5.923009e-04 0.5189714675 0.9697648 2 33585312 33585444 133 - 2.615 2.624 0.028
ENSG00000119812 E029 1.9623064 9.091795e-03 0.9280822494   2 33585445 33585529 85 - 0.484 0.466 -0.090
ENSG00000119812 E030 333.0202334 1.449610e-03 0.7039349890 0.9859242 2 33585530 33585613 84 - 2.531 2.516 -0.050
ENSG00000119812 E031 342.7505917 2.393360e-04 0.8889453854 0.9960600 2 33585614 33585697 84 - 2.537 2.535 -0.006
ENSG00000119812 E032 395.2467853 6.631194e-05 0.7722960922 0.9902314 2 33586562 33586678 117 - 2.597 2.598 0.002
ENSG00000119812 E033 3.1625388 9.418357e-02 0.2109265402   2 33586679 33587239 561 - 0.734 0.468 -1.190
ENSG00000119812 E034 320.8596161 8.443260e-05 0.0572980865 0.7124555 2 33587240 33587320 81 - 2.490 2.523 0.110
ENSG00000119812 E035 16.6495639 1.100010e-03 0.2547489548 0.9190179 2 33587321 33588334 1014 - 1.296 1.198 -0.348
ENSG00000119812 E036 481.4590630 7.544461e-05 0.9267662782 0.9977765 2 33588335 33588519 185 - 2.684 2.681 -0.010
ENSG00000119812 E037 60.4105960 1.799604e-03 0.0001665981 0.0502211 2 33588520 33592079 3560 - 1.874 1.683 -0.645
ENSG00000119812 E038 306.5853996 8.132741e-05 0.9277115896 0.9978762 2 33592080 33592135 56 - 2.489 2.487 -0.009
ENSG00000119812 E039 364.7654090 7.600652e-05 0.0623944492 0.7287004 2 33592136 33592214 79 - 2.583 2.544 -0.129
ENSG00000119812 E040 0.7955668 1.742709e-02 0.6150609849   2 33595220 33595332 113 - 0.306 0.215 -0.676
ENSG00000119812 E041 478.4474307 1.259893e-03 0.7419568869 0.9880726 2 33595489 33595637 149 - 2.687 2.675 -0.038
ENSG00000119812 E042 277.9897924 3.719562e-04 0.3760907242 0.9527257 2 33599169 33599194 26 - 2.437 2.453 0.053
ENSG00000119812 E043 262.2746952 2.719232e-04 0.8363029013 0.9930462 2 33599195 33599347 153 - 2.420 2.421 0.001