ENSG00000090621

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372856 ENSG00000090621 HEK293_DMSO_2hB HEK293_TMG_2hB PABPC4 protein_coding protein_coding 159.8563 137.3074 139.9366 2.048373 2.370139 0.02736173 9.295823 5.374969 11.668091 3.413790 0.8904123 1.11679457 0.05489167 0.03950000 0.08356667 0.0440666667 9.311750e-01 4.090551e-23 FALSE TRUE
ENST00000372857 ENSG00000090621 HEK293_DMSO_2hB HEK293_TMG_2hB PABPC4 protein_coding protein_coding 159.8563 137.3074 139.9366 2.048373 2.370139 0.02736173 17.406747 25.293622 25.938215 2.157748 2.9446773 0.03629141 0.11452917 0.18433333 0.18480000 0.0004666667 1.000000e+00 4.090551e-23 FALSE TRUE
ENST00000372858 ENSG00000090621 HEK293_DMSO_2hB HEK293_TMG_2hB PABPC4 protein_coding protein_coding 159.8563 137.3074 139.9366 2.048373 2.370139 0.02736173 4.420677 11.215859 0.000000 2.789025 0.0000000 -10.13261014 0.02616667 0.08170000 0.00000000 -0.0817000000 4.090551e-23 4.090551e-23 FALSE TRUE
ENST00000372862 ENSG00000090621 HEK293_DMSO_2hB HEK293_TMG_2hB PABPC4 protein_coding protein_coding 159.8563 137.3074 139.9366 2.048373 2.370139 0.02736173 15.837773 15.426107 13.716109 0.964953 1.3478653 -0.16938630 0.10030833 0.11220000 0.09790000 -0.0143000000 9.311750e-01 4.090551e-23 FALSE TRUE
ENST00000421687 ENSG00000090621 HEK293_DMSO_2hB HEK293_TMG_2hB PABPC4 protein_coding protein_coding 159.8563 137.3074 139.9366 2.048373 2.370139 0.02736173 8.886585 15.143363 12.239020 2.859748 1.3428544 -0.30697169 0.06093750 0.11000000 0.08720000 -0.0228000000 9.311750e-01 4.090551e-23 FALSE TRUE
ENST00000676523 ENSG00000090621 HEK293_DMSO_2hB HEK293_TMG_2hB PABPC4 protein_coding retained_intron 159.8563 137.3074 139.9366 2.048373 2.370139 0.02736173 9.084194 9.005775 10.789048 0.145318 0.4129288 0.26038072 0.06247083 0.06563333 0.07726667 0.0116333333 8.558478e-01 4.090551e-23 TRUE TRUE
ENST00000678625 ENSG00000090621 HEK293_DMSO_2hB HEK293_TMG_2hB PABPC4 protein_coding protein_coding 159.8563 137.3074 139.9366 2.048373 2.370139 0.02736173 10.847003 10.123603 8.912525 2.413481 2.4264879 -0.18362332 0.06532500 0.07393333 0.06360000 -0.0103333333 9.636082e-01 4.090551e-23 FALSE TRUE
MSTRG.918.6 ENSG00000090621 HEK293_DMSO_2hB HEK293_TMG_2hB PABPC4 protein_coding   159.8563 137.3074 139.9366 2.048373 2.370139 0.02736173 24.320665 4.328950 6.676746 2.658129 2.7538649 0.62395835 0.13837500 0.03113333 0.04783333 0.0167000000 9.325351e-01 4.090551e-23 FALSE TRUE
MSTRG.918.7 ENSG00000090621 HEK293_DMSO_2hB HEK293_TMG_2hB PABPC4 protein_coding   159.8563 137.3074 139.9366 2.048373 2.370139 0.02736173 13.987802 7.987236 16.208962 3.419962 0.3436343 1.02010816 0.09003750 0.05886667 0.11593333 0.0570666667 7.167347e-01 4.090551e-23 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_DMSO_2hB log2fold_HEK293_DMSO_2hB_HEK293_TMG_2hB
ENSG00000090621 E001 1.3166534 1.153588e-02 1.629988e-01   1 39560709 39560813 105 - 0.223 0.471 1.548
ENSG00000090621 E002 0.4913768 2.235198e-02 8.724279e-02   1 39560814 39560815 2 - 0.000 0.297 10.232
ENSG00000090621 E003 1.1824293 1.358674e-02 2.685625e-01   1 39560816 39560820 5 - 0.223 0.421 1.286
ENSG00000090621 E004 33.5076645 5.224532e-04 3.220133e-01 0.9419028209 1 39560821 39560836 16 - 1.567 1.506 -0.208
ENSG00000090621 E005 73.4174687 2.492896e-04 2.815256e-01 0.9314676791 1 39560837 39560844 8 - 1.893 1.847 -0.154
