ENSG00000102786

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000311234 ENSG00000102786 HEK293_DMSO_2hB HEK293_TMG_2hB INTS6 protein_coding protein_coding 7.782945 11.03252 13.66806 0.3829562 0.9417128 0.3087938 0.7593428 1.13162491 1.200030 0.12240245 0.01056203 0.08395426 0.103995833 0.102300000 0.08860000 -0.01370000 0.93117503 0.03414935 FALSE  
ENST00000476666 ENSG00000102786 HEK293_DMSO_2hB HEK293_TMG_2hB INTS6 protein_coding processed_transcript 7.782945 11.03252 13.66806 0.3829562 0.9417128 0.3087938 0.6092635 0.04600787 1.154042 0.04600787 0.28200353 4.37737004 0.105866667 0.004366667 0.08613333 0.08176667 0.03414935 0.03414935 TRUE  
ENST00000483746 ENSG00000102786 HEK293_DMSO_2hB HEK293_TMG_2hB INTS6 protein_coding protein_coding 7.782945 11.03252 13.66806 0.3829562 0.9417128 0.3087938 0.1478394 0.00000000 1.182715 0.00000000 1.18271519 6.89810577 0.009545833 0.000000000 0.07636667 0.07636667 0.94023116 0.03414935 FALSE  
ENST00000497989 ENSG00000102786 HEK293_DMSO_2hB HEK293_TMG_2hB INTS6 protein_coding protein_coding 7.782945 11.03252 13.66806 0.3829562 0.9417128 0.3087938 2.7784631 3.87014896 4.780815 0.49911106 0.27743130 0.30415896 0.366620833 0.348533333 0.35113333 0.00260000 1.00000000 0.03414935 FALSE  
MSTRG.8775.2 ENSG00000102786 HEK293_DMSO_2hB HEK293_TMG_2hB INTS6 protein_coding   7.782945 11.03252 13.66806 0.3829562 0.9417128 0.3087938 2.4599966 5.06193733 4.362013 0.27270137 0.59610006 -0.21423915 0.264429167 0.461333333 0.32706667 -0.13426667 0.83401480 0.03414935 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_DMSO_2hB log2fold_HEK293_DMSO_2hB_HEK293_TMG_2hB
ENSG00000102786 E001 2.3235188 0.0081961459 0.9526299550   13 51335646 51335702 57 - 0.516 0.526 0.047
ENSG00000102786 E002 0.8455976 0.0170772000 0.6851056773   13 51337933 51338011 79 - 0.296 0.224 -0.537
ENSG00000102786 E003 0.8598889 0.1586784833 0.2107600713   13 51346402 51346423 22 - 0.122 0.373 2.062
ENSG00000102786 E004 0.8598889 0.1586784833 0.2107600713   13 51346424 51346453 30 - 0.122 0.373 2.062
ENSG00000102786 E005 3.8244544 0.0053750810 0.0076087624   13 51354077 51354172 96 - 0.836 0.428 -1.801
ENSG00000102786 E006 2.6680887 0.0065539606 0.0020933983   13 51354173 51354176 4 - 0.745 0.223 -2.761
ENSG00000102786 E007 7.3558888 0.0275355112 0.0362045837   13 51354177 51354336 160 - 1.045 0.755 -1.106
ENSG00000102786 E008 0.1730468 0.0402816141 0.5011585625   13 51361565 51361576 12 - 0.122 0.000 -10.142
ENSG00000102786 E009 105.8310885 0.0021155539 0.7761591277 0.99033697 13 51361577 51365198 3622 - 2.034 2.025 -0.032
ENSG00000102786 E010 2.6264534 0.0067680312 0.1516801820   13 51365199 51365227 29 - 0.661 0.428 -1.091
ENSG00000102786 E011 36.0238214 0.0006632839 0.0556690870 0.70687935 13 51365228 51365502 275 - 1.620 1.509 -0.380
ENSG00000102786 E012 46.6180656 0.0004760291 0.4555635121 0.96208940 13 51365503 51365702 200 - 1.695 1.657 -0.128
ENSG00000102786 E013 29.8670262 0.0009214362 0.2990875220 0.93598876 13 51365703 51365735 33 - 1.522 1.456 -0.226
ENSG00000102786 E014 52.5781600 0.0010167297 0.0502116419 0.68819551 13 51365736 51365845 110 - 1.773 1.676 -0.329
ENSG00000102786 E015 65.6655549 0.0002949680 0.8517267928 0.99438362 13 51367805 51367898 94 - 1.827 1.819 -0.026
ENSG00000102786 E016 172.4326317 0.0001308976 0.1225350302 0.83218652 13 51368939 51369310 372 - 2.258 2.218 -0.134
ENSG00000102786 E017 132.7156803 0.0002017167 0.3107514465 0.93874845 13 51374208 51374439 232 - 2.110 2.141 0.104
ENSG00000102786 E018 108.1628645 0.0001791856 0.5761265530 0.97604378 13 51374654 51374796 143 - 2.029 2.048 0.064
ENSG00000102786 E019 111.4588288 0.0007844127 0.5920855455 0.97673088 13 51376048 51376174 127 - 2.043 2.062 0.063
ENSG00000102786 E020 132.8432071 0.0030677059 0.5154770368 0.96956294 13 51378239 51378454 216 - 2.115 2.139 0.082
