ENSG00000105202

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000221801 ENSG00000105202 HEK293_DMSO_2hB HEK293_TMG_2hB FBL protein_coding protein_coding 946.7887 556.1908 548.6775 11.90063 7.700817 -0.01962112 249.21325 206.82393 153.44744 2.815735 0.7925028 -0.4306343 0.2752333 0.3722333 0.2797667 -0.09246667 7.275138e-06 7.275138e-06 FALSE TRUE
ENST00000597224 ENSG00000105202 HEK293_DMSO_2hB HEK293_TMG_2hB FBL protein_coding protein_coding 946.7887 556.1908 548.6775 11.90063 7.700817 -0.01962112 189.30733 64.03882 88.62455 8.581502 15.5701294 0.4686972 0.1857333 0.1146333 0.1608667 0.04623333 9.311750e-01 7.275138e-06 FALSE FALSE
MSTRG.17149.11 ENSG00000105202 HEK293_DMSO_2hB HEK293_TMG_2hB FBL protein_coding   946.7887 556.1908 548.6775 11.90063 7.700817 -0.01962112 94.93982 59.06649 50.71405 15.350317 17.1143585 -0.2199142 0.0952875 0.1058333 0.0931000 -0.01273333 9.698669e-01 7.275138e-06 FALSE TRUE
MSTRG.17149.12 ENSG00000105202 HEK293_DMSO_2hB HEK293_TMG_2hB FBL protein_coding   946.7887 556.1908 548.6775 11.90063 7.700817 -0.01962112 77.28405 93.10976 103.61090 27.781164 33.9195920 0.1541557 0.1141833 0.1676667 0.1872667 0.01960000 1.000000e+00 7.275138e-06 FALSE TRUE
MSTRG.17149.2 ENSG00000105202 HEK293_DMSO_2hB HEK293_TMG_2hB FBL protein_coding   946.7887 556.1908 548.6775 11.90063 7.700817 -0.01962112 308.25720 122.47648 137.75526 13.426624 23.4861721 0.1695896 0.2977500 0.2204667 0.2523333 0.03186667 9.367466e-01 7.275138e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_DMSO_2hB log2fold_HEK293_DMSO_2hB_HEK293_TMG_2hB
ENSG00000105202 E001 2.965946 5.954405e-03 0.8724736545   19 39834412 39834452 41 - 0.611 0.588 -0.102
ENSG00000105202 E002 5.628695 3.376390e-03 0.9061353156   19 39834453 39834457 5 - 0.812 0.829 0.068
ENSG00000105202 E003 26.118647 7.045298e-04 0.7524875187 0.98840206 19 39834458 39834459 2 - 1.443 1.424 -0.065
ENSG00000105202 E004 508.890020 3.877300e-03 0.4593639824 0.96232402 19 39834460 39834502 43 - 2.694 2.720 0.089
ENSG00000105202 E005 1480.765565 1.828973e-03 0.4001156353 0.95623509 19 39834503 39834562 60 - 3.160 3.181 0.070
ENSG00000105202 E006 17.118176 4.275066e-03 0.0531287182 0.69797760 19 39834563 39834667 105 - 1.334 1.169 -0.583
ENSG00000105202 E007 1826.023007 1.106811e-03 0.7348580702 0.98779490 19 39834668 39834690 23 - 3.257 3.266 0.027
ENSG00000105202 E008 2329.453491 4.484015e-04 0.4489823130 0.96109709 19 39834691 39834716 26 - 3.371 3.364 -0.024
ENSG00000105202 E009 3814.084232 2.782829e-04 0.2218028203 0.90704963 19 39834717 39834813 97 - 3.586 3.577 -0.030
ENSG00000105202 E010 4335.003526 4.067532e-04 0.2753701908 0.92819938 19 39836556 39836668 113 - 3.642 3.633 -0.030
ENSG00000105202 E011 4224.510287 1.902977e-04 0.2466465486 0.91675931 19 39837711 39837819 109 - 3.630 3.623 -0.023
ENSG00000105202 E012 2342.443354 4.229473e-05 0.5629545796 0.97477966 19 39837820 39837843 24 - 3.371 3.369 -0.006
ENSG00000105202 E013 13.265273 5.413819e-03 0.0004680223 0.09282397 19 39837959 39838091 133 - 1.298 0.954 -1.239
ENSG00000105202 E014 36.832905 4.891738e-04 0.0013531495 0.16614218 19 39838260 39839034 775 - 1.662 1.478 -0.627
ENSG00000105202 E015 2660.698965 3.243023e-05 0.7099004337 0.98616038 19 39839035 39839073 39 - 3.425 3.425 0.000
ENSG00000105202 E016 4368.352185 1.630523e-04 0.4215199031 0.95920724 19 39839074 39839205 132 - 3.642 3.638 -0.013
ENSG00000105202 E017 3609.543254 1.486102e-04 0.2787475480 0.93006476 19 39840233 39840327 95 - 3.561 3.554 -0.021
ENSG00000105202 E018 2447.635768 2.739798e-04 0.3015858580 0.93682027 19 39840414 39840461 48 - 3.393 3.385 -0.029
ENSG00000105202 E019 1395.528854 7.627639e-04 0.5794688245 0.97608764 19 39840462 39840470 9 - 3.139 3.150 0.037
ENSG00000105202 E020 1272.550213 1.305782e-04 0.0595100414 0.71872319 19 39840471 39840509 39 - 3.093 3.116 0.079
ENSG00000105202 E021 150.763609 4.216603e-02 0.1400095733 0.84780503 19 39840510 39840515 6 - 2.076 2.264 0.628
ENSG00000105202 E022 89.656269 2.049124e-04 0.0889184030 0.78604037 19 39840617 39840619 3 - 1.922 1.989 0.224
ENSG00000105202 E023 101.995213 1.814144e-04 0.0110246214 0.42708113 19 39840620 39840655 36 - 1.965 2.057 0.311
ENSG00000105202 E024 251.095699 3.082717e-02 0.5979483871 0.97701528 19 39840656 39840670 15 - 2.418 2.384 -0.112
ENSG00000105202 E025 267.696114 4.843920e-03 0.0290010335 0.59644519 19 39840671 39840673 3 - 2.381 2.471 0.301
ENSG00000105202 E026 494.319930 3.561625e-03 0.1893104212 0.88687379 19 39840674 39840682 9 - 2.671 2.716 0.150
ENSG00000105202 E027 974.496092 3.599846e-03 0.3034357416 0.93704487 19 39840683 39840721 39 - 2.971 3.006 0.116
ENSG00000105202 E028 1108.655477 3.128831e-03 0.4355717114 0.95967051 19 39840722 39840727 6 - 3.032 3.058 0.085
ENSG00000105202 E029 1288.218590 3.160344e-03 0.5981057893 0.97703144 19 39840728 39840787 60 - 3.101 3.119 0.061
ENSG00000105202 E030 1271.710148 3.136141e-03 0.5878118328 0.97620656 19 39846291 39846448 158 - 3.095 3.114 0.062