ENSG00000090621 E006 86.0493826 2.377968e-04 3.036399e-01 0.9370816140 1 39560845 39560856 12 - 1.958 1.918 -0.137
ENSG00000090621 E007 88.8229447 2.670550e-04 3.299244e-01 0.9443447064 1 39560857 39560857 1 - 1.971 1.933 -0.128
ENSG00000090621 E008 863.0559880 5.763935e-05 6.329080e-03 0.3445158349 1 39560858 39561122 265 - 2.953 2.918 -0.116
ENSG00000090621 E009 31.1725746 4.486381e-03 6.770098e-01 0.9843509127 1 39561123 39561273 151 - 1.494 1.523 0.099
ENSG00000090621 E010 58.8340345 3.659585e-02 4.789354e-01 0.9653100666 1 39561274 39561551 278 - 1.813 1.738 -0.254
ENSG00000090621 E011 39.0570764 7.025081e-03 6.131283e-01 0.9794328556 1 39561552 39561684 133 - 1.619 1.583 -0.123
ENSG00000090621 E012 410.9184060 6.706175e-05 3.024392e-03 0.2460167175 1 39561685 39561686 2 - 2.641 2.587 -0.179
ENSG00000090621 E013 528.1621554 5.120401e-05 2.186107e-01 0.9052229245 1 39561687 39561727 41 - 2.734 2.713 -0.067
ENSG00000090621 E014 554.8389702 5.238394e-05 8.630494e-01 0.9951408077 1 39561728 39561787 60 - 2.747 2.743 -0.013
ENSG00000090621 E015 35.9958123 5.949158e-04 5.278560e-01 0.9708907786 1 39561788 39562072 285 - 1.586 1.548 -0.130
ENSG00000090621 E016 752.6762406 5.099052e-05 4.044413e-01 0.9567822613 1 39562073 39562203 131 - 2.872 2.882 0.033
ENSG00000090621 E017 505.9388579 1.566925e-04 4.634707e-02 0.6748320654 1 39562323 39562380 58 - 2.689 2.721 0.107
ENSG00000090621 E018 322.6402366 1.259006e-04 1.503717e-01 0.8563833817 1 39562381 39562383 3 - 2.496 2.524 0.094
ENSG00000090621 E019 392.9628124 7.428180e-05 2.998942e-02 0.6021704556 1 39562384 39562416 33 - 2.576 2.614 0.127
ENSG00000090621 E020 140.7162397 2.868009e-03 1.077355e-02 0.4239665120 1 39562417 39563445 1029 - 2.199 2.097 -0.342
ENSG00000090621 E021 22.2833056 2.595348e-03 2.325280e-01 0.9111891139 1 39563446 39563526 81 - 1.412 1.321 -0.316
ENSG00000090621 E022 23.9941465 1.128502e-02 1.602491e-01 0.8649007861 1 39563527 39563613 87 - 1.455 1.333 -0.422
ENSG00000090621 E023 256.3342556 9.658930e-05 9.216914e-03 0.4016693578 1 39563614 39563615 2 - 2.380 2.438 0.191
ENSG00000090621 E024 647.7124114 6.539471e-04 4.390949e-03 0.2930226964 1 39563616 39563741 126 - 2.785 2.837 0.173
ENSG00000090621 E025 66.1647871 5.502652e-03 1.157115e-01 0.8238291029 1 39563742 39563795 54 - 1.868 1.778 -0.302
ENSG00000090621 E026 70.7721668 1.771023e-03 7.485506e-02 0.7578612257 1 39563796 39563832 37 - 1.895 1.811 -0.281
ENSG00000090621 E027 59.2253887 2.017693e-03 2.671290e-01 0.9246567490 1 39563833 39563835 3 - 1.807 1.750 -0.191
ENSG00000090621 E028 560.6347281 9.495300e-04 6.391078e-02 0.7337317618 1 39563836 39563922 87 - 2.730 2.768 0.127
ENSG00000090621 E029 130.5437603 4.674642e-03 1.308445e-02 0.4579067075 1 39563923 39564232 310 - 2.172 2.058 -0.383
ENSG00000090621 E030 83.5684799 4.532395e-03 6.406275e-02 0.7339343120 1 39564233 39564384 152 - 1.973 1.877 -0.320
ENSG00000090621 E031 49.5434461 3.231439e-03 9.094380e-01 0.9966459667 1 39564385 39564422 38 - 1.701 1.707 0.020
ENSG00000090621 E032 421.5429483 8.983741e-04 6.973426e-02 0.7461099116 1 39564423 39564470 48 - 2.606 2.646 0.134
ENSG00000090621 E033 701.0677679 9.148747e-05 1.497758e-01 0.8557657755 1 39564471 39564542 72 - 2.837 2.856 0.063
ENSG00000090621 E034 16.2663599 7.505565e-02 2.068205e-01 0.8983185662 1 39564543 39564685 143 - 1.324 1.133 -0.676
ENSG00000090621 E035 444.0430128 5.247740e-04 1.453948e-01 0.8517583565 1 39564686 39564700 15 - 2.635 2.663 0.094