ENSG00000102786 E021 64.5997230 0.0003230622 0.6562093401 0.98288839 13 51379462 51379508 47 - 1.825 1.806 -0.064
ENSG00000102786 E022 57.9175130 0.0003278259 0.7694163727 0.98990885 13 51379509 51379541 33 - 1.775 1.762 -0.044
ENSG00000102786 E023 62.9071283 0.0004289287 0.5097559958 0.96934669 13 51379542 51379572 31 - 1.789 1.819 0.100
ENSG00000102786 E024 91.2244066 0.0015724311 0.7464011972 0.98807258 13 51382029 51382123 95 - 1.969 1.957 -0.042
ENSG00000102786 E025 106.4506466 0.0034391019 0.5378185453 0.97255154 13 51383329 51383461 133 - 2.043 2.018 -0.085
ENSG00000102786 E026 0.6080851 0.3999308631 0.5089368425   13 51383462 51383588 127 - 0.123 0.296 1.581
ENSG00000102786 E027 106.2187735 0.0018541271 0.2550767514 0.91919177 13 51383589 51383741 153 - 2.051 2.008 -0.144
ENSG00000102786 E028 1.2983024 0.3609992087 0.5497920520   13 51383742 51384372 631 - 0.298 0.424 0.750
ENSG00000102786 E029 1.1542747 0.4735292390 0.9967884736   13 51384373 51384636 264 - 0.365 0.299 -0.409
ENSG00000102786 E030 0.6631683 0.0331636415 0.9769293631   13 51384637 51384707 71 - 0.218 0.223 0.045
ENSG00000102786 E031 2.2726529 0.0074405821 0.9550517320   13 51384744 51385264 521 - 0.516 0.525 0.046
ENSG00000102786 E032 99.1438386 0.0001829553 0.6103107782 0.97910948 13 51387386 51387540 155 - 1.991 2.010 0.061
ENSG00000102786 E033 84.8645784 0.0002151606 0.3077008795 0.93743962 13 51389319 51389444 126 - 1.914 1.953 0.131
ENSG00000102786 E034 0.5104425 0.0224574521 0.5860739636   13 51395299 51395299 1 - 0.218 0.126 -0.953
ENSG00000102786 E035 90.5042959 0.0002118844 0.9822368332 0.99903573 13 51395300 51395483 184 - 1.960 1.961 0.004
ENSG00000102786 E036 0.0000000       13 51402529 51402803 275 -      
ENSG00000102786 E037 2.7996262 0.1195952012 0.5221531962   13 51421112 51421175 64 - 0.515 0.641 0.571
ENSG00000102786 E038 3.6621690 0.0537933822 0.2265566499   13 51421176 51421334 159 - 0.556 0.759 0.866
ENSG00000102786 E039 0.0000000       13 51421335 51421374 40 -      
ENSG00000102786 E040 0.1694011 0.0402066648 0.5015276502   13 51423003 51423029 27 - 0.122 0.000 -10.141
ENSG00000102786 E041 0.6558768 0.0223894598 0.9753425750   13 51423030 51423090 61 - 0.218 0.223 0.046
ENSG00000102786 E042 0.0000000       13 51430235 51430293 59 -      
ENSG00000102786 E043 35.0886948 0.0005059291 0.5544692056 0.97375634 13 51430294 51430304 11 - 1.574 1.540 -0.117
ENSG00000102786 E044 46.2016074 0.0004157537 0.5763021774 0.97608764 13 51430305 51430383 79 - 1.659 1.688 0.098
ENSG00000102786 E045 49.3411711 0.0037094248 0.3294465273 0.94432471 13 51436426 51451024 14599 - 1.725 1.670 -0.186
ENSG00000102786 E046 54.4461583 0.0037054482 0.6401741628 0.98141466 13 51451025 51451174 150 - 1.733 1.757 0.083
ENSG00000102786 E047 0.0000000       13 51451309 51451421 113 -      
ENSG00000102786 E048 0.0000000       13 51451422 51451496 75 -      
ENSG00000102786 E049 0.0000000       13 51451497 51451574 78 -      
ENSG00000102786 E050 47.9253160 0.0005397951 0.7107872440 0.98617859 13 51451978 51452055 78 - 1.698 1.679 -0.063
ENSG00000102786 E051 3.0409379 0.0375518067 0.2230031684   13 51452056 51452250 195 - 0.691 0.481 -0.951
ENSG00000102786 E052 0.3414630 0.0294491581 0.9810593189   13 51452251 51452414 164 - 0.122 0.126 0.047
ENSG00000102786 E053 49.9071674 0.0004056006 0.4660039451 0.96303098 13 51452415 51452500 86 - 1.689 1.725 0.123
ENSG00000102786 E054 93.3194323 0.0026702589 0.0016713953 0.18532231 13 51452501 51452992 492 - 1.902 2.038 0.457
ENSG00000102786 E055 26.3593174 0.0007040358 0.0001795557 0.05255653 13 51452993 51453283 291 - 1.291 1.548 0.886
ENSG00000102786 E056 0.0000000       13 51453523 51453592 70 -      
ENSG00000102786 E057 0.1720618 0.0404692667 0.4730275504   13 51454061 51454264 204 - 0.000 0.126 10.286