ENSG00000100614

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000325658 ENSG00000100614 HEK293_DMSO_2hB HEK293_TMG_2hB PPM1A protein_coding protein_coding 10.57246 17.49735 18.36707 1.369405 0.07390767 0.06994613 1.3482454 2.0241444 2.101043 0.19205898 0.01874299 0.05353385 0.12068333 0.11760000 0.1144000 -0.00320000 1.00000000 0.03347341 FALSE TRUE
ENST00000395076 ENSG00000100614 HEK293_DMSO_2hB HEK293_TMG_2hB PPM1A protein_coding protein_coding 10.57246 17.49735 18.36707 1.369405 0.07390767 0.06994613 2.5693162 4.1561172 4.417871 0.07534546 0.29019466 0.08790974 0.25958333 0.24100000 0.2406000 -0.00040000 1.00000000 0.03347341 FALSE TRUE
ENST00000525399 ENSG00000100614 HEK293_DMSO_2hB HEK293_TMG_2hB PPM1A protein_coding protein_coding 10.57246 17.49735 18.36707 1.369405 0.07390767 0.06994613 4.8655631 8.3492863 6.631836 0.46065278 0.16591664 -0.33179761 0.45845000 0.47936667 0.3611333 -0.11823333 0.03347341 0.03347341 FALSE TRUE
ENST00000528241 ENSG00000100614 HEK293_DMSO_2hB HEK293_TMG_2hB PPM1A protein_coding protein_coding 10.57246 17.49735 18.36707 1.369405 0.07390767 0.06994613 0.7234702 1.8481696 2.156520 0.93452224 0.89942744 0.22149753 0.05075833 0.09803333 0.1176333 0.01960000 0.97604940 0.03347341 FALSE FALSE
ENST00000531937 ENSG00000100614 HEK293_DMSO_2hB HEK293_TMG_2hB PPM1A protein_coding protein_coding 10.57246 17.49735 18.36707 1.369405 0.07390767 0.06994613 0.3217849 0.2772806 2.068198 0.27728055 1.09579439 2.85480095 0.02424167 0.01460000 0.1122333 0.09763333 0.93117503 0.03347341 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_DMSO_2hB log2fold_HEK293_DMSO_2hB_HEK293_TMG_2hB
ENSG00000100614 E001 0.0000000       14 60245752 60245756 5 +      
ENSG00000100614 E002 0.0000000       14 60245757 60245784 28 +      
ENSG00000100614 E003 0.0000000       14 60245785 60246046 262 +      
ENSG00000100614 E004 1.8447562 0.0095096598 0.7555082389   14 60248096 60249220 1125 + 0.477 0.423 -0.279
ENSG00000100614 E005 6.3526216 0.0071622431 0.0218668698   14 60249221 60249367 147 + 0.699 0.995 1.151
ENSG00000100614 E006 20.2019931 0.0105763089 0.2952561283 0.93558819 14 60249368 60249419 52 + 1.278 1.370 0.320
ENSG00000100614 E007 24.5225791 0.0042477797 0.2436136515 0.91485267 14 60249420 60249440 21 + 1.361 1.447 0.299
ENSG00000100614 E008 47.8006449 0.0003890358 0.0077354585 0.37388810 14 60249441 60249575 135 + 1.616 1.750 0.457
ENSG00000100614 E009 41.8493064 0.0009961014 0.0212812237 0.53998223 14 60249576 60249629 54 + 1.564 1.691 0.432
ENSG00000100614 E010 45.7718780 0.0016044104 0.1033884274 0.80932857 14 60249630 60249659 30 + 1.623 1.711 0.299
ENSG00000100614 E011 46.9925527 0.0014384421 0.2968555777 0.93569664 14 60249660 60249677 18 + 1.653 1.708 0.187
ENSG00000100614 E012 4.7135701 0.0049048979 0.2121482542   14 60250380 60250430 51 + 0.669 0.840 0.693
ENSG00000100614 E013 6.7064459 0.0032963330 0.4222299818   14 60250431 60250481 51 + 0.937 0.840 -0.371
ENSG00000100614 E014 1.0037899 0.0150654657 0.0906682548   14 60256762 60256866 105 + 0.426 0.124 -2.338
ENSG00000100614 E015 1.5260122 0.1636246280 0.4719615665   14 60259954 60260010 57 + 0.479 0.298 -1.024
ENSG00000100614 E016 1.4972635 0.0105565885 0.0937403964   14 60266692 60266735 44 + 0.222 0.519 1.791
ENSG00000100614 E017 0.6959536 0.5118836080 0.5576695658   14 60266882 60266955 74 + 0.125 0.304 1.598
ENSG00000100614 E018 3.8094297 0.0047123723 0.0647022088   14 60267215 60267261 47 + 0.523 0.797 1.176
ENSG00000100614 E019 2.1954580 0.0296202192 0.1878160467   14 60267262 60267291 30 + 0.368 0.599 1.159
ENSG00000100614 E020 11.2219399 0.0198543986 0.7386060853 0.98805564 14 60268293 60268435 143 + 1.067 1.108 0.151
ENSG00000100614 E021 14.7418481 0.0013778997 0.0423946378 0.65819322 14 60277005 60277091 87 + 1.102 1.281 0.635
ENSG00000100614 E022 4.2338319 0.1699424935 0.4706006824   14 60277313 60277365 53 + 0.637 0.793 0.641
ENSG00000100614 E023 123.8510949 0.0001885390 0.8575011879 0.99482428 14 60282684 60282794 111 + 2.099 2.093 -0.021
ENSG00000100614 E024 307.3138153 0.0001051029 0.5298595632 0.97112419 14 60282795 60283147 353 + 2.496 2.483 -0.042
ENSG00000100614 E025 324.9854755 0.0000808429 0.1711767035 0.87461005 14 60283148 60283537 390 + 2.501 2.526 0.083
ENSG00000100614 E026 175.6488283 0.0001288849 0.5616976993 0.97442064 14 60285624 60285741 118 + 2.254 2.238 -0.052
ENSG00000100614 E027 128.4559227 0.0023124743 0.6658009089 0.98377399 14 60285742 60288555 2814 + 2.121 2.105 -0.053
ENSG00000100614 E028 141.6949796 0.0001738281 0.8999710799 0.99638518 14 60289806 60289914 109 + 2.152 2.155 0.010
ENSG00000100614 E029 121.8235649 0.0001551229 0.8785706171 0.99568968 14 60291397 60291454 58 + 2.087 2.091 0.014
ENSG00000100614 E030 713.8736340 0.0001453100 0.0001730037 0.05112853 14 60292453 60299087 6635 + 2.876 2.831 -0.149