ENSG00000090621 E036 817.3611495 8.326324e-05 2.044679e-01 0.8971597491 1 39564701 39564773 73 - 2.906 2.921 0.051
ENSG00000090621 E037 14.8482753 3.363085e-02 6.297604e-02 0.7301739824 1 39564774 39565001 228 - 1.303 1.069 -0.831
ENSG00000090621 E038 1348.5900480 3.570192e-05 4.521196e-01 0.9617805370 1 39565106 39565298 193 - 3.127 3.133 0.021
ENSG00000090621 E039 798.6789048 4.806048e-05 3.463625e-01 0.9491143755 1 39565299 39565366 68 - 2.898 2.908 0.036
ENSG00000090621 E040 493.4172034 7.789945e-04 8.757785e-01 0.9956597810 1 39565367 39565378 12 - 2.697 2.692 -0.015
ENSG00000090621 E041 13.8363145 1.386775e-03 9.183455e-01 0.9970411388 1 39565379 39565395 17 - 1.178 1.168 -0.037
ENSG00000090621 E042 13.7936360 1.328116e-03 1.320412e-01 0.8415764878 1 39567357 39567373 17 - 1.233 1.095 -0.492
ENSG00000090621 E043 35.8247863 2.180882e-03 1.730091e-01 0.8762960881 1 39567374 39567750 377 - 1.605 1.519 -0.292
ENSG00000090621 E044 964.7475492 1.077119e-03 7.413895e-01 0.9880725824 1 39567751 39567846 96 - 2.989 2.981 -0.026
ENSG00000090621 E045 87.0088702 2.177009e-03 1.201320e-06 0.0018979558 1 39567847 39568676 830 - 2.039 1.822 -0.729
ENSG00000090621 E046 15.4617298 1.192317e-03 2.394784e-02 0.5616985517 1 39568677 39568697 21 - 1.303 1.106 -0.700
ENSG00000090621 E047 29.5454529 8.528171e-04 5.210586e-04 0.0989434779 1 39568698 39568801 104 - 1.582 1.354 -0.787
ENSG00000090621 E048 725.8661123 1.207062e-03 2.998902e-02 0.6021704556 1 39568802 39568824 23 - 2.884 2.837 -0.158
ENSG00000090621 E049 805.7960978 6.709349e-04 2.610501e-03 0.2288219077 1 39568825 39568861 37 - 2.933 2.879 -0.180
ENSG00000090621 E050 1130.5324037 5.783632e-04 3.454563e-02 0.6240380817 1 39568862 39568939 78 - 3.070 3.036 -0.111
ENSG00000090621 E051 8.8127211 7.232789e-03 4.442109e-03   1 39569495 39569594 100 - 1.127 0.794 -1.248
ENSG00000090621 E052 1158.1992725 9.401276e-04 2.383841e-01 0.9123084292 1 39569595 39569689 95 - 3.075 3.053 -0.072
ENSG00000090621 E053 1303.1314660 3.041875e-04 5.958929e-01 0.9768658229 1 39569863 39570002 140 - 3.112 3.118 0.019
ENSG00000090621 E054 114.4696902 5.250496e-04 3.094533e-01 0.9381862005 1 39571097 39571233 137 - 2.080 2.044 -0.121
ENSG00000090621 E055 1140.3701297 5.174061e-05 8.562631e-01 0.9946860932 1 39571234 39571349 116 - 3.057 3.058 0.003
ENSG00000090621 E056 2.1560883 4.430685e-02 1.949728e-01   1 39571607 39571705 99 - 0.603 0.363 -1.202
ENSG00000090621 E057 1212.5388942 1.152588e-04 3.213024e-01 0.9417499248 1 39572393 39572586 194 - 3.079 3.089 0.033
ENSG00000090621 E058 12.0545298 3.157058e-03 4.254750e-02 0.6587869836 1 39572587 39575095 2509 - 1.207 1.006 -0.722
ENSG00000090621 E059 0.9859791 5.304770e-02 1.109082e-01   1 39575632 39575686 55 - 0.126 0.421 2.284
ENSG00000090621 E060 663.3035082 1.487546e-03 1.331331e-01 0.8424924240 1 39575759 39575937 179 - 2.805 2.840 0.114
ENSG00000090621 E061 657.6515167 3.914150e-04 2.847324e-07 0.0006108355 1 39575938 39576223 286 - 2.774 2.858 0.281
ENSG00000090621 E062 269.9864289 8.516123e-04 2.228977e-01 0.9079240051 1 39576224 39576233 10 - 2.417 2.447 0.100
ENSG00000090621 E063 504.9479315 2.612243e-03 1.937124e-01 0.8898052618 1 39576234 39576551 318 - 2.684 2.722 0.125
ENSG00000090621 E064 267.7315567 7.284592e-03 7.598049e-01 0.9890715940 1 39576552 39576861 310 - 2.421 2.437 0.051